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P49336

- CDK8_HUMAN

UniProt

P49336 - CDK8_HUMAN

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Protein
Cyclin-dependent kinase 8
Gene
CDK8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.1 Publication

Cofactori

Magnesium By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei52 – 521ATP By similarity
Active sitei151 – 1511Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi27 – 359ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC
  3. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  4. protein binding Source: UniProtKB
  5. protein kinase activity Source: ProtInc

GO - Biological processi

  1. Notch signaling pathway Source: Reactome
  2. gene expression Source: Reactome
  3. positive regulation of transcription from RNA polymerase II promoter Source: Reactome
  4. transcription initiation from RNA polymerase II promoter Source: Reactome
  5. transcription, DNA-templated Source: Reactome
  6. transforming growth factor beta receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Activator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 2681.
ReactomeiREACT_116145. PPARA activates gene expression.
REACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_120734. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
REACT_12627. Generic Transcription Pathway.
REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_27161. Transcriptional regulation of white adipocyte differentiation.
SignaLinkiP49336.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 8 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cell division protein kinase 8
Mediator complex subunit CDK8
Mediator of RNA polymerase II transcription subunit CDK8
Protein kinase K35
Gene namesi
Name:CDK8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:1779. CDK8.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. mediator complex Source: MGI
  2. nucleoplasm Source: Reactome
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi173 – 1731D → A: Abrogates kinase activity and TFIIH-dependent transcriptional repression. 1 Publication

Organism-specific databases

PharmGKBiPA26315.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 464464Cyclin-dependent kinase 8
PRO_0000085797Add
BLAST

Proteomic databases

MaxQBiP49336.
PaxDbiP49336.
PRIDEiP49336.

PTM databases

PhosphoSiteiP49336.

Expressioni

Gene expression databases

ArrayExpressiP49336.
BgeeiP49336.
CleanExiHS_CDK8.
GenevestigatoriP49336.

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II. Interacts with CTNNB1, GLI3 and MAML1.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNCP248637EBI-394377,EBI-395261

Protein-protein interaction databases

BioGridi107458. 76 interactions.
DIPiDIP-32595N.
IntActiP49336. 41 interactions.
MINTiMINT-3017285.
STRINGi9606.ENSP00000370938.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1210
Helixi16 – 194
Beta strandi26 – 4217
Beta strandi49 – 5810
Helixi61 – 7212
Beta strandi83 – 875
Turni88 – 914
Beta strandi92 – 987
Beta strandi101 – 1033
Helixi104 – 11310
Helixi125 – 14420
Helixi154 – 1563
Beta strandi157 – 1593
Turni164 – 1674
Beta strandi169 – 1713
Helixi179 – 1813
Helixi202 – 2054
Helixi213 – 22917
Helixi249 – 25911
Helixi264 – 2663
Helixi268 – 2725
Helixi276 – 2827
Helixi285 – 2884
Helixi293 – 2997
Helixi307 – 3159
Helixi320 – 3223
Helixi326 – 3305
Helixi333 – 3353
Beta strandi337 – 3393
Turni345 – 3484

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3RGFX-ray2.20A1-403[»]
4F6SX-ray2.60A1-403[»]
4F6UX-ray2.10A1-403[»]
4F6WX-ray2.39A1-403[»]
4F70X-ray3.00A1-403[»]
4F7JX-ray2.60A1-403[»]
4F7LX-ray2.90A1-403[»]
4F7NX-ray2.65A1-403[»]
4F7SX-ray2.20A1-403[»]
4G6LX-ray2.70A1-403[»]
ProteinModelPortaliP49336.
SMRiP49336. Positions 1-359.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 335315Protein kinase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 1515Interaction with CCNC
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi373 – 3775Poly-Gln

