Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P49369

- PA1_VESVU

UniProt

P49369 - PA1_VESVU

Protein

Phospholipase A1

Gene
N/A
Organism
Vespula vulgaris (Yellow jacket) (Wasp)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities.By similarity

    Catalytic activityi

    Phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.
    Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei173 – 1731NucleophileBy similarity
    Active sitei201 – 2011Charge relay systemPROSITE-ProRule annotation
    Active sitei265 – 2651Charge relay systemPROSITE-ProRule annotation

    GO - Molecular functioni

    1. 1-acyl-2-lysophosphatidylserine acylhydrolase activity Source: UniProtKB-EC
    2. phosphatidylcholine 1-acylhydrolase activity Source: UniProtKB-EC
    3. phosphatidylserine 1-acylhydrolase activity Source: UniProtKB-EC
    4. phospholipase A2 activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phospholipase A1 (EC:3.1.1.32, EC:3.1.1.4)
    Alternative name(s):
    Allergen Ves v I
    Allergen: Ves v 1
    OrganismiVespula vulgaris (Yellow jacket) (Wasp)
    Taxonomic identifieri7454 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespula

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei3520. Ves v 1.0101.
    668. Ves v 1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Propeptidei28 – 3691 PublicationPRO_0000425190
    Chaini37 – 336300Phospholipase A1PRO_0000017813Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi40 ↔ 280By similarity
    Disulfide bondi123 ↔ 263By similarity
    Disulfide bondi212 ↔ 255By similarity
    Disulfide bondi217 ↔ 297By similarity
    Disulfide bondi275 ↔ 281By similarity
    Disulfide bondi304 ↔ 329By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP49369.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily. Lipase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR002334. Dol/Ves_allerg.
    IPR000734. Lipase.
    IPR013818. Lipase_N.
    [Graphical view]
    PANTHERiPTHR11610. PTHR11610. 1 hit.
    PfamiPF00151. Lipase. 1 hit.
    [Graphical view]
    PRINTSiPR00825. DOLALLERGEN.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00120. LIPASE_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P49369-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEENMNLKYL LLFVYFVQVL NCCYGHGDPL SYELDRGPKC PFNSDTVSII    50
    IETRENRNRD LYTLQTLQNH PEFKKKTITR PVVFITHGFT SSASETNFIN 100
    LAKALVDKDN YMVISIDWQT AACTNEAAGL KYLYYPTAAR NTRLVGQYIA 150
    TITQKLVKHY KISMANIRLI GHSLGAHASG FAGKKVQELK LGKYSEIIGL 200
    DPARPSFDSN HCSERLCETD AEYVQIIHTS NYLGTEKTLG TVDFYMNNGK 250
    NQPGCGRFFS EVCSHSRAVI YMAECIKHEC CLIGIPKSKS SQPISSCTKQ 300
    ECVCVGLNAK KYPSRGSFYV PVESTAPFCN NKGKII 336
    Length:336
    Mass (Da):37,676
    Last modified:February 1, 1996 - v1
    Checksum:i65548B7F5BE56456
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti37 – 371G → F AA sequence (PubMed:8828537)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43561 mRNA. Translation: AAB48072.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43561 mRNA. Translation: AAB48072.1 .

    3D structure databases

    ProteinModelPortali P49369.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 3520. Ves v 1.0101.
    668. Ves v 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR002334. Dol/Ves_allerg.
    IPR000734. Lipase.
    IPR013818. Lipase_N.
    [Graphical view ]
    PANTHERi PTHR11610. PTHR11610. 1 hit.
    Pfami PF00151. Lipase. 1 hit.
    [Graphical view ]
    PRINTSi PR00825. DOLALLERGEN.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00120. LIPASE_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Yellow jacket venom allergens, hyaluronidase and phospholipase: sequence similarity and antigenic cross-reactivity with their hornet and wasp homologs and possible implications for clinical allergy."
      King T.P., Lu G., Gonzalez M., Qian N., Soldatova L.
      J. Allergy Clin. Immunol. 98:588-600(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 37-65; 165-183; 247-263 AND 273-294.
      Tissue: Venom and Venom gland.

    Entry informationi

    Entry nameiPA1_VESVU
    AccessioniPrimary (citable) accession number: P49369
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3