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P49326

- FMO5_HUMAN

UniProt

P49326 - FMO5_HUMAN

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Protein

Dimethylaniline monooxygenase [N-oxide-forming] 5

Gene

FMO5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.

Catalytic activityi

N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

Cofactori

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156FADSequence Analysis
Nucleotide bindingi192 – 1976NADPBy similarity

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. N,N-dimethylaniline monooxygenase activity Source: UniProtKB-EC
  3. NADP binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC:1.14.13.8)
Alternative name(s):
Dimethylaniline oxidase 5
Hepatic flavin-containing monooxygenase 5
Short name:
FMO 5
Gene namesi
Name:FMO5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:3773. FMO5.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28189.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 533533Dimethylaniline monooxygenase [N-oxide-forming] 5PRO_0000147665Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei5 – 51Omega-N-methylated arginineBy similarity

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiP49326.
PaxDbiP49326.
PRIDEiP49326.

PTM databases

PhosphoSiteiP49326.

Expressioni

Tissue specificityi

Expressed in fetal and adult liver.

Gene expression databases

BgeeiP49326.
CleanExiHS_FMO5.
ExpressionAtlasiP49326. baseline and differential.
GenevestigatoriP49326.

Organism-specific databases

HPAiHPA012373.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000254090.

Structurei

3D structure databases

ProteinModelPortaliP49326.
SMRiP49326. Positions 5-219, 312-441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FMO family.Curated

Keywords - Domaini

Transmembrane

Phylogenomic databases

eggNOGiCOG2072.
GeneTreeiENSGT00760000119232.
HOGENOMiHOG000076537.
HOVERGENiHBG002037.
InParanoidiP49326.
KOiK00485.
OMAiLGPCTPI.
PhylomeDBiP49326.
TreeFamiTF105285.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR012143. DiMe-aniline_mOase.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
IPR002257. Flavin_mOase_5.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00743. FMO-like. 1 hit.
[Graphical view]
PIRSFiPIRSF000332. FMO. 1 hit.
PRINTSiPR00370. FMOXYGENASE.
PR01125. FMOXYGENASE5.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P49326-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTKKRIAVIG GGVSGLSSIK CCVEEGLEPV CFERTDDIGG LWRFQENPEE
60 70 80 90 100
GRASIYKSVI INTSKEMMCF SDYPIPDHYP NFMHNAQVLE YFRMYAKEFD
110 120 130 140 150
LLKYIRFKTT VCSVKKQPDF ATSGQWEVVT ESEGKKEMNV FDGVMVCTGH
160 170 180 190 200
HTNAHLPLES FPGIEKFKGQ YFHSRDYKNP EGFTGKRVII IGIGNSGGDL
210 220 230 240 250
AVEISQTAKQ VFLSTRRGAW ILNRVGDYGY PADVLFSSRL THFIWKICGQ
260 270 280 290 300
SLANKYLEKK INQRFDHEMF GLKPKHRALS QHPTLNDDLP NRIISGLVKV
310 320 330 340 350
KGNVKEFTET AAIFEDGSRE DDIDAVIFAT GYSFDFPFLE DSVKVVKNKI
360 370 380 390 400
SLYKKVFPPN LERPTLAIIG LIQPLGAIMP ISELQGRWAT QVFKGLKTLP
410 420 430 440 450
SQSEMMAEIS KAQEEIDKRY VESQRHTIQG DYIDTMEELA DLVGVRPNLL
460 470 480 490 500
SLAFTDPKLA LHLLLGPCTP IHYRVQGPGK WDGARKAILT TDDRIRKPLM
510 520 530
TRVVERSSSM TSTMTIGKFM LALAFFAIII AYF
Length:533
Mass (Da):60,221
Last modified:January 23, 2007 - v2
Checksum:iF9D9F092F1DD71DA
GO
Isoform 2 (identifier: P49326-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     278-285: ALSQHPTL → SKDIALTE
     286-533: Missing.

