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Protein

Dimethylaniline monooxygenase [N-oxide-forming] 5

Gene

FMO5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.

Catalytic activityi

N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 14FADBy similarity5
Nucleotide bindingi41 – 42FADBy similarity2
Nucleotide bindingi62 – 63FADBy similarity2
Nucleotide bindingi196 – 199NADPBy similarity4

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

BRENDAi1.14.13.8 2681
SABIO-RKiP49326

Chemistry databases

SwissLipidsiSLP:000001774

Names & Taxonomyi

Protein namesi
Recommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC:1.14.13.8)
Alternative name(s):
Dimethylaniline oxidase 5
Hepatic flavin-containing monooxygenase 5
Short name:
FMO 5
Gene namesi
Name:FMO5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000131781.12
HGNCiHGNC:3773 FMO5
MIMi603957 gene
neXtProtiNX_P49326

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei513 – 533HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi2330
OpenTargetsiENSG00000131781
PharmGKBiPA28189

Chemistry databases

ChEMBLiCHEMBL3430871

Polymorphism and mutation databases

BioMutaiFMO5
DMDMi1346021

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001476651 – 533Dimethylaniline monooxygenase [N-oxide-forming] 5Add BLAST533

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5Dimethylated arginine; alternateBy similarity1
Modified residuei5Omega-N-methylated arginine; alternateBy similarity1
Modified residuei54PhosphoserineCombined sources1
Modified residuei56PhosphotyrosineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei280PhosphoserineCombined sources1
Modified residuei284PhosphothreonineCombined sources1
Modified residuei401PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiP49326
MaxQBiP49326
PaxDbiP49326
PeptideAtlasiP49326
PRIDEiP49326

PTM databases

iPTMnetiP49326
PhosphoSitePlusiP49326

Expressioni

Tissue specificityi

Expressed in fetal and adult liver.

Gene expression databases

BgeeiENSG00000131781
CleanExiHS_FMO5
ExpressionAtlasiP49326 baseline and differential
GenevisibleiP49326 HS

Organism-specific databases

HPAiHPA012373

Interactioni

Protein-protein interaction databases

BioGridi108617, 6 interactors
STRINGi9606.ENSP00000254090

Structurei

3D structure databases

ProteinModelPortaliP49326
SMRiP49326
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FMO family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1399 Eukaryota
COG2072 LUCA
GeneTreeiENSGT00760000119232
HOGENOMiHOG000076537
HOVERGENiHBG002037
InParanoidiP49326
KOiK00485
OMAiQSLANKY
OrthoDBiEOG091G0465
PhylomeDBiP49326
TreeFamiTF105285

Family and domain databases

Gene3Di3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR000960 Flavin_mOase
IPR020946 Flavin_mOase-like
IPR002257 Flavin_mOase_5
PfamiView protein in Pfam
PF00743 FMO-like, 1 hit
PIRSFiPIRSF000332 FMO, 1 hit
PRINTSiPR00370 FMOXYGENASE
PR01125 FMOXYGENASE5
SUPFAMiSSF51905 SSF51905, 2 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P49326-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTKKRIAVIG GGVSGLSSIK CCVEEGLEPV CFERTDDIGG LWRFQENPEE
60 70 80 90 100
GRASIYKSVI INTSKEMMCF SDYPIPDHYP NFMHNAQVLE YFRMYAKEFD
110 120 130 140 150
LLKYIRFKTT VCSVKKQPDF ATSGQWEVVT ESEGKKEMNV FDGVMVCTGH
160 170 180 190 200
HTNAHLPLES FPGIEKFKGQ YFHSRDYKNP EGFTGKRVII IGIGNSGGDL
210 220 230 240 250
AVEISQTAKQ VFLSTRRGAW ILNRVGDYGY PADVLFSSRL THFIWKICGQ
260 270 280 290 300
SLANKYLEKK INQRFDHEMF GLKPKHRALS QHPTLNDDLP NRIISGLVKV
310 320 330 340 350
KGNVKEFTET AAIFEDGSRE DDIDAVIFAT GYSFDFPFLE DSVKVVKNKI
360 370 380 390 400
SLYKKVFPPN LERPTLAIIG LIQPLGAIMP ISELQGRWAT QVFKGLKTLP
410 420 430 440 450
SQSEMMAEIS KAQEEIDKRY VESQRHTIQG DYIDTMEELA DLVGVRPNLL
460 470 480 490 500
SLAFTDPKLA LHLLLGPCTP IHYRVQGPGK WDGARKAILT TDDRIRKPLM
510 520 530
TRVVERSSSM TSTMTIGKFM LALAFFAIII AYF
Length:533
Mass (Da):60,221
Last modified:January 23, 2007 - v2
Checksum:iF9D9F092F1DD71DA
GO
Isoform 2 (identifier: P49326-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     278-285: ALSQHPTL → SKDIALTE
     286-533: Missing.

