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P49331

- GTFD_STRMU

UniProt

P49331 - GTFD_STRMU

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Protein
Glucosyltransferase-S
Gene
gtfD, SMU_910
Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris.

Catalytic activityi

Sucrose + ((1->6)-alpha-D-glucosyl)(n) = D-fructose + ((1->6)-alpha-D-glucosyl)(n+1).

GO - Molecular functioni

  1. dextransucrase activity Source: UniProtKB-EC
  2. glucosyltransferase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glucan biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-869-MONOMER.

Protein family/group databases

CAZyiGH70. Glycoside Hydrolase Family 70.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucosyltransferase-S (EC:2.4.1.5)
Short name:
GTF-S
Alternative name(s):
Dextransucrase
Sucrose 6-glucosyltransferase
Gene namesi
Name:gtfD
Ordered Locus Names:SMU_910
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002512: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Dental caries

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 1462Glucosyltransferase-SPRO_0000021387
Signal peptidei1 – ? Reviewed prediction

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU.910.

Structurei

3D structure databases

ProteinModelPortaliP49331.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati171 – 19020Cell wall-binding 1
Add
BLAST
Repeati192 – 21120Cell wall-binding 2
Add
BLAST
Repeati1095 – 111521Cell wall-binding 3
Add
BLAST
Repeati1116 – 113621Cell wall-binding 4
Add
BLAST
Repeati1137 – 115620Cell wall-binding 5
Add
BLAST
Repeati1180 – 120122Cell wall-binding 6
Add
BLAST
Repeati1202 – 122120Cell wall-binding 7
Add
BLAST
Repeati1223 – 124422Cell wall-binding 8
Add
BLAST
Repeati1246 – 126621Cell wall-binding 9
Add
BLAST
Repeati1267 – 128620Cell wall-binding 10
Add
BLAST
Repeati1310 – 133021Cell wall-binding 11
Add
BLAST
Repeati1331 – 135020Cell wall-binding 12
Add
BLAST
Repeati1352 – 137221Cell wall-binding 13
Add
BLAST
Repeati1374 – 139421Cell wall-binding 14
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG5263.
KOiK00689.
OMAiKDHLQGG.
OrthoDBiEOG60PH6T.
PhylomeDBiP49331.

Family and domain databases

Gene3Di3.20.20.80. 2 hits.
InterProiIPR018337. Cell_wall/Cho-bd_repeat.
IPR027636. Glucan-bd_rpt.
IPR003318. Glyco_hydro70cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR022263. KxYKxGKxW.
[Graphical view]
PfamiPF01473. CW_binding_1. 5 hits.
PF02324. Glyco_hydro_70. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 3 hits.
TIGRFAMsiTIGR04035. glucan_65_rpt. 5 hits.
TIGR03715. KxYKxGKxW. 1 hit.
PROSITEiPS51170. CW. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49331-1 [UniParc]FASTAAdd to Basket

