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Protein

Alcohol dehydrogenase 3, mitochondrial

Gene

ADH3

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi70Zinc 1; catalyticBy similarity1
Metal bindingi93Zinc 1; catalyticBy similarity1
Metal bindingi124Zinc 2By similarity1
Metal bindingi127Zinc 2By similarity1
Metal bindingi130Zinc 2By similarity1
Metal bindingi138Zinc 2By similarity1
Metal bindingi180Zinc 1; catalyticBy similarity1
Binding sitei228NADBy similarity1
Binding sitei233NADBy similarity1
Binding sitei367NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi204 – 210NADBy similarity7
Nucleotide bindingi295 – 297NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BRENDAi1.1.1.2. 2825.
SABIO-RKiP49384.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 3, mitochondrial (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase III
Gene namesi
Name:ADH3
Ordered Locus Names:KLLA0B09064g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome B

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 26MitochondrionSequence analysisAdd BLAST26
ChainiPRO_000000087727 – 374Alcohol dehydrogenase 3, mitochondrialAdd BLAST348

Proteomic databases

PRIDEiP49384.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi284590.XP_451932.1.

Structurei

3D structure databases

ProteinModelPortaliP49384.
SMRiP49384.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0023. Eukaryota.
COG1064. LUCA.
HOGENOMiHOG000294685.
InParanoidiP49384.
KOiK13953.
OMAiNEHFAIM.
OrthoDBiEOG092C2Q8E.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49384-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLTSARSI VSPLRKGAFG SIRTLATSVP ETQKGVIFYE NGGKLEYKDI
60 70 80 90 100
PVPKPKPNEI LINVKYSGVC HTDLHAWKGD WPLPTKLPLV GGHEGAGVVV
110 120 130 140 150
AMGENVKGWN IGDFAGIKWL NGSCMSCEYC ELSNESNCPD ADLSGYTHDG
160 170 180 190 200
SFQQYATADA VQAARIPKGT DLAEVAPILC AGVTVYKALK SANLKAGDWV
210 220 230 240 250
AISGAAGGLG SLAVQYAKAM GYRVVGIDGG EEKGKLVKQL GGEAFVDFTK
260 270 280 290 300
TKDMVAEIQE ITNGGPHGVI NVSVSEAAMN ASTQFVRPTG TVVLVGLPAG
310 320 330 340 350
AVIKSEVFSH VVKSINIKGS YVGNRADTRE AINFFANGHV HSPIKVVGLS
360 370
ELPKVYELME QGKILGRYVV DTSN
Length:374
Mass (Da):39,609
Last modified:August 31, 2004 - v2
Checksum:iB6F932FDCF4163EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156A → R in CAA44613 (PubMed:1872030).Curated1
Sequence conflicti178I → T in CAA44613 (PubMed:1872030).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62766 Genomic DNA. Translation: CAA44613.1.
CR382122 Genomic DNA. Translation: CAH02325.1.
PIRiS17252.
RefSeqiXP_451932.1. XM_451932.1.

Genome annotation databases

EnsemblFungiiCAH02325; CAH02325; KLLA0_B09064g.
GeneIDi2897174.
KEGGikla:KLLA0B09064g.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiADH3_KLULA
AccessioniPrimary (citable) accession number: P49384
Secondary accession number(s): Q6CVV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: August 31, 2004
Last modified: June 7, 2017
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families