Note: No experimental confirmation available.

Show »
Length:285
Mass (Da):32,480
Checksum:i4DE507F329B99046
GO
Isoform 3 (identifier: P49326-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     419-464: RYVESQRHTI...TDPKLALHLL → SLTMRKTSDK...CPGIKGPKET
     465-533: Missing.

Note: No experimental confirmation available.

Show »
Length:464
Mass (Da):52,477
Checksum:i1989AA851C48E893
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti351 – 3511S → P in CAA87633. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti400 – 4001P → A.1 Publication
Corresponds to variant rs28381218 [ dbSNP | Ensembl ].
VAR_022308
Natural varianti457 – 4571P → L.1 Publication
VAR_015370
Natural varianti506 – 5061R → S.1 Publication
Corresponds to variant rs28381223 [ dbSNP | Ensembl ].
VAR_022309

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei278 – 2858ALSQHPTL → SKDIALTE in isoform 2. 1 PublicationVSP_042729
Alternative sequencei286 – 533248Missing in isoform 2. 1 PublicationVSP_042730Add
BLAST
Alternative sequencei419 – 46446RYVES…ALHLL → SLTMRKTSDKPKLKNILQIP DYLKTVKIINKESLRNCPGI KGPKET in isoform 3. 1 PublicationVSP_045616Add
BLAST
Alternative sequencei465 – 53369Missing in isoform 3. 1 PublicationVSP_045617Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37080 mRNA. Translation: AAA67849.1.
Z47553 mRNA. Translation: CAA87633.1.
AY902236 Genomic DNA. Translation: AAW69390.1.
AK314647 mRNA. Translation: BAG37208.1.
AK225739 mRNA. No translation available.
AL356378 Genomic DNA. Translation: CAH72648.1.
AL356378 Genomic DNA. Translation: CAH72649.1.
CH471223 Genomic DNA. Translation: EAW50939.1.
CH471223 Genomic DNA. Translation: EAW50940.1.
BC035687 mRNA. Translation: AAH35687.1.
CCDSiCCDS44209.1. [P49326-3]
CCDS44210.1. [P49326-2]
CCDS926.1. [P49326-1]
PIRiS51131.
S71618.
RefSeqiNP_001138301.1. NM_001144829.2. [P49326-3]
NP_001138302.1. NM_001144830.2. [P49326-2]
NP_001452.2. NM_001461.3. [P49326-1]
XP_005273003.1. XM_005272946.2. [P49326-1]
XP_005273004.1. XM_005272947.2. [P49326-1]
XP_005273005.1. XM_005272948.2. [P49326-1]
XP_006711308.1. XM_006711245.1. [P49326-2]
UniGeneiHs.642706.

Genome annotation databases

EnsembliENST00000254090; ENSP00000254090; ENSG00000131781. [P49326-1]
ENST00000369272; ENSP00000358277; ENSG00000131781. [P49326-2]
ENST00000441068; ENSP00000416011; ENSG00000131781. [P49326-3]
ENST00000578284; ENSP00000462062; ENSG00000131781. [P49326-3]
GeneIDi2330.
KEGGihsa:2330.
UCSCiuc001epi.2. human. [P49326-1]
uc001epj.2. human. [P49326-2]

