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Protein

60S ribosomal protein L5

Gene

rpl-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-CEL-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-CEL-72689. Formation of a pool of free 40S subunits.
R-CEL-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-CEL-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-CEL-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L5
Gene namesi
Name:rpl-5
ORF Names:F54C9.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF54C9.5; CE02255; WBGene00004416; rpl-5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001314431 – 29360S ribosomal protein L5Add BLAST293

Proteomic databases

EPDiP49405.
PaxDbiP49405.
PeptideAtlasiP49405.
PRIDEiP49405.

PTM databases

iPTMnetiP49405.

Expressioni

Gene expression databases

BgeeiWBGene00004416.

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU).By similarity

Protein-protein interaction databases

BioGridi39699. 5 interactors.
DIPiDIP-24622N.
IntActiP49405. 6 interactors.
MINTiMINT-1106928.
STRINGi6239.F54C9.5.1.

Structurei

3D structure databases

ProteinModelPortaliP49405.
SMRiP49405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0875. Eukaryota.
COG0256. LUCA.
GeneTreeiENSGT00390000008456.
HOGENOMiHOG000105947.
InParanoidiP49405.
KOiK02932.
OMAiVAEYMES.
OrthoDBiEOG091G0GZO.
PhylomeDBiP49405.

Family and domain databases

HAMAPiMF_01337_A. Ribosomal_L18_A. 1 hit.
InterProiView protein in InterPro
IPR005485. Rbsml_L5_euk/L18_arc.
IPR025607. Rbsml_L5e/L18P_C.
PANTHERiPTHR23410. PTHR23410. 1 hit.
PfamiView protein in Pfam
PF14204. Ribosomal_L18_c. 1 hit.
PF17144. Ribosomal_L5e. 1 hit.
PRINTSiPR00058. RIBOSOMALL5.

Sequencei

Sequence statusi: Complete.

P49405-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLVKVIKNK AYFKRYQVKL RRRREGKTDY YARKRLTVQD KNKYNTPKYR
60 70 80 90 100
LIVRITNKDV VAQLAYSKIE GDVVVASAYS HELPRYGLKV GLTNYAAAYA
110 120 130 140 150
TGLLLARRHL KTIGLDSTYK GHEELTGEDY NVEEEGDRAP FKAVLDIGLA
160 170 180 190 200
RTTTGSKIFA VMKGVADGGI NVPHSESRFF GFDQESKEYN AEAHRDRILG
210 220 230 240 250
KHVADYMTYL KEEDEDRYKR QFSKFLAAGL NADNLVATYQ KVHSAIRADA
260 270 280 290
SPAAKKAAKP SKRHTAKRLT YDERKQRVAD KKALLLQLKE QQE
Length:293
Mass (Da):33,386
Last modified:February 1, 1996 - v1
Checksum:iF55F3D333BA6D3FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49967 Genomic DNA. Translation: CAA90251.1.
PIRiT22631.
RefSeqiNP_495811.1. NM_063410.4.
UniGeneiCel.23311.

Genome annotation databases

EnsemblMetazoaiF54C9.5; F54C9.5; WBGene00004416.
GeneIDi174371.
KEGGicel:CELE_F54C9.5.
UCSCiF54C9.5.1. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiRL5_CAEEL
AccessioniPrimary (citable) accession number: P49405
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 27, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families