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P49369

- PA1_VESVU

UniProt

P49369 - PA1_VESVU

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Protein
Phospholipase A1
Gene
N/A
Organism
Vespula vulgaris (Yellow jacket) (Wasp)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities By similarity.

Catalytic activityi

Phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.
Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei173 – 1731Nucleophile By similarity
Active sitei201 – 2011Charge relay system By similarity
Active sitei265 – 2651Charge relay system By similarity

GO - Molecular functioni

  1. 1-acyl-2-lysophosphatidylserine acylhydrolase activity Source: UniProtKB-EC
  2. phosphatidylcholine 1-acylhydrolase activity Source: UniProtKB-EC
  3. phosphatidylserine 1-acylhydrolase activity Source: UniProtKB-EC
  4. phospholipase A2 activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase A1 (EC:3.1.1.32, EC:3.1.1.4)
Alternative name(s):
Allergen Ves v I
Allergen: Ves v 1
OrganismiVespula vulgaris (Yellow jacket) (Wasp)
Taxonomic identifieri7454 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespula

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3520. Ves v 1.0101.
668. Ves v 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed prediction
Add
BLAST
Propeptidei28 – 369
PRO_0000425190
Chaini37 – 336300Phospholipase A1
PRO_0000017813Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 280 By similarity
Disulfide bondi123 ↔ 263 By similarity
Disulfide bondi212 ↔ 255 By similarity
Disulfide bondi217 ↔ 297 By similarity
Disulfide bondi275 ↔ 281 By similarity
Disulfide bondi304 ↔ 329 By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP49369.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002334. Dol/Ves_allerg.
IPR000734. Lipase.
IPR013818. Lipase_N.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
[Graphical view]
PRINTSiPR00825. DOLALLERGEN.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49369-1 [UniParc]FASTAAdd to Basket

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MEENMNLKYL LLFVYFVQVL NCCYGHGDPL SYELDRGPKC PFNSDTVSII    50
IETRENRNRD LYTLQTLQNH PEFKKKTITR PVVFITHGFT SSASETNFIN 100
LAKALVDKDN YMVISIDWQT AACTNEAAGL KYLYYPTAAR NTRLVGQYIA 150
TITQKLVKHY KISMANIRLI GHSLGAHASG FAGKKVQELK LGKYSEIIGL 200
DPARPSFDSN HCSERLCETD AEYVQIIHTS NYLGTEKTLG TVDFYMNNGK 250
NQPGCGRFFS EVCSHSRAVI YMAECIKHEC CLIGIPKSKS SQPISSCTKQ 300
ECVCVGLNAK KYPSRGSFYV PVESTAPFCN NKGKII 336
Length:336
Mass (Da):37,676
Last modified:February 1, 1996 - v1
Checksum:i65548B7F5BE56456
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371G → F AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43561 mRNA. Translation: AAB48072.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43561 mRNA. Translation: AAB48072.1 .

3D structure databases

ProteinModelPortali P49369.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 3520. Ves v 1.0101.
668. Ves v 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002334. Dol/Ves_allerg.
IPR000734. Lipase.
IPR013818. Lipase_N.
[Graphical view ]
PANTHERi PTHR11610. PTHR11610. 1 hit.
Pfami PF00151. Lipase. 1 hit.
[Graphical view ]
PRINTSi PR00825. DOLALLERGEN.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00120. LIPASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Yellow jacket venom allergens, hyaluronidase and phospholipase: sequence similarity and antigenic cross-reactivity with their hornet and wasp homologs and possible implications for clinical allergy."
    King T.P., Lu G., Gonzalez M., Qian N., Soldatova L.
    J. Allergy Clin. Immunol. 98:588-600(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 37-65; 165-183; 247-263 AND 273-294.
    Tissue: Venom and Venom gland.

Entry informationi

Entry nameiPA1_VESVU
AccessioniPrimary (citable) accession number: P49369
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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