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P49369 (PA1_VESVU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phospholipase A1

EC=3.1.1.32
EC=3.1.1.4
Alternative name(s):
Allergen Ves v I
Allergen=Ves v 1
OrganismVespula vulgaris (Yellow jacket) (Wasp)
Taxonomic identifier7454 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespula

Protein attributes

Sequence length336 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities By similarity.

Catalytic activity

Phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.

Subunit structure

Monomer By similarity.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Allergenic properties

Causes an allergic reaction in human.

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Propeptide28 – 369
PRO_0000425190
Chain37 – 336300Phospholipase A1
PRO_0000017813

Sites

Active site1731Nucleophile By similarity
Active site2011Charge relay system By similarity
Active site2651Charge relay system By similarity

Amino acid modifications

Disulfide bond40 ↔ 280 By similarity
Disulfide bond123 ↔ 263 By similarity
Disulfide bond212 ↔ 255 By similarity
Disulfide bond217 ↔ 297 By similarity
Disulfide bond275 ↔ 281 By similarity
Disulfide bond304 ↔ 329 By similarity

Experimental info

Sequence conflict371G → F AA sequence Ref.1

Sequences

Sequence LengthMass (Da)Tools
P49369 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 65548B7F5BE56456

FASTA33637,676
        10         20         30         40         50         60 
MEENMNLKYL LLFVYFVQVL NCCYGHGDPL SYELDRGPKC PFNSDTVSII IETRENRNRD 

        70         80         90        100        110        120 
LYTLQTLQNH PEFKKKTITR PVVFITHGFT SSASETNFIN LAKALVDKDN YMVISIDWQT 

       130        140        150        160        170        180 
AACTNEAAGL KYLYYPTAAR NTRLVGQYIA TITQKLVKHY KISMANIRLI GHSLGAHASG 

       190        200        210        220        230        240 
FAGKKVQELK LGKYSEIIGL DPARPSFDSN HCSERLCETD AEYVQIIHTS NYLGTEKTLG 

       250        260        270        280        290        300 
TVDFYMNNGK NQPGCGRFFS EVCSHSRAVI YMAECIKHEC CLIGIPKSKS SQPISSCTKQ 

       310        320        330 
ECVCVGLNAK KYPSRGSFYV PVESTAPFCN NKGKII 

« Hide

References

[1]"Yellow jacket venom allergens, hyaluronidase and phospholipase: sequence similarity and antigenic cross-reactivity with their hornet and wasp homologs and possible implications for clinical allergy."
King T.P., Lu G., Gonzalez M., Qian N., Soldatova L.
J. Allergy Clin. Immunol. 98:588-600(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 37-65; 165-183; 247-263 AND 273-294.
Tissue: Venom and Venom gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43561 mRNA. Translation: AAB48072.1.

3D structure databases

ProteinModelPortalP49369.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome3520. Ves v 1.0101.
668. Ves v 1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002334. Dol/Ves_allerg.
IPR000734. Lipase.
IPR013818. Lipase_N.
[Graphical view]
PANTHERPTHR11610. PTHR11610. 1 hit.
PfamPF00151. Lipase. 1 hit.
[Graphical view]
PRINTSPR00825. DOLALLERGEN.
PROSITEPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePA1_VESVU
AccessionPrimary (citable) accession number: P49369
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 22, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries