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Protein

ADP,ATP carrier protein

Gene

AAC

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei83NucleotideBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein
Alternative name(s):
ADP/ATP translocase
Adenine nucleotide translocator
Short name:
ANT
Gene namesi
Name:AAC
Ordered Locus Names:KLLA0E12353g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome E

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 41Helical; Name=1By similarityAdd BLAST35
Transmembranei78 – 102Helical; Name=2By similarityAdd BLAST25
Transmembranei110 – 144Helical; Name=3By similarityAdd BLAST35
Transmembranei179 – 206Helical; Name=4By similarityAdd BLAST28
Transmembranei211 – 245Helical; Name=5By similarityAdd BLAST35
Transmembranei274 – 299Helical; Name=6By similarityAdd BLAST26

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000905901 – 305ADP,ATP carrier proteinAdd BLAST305

Proteomic databases

PRIDEiP49382.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi284590.XP_454505.1.

Structurei

3D structure databases

ProteinModelPortaliP49382.
SMRiP49382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 101Solcar 1Add BLAST94
Repeati112 – 204Solcar 2Add BLAST93
Repeati212 – 298Solcar 3Add BLAST87

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi239 – 244Substrate recognitionBy similarity6

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749. Eukaryota.
ENOG410XNW0. LUCA.
HOGENOMiHOG000165727.
InParanoidiP49382.
KOiK05863.
OMAiGMPPFVA.
OrthoDBiEOG092C3PSA.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom_sf.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

P49382-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTDKKQSNF AIDFLMGGVS AAVSKTAAAP IERVKLLIQN QDEMIKQGSL
60 70 80 90 100
DRRYTGIVEC FKRTAADEGV ASFWRGNTAN VIRYFPTQAL NFAFKDKIKA
110 120 130 140 150
MFGFKKEEGY AKWFAGNLAS GGLAGGLSLL FVYSLDYART RLAADSKSAK
160 170 180 190 200
KGGERQFNGL VDVYKKTLAS DGVAGLYRGF LPSVVGIVVY RGLYFGLYDS
210 220 230 240 250
LKPLLLTGSL ENSFLASFLL GWAVTTGAST ASYPLDTVRR RMMMTSGQAV
260 270 280 290 300
KYDGAFDAFR KIVAAEGIKS LFKGCGANIL RGVAGAGVIS MYDQLQVILF

GKTFK
Length:305
Mass (Da):33,094
Last modified:February 1, 1996 - v1
Checksum:i7FB95BCCC18481A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33797 Genomic DNA. Translation: AAC41655.1.
CR382125 Genomic DNA. Translation: CAG99592.1.
PIRiS68154.
RefSeqiXP_454505.1. XM_454505.1.

Genome annotation databases

EnsemblFungiiCAG99592; CAG99592; KLLA0_E12365g.
GeneIDi2894290.
KEGGikla:KLLA0E12365g.

Similar proteinsi

Entry informationi

Entry nameiADT_KLULA
AccessioniPrimary (citable) accession number: P49382
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 22, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families