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P49358 (GLYN_FLAPR) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine hydroxymethyltransferase 2, mitochondrial
Short name=SHMT
EC=2.1.2.1
Alternative name(s):
Glycine hydroxymethyltransferase
Serine methylase
OrganismFlaveria pringlei
Taxonomic identifier4226 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › campanulids › Asterales › Asteraceae › Asteroideae › Heliantheae alliance › Tageteae › Flaveria

Protein attributes

Sequence length517 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Interconversion of serine and glycine.

Catalytic activity

5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

Subunit structure

Homotetramer By similarity.

Subcellular location

Mitochondrion.

Miscellaneous

In eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one.

Sequence similarities

Belongs to the SHMT family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandPyridoxal phosphate
   Molecular functionTransferase
Gene Ontology (GO)
   Biological_processL-serine metabolic process

Inferred from electronic annotation. Source: InterPro

glycine metabolic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglycine hydroxymethyltransferase activity

Inferred from electronic annotation. Source: EC

pyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3131Mitochondrion By similarity
Chain32 – 517486Serine hydroxymethyltransferase 2, mitochondrial
PRO_0000032572

Amino acid modifications

Modified residue2871N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P49358 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 8D007DB76E5AED3F

FASTA51756,933
        10         20         30         40         50         60 
MAMASALRRL SSSSNKPLQR LFNGGHLYSM SSLPSEAVYE KERPGVTWPK QLNAPLEVGD 

        70         80         90        100        110        120 
PEIADIIELE KARQWKGLEL ILSENFTSLS VMQAVGSVMT NKYSEGYPGA RYYGGNEYID 

       130        140        150        160        170        180 
MAETLCQKRA LEAFRLDAAK WGVNVQPLSG SPANFHVYTA LLKAHDRIMA LDLPHGGHLS 

       190        200        210        220        230        240 
HGYQTDTKKI SAVSIFFETM PYRLNESTGY IDYDQLEKSA TLFRPKLIVA GASAYARLYD 

       250        260        270        280        290        300 
YARIRKVCDK QKAILLADMA HISGLVAAGV IPSPFDYADV VTTTTHKSLR GPRGAMIFFR 

       310        320        330        340        350        360 
KGVKEVNKQG KEVLYDYEDK INQAVFPGLQ GGPHNHTITG LAVALKQATT AEYKAYQEQV 

       370        380        390        400        410        420 
MSNCAKFAET LVKSGYELVS GGTENHLVLV NLKNKGIDGS RVEKVLEAVH IAANKNTVPG 

       430        440        450        460        470        480 
DVSAMVPGGI RMGTPALTSR GFVEEDFAKV AYLFDLAVKL AVKIKGEAQG TKLKDFVAAM 

       490        500        510 
QSSAFQSEIS KLRHDVEEYA KQFPTIGFEK ETMKYKN

« Hide

References

[1]"Cloning and sequencing of two isoforms of serine hydroxymethyltransferase from Flaveria pringlei."
Kopriva S., Bauwe H.
Plant Gene Register PGR98-051
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Leaf.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z25860 mRNA. Translation: CAA81079.1.
PIRS40213.

3D structure databases

ProteinModelPortalP49358.
SMRP49358. Positions 52-508.
ModBaseSearch...

Proteomic databases

PRIDEP49358.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
PANTHERPTHR11680. PTHR11680. 1 hit.
PfamPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFPIRSF000412. SHMT. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00096. SHMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLYN_FLAPR
AccessionPrimary (citable) accession number: P49358
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 6, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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