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P49326

- FMO5_HUMAN

UniProt

P49326 - FMO5_HUMAN

Protein

Dimethylaniline monooxygenase [N-oxide-forming] 5

Gene

FMO5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.

    Catalytic activityi

    N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

    Cofactori

    FAD.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156FADSequence Analysis
    Nucleotide bindingi192 – 1976NADPBy similarity

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. N,N-dimethylaniline monooxygenase activity Source: UniProtKB-EC
    3. NADP binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC:1.14.13.8)
    Alternative name(s):
    Dimethylaniline oxidase 5
    Hepatic flavin-containing monooxygenase 5
    Short name:
    FMO 5
    Gene namesi
    Name:FMO5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:3773. FMO5.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28189.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 533533Dimethylaniline monooxygenase [N-oxide-forming] 5PRO_0000147665Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei5 – 51Omega-N-methylated arginineBy similarity

    Keywords - PTMi

    Methylation

    Proteomic databases

    MaxQBiP49326.
    PaxDbiP49326.
    PRIDEiP49326.

    PTM databases

    PhosphoSiteiP49326.

    Expressioni

    Tissue specificityi

    Expressed in fetal and adult liver.

    Gene expression databases

    ArrayExpressiP49326.
    BgeeiP49326.
    CleanExiHS_FMO5.
    GenevestigatoriP49326.

    Organism-specific databases

    HPAiHPA012373.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000254090.

    Structurei

    3D structure databases

    ProteinModelPortaliP49326.
    SMRiP49326. Positions 5-219, 312-441.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FMO family.Curated

    Keywords - Domaini

    Transmembrane

    Phylogenomic databases

    eggNOGiCOG2072.
    HOGENOMiHOG000076537.
    HOVERGENiHBG002037.
    InParanoidiP49326.
    KOiK00485.
    OMAiLGPCTPI.
    PhylomeDBiP49326.
    TreeFamiTF105285.

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    InterProiIPR012143. DiMe-aniline_mOase.
    IPR000960. Flavin_mOase.
    IPR020946. Flavin_mOase-like.
    IPR002257. Flavin_mOase_5.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00743. FMO-like. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000332. FMO. 1 hit.
    PRINTSiPR00370. FMOXYGENASE.
    PR01125. FMOXYGENASE5.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P49326-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTKKRIAVIG GGVSGLSSIK CCVEEGLEPV CFERTDDIGG LWRFQENPEE    50
    GRASIYKSVI INTSKEMMCF SDYPIPDHYP NFMHNAQVLE YFRMYAKEFD 100
    LLKYIRFKTT VCSVKKQPDF ATSGQWEVVT ESEGKKEMNV FDGVMVCTGH 150
    HTNAHLPLES FPGIEKFKGQ YFHSRDYKNP EGFTGKRVII IGIGNSGGDL 200
    AVEISQTAKQ VFLSTRRGAW ILNRVGDYGY PADVLFSSRL THFIWKICGQ 250
    SLANKYLEKK INQRFDHEMF GLKPKHRALS QHPTLNDDLP NRIISGLVKV 300
    KGNVKEFTET AAIFEDGSRE DDIDAVIFAT GYSFDFPFLE DSVKVVKNKI 350
    SLYKKVFPPN LERPTLAIIG LIQPLGAIMP ISELQGRWAT QVFKGLKTLP 400
    SQSEMMAEIS KAQEEIDKRY VESQRHTIQG DYIDTMEELA DLVGVRPNLL 450
    SLAFTDPKLA LHLLLGPCTP IHYRVQGPGK WDGARKAILT TDDRIRKPLM 500
    TRVVERSSSM TSTMTIGKFM LALAFFAIII AYF 533
    Length:533
    Mass (Da):60,221
    Last modified:January 23, 2007 - v2
    Checksum:iF9D9F092F1DD71DA
    GO
    Isoform 2 (identifier: P49326-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         278-285: ALSQHPTL → SKDIALTE
         286-533: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:285
    Mass (Da):32,480
    Checksum:i4DE507F329B99046
    GO
    Isoform 3 (identifier: P49326-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         419-464: RYVESQRHTI...TDPKLALHLL → SLTMRKTSDK...CPGIKGPKET
         465-533: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:464
    Mass (Da):52,477
    Checksum:i1989AA851C48E893
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti351 – 3511S → P in CAA87633. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti400 – 4001P → A.1 Publication
    Corresponds to variant rs28381218 [ dbSNP | Ensembl ].
    VAR_022308
    Natural varianti457 – 4571P → L.1 Publication
    VAR_015370
    Natural varianti506 – 5061R → S.1 Publication
    Corresponds to variant rs28381223 [ dbSNP | Ensembl ].
    VAR_022309

