P49372 (ALL1_APIGR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Major allergen Api g 1 Alternative name(s): Allergen Api g 1.0101 Allergen Api g I Allergen=Api g 1
Organism	Apium graveolens (Celery)
Taxonomic identifier	4045 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › campanulids › Apiales › Apiaceae › Apioideae › apioid superclade › Apieae › Apium

Protein attributes

Sequence length	154 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the BetVI family.

Ontologies

Keywords
Biological process	Plant defense
Disease	Allergen
Molecular function	Pathogenesis-related protein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	defense response Inferred from electronic annotation. Source: UniProtKB-KW response to biotic stimulus Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 154

154

Major allergen Api g 1

PRO_0000154172

Secondary structure

1

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154

Helix Strand Turn

Details...

Beta strand

3 – 14

12

Helix

16 – 23

8

Helix

27 – 34

8

Helix

36 – 38

3

Beta strand

40 – 49

10

Beta strand

53 – 57

5

Beta strand

66 – 75

10

Turn

76 – 79

4

Beta strand

80 – 88

9

Helix

89 – 91

3

Turn

92 – 94

3

Beta strand

95 – 106

12

Beta strand

112 – 123

12

Helix

130 – 153

24

Sequences

	Sequence		Length	Mass (Da)
	P49372 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 86C47DDB0A9B7ABB	FASTA	154	16,321
	10 20 30 40 50 60 MGVQTHVLEL TSSVSAEKIF QGFVIDVDTV LPKAAPGAYK SVEIKGDGGP GTLKIITLPD 70 80 90 100 110 120 GGPITTMTLR IDGVNKEALT FDYSVIDGDI LLGFIESIEN HVVLVPTADG GSICKTTAIF 130 140 150 HTKGDAVVPE ENIKYANEQN TALFKALEAY LIAN

References

[1]	"Molecular characterization of Api g 1, the major allergen of celery (Apium graveolens), and its immunological and structural relationships to a group of 17-kDa tree pollen allergens." Breiteneder H., Hoffmann-Sommergruber K., O'Riordain G., Susani M., Ahorn H., Ebner C., Kraft D., Scheiner O. Eur. J. Biochem. 233:484-489(1995) [PubMed: 7588792] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Bulb and Leaf.
[2]	"Crystal structure of the major celery allergen Api g 1: molecular analysis of cross-reactivity." Schirmer T., Hoffimann-Sommergrube K., Susani M., Breiteneder H., Markovic-Housley Z. J. Mol. Biol. 351:1101-1109(2005) [PubMed: 16051263] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Z48967 mRNA. Translation: CAA88831.1.

PIR

S63984.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2BK0	X-ray	2.90	A/B	1-154	[»]

ProteinModelPortal

P49372.

SMR

P49372. Positions 2-154.

ModBase

Search...

Protein family/group databases

Allergome

40. Api g 1.
41. Api g 1.0101.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR000916. Bet_v_I_dom.
IPR023393. START-like_dom.
[Graphical view]

Gene3D

G3DSA:3.30.530.20. G3DSA:3.30.530.20. 1 hit.

Pfam

PF00407. Bet_v_1. 1 hit.
[Graphical view]

PROSITE

PS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

ALL1_APIGR

Accession

Primary (citable) accession number: P49372

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program