Reviewed, UniProtKB/Swiss-Prot P49328 (FMO1_CAVPO)

Names and origin

Protein names

Recommended name:
    Dimethylaniline monooxygenase [N-oxide-forming] 1
    EC=1.14.13.8
Alternative name(s):
    Hepatic flavin-containing monooxygenase 1
      Short name=FMO 1
    Dimethylaniline oxidase 1

Gene names

Name:	FMO1
Synonyms:	FMO-1

Organism

Cavia porcellus (Guinea pig)

Taxonomic identifier

10141 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia

Protein attributes

Sequence length	19 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.
Catalytic activity	N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O.
Cofactor	FAD.
Subcellular location	Microsome membrane. Endoplasmic reticulum membrane.
Tissue specificity	Liver.
Sequence similarities	Belongs to the FMO family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Transmembrane
Ligand	FAD Flavoprotein NADP
Molecular function	Monooxygenase Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro NADP binding Inferred from electronic annotation. Source: InterPro flavin-containing monooxygenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›19	›19	Dimethylaniline monooxygenase [N-oxide-forming] 1		PRO_0000147638
Experimental info
	Non-terminal residue	19	1

Sequences

	Sequence		Length	Mass (Da)
	P49328-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 324DDEB75CA05522	FASTA	19	1,826
	10 VKKVAIIGAG VSGLASIRS

References

[1]	"Multiplicity of liver microsomal flavin-containing monooxygenase in the guinea pig: its purification and characterization." Yamada H., Yuno K., Oguri K., Yoshimura H. Arch. Biochem. Biophys. 280:305-312(1990) [PubMed: 2369122] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Liver.

Cross-references

Sequence databases
PIR	S10747.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P49328.
Family and domain databases
InterPro	IPR000960. Flavin_mOase. [Graphical view]
Pfam	PF00743. FMO-like. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FMO1_CAVPO

Accession

Primary (citable) accession number: P49328

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	November 25, 2008
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)