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Protein

Probable glutathione S-transferase parC

Gene

PARC

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141GlutathioneBy similarity
Binding sitei41 – 411GlutathioneBy similarity
Binding sitei55 – 551Glutathione; via amide nitrogen and carbonyl oxygenBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Auxin signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione S-transferase parC (EC:2.5.1.18)
Alternative name(s):
Auxin-regulated protein parC
Gene namesi
Name:PARC
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Probable glutathione S-transferase parCPRO_0000185864Add
BLAST

Expressioni

Tissue specificityi

Abundant in seedlings and roots. It is also found in the shoot tips, flowers and leaves.

Inductioni

By auxin.

Structurei

3D structure databases

ProteinModelPortaliP49332.
SMRiP49332. Positions 3-220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 8380GST N-terminalAdd
BLAST
Domaini90 – 214125GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni67 – 682Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Phi family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49332-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANEEVILLD FWPSMFGMRL RIALAEKEIK YEYKQEDLRN KSPLLLQMNP
60 70 80 90 100
IHKKIPVLIH NGKPICESII AVEYIEEVWK DKAPSLLPSD PYDRAQARFW
110 120 130 140 150
ADYIDKKLYD FGRKLWATKG EEQEAAKKDF IECLKVLEGA LGDRPYFGGE
160 170 180 190 200
SFGFVDIALI GFYSWFYAYE TFGNFSTEAE CPKFVAWAKR CMQRESVAKS
210 220
LPDQPKVLEF VKVLRQKFGL E
Length:221
Mass (Da):25,743
Last modified:February 1, 1996 - v1
Checksum:i18D27C69857EB3AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64398 mRNA. Translation: CAA45740.1.
PIRiS19185.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64398 mRNA. Translation: CAA45740.1.
PIRiS19185.

3D structure databases

ProteinModelPortaliP49332.
SMRiP49332. Positions 3-220.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Differential expression of an auxin-regulated gene, parC, and a novel related gene, C-7 from tobacco mesophyll protoplasts in response to external stimuli and plant tissues."
    Takahashi Y., Nagata T.
    Plant Cell Physiol. 33:779-787(1992)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Xanthi NC.
    Tissue: Leaf mesophyll.

Entry informationi

Entry nameiGSTXC_TOBAC
AccessioniPrimary (citable) accession number: P49332
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 1, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.