« Hide

METKRRYKMY KVKKHWVTIA VASGLITLGT TTLGSSVSAE TEQQTSDKVV     50
TQKSEDDKAA SESSQTDAPK TKQAQTEQTQ AQSQANVADT STSITKETPS 100
QNITTQANSD DKTVTNTKSE EAQTSEERTK QAEEAQATAS SQALTQAKAE 150
LTKQRQTAAQ ENKNPVDLAA IPNVKQIDGK YYYIGSDGQP KKNFALTVNN 200
KVLYFDKNTG ALTDTSQYQF KQGLTKLNND YTPHNQIVNF ENTSLETIDN 250
YVTADSWYRP KDILKNGKTW TASSESDLRP LLMSWWPDKQ TQIAYLNYMN 300
QQGLGTGENY TADSSQESLN LAAQTVQVKI ETKISQTQQT QWLRDIINSF 350
VKTQPNWNSQ TESDTSAGEK DHLQGGALLY SNSDKTAYAN SDYRLLNRTP 400
TSQTGKPKYF EDNSSGGYDF LLANDIDNSN PVVQAEQLNW LHYLMNYGSI 450
VANDPEANFD GVRVDAVDNV NADLLQIASD YLKAHYGVDK SEKNAINHLS 500
ILEAWSDNDP QYNKDTKGAQ LPIDNKLRLS LLYALTRPLE KDASNKNEIR 550
SGLEPVITNS LNNRSAEGKN SERMANYIFI RAHDSEVQTV IAKIIKAQIN 600
PKTDGLTFTL DELKQAFKIY NEDMRQAKKK YTQSNIPTAY ALMLSNKDSI 650
TRLYYGDMYS DDGQYMATKS PYYDAIDTLL KARIKYAAGG QDMKITYVEG 700
DKSHMDWDYT GVLTSVRYGT GANEATDQGS EATKTQGMAV ITSNNPSLKL 750
NQNDKVIVNM GTAHKNQEYR PLLLTTKDGL TSYTSDAAAK SLYRKTNDKG 800
ELVFDASDIQ GYLNPQVSGY LAVWVPVGAS DNQDVRVAAS NKANATGQVY 850
ESSSALDSQL IYEGFSNFQD FVTKDSDYTN KKIAQNVQLF KSWGVTSFEM 900
APQYVSSEDG SFLDSIIQNG YAFEDRYDLA MSKNNKYGSQ QDMINAVKAL 950
HKSGIQVIAD WVPDQIYNLP GKEVVTATRV NDYGEYRKDS EIKNTLYAAN 1000
TKSNGKDYQA KYGGAFLSEL AAKYPSIFNR TQISNGKKID PSEKITAWKA 1050
KYFNGTNILG RGVGYVLKDN ASDKYFELKG NQTYLPKQMT NKEASTGFVN 1100
DGNGMTFYST SGYQAKNSFV QDAKGNWYYF DNNGHMVYGL QHLNGEVQYF 1150
LSNGVQLRES FLENADGSKN YFGHLGNRYS NGYYSFDNDS KWRYFDASGV 1200
MAVGLKTING NTQYFDQDGY QVKGAWITGS DGKKRYFDDG SGNMAVNRFA 1250
NDKNGDWYYL NSDGIALVGV QTINGKTYYF GQDGKQIKGK IITDNGKLKY 1300
FLANSGELAR NIFATDSQNN WYYFGSDGVA VTGSQTIAGK KLYFASDGKQ 1350
VKGSFVTYNG KVHYYHADSG ELQVNRFEAD KDGNWYYLDS NGEALTGSQR 1400
INGQRVFFTR EGKQVKGDVA YDERGLLRYY DKNSGNMVYN KVVTLANGRR 1450
IGIDRWGIAR YY 1462
Length:1,462
Mass (Da):163,388
Last modified:November 28, 2002 - v3
Checksum:iCE4A279C4D708645
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101Y → H in strain: GS-5, MT4239, MT4245, MT4251, MT4467 and MT8148.
Natural varianti19 – 191I → V in strain: GS-5, MT4239, MT4245, MT4251, MT4467 and MT8148.
Natural varianti58 – 581K → E in strain: MT4467.
Natural varianti68 – 681A → S in strain: MT4239 and MT4245.
Natural varianti81 – 811A → T in strain: MT4251 and MT8148.
Natural varianti113 – 1131T → I in strain: MT4239 and MT4245.
Natural varianti122 – 1221A → V in strain: MT4239, MT4245 and MT8148.
Natural varianti132 – 1321A → S in strain: GS-5 and MT4467.
Natural varianti135 – 1351A → V in strain: MT4245.
Natural varianti137 – 1371A → T in strain: GS-5, MT4239, MT4245, MT4251, MT4467 and MT8148.
Natural varianti202 – 2021V → L in strain: MT4239.
Natural varianti255 – 2551D → N in strain: MT8148.
Natural varianti275 – 2751E → D in strain: MT4239, MT4245 and MT4251.
Natural varianti288 – 2881D → N in strain: MT4239, MT4245 and MT4251.
Natural varianti301 – 3011Q → H in strain: MT4245.
Natural varianti313 – 3131D → N in strain: MT4239 and MT4251.
Natural varianti317 – 3171E → K in strain: MT4239.
Natural varianti328 – 3281V → F in strain: MT4239.
Natural varianti350 – 3501F → L in strain: MT4239, MT4251 and MT4467.
Natural varianti628 – 6336KKKYTQ → EKEYTL in strain: MT4251.
Natural varianti688 – 6881A → S in strain: MT4239.
Natural varianti726 – 7327TDQGSEA → ADKGNDS in strain: MT4251.
Natural varianti726 – 7305TDQGS → ADKGN in strain: MT4239 and MT4245.
Natural varianti762 – 7621T → A in strain: GS-5, MT4239, MT4245, MT4251, MT4467 and MT8148.
Natural varianti964 – 9641D → Y in strain: MT4251.
Natural varianti1019 – 10191E → K in strain: MT4245 and MT4251.
Natural varianti1059 – 10602LG → IR in strain: MT4251.
Natural varianti1060 – 10601G → R in strain: MT4245.
Natural varianti1080 – 10801G → R in strain: MT4239.
Natural varianti1142 – 11421H → Q in strain: GS-5.
Natural varianti1198 – 11981S → N in strain: MT4239.
Natural varianti1220 – 12201Y → C in strain: MT4251 and MT4467.
Natural varianti1280 – 12801F → L in strain: MT4467.
Natural varianti1282 – 12821Q → P in strain: MT4245.
Natural varianti1290 – 12901K → T in strain: MT4245.
Natural varianti1311 – 13111N → D in strain: MT4245.
Natural varianti1403 – 14031G → D in strain: GS-5 and MT4467.
Natural varianti1425 – 14251G → R in strain: GS-5.
Natural varianti1449 – 14491R → K in strain: MT4467.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1428 – 146235RYYDK…IARYY → VYR in AAA26895. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29296 Genomic DNA. Translation: AAA26895.1.
D88653 Genomic DNA. Translation: BAA26103.1.
D88656 Genomic DNA. Translation: BAA26107.1.
D88659 Genomic DNA. Translation: BAA26111.1.
D88662 Genomic DNA. Translation: BAA26115.1.
D89979 Genomic DNA. Translation: BAA26121.1.
AE014133 Genomic DNA. Translation: AAN58619.1.
RefSeqiNP_721313.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN58619; AAN58619; SMU_910.
GeneIDi1028270.
KEGGismu:SMU_910.
PATRICi19663961. VBIStrMut61772_0813.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29296 Genomic DNA. Translation: AAA26895.1 .
D88653 Genomic DNA. Translation: BAA26103.1 .
D88656 Genomic DNA. Translation: BAA26107.1 .
D88659 Genomic DNA. Translation: BAA26111.1 .
D88662 Genomic DNA. Translation: BAA26115.1 .
D89979 Genomic DNA. Translation: BAA26121.1 .
AE014133 Genomic DNA. Translation: AAN58619.1 .
RefSeqi NP_721313.1. NC_004350.2.

