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P49350 (FPPS_ARTAN) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Farnesyl pyrophosphate synthase
Short name=FPP synthase
Short name=FPS
EC=2.5.1.10
Alternative name(s):
(2E,6E)-farnesyl diphosphate synthase
Dimethylallyltranstransferase
EC=2.5.1.1
Farnesyl diphosphate synthase
Geranyltranstransferase
Gene names
Name:FPS1
OrganismArtemisia annua (Sweet wormwood)
Taxonomic identifier35608 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › campanulids › Asterales › Asteraceae › Asteroideae › Anthemideae › Artemisiinae › Artemisia

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

Catalytic activity

Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.

Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.

Cofactor

Binds 3 magnesium ions per subunit By similarity.

Pathway

Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.

Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the FPP/GGPP synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Farnesyl pyrophosphate synthase
PRO_0000123954

Sites

Metal binding941Magnesium 1 By similarity
Metal binding941Magnesium 2 By similarity
Metal binding981Magnesium 1 By similarity
Metal binding981Magnesium 2 By similarity
Metal binding2331Magnesium 3 By similarity
Binding site491Isopentenyl diphosphate By similarity
Binding site521Isopentenyl diphosphate By similarity
Binding site871Isopentenyl diphosphate By similarity
Binding site1031Dimethylallyl diphosphate By similarity
Binding site1041Isopentenyl diphosphate By similarity
Binding site1911Dimethylallyl diphosphate By similarity
Binding site1921Dimethylallyl diphosphate By similarity
Binding site2301Dimethylallyl diphosphate By similarity
Binding site2471Dimethylallyl diphosphate By similarity
Binding site2561Dimethylallyl diphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
P49350 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 431372214500AF68

FASTA34339,420
        10         20         30         40         50         60 
MSSTDLKSKF LKVYDTLKSE LINDPAFEFD DDSRQWIEKM LDYNVPGGKL NRGLSVVDSY 

        70         80         90        100        110        120 
QLLKGGELSD DEIFLSSALG WCIEWLQAYF LVLDDIMDES HTRRGQPCWF RLPKVGMIAA 

       130        140        150        160        170        180 
NDGILLRNHV PRILKKHFRG KPYYVDLVDL FNEVEFQTAS GQMIDLITTL VGEKDLSKYS 

       190        200        210        220        230        240 
LSIHRRIVQY KTAYYSFYLP VACALLMFGE DLDKHVEVKN VLVEMGTYFQ VQDDYLDCFG 

       250        260        270        280        290        300 
APEVIGKIGT DIEDFKCSWL VVKALELPNE EQKKTLHENY GKKDPASVAK VKEVYHTLNL 

       310        320        330        340 
QAVFEDYEAT SYKKLITSIE NHPSKAVQAV LKSFLGKIYK RQK

« Hide

References

[1]"Cloning and analysis of a cDNA encoding farnesyl diphosphate synthase from Artemisia annua."
Matsushita Y., Kang W., Charlwood B.V.
Gene 172:207-209(1996) [PubMed: 8682304] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U36376 mRNA. Translation: AAC49452.1.
PIRJC4846.

3D structure databases

ProteinModelPortalP49350.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000092. Polyprenyl_synt.
IPR008949. Terpenoid_synth.
[Graphical view]
Gene3DG3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
PfamPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMSSF48576. Terpenoid_synth. 1 hit.
PROSITEPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFPPS_ARTAN
AccessionPrimary (citable) accession number: P49350
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 21, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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