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P49371

- HUGA_DOLMA

UniProt

P49371 - HUGA_DOLMA

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Protein

Hyaluronidase

Gene
N/A
Organism
Dolichovespula maculata (Bald-faced hornet) (Vespula maculata)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides By similarity.

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei109 – 1091Proton donor By similarity

GO - Molecular functioni

  1. hyalurononglucosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. defense response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronidase (EC:3.2.1.35)
Short name:
Hya
Alternative name(s):
Allergen Dol m II
Hyaluronoglucosaminidase
Allergen: Dol m 2
OrganismiDolichovespula maculata (Bald-faced hornet) (Vespula maculata)
Taxonomic identifieri7441 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeDolichovespula

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3273. Dol m 2.0101.
329. Dol m 2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331HyaluronidasePRO_0000191285Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi19 ↔ 308 By similarity
Glycosylationi79 – 791N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi185 ↔ 197 By similarity
Glycosylationi325 – 3251N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP49371.
SMRiP49371. Positions 6-328.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR001329. Venom_Hyaluronidase.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PRINTSiPR00846. GLHYDRLASE56.
PR00847. HYALURONDASE.
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

P49371-1 [UniParc]FASTAAdd to Basket

« Hide

SERPKRVFNI YWNVPTFMCH QYGLYFDEVT NFNIKHNSKD DFQGDKISIF    50
YDPGEFPALL PLKEGNYKIR NGGVPQEGNI TIHLQRFIEN LDKTYPNRNF 100
NGIGVIDFER WRPIFRQNWG NMMIHKKFSI DLVRNEHPFW DKKMIELEAS 150
KRFEKYARLF MEETLKLAKK TRKQADWGYY GYPYCFNMSP NNLVPDCDAT 200
AMLENDKMSW LFNNQNVLLP SVYIRHELTP DQRVGLVQGR VKEAVRISNN 250
LKHSPKVLSY WWYVYQDDTN TFLTETDVKK TFQEIAINGG DGIIIWGSSS 300
DVNSLSKCKR LREYLLTVLG PITVNVTETV N 331
Length:331
Mass (Da):38,929
Last modified:February 1, 1996 - v1
Checksum:iDD07C11CE7865570
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34548 mRNA. Translation: AAA68279.1.
PIRiA56090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34548 mRNA. Translation: AAA68279.1 .
PIRi A56090.

3D structure databases

ProteinModelPortali P49371.
SMRi P49371. Positions 6-328.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 3273. Dol m 2.0101.
329. Dol m 2.
CAZyi GH56. Glycoside Hydrolase Family 56.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR001329. Venom_Hyaluronidase.
[Graphical view ]
PANTHERi PTHR11769. PTHR11769. 1 hit.
Pfami PF01630. Glyco_hydro_56. 1 hit.
[Graphical view ]
PRINTSi PR00846. GLHYDRLASE56.
PR00847. HYALURONDASE.
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence identity and antigenic cross-reactivity of white face hornet venom allergen, also a hyaluronidase, with other proteins."
    Lu G., Kochoumian L., King T.P.
    J. Biol. Chem. 270:4457-4465(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-45.
    Tissue: Venom and Venom gland.

Entry informationi

Entry nameiHUGA_DOLMA
AccessioniPrimary (citable) accession number: P49371
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: December 11, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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