3D structure databases

ProteinModelPortali P49331.
ModBasei Search...

Protein-protein interaction databases

STRINGi 210007.SMU.910.

Protein family/group databases

CAZyi GH70. Glycoside Hydrolase Family 70.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN58619 ; AAN58619 ; SMU_910 .
GeneIDi 1028270.
KEGGi smu:SMU_910.
PATRICi 19663961. VBIStrMut61772_0813.

Phylogenomic databases

eggNOGi COG5263.
KOi K00689.
OMAi KDHLQGG.
OrthoDBi EOG60PH6T.
PhylomeDBi P49331.

Enzyme and pathway databases

BioCyci SMUT210007:GC7Z-869-MONOMER.

Family and domain databases

Gene3Di 3.20.20.80. 2 hits.
InterProi IPR018337. Cell_wall/Cho-bd_repeat.
IPR027636. Glucan-bd_rpt.
IPR003318. Glyco_hydro70cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR022263. KxYKxGKxW.
[Graphical view ]
Pfami PF01473. CW_binding_1. 5 hits.
PF02324. Glyco_hydro_70. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 3 hits.
TIGRFAMsi TIGR04035. glucan_65_rpt. 5 hits.
TIGR03715. KxYKxGKxW. 1 hit.
PROSITEi PS51170. CW. 14 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the Streptococcus mutans gtfD gene encoding the glucosyltransferase-S enzyme."
    Honda O., Kato C., Kuramitsu H.K.
    J. Gen. Microbiol. 136:2099-2105(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: GS-5.
  2. "Molecular analyses of glucosyltransferase genes among strains of Streptococcus mutans."
    Fujiwara T., Terao Y., Hoshino T., Kawabata S., Ooshima T., Sobue S., Kimura S., Hamada S.
    FEMS Microbiol. Lett. 161:331-336(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: MT4239 / Serotype c, MT4245 / Serotype e, MT4251 / Serotype f, MT4467 / Serotype e and MT8148 / Serotype c.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159.

Entry informationi

Entry nameiGTFD_STRMU
AccessioniPrimary (citable) accession number: P49331
Secondary accession number(s): O69383
, O69386, O69389, O69392, O69398
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 28, 2002
Last modified: July 9, 2014
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

GTF-I synthesizes water-insoluble glucans (alpha 1,3-linked glucose and some 1,6 linkages), GTF-S synthesizes water-soluble glucans (alpha 1,6-glucose). GTF-SI synthesizes both forms of glucans.

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi