Reviewed,
UniProtKB/Swiss-Prot P49350 (FPPS_ARTAN)
Last modified
November 25, 2008.
Version 42.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Farnesyl pyrophosphate synthetase Short name=FPP synthetase Short name=FPS Alternative name(s): Farnesyl diphosphate synthetase Including the following 2 domains: 1- Recommended name: Dimethylallyltranstransferase EC=2.5.1.1 2- Recommended name: Geranyltranstransferase EC=2.5.1.10 | ||
| Gene names |
| ||
| Organism | Artemisia annua (Sweet wormwood) | ||
| Taxonomic identifier | 35608 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › campanulids › Asterales › Asteraceae › Asteroideae › Anthemideae › Artemisia |
Protein attributes
| Sequence length | 343 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. |
| Catalytic activity | Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate. |
| Pathway | |
| Subcellular location | CytoplasmBy similarity. |
| Sequence similarities | Belongs to the FPP/GGPP synthetase family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Cholesterol biosynthesis Isoprene biosynthesis Lipid synthesis Steroid biosynthesis Sterol biosynthesis |
| Cellular component | Cytoplasm |
| Molecular function | Transferase |
Gene Ontology (GO) | |
| Biological process | cholesterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW isoprenoid biosynthetic processInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | dimethylallyltranstransferase activity Inferred from electronic annotation. Source: EC geranyltranstransferase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 343 | 343 | Farnesyl pyrophosphate synthetase | PRO_0000123954 | |||
Sequences
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References
| [1] | "Cloning and analysis of a cDNA encoding farnesyl diphosphate synthase from Artemisia annua." Matsushita Y., Kang W., Charlwood B.V. Gene 172:207-209(1996) [PubMed: 8682304] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
Cross-references
Sequence databases | |
|---|---|
| U36376 mRNA. Translation: AAC49452.1. | |
| PIR | JC4846. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FPS based on UniProtKB P08836. |
| ModBase | Search... |
Family and domain databases | |
| InterPro | IPR000092. Polyprenyl_synt. IPR008949. Terpenoid_synth. [Graphical view] |
| Gene3D | G3DSA:1.10.600.10. Terpenoid_synth. 1 hit. |
| Pfam | PF00348. polyprenyl_synt. 1 hit. [Graphical view] |
| PROSITE | PS00723. POLYPRENYL_SYNTHET_1. 1 hit. PS00444. POLYPRENYL_SYNTHET_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FPPS_ARTAN | ||||||||
| Accession | Primary (citable) accession number: P49350 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