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiP49336.
KOiK02208.
OMAiNVITLIR.
PhylomeDBiP49336.
TreeFamiTF101025.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P49336-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDYDFKVKLS SERERVEDLF EYEGCKVGRG TYGHVYKAKR KDGKDDKDYA    50
LKQIEGTGIS MSACREIALL RELKHPNVIS LQKVFLSHAD RKVWLLFDYA 100
EHDLWHIIKF HRASKANKKP VQLPRGMVKS LLYQILDGIH YLHANWVLHR 150
DLKPANILVM GEGPERGRVK IADMGFARLF NSPLKPLADL DPVVVTFWYR 200
APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED IKTSNPYHHD 250
QLDRIFNVMG FPADKDWEDI KKMPEHSTLM KDFRRNTYTN CSLIKYMEKH 300
KVKPDSKAFH LLQKLLTMDP IKRITSEQAM QDPYFLEDPL PTSDVFAGCQ 350
IPYPKREFLT EEEPDDKGDK KNQQQQQGNN HTNGTGHPGN QDSSHTQGPP 400
LKKVRVVPPT TTSGGLIMTS DYQRSNPHAA YPNPGPSTSQ PQSSMGYSAT 450
SQQPPQYSHQ THRY 464
Length:464
Mass (Da):53,284
Last modified:February 1, 1996 - v1
Checksum:i00CBAB6CE354605F
GO
Isoform 2 (identifier: P49336-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     370-370: Missing.

Show »
Length:463
Mass (Da):53,156
Checksum:i8C74EEBD24CBA5DB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti189 – 1891D → N in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication
VAR_041980
Natural varianti424 – 4241R → C in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
VAR_041981

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei370 – 3701Missing in isoform 2.
VSP_029970

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X85753 mRNA. Translation: CAA59754.1.
AL590108, AL159159 Genomic DNA. Translation: CAH72300.1.
AL159159, AL590108 Genomic DNA. Translation: CAI16960.1.
CH471075 Genomic DNA. Translation: EAX08386.1.
CH471075 Genomic DNA. Translation: EAX08387.1.
BC069634 mRNA. Translation: AAH69634.1.
BC104492 mRNA. Translation: AAI04493.1.
BC105950 mRNA. Translation: AAI05951.1.
BC107601 mRNA. Translation: AAI07602.1.
CCDSiCCDS9317.1. [P49336-1]
PIRiI37227.
RefSeqiNP_001251.1. NM_001260.1. [P49336-1]
XP_005266272.1. XM_005266215.1. [P49336-2]
UniGeneiHs.382306.
Hs.695166.

Genome annotation databases

EnsembliENST00000381527; ENSP00000370938; ENSG00000132964. [P49336-1]
GeneIDi1024.
KEGGihsa:1024.
UCSCiuc001uqr.1. human. [P49336-1]
uc001uqs.1. human. [P49336-2]

Polymorphism databases

DMDMi1345718.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X85753 mRNA. Translation: CAA59754.1 .
AL590108 , AL159159 Genomic DNA. Translation: CAH72300.1 .
AL159159 , AL590108 Genomic DNA. Translation: CAI16960.1 .
CH471075 Genomic DNA. Translation: EAX08386.1 .
CH471075 Genomic DNA. Translation: EAX08387.1 .
BC069634 mRNA. Translation: AAH69634.1 .
BC104492 mRNA. Translation: AAI04493.1 .
BC105950 mRNA. Translation: AAI05951.1 .
BC107601 mRNA. Translation: AAI07602.1 .
CCDSi CCDS9317.1. [P49336-1 ]
PIRi I37227.
RefSeqi NP_001251.1. NM_001260.1. [P49336-1 ]
XP_005266272.1. XM_005266215.1. [P49336-2 ]
UniGenei Hs.382306.
Hs.695166.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3RGF X-ray 2.20 A 1-403 [» ]
4F6S X-ray 2.60 A 1-403 [» ]
4F6U X-ray 2.10 A 1-403 [» ]
4F6W X-ray 2.39 A 1-403 [» ]
4F70 X-ray 3.00 A 1-403 [» ]
4F7J X-ray 2.60 A 1-403 [» ]
4F7L X-ray 2.90 A 1-403 [» ]
4F7N X-ray 2.65 A 1-403 [» ]
4F7S X-ray 2.20 A 1-403 [» ]
4G6L X-ray 2.70 A 1-403 [» ]
ProteinModelPortali P49336.
SMRi P49336. Positions 1-359.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107458. 76 interactions.
DIPi DIP-32595N.
IntActi P49336. 41 interactions.
MINTi MINT-3017285.
STRINGi 9606.ENSP00000370938.