Note: No experimental confirmation available.
Show »
Length:285
Mass (Da):32,480
Checksum:i4DE507F329B99046
GO
Isoform 3 (identifier: P49326-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     419-464: RYVESQRHTI...TDPKLALHLL → SLTMRKTSDK...CPGIKGPKET
     465-533: Missing.

Note: No experimental confirmation available.
Show »
Length:464
Mass (Da):52,477
Checksum:i1989AA851C48E893
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti351S → P in CAA87633 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022308400P → A1 PublicationCorresponds to variant dbSNP:rs28381218Ensembl.1
Natural variantiVAR_015370457P → L1 PublicationCorresponds to variant dbSNP:rs72549314Ensembl.1
Natural variantiVAR_022309506R → S1 PublicationCorresponds to variant dbSNP:rs28381223Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042729278 – 285ALSQHPTL → SKDIALTE in isoform 2. 1 Publication8
Alternative sequenceiVSP_042730286 – 533Missing in isoform 2. 1 PublicationAdd BLAST248
Alternative sequenceiVSP_045616419 – 464RYVES…ALHLL → SLTMRKTSDKPKLKNILQIP DYLKTVKIINKESLRNCPGI KGPKET in isoform 3. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_045617465 – 533Missing in isoform 3. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37080 mRNA Translation: AAA67849.1
Z47553 mRNA Translation: CAA87633.1
AY902236 Genomic DNA Translation: AAW69390.1
AK314647 mRNA Translation: BAG37208.1
AK225739 mRNA No translation available.
AL356378 Genomic DNA Translation: CAH72648.1
AL356378 Genomic DNA Translation: CAH72649.1
CH471223 Genomic DNA Translation: EAW50939.1
CH471223 Genomic DNA Translation: EAW50940.1
BC035687 mRNA Translation: AAH35687.1
CCDSiCCDS44209.1 [P49326-3]
CCDS44210.1 [P49326-2]
CCDS926.1 [P49326-1]
PIRiS51131
S71618
RefSeqiNP_001138301.1, NM_001144829.2 [P49326-3]
NP_001138302.1, NM_001144830.2 [P49326-2]
NP_001452.2, NM_001461.3 [P49326-1]
XP_005273003.1, XM_005272946.4 [P49326-1]
XP_005273004.1, XM_005272947.4 [P49326-1]
XP_005273005.1, XM_005272948.4 [P49326-1]
XP_006711308.1, XM_006711245.3 [P49326-2]
XP_011507652.1, XM_011509350.2 [P49326-1]
UniGeneiHs.642706

Genome annotation databases

EnsembliENST00000254090; ENSP00000254090; ENSG00000131781 [P49326-1]
ENST00000369272; ENSP00000358277; ENSG00000131781 [P49326-2]
ENST00000441068; ENSP00000416011; ENSG00000131781 [P49326-3]
ENST00000578284; ENSP00000462062; ENSG00000131781 [P49326-3]
GeneIDi2330
KEGGihsa:2330
UCSCiuc001eph.5 human [P49326-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Entry informationi

Entry nameiFMO5_HUMAN
AccessioniPrimary (citable) accession number: P49326
Secondary accession number(s): B2RBG1, C9JJD1, Q8IV22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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