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Protein

Alcohol dehydrogenase 4, mitochondrial

Gene

ADH4

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi71Zinc 1; catalyticBy similarity1
Metal bindingi94Zinc 1; catalyticBy similarity1
Metal bindingi125Zinc 2By similarity1
Metal bindingi128Zinc 2By similarity1
Metal bindingi131Zinc 2By similarity1
Metal bindingi139Zinc 2By similarity1
Metal bindingi181Zinc 1; catalyticBy similarity1
Binding sitei229NADBy similarity1
Binding sitei234NADBy similarity1
Binding sitei368NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi205 – 211NADBy similarity7
Nucleotide bindingi296 – 298NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 4, mitochondrial (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase IV
Gene namesi
Name:ADH4
Ordered Locus Names:KLLA0F13530g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome F

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionSequence analysisAdd BLAST27
ChainiPRO_000000087828 – 375Alcohol dehydrogenase 4, mitochondrialAdd BLAST348

Proteomic databases

PRIDEiP49385.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi284590.XP_455689.1.

Structurei

3D structure databases

ProteinModelPortaliP49385.
SMRiP49385.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0023. Eukaryota.
COG1064. LUCA.
HOGENOMiHOG000294685.
InParanoidiP49385.
KOiK13953.
OMAiRKGAFPH.
OrthoDBiEOG092C2Q8E.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49385-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRLARAQTA LANKASVSRS FLRLNSSFAI PETQKGVIFY ENGGKLEYKD
60 70 80 90 100
LPVPKPKANE ILINVKYSGV CHTDLHAWKG DWPLPVKLPL VGGHEGAGIV
110 120 130 140 150
VAKGENVKNF EIGDYAGIKW LNGSCMSCEL CEQGYESNCL QADLSGYTHD
160 170 180 190 200
GSFQQYATAD AVQAAQIPKG TDLAEIAPIL CAGVTVYKAL KTADLKPGQW
210 220 230 240 250
VAISGAAGGL GSLAVQYAKA MGLRVLGIDG GDGKEELFKQ CGGEVFIDFR
260 270 280 290 300
KSKDMVADIQ EATNGGPHGV INVSVSEAAI SMSTEYVRPT GVVVLVGLPA
310 320 330 340 350
DAYVKSEVFS HVVKSISIKG SYVGNRADTR EATDFFTRGL VKSPIKIIGL
360 370
SELPEAYELM EQGKILGRFV VDTYK
Length:375
Mass (Da):40,163
Last modified:August 31, 2004 - v2
Checksum:i14E66B615564F756
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti157A → R in CAA44614 (PubMed:1872030).Curated1
Sequence conflicti218A → R in CAA44614 (PubMed:1872030).Curated1
Sequence conflicti280I → V in CAA44614 (PubMed:1872030).Curated1
Sequence conflicti287V → L in CAA44614 (PubMed:1872030).Curated1
Sequence conflicti292V → L in CAA44614 (PubMed:1872030).Curated1
Sequence conflicti335F → L in CAA44614 (PubMed:1872030).Curated1
Sequence conflicti358E → A in CAA44614 (PubMed:1872030).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62767 Genomic DNA. Translation: CAA44614.1.
CR382126 Genomic DNA. Translation: CAG98397.1.
PIRiS17253.
RefSeqiXP_455689.1. XM_455689.1.

Genome annotation databases

EnsemblFungiiCAG98397; CAG98397; KLLA0_F13530g.
GeneIDi2894943.
KEGGikla:KLLA0F13530g.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiADH4_KLULA
AccessioniPrimary (citable) accession number: P49385
Secondary accession number(s): Q6CK50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: August 31, 2004
Last modified: June 7, 2017
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families