SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P49362

- GCSPB_FLAPR

UniProt

P49362 - GCSPB_FLAPR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glycine dehydrogenase (decarboxylating) B, mitochondrial

Gene
GDCSPB
Organism
Flaveria pringlei
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) B, mitochondrial (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P protein B
Glycine decarboxylase B
Glycine dehydrogenase (aminomethyl-transferring) B
Gene namesi
Name:GDCSPB
OrganismiFlaveria pringlei
Taxonomic identifieri4226 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeHeliantheae allianceTageteaeFlaveria

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6363Mitochondrion Reviewed predictionAdd
BLAST
Chaini64 – 1034971Glycine dehydrogenase (decarboxylating) B, mitochondrialUniRule annotationPRO_0000010747Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei770 – 7701N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity. The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP49362.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49362-1 [UniParc]FASTAAdd to Basket

« Hide

MERARRLAIL GRLVSQTKHN PSISSPALCS PSRYVSSLSP YVCSGTNVRS     50
DRNLNGFGSQ VRTISVEALK PSDTFPRRHN SATPEEQTKM AEFVGFPNLD 100
SLIDATVPKS IRLDSMKYSK FDEGLTESQM IAHMQDLASK NKIFKSFIGM 150
GYYNTSVPTV ILRNIMENPG WYTQYTPYQA EIAQGRLESL LNFQTMITDL 200
TGLPMSNASL LDEGTAAAEA MAMCNNIQKG KKKTFIIASN CHPQTIDICK 250
TRADGFDLKV VTSDLKDFDY SSGDVCGVLV QYPGTEGELL DYSEFIKNAH 300
ANGVKVVMAS DLLALTILKP PGELGADIVV GSAQRFGVPM GYGGPHAAFL 350
ATSQEYKRMM PGRIIGVSVD SSGKPALRMA MQTREQHIRR DKATSNICTA 400
QALLANMAAM FGVYHGPEGL KTIAKRVHGL AGTFASGLKK LGTVQVQDLP 450
FFDTVKVTCA DSKAIAEEAY KHKMNLRIVD KNTITVAFDE TTTIEDVDTL 500
FKVFALGKPV TFTAASIAPE VQDAIPSGLV RETPYLTHPI FNMYHTEHEL 550
LRYISKLQSK DLSLCHSMIP LGSCTMKLNA TTEMMPVTWP AFADIHPFAP 600
TEQAQGYQEM FKNLGDLLCT ITGFDSFSLQ PNAGAAGEYA GLMVIRAYHM 650
ARGDHHRNVC IIPVSAHGTN PASAAMCGMK IITVGTDSKG NINIEELRKA 700
AEANKENLSA LMVTYPSTHG VYEEGIDEIC KIIHDNGGQV YMDGANMNAQ 750
VGLTSPGWIG ADVCHLNLHK TFCIPHGGGG PGMGPIGVKK HLAPYLPSHP 800
VVPTGGIPAP EQSQPLGTIA AAPWGSALIL PISYTYIAMM GSQGITNASK 850
IAILNANYMA KRLENHYPIL FRGVNGTVAH EFIVDLRPLK TTAGIEPEDV 900
AKRLIDYGFH GPTMSWPVPG TLMIEPTESE SKAELDRFCD ALISIRQEIA 950
EIEKGNVDFN NNVIKGAPHP PQLLMADKWT KPYSREYAAY PAPWLRAAKF 1000
WPTTCRVDNV YGDRNLICTL QPPQEYEEKA EATA 1034
Length:1,034
Mass (Da):112,780
Last modified:February 1, 1996 - v1
Checksum:i713D6490B48C2932
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z54239 Genomic DNA. Translation: CAA91000.1.
PIRiS63536.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z54239 Genomic DNA. Translation: CAA91000.1 .
PIRi S63536.

3D structure databases

ProteinModelPortali P49362.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Structure and expression analysis of the gdcsPA and gdcsPB genes encoding two P-isoproteins of the glycine-cleavage system from Flaveria pringlei."
    Bauwe H., Chu C.-C., Kopriva S., Nan Q.
    Eur. J. Biochem. 234:116-124(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Leaf.

Entry informationi

Entry nameiGCSPB_FLAPR
AccessioniPrimary (citable) accession number: P49362
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi