Reviewed,
UniProtKB/Swiss-Prot P49326 (FMO5_HUMAN)
Last modified
November 25, 2008.
Version 77.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dimethylaniline monooxygenase [N-oxide-forming] 5 EC=1.14.13.8 Alternative name(s): Hepatic flavin-containing monooxygenase 5 Short name=FMO 5 Dimethylaniline oxidase 5 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 533 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme. |
| Catalytic activity | N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O. |
| Cofactor | FAD. |
| Subcellular location | |
| Tissue specificity | Expressed in fetal and adult liver. |
| Sequence similarities | Belongs to the FMO family. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum Membrane Microsome |
| Coding sequence diversity | Polymorphism |
| Domain | Transmembrane |
| Ligand | FAD Flavoprotein NADP |
| Molecular function | Monooxygenase Oxidoreductase |
| PTM | Acetylation Methylation |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intrinsic to endoplasmic reticulum membraneInferred from electronic annotation. Source: InterPro microsomeNon-traceable author statement. Source: UniProtKB |
| Molecular function | FAD binding Inferred from electronic annotation. Source: InterPro NADP bindingInferred from electronic annotation. Source: InterPro flavin-containing monooxygenase activityNon-traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 533 | 532 | Dimethylaniline monooxygenase [N-oxide-forming] 5 | PRO_0000147665 | |||||
Regions | |||||||||
| Nucleotide binding | 10 – 15 | 6 | FAD Potential | ||||||
| Nucleotide binding | 192 – 197 | 6 | NADP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylthreonine By similarity | ||||||
| Modified residue | 5 | 1 | Omega-N-methylated arginine By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 400 | 1 | P → A | VAR_022308 | |||||
| Natural variant | 457 | 1 | P → L | VAR_015370 | |||||
| Natural variant | 506 | 1 | R → S | VAR_022309 | |||||
Experimental info | |||||||||
| Sequence conflict | 351 | 1 | S → P in CAA87633. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog." Overby L.H., Buckpitt A.R., Lawton M.P., Atta-Asafo-Adjei E., Schulze J., Philpot R.M. Arch. Biochem. Biophys. 317:275-284(1995) [PubMed: 7872795] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver. |
| [2] | "Cloning, primary sequence and chromosomal localisation of human flavin-containing monooxygenase 5 (FMO5)." Dolphin C.T., Povey S., Shephard E.A., Smith R.L., Phillips I.R. Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver and Placenta. |
| [3] | "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)." Livingston R.J., Rieder M.J., Rajkumar N., Downing T.K., Olson A.N., Nguyen C.P., Gildersleeve H., Cassidy C.M., Johnson E.J., Swanson J.E., McFarland I., Yool B., Park C., Nickerson D.A. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-400 AND SER-506. |
| [4] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans." Furnes B., Feng J., Sommer S.S., Schlenk D. Drug Metab. Dispos. 31:187-193(2003) [PubMed: 12527699] [Abstract] Cited for: VARIANT LEU-457. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| L37080 mRNA. Translation: AAA67849.1. Z47553 mRNA. Translation: CAA87633.1. AY902236 Genomic DNA. Translation: AAW69390.1. AL356378 Genomic DNA. Translation: CAH72648.1. | |
| PIR | S51131. S71618. |
| RefSeq | NP_001452.1. |
| UniGene | Hs.642706 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P49326. |
Polymorphism databases | |
| NIEHS-SNPs | Search... |
Genome annotation databases | |
| Ensembl | ENSG00000131781. Homo sapiens. [Contig view] |
| GeneID | 2330. |
| KEGG | hsa:2330. |
Organism-specific databases | |
| HGNC | HGNC:3773. FMO5. |
| HPA | HPA012373. |
| MIM | 603957. gene. |
| PharmGKB | PA28189. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | P49326. |
| HOVERGEN | P49326. |
Gene expression databases | |
| ArrayExpress | P49326. |
| CleanEx | HS_FMO5. |
| GermOnline | ENSG00000131781. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR012143. dManiline_mOase. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR000960. Flavin_mOase. IPR002257. Flavin_mOase_5. [Graphical view] |
| Pfam | PF00743. FMO-like. 1 hit. [Graphical view] |
| PIRSF | PIRSF000332. FMO. 1 hit. |
| PRINTS | PR00368. FADPNR. PR00370. FMOXYGENASE. PR01125. FMOXYGENASE5. |
| ProDom | PD000139. FAD_pyr_redox. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 9457. |
| SOURCE | Search... |
Entry information
| Entry name | FMO5_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P49326 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


