P49355 (FNTB_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein farnesyltransferase subunit beta
Short name=FTase-beta
EC=2.5.1.58

Alternative name(s):
CAAX farnesyltransferase subunit beta
Ras proteins prenyltransferase subunit beta

Gene names

Name:

FNTB

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
Catalytic activity	Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subunit structure	Heterodimer of an alpha and a beta subunit.
Sequence similarities	Belongs to the protein prenyltransferase subunit beta family. Contains 5 PFTB repeats.

Ontologies

Keywords
Domain	Repeat
Ligand	Metal-binding Zinc
Molecular function	Prenyltransferase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein farnesyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 437	437	Protein farnesyltransferase subunit beta		PRO_0000119760
Regions
	Repeat	123 – 164	42	PFTB 1
	Repeat	174 – 215	42	PFTB 2
	Repeat	222 – 263	42	PFTB 3
	Repeat	270 – 312	43	PFTB 4
	Repeat	332 – 374	43	PFTB 5
Sites
	Metal binding	297	1	Zinc By similarity
	Metal binding	299	1	Zinc By similarity
	Metal binding	362	1	Zinc By similarity
Amino acid modifications
	Modified residue	300	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P49355 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: CE09DFA86AC6AB64	FASTA	437	48,768
	10 20 30 40 50 60 MASPSSFTYC CPPSSSPIWS EPLYSLRPEH ARERLQDDSV ETVTSIEQAK VEEKIQEVFS 70 80 90 100 110 120 SYKFNHLVPR LVLQREKHFH YLKRGLRQLT DAYECLDASR PWLCYWILHS LELLDEPIPQ 130 140 150 160 170 180 MVATDVCQFL ELCQSPEGGF GGGPGQYPHL APTYAAVNAL CIIGTEEAYD VINREKLLQY 190 200 210 220 230 240 LYSLKQPDGS FLMHDGGEVD VRSAYCAASV ASLTNIITPD LFEGTAEWIA RCQNWEGGIG 250 260 270 280 290 300 GVPGMEAHGG YTFCGLAALV ILKKERSLNL KSLLQWVTSR QMRFEGGFQG RCNKLVDGCY 310 320 330 340 350 360 SFWQAGLLPL LHRALHAQGD PALSMSRWMF HQQALQEYIL MCCQCPTGGL LDKPGKSRDF 370 380 390 400 410 420 YHTCYCLSGL SIAQHFGSGA MLHDVVLGVP ENALQPTHPV YNIGPDKVIQ ATMHFLQKPV 430 PGFEEHEDEA SAEPATD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases." Omer C.A., Kral A.M., Diehl R.E., Prendergast G.C., Powers S., Allen C.M., Gibbs J.B., Kohl N.E. Biochemistry 32:5167-5176(1993) [PubMed: 8494894] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Hippocampus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L00633 mRNA. Translation: AAA30524.1. BC123393 mRNA. Translation: AAI23394.1.
IPI	IPI00705098.
PIR	C49274.
RefSeq	NP_786999.1. NM_175805.3.
UniGene	Bt.4529.
3D structure databases
ProteinModelPortal	P49355.
SMR	P49355. Positions 15-424.
ModBase	Search...
Protein-protein interaction databases
STRING	P49355.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000007751; ENSBTAP00000007751; ENSBTAG00000005897.
GeneID	327686.
KEGG	bta:327686.
Organism-specific databases
CTD	2342.
Phylogenomic databases
HOVERGEN	HBG008173.
InParanoid	P49355.
OrthoDB	EOG4KKZ33.
PhylomeDB	P49355.
Family and domain databases
InterPro	IPR001330. Prenyltrans. IPR008930. Terpenoid_cyclase/PrenylTrfase. [Graphical view]
KO	K05954.
Pfam	PF00432. Prenyltrans. 5 hits. [Graphical view]
SUPFAM	SSF48239. Terp_cyc_toroid. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FNTB_BOVIN

Accession

Primary (citable) accession number: P49355
Secondary accession number(s): A4FUX0, Q9TS25

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	November 16, 2011
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program