ID   FPPS_ARTAN              Reviewed;         343 AA.
AC   P49350;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   16-JUN-2009, entry version 45.
DE   RecName: Full=Farnesyl pyrophosphate synthetase;
DE            Short=FPP synthetase;
DE            Short=FPS;
DE   AltName: Full=Farnesyl diphosphate synthetase;
DE   Includes:
DE     RecName: Full=Dimethylallyltranstransferase;
DE              EC=2.5.1.1;
DE   Includes:
DE     RecName: Full=Geranyltranstransferase;
DE              EC=2.5.1.10;
GN   Name=FPS1;
OS   Artemisia annua (Sweet wormwood).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   asterids; campanulids; Asterales; Asteraceae; Asteroideae;
OC   Anthemideae; Artemisia.
OX   NCBI_TaxID=35608;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=96269405; PubMed=8682304; DOI=10.1016/0378-1119(96)00054-6;
RA   Matsushita Y., Kang W., Charlwood B.V.;
RT   "Cloning and analysis of a cDNA encoding farnesyl diphosphate synthase
RT   from Artemisia annua.";
RL   Gene 172:207-209(1996).
CC   -!- FUNCTION: Catalyzes the sequential condensation of isopentenyl
CC       pyrophosphate with the allylic pyrophosphates, dimethylallyl
CC       pyrophosphate, and then with the resultant geranylpyrophosphate to
CC       the ultimate product farnesyl pyrophosphate.
CC   -!- CATALYTIC ACTIVITY: Dimethylallyl diphosphate + isopentenyl
CC       diphosphate = diphosphate + geranyl diphosphate.
CC   -!- CATALYTIC ACTIVITY: Geranyl diphosphate + isopentenyl diphosphate
CC       = diphosphate + trans,trans-farnesyl diphosphate.
CC   -!- PATHWAY: Isoprenoid biosynthesis; farnesyl-PP biosynthesis;
CC       farnesyl-PP from geranyl-PP and isopentenyl-PP: step 1/1.
CC   -!- PATHWAY: Isoprenoid biosynthesis; geranyl-PP biosynthesis;
CC       geranyl-PP from dimethylallyl-PP and isopentenyl-PP: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the FPP/GGPP synthetase family.
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DR   EMBL; U36376; AAC49452.1; -; mRNA.
DR   PIR; JC4846; JC4846.
DR   HSSP; P08836; 1FPS.
DR   BRENDA; 2.5.1.1; 275466.
DR   BRENDA; 2.5.1.10; 275466.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004161; F:dimethylallyltranstransferase activity; IEA:EC.
DR   GO; GO:0004337; F:geranyltranstransferase activity; IEA:EC.
DR   GO; GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000092; Polyprenyl_synt.
DR   InterPro; IPR008949; Terpenoid_synth.
DR   Gene3D; G3DSA:1.10.600.10; Terpenoid_synth; 1.
DR   Pfam; PF00348; polyprenyl_synt; 1.
DR   PROSITE; PS00723; POLYPRENYL_SYNTHET_1; 1.
DR   PROSITE; PS00444; POLYPRENYL_SYNTHET_2; 1.
PE   2: Evidence at transcript level;
KW   Cholesterol biosynthesis; Cytoplasm; Isoprene biosynthesis;
KW   Lipid synthesis; Steroid biosynthesis; Sterol biosynthesis;
KW   Transferase.
FT   CHAIN         1    343       Farnesyl pyrophosphate synthetase.
FT                                /FTId=PRO_0000123954.
SQ   SEQUENCE   343 AA;  39420 MW;  431372214500AF68 CRC64;
     MSSTDLKSKF LKVYDTLKSE LINDPAFEFD DDSRQWIEKM LDYNVPGGKL NRGLSVVDSY
     QLLKGGELSD DEIFLSSALG WCIEWLQAYF LVLDDIMDES HTRRGQPCWF RLPKVGMIAA
     NDGILLRNHV PRILKKHFRG KPYYVDLVDL FNEVEFQTAS GQMIDLITTL VGEKDLSKYS
     LSIHRRIVQY KTAYYSFYLP VACALLMFGE DLDKHVEVKN VLVEMGTYFQ VQDDYLDCFG
     APEVIGKIGT DIEDFKCSWL VVKALELPNE EQKKTLHENY GKKDPASVAK VKEVYHTLNL
     QAVFEDYEAT SYKKLITSIE NHPSKAVQAV LKSFLGKIYK RQK
//