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P49336

- CDK8_HUMAN

UniProt

P49336 - CDK8_HUMAN

Protein

Cyclin-dependent kinase 8

Gene

CDK8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.2 Publications

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.1 Publication
    ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.1 Publication

    Cofactori

    Magnesium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei52 – 521ATPPROSITE-ProRule annotation
    Active sitei151 – 1511Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi27 – 359ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. protein binding Source: UniProtKB
    4. protein kinase activity Source: ProtInc
    5. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. gene expression Source: Reactome
    2. Notch signaling pathway Source: Reactome
    3. positive regulation of transcription from RNA polymerase II promoter Source: Reactome
    4. transcription, DNA-templated Source: Reactome
    5. transcription initiation from RNA polymerase II promoter Source: Reactome
    6. transforming growth factor beta receptor signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Activator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.22. 2681.
    ReactomeiREACT_116145. PPARA activates gene expression.
    REACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_120734. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
    REACT_12627. Generic Transcription Pathway.
    REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_27161. Transcriptional regulation of white adipocyte differentiation.
    SignaLinkiP49336.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 8 (EC:2.7.11.22, EC:2.7.11.23)
    Alternative name(s):
    Cell division protein kinase 8
    Mediator complex subunit CDK8
    Mediator of RNA polymerase II transcription subunit CDK8
    Protein kinase K35
    Gene namesi
    Name:CDK8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:1779. CDK8.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. mediator complex Source: MGI
    2. nucleoplasm Source: Reactome
    3. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi173 – 1731D → A: Abrogates kinase activity and TFIIH-dependent transcriptional repression. 1 Publication

    Organism-specific databases

    PharmGKBiPA26315.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 464464Cyclin-dependent kinase 8PRO_0000085797Add
    BLAST

    Proteomic databases

    MaxQBiP49336.
    PaxDbiP49336.
    PRIDEiP49336.

    PTM databases

    PhosphoSiteiP49336.

    Expressioni

    Gene expression databases

    ArrayExpressiP49336.
    BgeeiP49336.
    CleanExiHS_CDK8.
    GenevestigatoriP49336.

    Interactioni

    Subunit structurei

    Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II. Interacts with CTNNB1, GLI3 and MAML1.7 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CCNCP248637EBI-394377,EBI-395261

    Protein-protein interaction databases

    BioGridi107458. 76 interactions.
    DIPiDIP-32595N.
    IntActiP49336. 41 interactions.
    MINTiMINT-3017285.
    STRINGi9606.ENSP00000370938.

    Structurei

    Secondary structure

    1
    464
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 1210
    Helixi16 – 194
    Beta strandi26 – 4217
    Beta strandi49 – 5810
    Helixi61 – 7212
    Beta strandi83 – 875
    Turni88 – 914
    Beta strandi92 – 987
    Beta strandi101 – 1033
    Helixi104 – 11310
    Helixi125 – 14420
    Helixi154 – 1563
    Beta strandi157 – 1593
    Turni164 – 1674
    Beta strandi169 – 1713
    Helixi179 – 1813
    Helixi202 – 2054
    Helixi213 – 22917
    Helixi249 – 25911
    Helixi264 – 2663
    Helixi268 – 2725
    Helixi276 – 2827
    Helixi285 – 2884
    Helixi293 – 2997
    Helixi307 – 3159
    Helixi320 – 3223
    Helixi326 – 3305
    Helixi333 – 3353
    Beta strandi337 – 3393
    Turni345 – 3484

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3RGFX-ray2.20A1-403[»]
    4F6SX-ray2.60A1-403[»]
    4F6UX-ray2.10A1-403[»]
    4F6WX-ray2.39A1-403[»]
    4F70X-ray3.00A1-403[»]
    4F7JX-ray2.60A1-403[»]
    4F7LX-ray2.90A1-403[»]
    4F7NX-ray2.65A1-403[»]
    4F7SX-ray2.20A1-403[»]
    4G6LX-ray2.70A1-403[»]
    ProteinModelPortaliP49336.
    SMRiP49336. Positions 1-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 335315Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 1515Interaction with CCNCAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi373 – 3775Poly-Gln

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    HOVERGENiHBG014652.
    InParanoidiP49336.
    KOiK02208.
    OMAiNVITLIR.
    PhylomeDBiP49336.
    TreeFamiTF101025.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P49336-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDYDFKVKLS SERERVEDLF EYEGCKVGRG TYGHVYKAKR KDGKDDKDYA    50
    LKQIEGTGIS MSACREIALL RELKHPNVIS LQKVFLSHAD RKVWLLFDYA 100
    EHDLWHIIKF HRASKANKKP VQLPRGMVKS LLYQILDGIH YLHANWVLHR 150
    DLKPANILVM GEGPERGRVK IADMGFARLF NSPLKPLADL DPVVVTFWYR 200
    APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED IKTSNPYHHD 250
    QLDRIFNVMG FPADKDWEDI KKMPEHSTLM KDFRRNTYTN CSLIKYMEKH 300
    KVKPDSKAFH LLQKLLTMDP IKRITSEQAM QDPYFLEDPL PTSDVFAGCQ 350
    IPYPKREFLT EEEPDDKGDK KNQQQQQGNN HTNGTGHPGN QDSSHTQGPP 400
    LKKVRVVPPT TTSGGLIMTS DYQRSNPHAA YPNPGPSTSQ PQSSMGYSAT 450
    SQQPPQYSHQ THRY 464
    Length:464
    Mass (Da):53,284
    Last modified:February 1, 1996 - v1
    Checksum:i00CBAB6CE354605F
    GO
    Isoform 2 (identifier: P49336-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         370-370: Missing.

    Show »
    Length:463
    Mass (Da):53,156
    Checksum:i8C74EEBD24CBA5DB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti189 – 1891D → N in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication
    VAR_041980
    Natural varianti424 – 4241R → C in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_041981

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei370 – 3701Missing in isoform 2. 1 PublicationVSP_029970

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X85753 mRNA. Translation: CAA59754.1.
    AL590108, AL159159 Genomic DNA. Translation: CAH72300.1.
    AL159159, AL590108 Genomic DNA. Translation: CAI16960.1.
    CH471075 Genomic DNA. Translation: EAX08386.1.
    CH471075 Genomic DNA. Translation: EAX08387.1.
    BC069634 mRNA. Translation: AAH69634.1.
    BC104492 mRNA. Translation: AAI04493.1.
    BC105950 mRNA. Translation: AAI05951.1.
    BC107601 mRNA. Translation: AAI07602.1.
    CCDSiCCDS9317.1. [P49336-1]
    PIRiI37227.
    RefSeqiNP_001251.1. NM_001260.1. [P49336-1]
    XP_005266272.1. XM_005266215.1. [P49336-2]
    UniGeneiHs.382306.
    Hs.695166.

    Genome annotation databases

    EnsembliENST00000381527; ENSP00000370938; ENSG00000132964. [P49336-1]
    GeneIDi1024.
    KEGGihsa:1024.
    UCSCiuc001uqr.1. human. [P49336-1]
    uc001uqs.1. human. [P49336-2]

    Polymorphism databases

    DMDMi1345718.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X85753 mRNA. Translation: CAA59754.1 .
    AL590108 , AL159159 Genomic DNA. Translation: CAH72300.1 .
    AL159159 , AL590108 Genomic DNA. Translation: CAI16960.1 .
    CH471075 Genomic DNA. Translation: EAX08386.1 .
    CH471075 Genomic DNA. Translation: EAX08387.1 .
    BC069634 mRNA. Translation: AAH69634.1 .
    BC104492 mRNA. Translation: AAI04493.1 .
    BC105950 mRNA. Translation: AAI05951.1 .
    BC107601 mRNA. Translation: AAI07602.1 .
    CCDSi CCDS9317.1. [P49336-1 ]
    PIRi I37227.
    RefSeqi NP_001251.1. NM_001260.1. [P49336-1 ]
    XP_005266272.1. XM_005266215.1. [P49336-2 ]
    UniGenei Hs.382306.
    Hs.695166.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3RGF X-ray 2.20 A 1-403 [» ]
    4F6S X-ray 2.60 A 1-403 [» ]
    4F6U X-ray 2.10 A 1-403 [» ]
    4F6W X-ray 2.39 A 1-403 [» ]
    4F70 X-ray 3.00 A 1-403 [» ]
    4F7J X-ray 2.60 A 1-403 [» ]
    4F7L X-ray 2.90 A 1-403 [» ]
    4F7N X-ray 2.65 A 1-403 [» ]
    4F7S X-ray 2.20 A 1-403 [» ]
    4G6L X-ray 2.70 A 1-403 [» ]
    ProteinModelPortali P49336.
    SMRi P49336. Positions 1-359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107458. 76 interactions.
    DIPi DIP-32595N.
    IntActi P49336. 41 interactions.
    MINTi MINT-3017285.
    STRINGi 9606.ENSP00000370938.