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei278 – 2858ALSQHPTL → SKDIALTE in isoform 2. 1 PublicationVSP_042729
    Alternative sequencei286 – 533248Missing in isoform 2. 1 PublicationVSP_042730Add
    BLAST
    Alternative sequencei419 – 46446RYVES…ALHLL → SLTMRKTSDKPKLKNILQIP DYLKTVKIINKESLRNCPGI KGPKET in isoform 3. 1 PublicationVSP_045616Add
    BLAST
    Alternative sequencei465 – 53369Missing in isoform 3. 1 PublicationVSP_045617Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37080 mRNA. Translation: AAA67849.1.
    Z47553 mRNA. Translation: CAA87633.1.
    AY902236 Genomic DNA. Translation: AAW69390.1.
    AK314647 mRNA. Translation: BAG37208.1.
    AK225739 mRNA. No translation available.
    AL356378 Genomic DNA. Translation: CAH72648.1.
    AL356378 Genomic DNA. Translation: CAH72649.1.
    CH471223 Genomic DNA. Translation: EAW50939.1.
    CH471223 Genomic DNA. Translation: EAW50940.1.
    BC035687 mRNA. Translation: AAH35687.1.
    CCDSiCCDS44209.1. [P49326-3]
    CCDS44210.1. [P49326-2]
    CCDS926.1. [P49326-1]
    PIRiS51131.
    S71618.
    RefSeqiNP_001138301.1. NM_001144829.2. [P49326-3]
    NP_001138302.1. NM_001144830.2. [P49326-2]
    NP_001452.2. NM_001461.3. [P49326-1]
    XP_005273003.1. XM_005272946.2. [P49326-1]
    XP_005273004.1. XM_005272947.2. [P49326-1]
    XP_005273005.1. XM_005272948.2. [P49326-1]
    XP_006711308.1. XM_006711245.1. [P49326-2]
    UniGeneiHs.642706.

    Genome annotation databases

    EnsembliENST00000254090; ENSP00000254090; ENSG00000131781. [P49326-1]
    ENST00000369272; ENSP00000358277; ENSG00000131781. [P49326-2]
    ENST00000441068; ENSP00000416011; ENSG00000131781. [P49326-3]
    ENST00000578284; ENSP00000462062; ENSG00000131781. [P49326-1]
    GeneIDi2330.
    KEGGihsa:2330.
    UCSCiuc001epi.2. human. [P49326-1]
    uc001epj.2. human. [P49326-2]

