Reviewed,
UniProtKB/Swiss-Prot P49369 (PA1_VESVU)
Last modified
November 25, 2008.
Version 54.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Phospholipase A1 EC=3.1.1.32 EC=3.1.1.4 Alternative name(s): Allergen Ves v I Allergen=Ves v 1 |
| Organism | Vespula vulgaris (Yellow jacket) (Wasp) |
| Taxonomic identifier | 7454 [NCBI] |
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Hymenoptera › Apocrita › Aculeata › Vespoidea › Vespidae › Vespinae › Vespula |
Protein attributes
| Sequence length | 336 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities By similarity. |
| Catalytic activity | Phosphatidylcholine + H(2)O = 2-acylglycerophosphocholine + a carboxylate. Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate. |
| Subunit structure | Monomer By similarity. |
| Subcellular location | |
| Tissue specificity | Expressed by the venom gland. |
| Post-translational modification | Contains six disulfide bonds By similarity. |
| Allergenic properties | Causes an allergic reaction in human. |
| Sequence similarities | Belongs to the AB hydrolase superfamily. Lipase family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Lipid degradation |
| Cellular component | Secreted |
| Disease | Allergen |
| Domain | Signal |
| Molecular function | Hydrolase |
| Technical term | Direct protein sequencing |
Gene Ontology (GO) | |
| Biological process | lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | phospholipase A1 activity Inferred from electronic annotation. Source: InterPro phospholipase A2 activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 36 | 36 | |||||||
| Chain | 37 – 336 | 300 | Phospholipase A1 | PRO_0000017813 | |||||
Sites | |||||||||
| Active site | 173 | 1 | Charge relay system By similarity | ||||||
| Active site | 201 | 1 | Charge relay system By similarity | ||||||
| Active site | 265 | 1 | Charge relay system By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 37 | 1 | G → F AA sequence Ref.1 | ||||||
Sequences
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References
| [1] | "Yellow jacket venom allergens, hyaluronidase and phospholipase: sequence similarity and antigenic cross-reactivity with their hornet and wasp homologs and possible implications for clinical allergy." King T.P., Lu G., Gonzalez M., Qian N., Soldatova L. J. Allergy Clin. Immunol. 98:588-600(1996) [PubMed: 8828537] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 37-65; 165-183; 247-263 AND 273-294. Tissue: Venom and Venom gland. |
Cross-references
Sequence databases | |
|---|---|
| L43561 mRNA. Translation: AAB48072.1. | |
3D structure databases | |
| HSSP | HSSP built from PDB template 1LPB based on UniProtKB P16233. |
| ModBase | Search... |
Family and domain databases | |
| InterPro | IPR002334. Dol/Ves_allerg. IPR000734. Lipase. IPR008262. Lipase_AS. IPR013818. Lipase_N. [Graphical view] |
| PANTHER | PTHR11610. Lipase. 1 hit. |
| Pfam | PF00151. Lipase. 1 hit. [Graphical view] |
| PRINTS | PR00825. DOLALLERGEN. |
| PROSITE | PS00120. LIPASE_SER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PA1_VESVU | ||||||||
| Accession | Primary (citable) accession number: P49369 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Allergens Nomenclature of allergens and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