    Chemistry

    BindingDBi P49336.
    ChEMBLi CHEMBL3038474.
    GuidetoPHARMACOLOGYi 1980.

    PTM databases

    PhosphoSitei P49336.

    Polymorphism databases

    DMDMi 1345718.

    Proteomic databases

    MaxQBi P49336.
    PaxDbi P49336.
    PRIDEi P49336.

    Protocols and materials databases

    DNASUi 1024.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381527 ; ENSP00000370938 ; ENSG00000132964 . [P49336-1 ]
    GeneIDi 1024.
    KEGGi hsa:1024.
    UCSCi uc001uqr.1. human. [P49336-1 ]
    uc001uqs.1. human. [P49336-2 ]

    Organism-specific databases

    CTDi 1024.
    GeneCardsi GC13P026828.
    HGNCi HGNC:1779. CDK8.
    MIMi 603184. gene.
    neXtProti NX_P49336.
    PharmGKBi PA26315.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    HOVERGENi HBG014652.
    InParanoidi P49336.
    KOi K02208.
    OMAi NVITLIR.
    PhylomeDBi P49336.
    TreeFami TF101025.

    Enzyme and pathway databases

    BRENDAi 2.7.11.22. 2681.
    Reactomei REACT_116145. PPARA activates gene expression.
    REACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_120734. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
    REACT_12627. Generic Transcription Pathway.
    REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_27161. Transcriptional regulation of white adipocyte differentiation.
    SignaLinki P49336.

    Miscellaneous databases

    ChiTaRSi CDK8. human.
    GeneWikii Cyclin-dependent_kinase_8.
    GenomeRNAii 1024.
    NextBioi 4301.
    PROi P49336.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P49336.
    Bgeei P49336.
    CleanExi HS_CDK8.
    Genevestigatori P49336.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C."
      Tassan J.-P., Jaquenoud M., Leopold P., Schultz S.J., Nigg E.A.
      Proc. Natl. Acad. Sci. U.S.A. 92:8871-8875(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    5. "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription."
      Sun X., Zhang Y., Cho H., Rickert P., Lees E., Lane W.S., Reinberg D.
      Mol. Cell 2:213-222(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX.
    6. "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation."
      Gu W., Malik S., Ito M., Yuan C.-X., Fondell J.D., Zhang X., Martinez E., Qin J., Roeder R.G.
      Mol. Cell 3:97-108(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SMCC COMPLEX.
    7. "TFIIH is negatively regulated by cdk8-containing mediator complexes."
      Akoulitchev S., Chuikov S., Reinberg D.
      Nature 407:102-106(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, MUTAGENESIS OF ASP-173.
    8. "Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover."
      Fryer C.J., White J.B., Jones K.A.
      Mol. Cell 16:509-520(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MAML1.
    9. "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."
      Sato S., Tomomori-Sato C., Parmely T.J., Florens L., Zybailov B., Swanson S.K., Banks C.A.S., Jin J., Cai Y., Washburn M.P., Conaway J.W., Conaway R.C.
      Mol. Cell 14:685-691(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX.
    10. "MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."
      Zhang X., Krutchinsky A., Fukuda A., Chen W., Yamamura S., Chait B.T., Roeder R.G.
      Mol. Cell 19:89-100(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX, ASSOCIATION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE II.
    11. "Mediator modulates Gli3-dependent Sonic hedgehog signaling."
      Zhou H., Kim S., Ishii S., Boyer T.G.
      Mol. Cell. Biol. 26:8667-8682(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CTNNB1; GLI3; MED1; MED6; MED12 AND MED23.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder."
      Schneider E.V., Bottcher J., Blaesse M., Neumann L., Huber R., Maskos K.
      J. Mol. Biol. 412:251-266(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1-403 IN COMPLEX WITH CCNC AND INHIBITOR.
    14. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASN-189 AND CYS-424.

    Entry informationi

    Entry nameiCDK8_HUMAN
    AccessioniPrimary (citable) accession number: P49336
    Secondary accession number(s): Q5VUF3, Q6ISB5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3