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P49361

- GCSPA_FLAPR

UniProt

P49361 - GCSPA_FLAPR

Protein

Glycine dehydrogenase (decarboxylating) A, mitochondrial

Gene

GDCSPA

Organism
Flaveria pringlei
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.

    Cofactori

    Pyridoxal phosphate.

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating) A, mitochondrial (EC:1.4.4.2)
    Alternative name(s):
    Glycine cleavage system P protein A
    Glycine decarboxylase A
    Glycine dehydrogenase (aminomethyl-transferring) A
    Gene namesi
    Name:GDCSPA
    OrganismiFlaveria pringlei
    Taxonomic identifieri4226 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeHeliantheae allianceTageteaeFlaveria

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 6666MitochondrionSequence AnalysisAdd
    BLAST
    Chaini67 – 1037971Glycine dehydrogenase (decarboxylating) A, mitochondrialPRO_0000010746Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei773 – 7731N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PRIDEiP49361.

    Expressioni

    Tissue specificityi

    Expressed in leaves, stems and roots.1 Publication

    Interactioni

    Subunit structurei

    Homodimer By similarity. The glycine cleavage system is composed of four proteins: P, T, L and H.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP49361.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.Curated

    Keywords - Domaini

    Transit peptide

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P49361-1 [UniParc]FASTAAdd to Basket

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    MERARRLANK AILGRLVSQT KHNPSISSPA LCSPSRYVSS LSPYVCSGTN     50
    VRSDRNLNGF GSQVRTISVE ALKPSDTFPR RHNSATPEEQ TKMAEFVGFP 100
    NLDSLIDATV PKSIRLDSMK YSKFDEGLTE SQMIAHMQDL ASKNKIFKSF 150
    IGMGYYNTSV PTVILRNIME NPGWYTQYTP YQAEIAQGRL ESLLNFQTMV 200
    TDLTGLPMSN ASLLDEGTAA AEAMAMCNNI QKGKKKTFII ASNCHPQTID 250
    ICKTRADGFD LKVVTSDLKD FDYSSGDVCG VLVQYPGTEG ELLDYSEFIK 300
    NAHANGVKVV MASDLLALTI LKPPGELGAD IVVGSAQRFG VPMGYGGPHA 350
    AFLATSQEYK RMMPGRIIGV SVDSSGKPAL RMAMQTREQH IRRDKATSNI 400
    CTAQALLANM AAMFGVYHGP EGLKTIAKRV HGLAGTFAAG LKKLGTVQVQ 450
    DLPFFDTVKV TCVDSKAIAE EAYKHKMNLR IVDKNTITVA FDETTTIEDV 500
    DTLFKVFALG KPVTFTAASI APEVQDAIPS GLVRETPYLT HPIFNMYHTE 550
    HELLRYISKL QSKDLSLCHS MIPLGSCTMK LNATTEMMPV TWPAFADIHP 600
    FAPTEQAQGY QEMFKNLGDL LCTITGFDSF SLQPNAGAAG EYAGLMVIRA 650
    YHMARGDHHR NVCIIPVSAH GTNPASAAMC GMKIITVGTD SKGNINIEEL 700
    RKAAEANKEN LSALMVTYPS THGVYEEGID EICKIIHDNG GQVYMDGANM 750
    NAQVGLTSPG WIGADVCHLN LHKTFCIPHG GGGPGMGPIG VKKHLAPYLP 800
    SHPVVATGGI PAPEQSQPLG TIAAAPWGSA LILPISYTYI AMMGSQGITN 850
    ASKIAILNAN YMAKRLENHY PILFRGVNGT VAHEFIVDLR PLKTTAGIEP 900
    EDVAKRLIDY GFHGPTMSWP VPGTLMIEPT ESESKAELDR FCDALISIRQ 950
    EIAEIEKGNV DLNNNVIKGA PHPPQLLMAD KWTKPYSREY AAYPAPWLRA 1000
    AKFWPTTCRV DNVYGDRNLI CTLQPPQEYE EKAEATA 1037
    Length:1,037
    Mass (Da):113,032
    Last modified:February 1, 1996 - v1
    Checksum:iED248FA227F9E0F3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21E → D in CAA81076. (PubMed:8165245)Curated
    Sequence conflicti495 – 4951T → I in CAA81076. (PubMed:8165245)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36879 Genomic DNA. Translation: CAA85353.1.
    Z25857 mRNA. Translation: CAA81076.1.
    PIRiS63535.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36879 Genomic DNA. Translation: CAA85353.1 .
    Z25857 mRNA. Translation: CAA81076.1 .
    PIRi S63535.

    3D structure databases

    ProteinModelPortali P49361.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P49361.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The gdcsPA gene from Flaveria pringlei (Asteraceae)."
      Bauwe H., Kopriva S.
      Plant Physiol. 107:655-655(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Leaf.
    2. "P-protein of glycine decarboxylase from Flaveria pringlei."
      Kopriva S., Bauwe H.
      Plant Physiol. 104:1077-1078(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Leaf.
    3. "Structure and expression analysis of the gdcsPA and gdcsPB genes encoding two P-isoproteins of the glycine-cleavage system from Flaveria pringlei."
      Bauwe H., Chu C.-C., Kopriva S., Nan Q.
      Eur. J. Biochem. 234:116-124(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
      Tissue: Leaf.

    Entry informationi

    Entry nameiGCSPA_FLAPR
    AccessioniPrimary (citable) accession number: P49361
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3