P49349 (FPPS_KLULA) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 80.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Farnesyl pyrophosphate synthase Short name=FPP synthase Short name=FPS EC=2.5.1.10 Alternative name(s): (2E,6E)-farnesyl diphosphate synthase Dimethylallyltranstransferase EC=2.5.1.1 Farnesyl diphosphate synthase Geranyltranstransferase | ||||||
| Gene names |
| ||||||
| Organism | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome] | ||||||
| Taxonomic identifier | 284590 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces |
Protein attributes
| Sequence length | 349 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. |
| Catalytic activity | Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate. |
| Cofactor | Binds 3 magnesium ions per subunit By similarity. |
| Pathway | |
| Subcellular location | |
| Sequence similarities | Belongs to the FPP/GGPP synthase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cholesterol biosynthesis Isoprene biosynthesis Lipid synthesis Steroid biosynthesis Sterol biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | Magnesium Metal-binding |
| Molecular function | Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cholesterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW isoprenoid biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | dimethylallyltranstransferase activity Inferred from electronic annotation. Source: EC geranyltranstransferase activityInferred from electronic annotation. Source: EC metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 349 | 349 | Farnesyl pyrophosphate synthase | PRO_0000123949 | |||||
Sites | |||||||||
| Metal binding | 97 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 97 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 101 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 101 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 237 | 1 | Magnesium 3 By similarity | ||||||
| Binding site | 48 | 1 | Isopentenyl diphosphate By similarity | ||||||
| Binding site | 51 | 1 | Isopentenyl diphosphate By similarity | ||||||
| Binding site | 90 | 1 | Isopentenyl diphosphate By similarity | ||||||
| Binding site | 106 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 107 | 1 | Isopentenyl diphosphate By similarity | ||||||
| Binding site | 194 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 195 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 234 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 251 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 260 | 1 | Dimethylallyl diphosphate By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isolation and characterisation of the linked genes, FPS1 and QCR8, coding for farnesyl-diphosphate synthase and the 11 kDa subunit VIII of the mitochondrial bc1-complex in the yeast Kluyveromyces lactis." Mulder W., Scholten I.H.J.M., Nagelkerken B., Grivell L.A. Biochim. Biophys. Acta 1219:713-718(1994) [PubMed: 7948032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37. |
| [2] | "Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. Souciet J.-L.Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X76026 Genomic DNA. Translation: CAA53614.1. CR382121 Genomic DNA. Translation: CAH02888.1. |
| PIR | S50214. |
| RefSeq | XP_451300.1. XM_451300.1. |
3D structure databases | |
| ProteinModelPortal | P49349. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P49349. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 2896751. |
| GenomeReviews | Gene locus KLLA0A06732g in contig CR382121_GR. |
| KEGG | kla:KLLA0A06732g. |
Phylogenomic databases | |
| eggNOG | fuNOG05213. |
| HOGENOM | HBG328346. |
| OMA | ENKTSHY. |
| OrthoDB | EOG4SFDFW. |
Family and domain databases | |
| InterPro | IPR000092. Polyprenyl_synt. IPR008949. Terpenoid_synth. [Graphical view] |
| Gene3D | G3DSA:1.10.600.10. Terpenoid_synth. 1 hit. |
| KO | K00787. |
| Pfam | PF00348. polyprenyl_synt. 1 hit. [Graphical view] |
| SUPFAM | SSF48576. Terpenoid_synth. 1 hit. |
| PROSITE | PS00723. POLYPRENYL_SYNTHASE_1. 1 hit. PS00444. POLYPRENYL_SYNTHASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FPPS_KLULA | ||||||||
| Accession | Primary (citable) accession number: P49349 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with