Reviewed, UniProtKB/Swiss-Prot P49351 (FPPS1_LUPAL)

Names and origin

Protein names

Recommended name:
    Farnesyl pyrophosphate synthetase 1
      Short name=FPP synthetase 1
      Short name=FPS 1
Alternative name(s):
    Farnesyl diphosphate synthetase 1
Including the following 2 domains:
    1- Recommended name:
            Dimethylallyltranstransferase
              EC=2.5.1.1
    2- Recommended name:
            Geranyltranstransferase
              EC=2.5.1.10

Gene names

Name:

FPS1

Organism

Lupinus albus (White lupin)

Taxonomic identifier

3870 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids I › Fabales › Fabaceae › Papilionoideae › Genisteae › Lupinus

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Catalytic activity	Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate.
Pathway	Isoprenoid biosynthesis; farnesyl-PP biosynthesis; farnesyl-PP from geranyl-PP and isopentenyl-PP: step 1/1. Isoprenoid biosynthesis; geranyl-PP biosynthesis; geranyl-PP from dimethylallyl-PP and isopentenyl-PP: step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the FPP/GGPP synthetase family.

Ontologies

Keywords
Biological process	Cholesterol biosynthesis Isoprene biosynthesis Lipid synthesis Steroid biosynthesis Sterol biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Gene Ontology (GO)
Biological process	cholesterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW isoprenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	dimethylallyltranstransferase activity Inferred from electronic annotation. Source: EC geranyltranstransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 342	342	Farnesyl pyrophosphate synthetase 1		PRO_0000123956

Sequences

	Sequence		Length	Mass (Da)
	P49351-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 591DE4CD29CC711C	FASTA	342	39,269
	10 20 30 40 50 60 MADLRSTFLN VYSVLKSELL HDPAFEFSPD SRQWLDRMLD YNVPGGKLNR GLSVIDSYRL 70 80 90 100 110 120 LKDGHELNDD EIFLASALGW CIEWLQAYFL VLDDIMDNSH TRRGQPCWFR VPKVGMIAAN 130 140 150 160 170 180 DGVLLRNHIP RILKKHFRGK PYYADLLDLF NEVEFQTASG QMIDLITTLE GEKDLSKYTL 190 200 210 220 230 240 SLHRRIVQYK TAYYSFYLPV ACALLMVGEN LDNHIDVKNI LVDMGTYFQV QDDYLDCFGA 250 260 270 280 290 300 PETIGKIGTD IEDFKCSWLV VKALELSNDE QKKVLYDNYG KPDPANVAKV KALYDELNLQ 310 320 330 340 GVFTEYESKS YEKLVTSIEA HPSKAVQALL KSFLGKIYKR QK

References

[1]

"Farnesyl pyrophosphate synthase from white lupin: molecular cloning, expression, and purification of the expressed protein." Attucci S., Aitken S.M., Gulick P.J., Ibrahim R.K. Arch. Biochem. Biophys. 321:493-500(1995) [PubMed: 7646076] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Root.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U15777 mRNA. Translation: AAA86687.1.
PIR	S66470.
3D structure databases
HSSP	HSSP built from PDB template 1UBY based on UniProtKB P08836.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.5.1.1. 956. 2.5.1.10. 956.
Family and domain databases
InterPro	IPR000092. Polyprenyl_synt. IPR008949. Terpenoid_synth. [Graphical view]
Gene3D	G3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
Pfam	PF00348. polyprenyl_synt. 1 hit. [Graphical view]
PROSITE	PS00723. POLYPRENYL_SYNTHET_1. 1 hit. PS00444. POLYPRENYL_SYNTHET_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FPPS1_LUPAL

Accession

Primary (citable) accession number: P49351

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	June 16, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)