Reviewed,
UniProtKB/Swiss-Prot P49349 (FPPS_KLULA)
Last modified
January 19, 2010.
Version 67.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Farnesyl pyrophosphate synthetase Short name=FPP synthetase Short name=FPS Alternative name(s): Farnesyl diphosphate synthetase Including the following 2 domains: 1- Recommended name: Dimethylallyltranstransferase EC=2.5.1.1 2- Recommended name: Geranyltranstransferase EC=2.5.1.10 | ||||||
| Gene names |
| ||||||
| Organism | Kluyveromyces lactis (Yeast) (Candida sphaerica) [Complete proteome] | ||||||
| Taxonomic identifier | 28985 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces |
Protein attributes
| Sequence length | 349 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. |
| Catalytic activity | Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate. |
| Cofactor | Binds 3 magnesium ions per subunit By similarity. |
| Pathway | |
| Subcellular location | |
| Sequence similarities | Belongs to the FPP/GGPP synthetase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cholesterol biosynthesis Isoprene biosynthesis Lipid synthesis Steroid biosynthesis Sterol biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | Magnesium Metal-binding |
| Molecular function | Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cholesterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW isoprenoid biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | dimethylallyltranstransferase activity Inferred from electronic annotation. Source: EC geranyltranstransferase activityInferred from electronic annotation. Source: EC magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 349 | 349 | Farnesyl pyrophosphate synthetase | PRO_0000123949 | |||||
Sites | |||||||||
| Metal binding | 97 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 97 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 101 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 101 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 237 | 1 | Magnesium 3 By similarity | ||||||
| Binding site | 48 | 1 | Isopentenyl diphosphate By similarity | ||||||
| Binding site | 51 | 1 | Isopentenyl diphosphate By similarity | ||||||
| Binding site | 90 | 1 | Isopentenyl diphosphate By similarity | ||||||
| Binding site | 106 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 107 | 1 | Isopentenyl diphosphate By similarity | ||||||
| Binding site | 194 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 195 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 234 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 251 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 260 | 1 | Dimethylallyl diphosphate By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isolation and characterisation of the linked genes, FPS1 and QCR8, coding for farnesyl-diphosphate synthase and the 11 kDa subunit VIII of the mitochondrial bc1-complex in the yeast Kluyveromyces lactis." Mulder W., Scholten I.H.J.M., Nagelkerken B., Grivell L.A. Biochim. Biophys. Acta 1219:713-718(1994) [PubMed: 7948032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37. |
| [2] | "Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. Souciet J.-L.Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X76026 Genomic DNA. Translation: CAA53614.1. CR382121 Genomic DNA. Translation: CAH02888.1. |
| PIR | S50214. |
| RefSeq | XP_451300.1. |
3D structure databases | |
| SMR | P49349. Positions 2-349. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P49349. |
Genome annotation databases | |
| GeneID | 2896751. |
| GenomeReviews | Gene locus KLLA0A06732g in contig CR382121_GR. |
| KEGG | kla:KLLA0A06732g. |
Phylogenomic databases | |
| eggNOG | fuNOG05213. |
| HOGENOM | HBG328346. |
| OMA | MIKTHIQ. |
| OrthoDB | EOG9D286Q. |
| PhylomeDB | P49349. |
Enzyme and pathway databases | |
| BRENDA | 2.5.1.1. 74088. 2.5.1.10. 74088. |
Family and domain databases | |
| InterPro | IPR000092. Polyprenyl_synt. IPR008949. Terpenoid_synth. [Graphical view] |
| Gene3D | G3DSA:1.10.600.10. Terpenoid_synth. 1 hit. |
| Pfam | PF00348. polyprenyl_synt. 1 hit. [Graphical view] |
| PROSITE | PS00723. POLYPRENYL_SYNTHET_1. 1 hit. PS00444. POLYPRENYL_SYNTHET_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FPPS_KLULA | ||||||||
| Accession | Primary (citable) accession number: P49349 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


