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P49361

- GCSPA_FLAPR

UniProt

P49361 - GCSPA_FLAPR

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Protein

Glycine dehydrogenase (decarboxylating) A, mitochondrial

Gene

GDCSPA

Organism
Flaveria pringlei
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.

Cofactori

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) A, mitochondrial (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P protein A
Glycine decarboxylase A
Glycine dehydrogenase (aminomethyl-transferring) A
Gene namesi
Name:GDCSPA
OrganismiFlaveria pringlei
Taxonomic identifieri4226 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeHeliantheae allianceTageteaeFlaveria

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6666MitochondrionSequence AnalysisAdd
BLAST
Chaini67 – 1037971Glycine dehydrogenase (decarboxylating) A, mitochondrialPRO_0000010746Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei773 – 7731N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PRIDEiP49361.

Expressioni

Tissue specificityi

Expressed in leaves, stems and roots.1 Publication

Interactioni

Subunit structurei

Homodimer (By similarity). The glycine cleavage system is composed of four proteins: P, T, L and H.By similarity

Structurei

3D structure databases

ProteinModelPortaliP49361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.Curated

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49361-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERARRLANK AILGRLVSQT KHNPSISSPA LCSPSRYVSS LSPYVCSGTN
60 70 80 90 100
VRSDRNLNGF GSQVRTISVE ALKPSDTFPR RHNSATPEEQ TKMAEFVGFP
110 120 130 140 150
NLDSLIDATV PKSIRLDSMK YSKFDEGLTE SQMIAHMQDL ASKNKIFKSF
160 170 180 190 200
IGMGYYNTSV PTVILRNIME NPGWYTQYTP YQAEIAQGRL ESLLNFQTMV
210 220 230 240 250
TDLTGLPMSN ASLLDEGTAA AEAMAMCNNI QKGKKKTFII ASNCHPQTID
260 270 280 290 300
ICKTRADGFD LKVVTSDLKD FDYSSGDVCG VLVQYPGTEG ELLDYSEFIK
310 320 330 340 350
NAHANGVKVV MASDLLALTI LKPPGELGAD IVVGSAQRFG VPMGYGGPHA
360 370 380 390 400
AFLATSQEYK RMMPGRIIGV SVDSSGKPAL RMAMQTREQH IRRDKATSNI
410 420 430 440 450
CTAQALLANM AAMFGVYHGP EGLKTIAKRV HGLAGTFAAG LKKLGTVQVQ
460 470 480 490 500
DLPFFDTVKV TCVDSKAIAE EAYKHKMNLR IVDKNTITVA FDETTTIEDV
510 520 530 540 550
DTLFKVFALG KPVTFTAASI APEVQDAIPS GLVRETPYLT HPIFNMYHTE
560 570 580 590 600
HELLRYISKL QSKDLSLCHS MIPLGSCTMK LNATTEMMPV TWPAFADIHP
610 620 630 640 650
FAPTEQAQGY QEMFKNLGDL LCTITGFDSF SLQPNAGAAG EYAGLMVIRA
660 670 680 690 700
YHMARGDHHR NVCIIPVSAH GTNPASAAMC GMKIITVGTD SKGNINIEEL
710 720 730 740 750
RKAAEANKEN LSALMVTYPS THGVYEEGID EICKIIHDNG GQVYMDGANM
760 770 780 790 800
NAQVGLTSPG WIGADVCHLN LHKTFCIPHG GGGPGMGPIG VKKHLAPYLP
810 820 830 840 850
SHPVVATGGI PAPEQSQPLG TIAAAPWGSA LILPISYTYI AMMGSQGITN
860 870 880 890 900
ASKIAILNAN YMAKRLENHY PILFRGVNGT VAHEFIVDLR PLKTTAGIEP
910 920 930 940 950
EDVAKRLIDY GFHGPTMSWP VPGTLMIEPT ESESKAELDR FCDALISIRQ
960 970 980 990 1000
EIAEIEKGNV DLNNNVIKGA PHPPQLLMAD KWTKPYSREY AAYPAPWLRA
1010 1020 1030
AKFWPTTCRV DNVYGDRNLI CTLQPPQEYE EKAEATA
Length:1,037
Mass (Da):113,032
Last modified:February 1, 1996 - v1
Checksum:iED248FA227F9E0F3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21E → D in CAA81076. (PubMed:8165245)Curated
Sequence conflicti495 – 4951T → I in CAA81076. (PubMed:8165245)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36879 Genomic DNA. Translation: CAA85353.1.
Z25857 mRNA. Translation: CAA81076.1.
PIRiS63535.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36879 Genomic DNA. Translation: CAA85353.1 .
Z25857 mRNA. Translation: CAA81076.1 .
PIRi S63535.

3D structure databases

ProteinModelPortali P49361.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P49361.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The gdcsPA gene from Flaveria pringlei (Asteraceae)."
    Bauwe H., Kopriva S.
    Plant Physiol. 107:655-655(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Leaf.
  2. "P-protein of glycine decarboxylase from Flaveria pringlei."
    Kopriva S., Bauwe H.
    Plant Physiol. 104:1077-1078(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Leaf.
  3. "Structure and expression analysis of the gdcsPA and gdcsPB genes encoding two P-isoproteins of the glycine-cleavage system from Flaveria pringlei."
    Bauwe H., Chu C.-C., Kopriva S., Nan Q.
    Eur. J. Biochem. 234:116-124(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Tissue: Leaf.

Entry informationi

Entry nameiGCSPA_FLAPR
AccessioniPrimary (citable) accession number: P49361
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 26, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3