Chemistry

BindingDBi P49336.
ChEMBLi CHEMBL3038474.
GuidetoPHARMACOLOGYi 1980.

PTM databases

PhosphoSitei P49336.

Polymorphism databases

DMDMi 1345718.

Proteomic databases

MaxQBi P49336.
PaxDbi P49336.
PRIDEi P49336.

Protocols and materials databases

DNASUi 1024.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381527 ; ENSP00000370938 ; ENSG00000132964 . [P49336-1 ]
GeneIDi 1024.
KEGGi hsa:1024.
UCSCi uc001uqr.1. human. [P49336-1 ]
uc001uqs.1. human. [P49336-2 ]

Organism-specific databases

CTDi 1024.
GeneCardsi GC13P026828.
HGNCi HGNC:1779. CDK8.
MIMi 603184. gene.
neXtProti NX_P49336.
PharmGKBi PA26315.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
HOVERGENi HBG014652.
InParanoidi P49336.
KOi K02208.
OMAi NVITLIR.
PhylomeDBi P49336.
TreeFami TF101025.

Enzyme and pathway databases

BRENDAi 2.7.11.22. 2681.
Reactomei REACT_116145. PPARA activates gene expression.
REACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_120734. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
REACT_12627. Generic Transcription Pathway.
REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_27161. Transcriptional regulation of white adipocyte differentiation.
SignaLinki P49336.

Miscellaneous databases

ChiTaRSi CDK8. human.
GeneWikii Cyclin-dependent_kinase_8.
GenomeRNAii 1024.
NextBioi 4301.
PROi P49336.
SOURCEi Search...

Gene expression databases

ArrayExpressi P49336.
Bgeei P49336.
CleanExi HS_CDK8.
Genevestigatori P49336.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C."
    Tassan J.-P., Jaquenoud M., Leopold P., Schultz S.J., Nigg E.A.
    Proc. Natl. Acad. Sci. U.S.A. 92:8871-8875(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  5. "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription."
    Sun X., Zhang Y., Cho H., Rickert P., Lees E., Lane W.S., Reinberg D.
    Mol. Cell 2:213-222(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX.
  6. "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation."
    Gu W., Malik S., Ito M., Yuan C.-X., Fondell J.D., Zhang X., Martinez E., Qin J., Roeder R.G.
    Mol. Cell 3:97-108(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SMCC COMPLEX.
  7. "TFIIH is negatively regulated by cdk8-containing mediator complexes."
    Akoulitchev S., Chuikov S., Reinberg D.
    Nature 407:102-106(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, MUTAGENESIS OF ASP-173.
  8. "Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover."
    Fryer C.J., White J.B., Jones K.A.
    Mol. Cell 16:509-520(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH MAML1.
  9. "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."
    Sato S., Tomomori-Sato C., Parmely T.J., Florens L., Zybailov B., Swanson S.K., Banks C.A.S., Jin J., Cai Y., Washburn M.P., Conaway J.W., Conaway R.C.
    Mol. Cell 14:685-691(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX.
  10. "MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."
    Zhang X., Krutchinsky A., Fukuda A., Chen W., Yamamura S., Chait B.T., Roeder R.G.
    Mol. Cell 19:89-100(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX, ASSOCIATION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE II.
  11. "Mediator modulates Gli3-dependent Sonic hedgehog signaling."
    Zhou H., Kim S., Ishii S., Boyer T.G.
    Mol. Cell. Biol. 26:8667-8682(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CTNNB1; GLI3; MED1; MED6; MED12 AND MED23.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder."
    Schneider E.V., Bottcher J., Blaesse M., Neumann L., Huber R., Maskos K.
    J. Mol. Biol. 412:251-266(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1-403 IN COMPLEX WITH CCNC AND INHIBITOR.
  14. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASN-189 AND CYS-424.

Entry informationi

Entry nameiCDK8_HUMAN
AccessioniPrimary (citable) accession number: P49336
Secondary accession number(s): Q5VUF3, Q6ISB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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