    Polymorphism databases

    DMDMi1346021.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37080 mRNA. Translation: AAA67849.1 .
    Z47553 mRNA. Translation: CAA87633.1 .
    AY902236 Genomic DNA. Translation: AAW69390.1 .
    AK314647 mRNA. Translation: BAG37208.1 .
    AK225739 mRNA. No translation available.
    AL356378 Genomic DNA. Translation: CAH72648.1 .
    AL356378 Genomic DNA. Translation: CAH72649.1 .
    CH471223 Genomic DNA. Translation: EAW50939.1 .
    CH471223 Genomic DNA. Translation: EAW50940.1 .
    BC035687 mRNA. Translation: AAH35687.1 .
    CCDSi CCDS44209.1. [P49326-3 ]
    CCDS44210.1. [P49326-2 ]
    CCDS926.1. [P49326-1 ]
    PIRi S51131.
    S71618.
    RefSeqi NP_001138301.1. NM_001144829.2. [P49326-3 ]
    NP_001138302.1. NM_001144830.2. [P49326-2 ]
    NP_001452.2. NM_001461.3. [P49326-1 ]
    XP_005273003.1. XM_005272946.2. [P49326-1 ]
    XP_005273004.1. XM_005272947.2. [P49326-1 ]
    XP_005273005.1. XM_005272948.2. [P49326-1 ]
    XP_006711308.1. XM_006711245.1. [P49326-2 ]
    UniGenei Hs.642706.

    3D structure databases

    ProteinModelPortali P49326.
    SMRi P49326. Positions 5-219, 312-441.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000254090.

    PTM databases

    PhosphoSitei P49326.

    Polymorphism databases

    DMDMi 1346021.

    Proteomic databases

    MaxQBi P49326.
    PaxDbi P49326.
    PRIDEi P49326.

    Protocols and materials databases

    DNASUi 2330.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000254090 ; ENSP00000254090 ; ENSG00000131781 . [P49326-1 ]
    ENST00000369272 ; ENSP00000358277 ; ENSG00000131781 . [P49326-2 ]
    ENST00000441068 ; ENSP00000416011 ; ENSG00000131781 . [P49326-3 ]
    ENST00000578284 ; ENSP00000462062 ; ENSG00000131781 . [P49326-1 ]
    GeneIDi 2330.
    KEGGi hsa:2330.
    UCSCi uc001epi.2. human. [P49326-1 ]
    uc001epj.2. human. [P49326-2 ]

    Organism-specific databases

    CTDi 2330.
    GeneCardsi GC01M146655.
    HGNCi HGNC:3773. FMO5.
    HPAi HPA012373.
    MIMi 603957. gene.
    neXtProti NX_P49326.
    PharmGKBi PA28189.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2072.
    HOGENOMi HOG000076537.
    HOVERGENi HBG002037.
    InParanoidi P49326.
    KOi K00485.
    OMAi LGPCTPI.
    PhylomeDBi P49326.
    TreeFami TF105285.

    Miscellaneous databases

    ChiTaRSi FMO5. human.
    GeneWikii FMO5.
    GenomeRNAii 2330.
    NextBioi 9457.
    PROi P49326.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P49326.
    Bgeei P49326.
    CleanExi HS_FMO5.
    Genevestigatori P49326.

    Family and domain databases

    Gene3Di 3.40.50.720. 2 hits.
    InterProi IPR012143. DiMe-aniline_mOase.
    IPR000960. Flavin_mOase.
    IPR020946. Flavin_mOase-like.
    IPR002257. Flavin_mOase_5.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00743. FMO-like. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000332. FMO. 1 hit.
    PRINTSi PR00370. FMOXYGENASE.
    PR01125. FMOXYGENASE5.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog."
      Overby L.H., Buckpitt A.R., Lawton M.P., Atta-Asafo-Adjei E., Schulze J., Philpot R.M.
      Arch. Biochem. Biophys. 317:275-284(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Liver.
    2. "Cloning, primary sequence and chromosomal localisation of human flavin-containing monooxygenase 5 (FMO5)."
      Dolphin C.T., Povey S., Shephard E.A., Smith R.L., Phillips I.R.
      Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Liver and Placenta.
    3. NIEHS SNPs program
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-400 AND SER-506.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Trachea.
    5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Testis.
    6. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    9. "Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans."
      Furnes B., Feng J., Sommer S.S., Schlenk D.
      Drug Metab. Dispos. 31:187-193(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LEU-457.

    Entry informationi

    Entry nameiFMO5_HUMAN
    AccessioniPrimary (citable) accession number: P49326
    Secondary accession number(s): B2RBG1, C9JJD1, Q8IV22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 137 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3