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Protein

Protein farnesyltransferase subunit beta

Gene

FNTB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X (By similarity).By similarity

Catalytic activityi

Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei102 – 1021Important for selectivity against geranylgeranyl diphosphateBy similarity
Metal bindingi297 – 2971Zinc; catalyticBy similarity
Metal bindingi299 – 2991Zinc; catalyticBy similarity
Metal bindingi362 – 3621Zinc; via tele nitrogen; catalyticBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein farnesyltransferase subunit beta (EC:2.5.1.58)
Short name:
FTase-beta
Alternative name(s):
CAAX farnesyltransferase subunit beta
Ras proteins prenyltransferase subunit beta
Gene namesi
Name:FNTB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2095178.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Protein farnesyltransferase subunit betaPRO_0000119760Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei436 – 4361PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP49355.

Interactioni

Subunit structurei

Heterodimer of FNTA and FNTB.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007751.

Chemistry

BindingDBiP49355.

Structurei

3D structure databases

ProteinModelPortaliP49355.
SMRiP49355. Positions 15-424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati123 – 16442PFTB 1Add
BLAST
Repeati174 – 21542PFTB 2Add
BLAST
Repeati222 – 26342PFTB 3Add
BLAST
Repeati270 – 31243PFTB 4Add
BLAST
Repeati332 – 37443PFTB 5Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni248 – 2514Farnesyl diphosphate bindingBy similarity
Regioni291 – 2944Farnesyl diphosphate bindingBy similarity
Regioni300 – 3034Farnesyl diphosphate bindingBy similarity

Sequence similaritiesi

Contains 5 PFTB repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0365. Eukaryota.
COG5029. LUCA.
GeneTreeiENSGT00550000075042.
HOGENOMiHOG000190594.
HOVERGENiHBG008173.
InParanoidiP49355.
KOiK05954.
OMAiPIHPLYN.
OrthoDBiEOG7P02HV.
TreeFamiTF353162.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR026872. FTB.
IPR001330. PFTB_repeat.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PANTHERiPTHR11774:SF6. PTHR11774:SF6. 1 hit.
PfamiPF00432. Prenyltrans. 5 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.

Sequencei

Sequence statusi: Complete.

P49355-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPSSFTYC CPPSSSPIWS EPLYSLRPEH ARERLQDDSV ETVTSIEQAK
60 70 80 90 100
VEEKIQEVFS SYKFNHLVPR LVLQREKHFH YLKRGLRQLT DAYECLDASR
110 120 130 140 150
PWLCYWILHS LELLDEPIPQ MVATDVCQFL ELCQSPEGGF GGGPGQYPHL
160 170 180 190 200
APTYAAVNAL CIIGTEEAYD VINREKLLQY LYSLKQPDGS FLMHDGGEVD
210 220 230 240 250
VRSAYCAASV ASLTNIITPD LFEGTAEWIA RCQNWEGGIG GVPGMEAHGG
260 270 280 290 300
YTFCGLAALV ILKKERSLNL KSLLQWVTSR QMRFEGGFQG RCNKLVDGCY
310 320 330 340 350
SFWQAGLLPL LHRALHAQGD PALSMSRWMF HQQALQEYIL MCCQCPTGGL
360 370 380 390 400
LDKPGKSRDF YHTCYCLSGL SIAQHFGSGA MLHDVVLGVP ENALQPTHPV
410 420 430
YNIGPDKVIQ ATMHFLQKPV PGFEEHEDEA SAEPATD
Length:437
Mass (Da):48,768
Last modified:February 1, 1996 - v1
Checksum:iCE09DFA86AC6AB64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00633 mRNA. Translation: AAA30524.1.
BC123393 mRNA. Translation: AAI23394.1.
PIRiC49274.
RefSeqiNP_786999.1. NM_175805.3.
UniGeneiBt.4529.

Genome annotation databases

EnsembliENSBTAT00000007751; ENSBTAP00000007751; ENSBTAG00000005897.
GeneIDi327686.
KEGGibta:327686.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00633 mRNA. Translation: AAA30524.1.
BC123393 mRNA. Translation: AAI23394.1.
PIRiC49274.
RefSeqiNP_786999.1. NM_175805.3.
UniGeneiBt.4529.

3D structure databases

ProteinModelPortaliP49355.
SMRiP49355. Positions 15-424.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007751.

Chemistry

BindingDBiP49355.
ChEMBLiCHEMBL2095178.

Proteomic databases

PaxDbiP49355.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000007751; ENSBTAP00000007751; ENSBTAG00000005897.
GeneIDi327686.
KEGGibta:327686.

Organism-specific databases

CTDi2342.

Phylogenomic databases

eggNOGiKOG0365. Eukaryota.
COG5029. LUCA.
GeneTreeiENSGT00550000075042.
HOGENOMiHOG000190594.
HOVERGENiHBG008173.
InParanoidiP49355.
KOiK05954.
OMAiPIHPLYN.
OrthoDBiEOG7P02HV.
TreeFamiTF353162.

Enzyme and pathway databases

ReactomeiR-BTA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Miscellaneous databases

NextBioi20810151.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR026872. FTB.
IPR001330. PFTB_repeat.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PANTHERiPTHR11774:SF6. PTHR11774:SF6. 1 hit.
PfamiPF00432. Prenyltrans. 5 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases."
    Omer C.A., Kral A.M., Diehl R.E., Prendergast G.C., Powers S., Allen C.M., Gibbs J.B., Kohl N.E.
    Biochemistry 32:5167-5176(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hippocampus.

Entry informationi

Entry nameiFNTB_BOVIN
AccessioniPrimary (citable) accession number: P49355
Secondary accession number(s): A4FUX0, Q9TS25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 17, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.