Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P49362

- GCSPB_FLAPR

UniProt

P49362 - GCSPB_FLAPR

Protein

Glycine dehydrogenase (decarboxylating) B, mitochondrial

Gene

GDCSPB

Organism
Flaveria pringlei
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.

    Cofactori

    Pyridoxal phosphate.

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating) B, mitochondrial (EC:1.4.4.2)
    Alternative name(s):
    Glycine cleavage system P protein B
    Glycine decarboxylase B
    Glycine dehydrogenase (aminomethyl-transferring) B
    Gene namesi
    Name:GDCSPB
    OrganismiFlaveria pringlei
    Taxonomic identifieri4226 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeHeliantheae allianceTageteaeFlaveria

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 6363MitochondrionSequence AnalysisAdd
    BLAST
    Chaini64 – 1034971Glycine dehydrogenase (decarboxylating) B, mitochondrialPRO_0000010747Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei770 – 7701N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Subunit structurei

    Homodimer By similarity. The glycine cleavage system is composed of four proteins: P, T, L and H.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP49362.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.Curated

    Keywords - Domaini

    Transit peptide

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P49362-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERARRLAIL GRLVSQTKHN PSISSPALCS PSRYVSSLSP YVCSGTNVRS     50
    DRNLNGFGSQ VRTISVEALK PSDTFPRRHN SATPEEQTKM AEFVGFPNLD 100
    SLIDATVPKS IRLDSMKYSK FDEGLTESQM IAHMQDLASK NKIFKSFIGM 150
    GYYNTSVPTV ILRNIMENPG WYTQYTPYQA EIAQGRLESL LNFQTMITDL 200
    TGLPMSNASL LDEGTAAAEA MAMCNNIQKG KKKTFIIASN CHPQTIDICK 250
    TRADGFDLKV VTSDLKDFDY SSGDVCGVLV QYPGTEGELL DYSEFIKNAH 300
    ANGVKVVMAS DLLALTILKP PGELGADIVV GSAQRFGVPM GYGGPHAAFL 350
    ATSQEYKRMM PGRIIGVSVD SSGKPALRMA MQTREQHIRR DKATSNICTA 400
    QALLANMAAM FGVYHGPEGL KTIAKRVHGL AGTFASGLKK LGTVQVQDLP 450
    FFDTVKVTCA DSKAIAEEAY KHKMNLRIVD KNTITVAFDE TTTIEDVDTL 500
    FKVFALGKPV TFTAASIAPE VQDAIPSGLV RETPYLTHPI FNMYHTEHEL 550
    LRYISKLQSK DLSLCHSMIP LGSCTMKLNA TTEMMPVTWP AFADIHPFAP 600
    TEQAQGYQEM FKNLGDLLCT ITGFDSFSLQ PNAGAAGEYA GLMVIRAYHM 650
    ARGDHHRNVC IIPVSAHGTN PASAAMCGMK IITVGTDSKG NINIEELRKA 700
    AEANKENLSA LMVTYPSTHG VYEEGIDEIC KIIHDNGGQV YMDGANMNAQ 750
    VGLTSPGWIG ADVCHLNLHK TFCIPHGGGG PGMGPIGVKK HLAPYLPSHP 800
    VVPTGGIPAP EQSQPLGTIA AAPWGSALIL PISYTYIAMM GSQGITNASK 850
    IAILNANYMA KRLENHYPIL FRGVNGTVAH EFIVDLRPLK TTAGIEPEDV 900
    AKRLIDYGFH GPTMSWPVPG TLMIEPTESE SKAELDRFCD ALISIRQEIA 950
    EIEKGNVDFN NNVIKGAPHP PQLLMADKWT KPYSREYAAY PAPWLRAAKF 1000
    WPTTCRVDNV YGDRNLICTL QPPQEYEEKA EATA 1034
    Length:1,034
    Mass (Da):112,780
    Last modified:February 1, 1996 - v1
    Checksum:i713D6490B48C2932
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z54239 Genomic DNA. Translation: CAA91000.1.
    PIRiS63536.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z54239 Genomic DNA. Translation: CAA91000.1 .
    PIRi S63536.

    3D structure databases

    ProteinModelPortali P49362.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression analysis of the gdcsPA and gdcsPB genes encoding two P-isoproteins of the glycine-cleavage system from Flaveria pringlei."
      Bauwe H., Chu C.-C., Kopriva S., Nan Q.
      Eur. J. Biochem. 234:116-124(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Leaf.

    Entry informationi

    Entry nameiGCSPB_FLAPR
    AccessioniPrimary (citable) accession number: P49362
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3