Polymorphism databases

DMDMi1346021.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37080 mRNA. Translation: AAA67849.1 .
Z47553 mRNA. Translation: CAA87633.1 .
AY902236 Genomic DNA. Translation: AAW69390.1 .
AK314647 mRNA. Translation: BAG37208.1 .
AK225739 mRNA. No translation available.
AL356378 Genomic DNA. Translation: CAH72648.1 .
AL356378 Genomic DNA. Translation: CAH72649.1 .
CH471223 Genomic DNA. Translation: EAW50939.1 .
CH471223 Genomic DNA. Translation: EAW50940.1 .
BC035687 mRNA. Translation: AAH35687.1 .
CCDSi CCDS44209.1. [P49326-3 ]
CCDS44210.1. [P49326-2 ]
CCDS926.1. [P49326-1 ]
PIRi S51131.
S71618.
RefSeqi NP_001138301.1. NM_001144829.2. [P49326-3 ]
NP_001138302.1. NM_001144830.2. [P49326-2 ]
NP_001452.2. NM_001461.3. [P49326-1 ]
XP_005273003.1. XM_005272946.2. [P49326-1 ]
XP_005273004.1. XM_005272947.2. [P49326-1 ]
XP_005273005.1. XM_005272948.2. [P49326-1 ]
XP_006711308.1. XM_006711245.1. [P49326-2 ]
UniGenei Hs.642706.

3D structure databases

ProteinModelPortali P49326.
SMRi P49326. Positions 5-219, 312-441.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000254090.

PTM databases

PhosphoSitei P49326.

Polymorphism databases

DMDMi 1346021.

Proteomic databases

MaxQBi P49326.
PaxDbi P49326.
PRIDEi P49326.

Protocols and materials databases

DNASUi 2330.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000254090 ; ENSP00000254090 ; ENSG00000131781 . [P49326-1 ]
ENST00000369272 ; ENSP00000358277 ; ENSG00000131781 . [P49326-2 ]
ENST00000441068 ; ENSP00000416011 ; ENSG00000131781 . [P49326-3 ]
ENST00000578284 ; ENSP00000462062 ; ENSG00000131781 . [P49326-3 ]
GeneIDi 2330.
KEGGi hsa:2330.
UCSCi uc001epi.2. human. [P49326-1 ]
uc001epj.2. human. [P49326-2 ]

Organism-specific databases

CTDi 2330.
GeneCardsi GC01M146655.
HGNCi HGNC:3773. FMO5.
HPAi HPA012373.
MIMi 603957. gene.
neXtProti NX_P49326.
PharmGKBi PA28189.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2072.
GeneTreei ENSGT00760000119232.
HOGENOMi HOG000076537.
HOVERGENi HBG002037.
InParanoidi P49326.
KOi K00485.
OMAi LGPCTPI.
PhylomeDBi P49326.
TreeFami TF105285.

Miscellaneous databases

ChiTaRSi FMO5. human.
GeneWikii FMO5.
GenomeRNAii 2330.
NextBioi 9457.
PROi P49326.
SOURCEi Search...

Gene expression databases

Bgeei P49326.
CleanExi HS_FMO5.
ExpressionAtlasi P49326. baseline and differential.
Genevestigatori P49326.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR012143. DiMe-aniline_mOase.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
IPR002257. Flavin_mOase_5.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00743. FMO-like. 1 hit.
[Graphical view ]
PIRSFi PIRSF000332. FMO. 1 hit.
PRINTSi PR00370. FMOXYGENASE.
PR01125. FMOXYGENASE5.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog."
    Overby L.H., Buckpitt A.R., Lawton M.P., Atta-Asafo-Adjei E., Schulze J., Philpot R.M.
    Arch. Biochem. Biophys. 317:275-284(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  2. "Cloning, primary sequence and chromosomal localisation of human flavin-containing monooxygenase 5 (FMO5)."
    Dolphin C.T., Povey S., Shephard E.A., Smith R.L., Phillips I.R.
    Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver and Placenta.
  3. NIEHS SNPs program
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-400 AND SER-506.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Trachea.
  5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  6. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  9. "Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans."
    Furnes B., Feng J., Sommer S.S., Schlenk D.
    Drug Metab. Dispos. 31:187-193(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT LEU-457.

Entry informationi

Entry nameiFMO5_HUMAN
AccessioniPrimary (citable) accession number: P49326
Secondary accession number(s): B2RBG1, C9JJD1, Q8IV22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3