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Protein

Dimethylaniline monooxygenase [N-oxide-forming] 5

Gene

FMO5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.

Catalytic activityi

N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

Cofactori

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15FADSequence analysis6
Nucleotide bindingi192 – 197NADPBy similarity6

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

BRENDAi1.14.13.8. 2681.
SABIO-RKiP49326.

Names & Taxonomyi

Protein namesi
Recommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC:1.14.13.8)
Alternative name(s):
Dimethylaniline oxidase 5
Hepatic flavin-containing monooxygenase 5
Short name:
FMO 5
Gene namesi
Name:FMO5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:3773. FMO5.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi2330.
OpenTargetsiENSG00000131781.
PharmGKBiPA28189.

Chemistry databases

ChEMBLiCHEMBL3430871.

Polymorphism and mutation databases

BioMutaiFMO5.
DMDMi1346021.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001476651 – 533Dimethylaniline monooxygenase [N-oxide-forming] 5Add BLAST533

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5Dimethylated arginine; alternateBy similarity1
Modified residuei5Omega-N-methylated arginine; alternateBy similarity1
Modified residuei54PhosphoserineCombined sources1
Modified residuei56PhosphotyrosineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei280PhosphoserineCombined sources1
Modified residuei284PhosphothreonineCombined sources1
Modified residuei401PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiP49326.
MaxQBiP49326.
PaxDbiP49326.
PeptideAtlasiP49326.
PRIDEiP49326.

PTM databases

iPTMnetiP49326.
PhosphoSitePlusiP49326.

Expressioni

Tissue specificityi

Expressed in fetal and adult liver.

Gene expression databases

BgeeiENSG00000131781.
CleanExiHS_FMO5.
ExpressionAtlasiP49326. baseline and differential.
GenevisibleiP49326. HS.

Organism-specific databases

HPAiHPA012373.

Interactioni

Protein-protein interaction databases

BioGridi108617. 6 interactors.
STRINGi9606.ENSP00000254090.

Structurei

3D structure databases

ProteinModelPortaliP49326.
SMRiP49326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FMO family.Curated

Keywords - Domaini

Transmembrane

Phylogenomic databases

eggNOGiKOG1399. Eukaryota.
COG2072. LUCA.
GeneTreeiENSGT00760000119232.
HOGENOMiHOG000076537.
HOVERGENiHBG002037.
InParanoidiP49326.
KOiK00485.
OMAiQSLANKY.
OrthoDBiEOG091G0465.
PhylomeDBiP49326.
TreeFamiTF105285.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiView protein in InterPro
IPR023753. FAD/NAD-binding_dom.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
IPR002257. Flavin_mOase_5.
PfamiView protein in Pfam
PF00743. FMO-like. 1 hit.
PRINTSiPR00370. FMOXYGENASE.
PR01125. FMOXYGENASE5.
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P49326-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTKKRIAVIG GGVSGLSSIK CCVEEGLEPV CFERTDDIGG LWRFQENPEE
60 70 80 90 100
GRASIYKSVI INTSKEMMCF SDYPIPDHYP NFMHNAQVLE YFRMYAKEFD
110 120 130 140 150
LLKYIRFKTT VCSVKKQPDF ATSGQWEVVT ESEGKKEMNV FDGVMVCTGH
160 170 180 190 200
HTNAHLPLES FPGIEKFKGQ YFHSRDYKNP EGFTGKRVII IGIGNSGGDL
210 220 230 240 250
AVEISQTAKQ VFLSTRRGAW ILNRVGDYGY PADVLFSSRL THFIWKICGQ
260 270 280 290 300
SLANKYLEKK INQRFDHEMF GLKPKHRALS QHPTLNDDLP NRIISGLVKV
310 320 330 340 350
KGNVKEFTET AAIFEDGSRE DDIDAVIFAT GYSFDFPFLE DSVKVVKNKI
360 370 380 390 400
SLYKKVFPPN LERPTLAIIG LIQPLGAIMP ISELQGRWAT QVFKGLKTLP
410 420 430 440 450
SQSEMMAEIS KAQEEIDKRY VESQRHTIQG DYIDTMEELA DLVGVRPNLL
460 470 480 490 500
SLAFTDPKLA LHLLLGPCTP IHYRVQGPGK WDGARKAILT TDDRIRKPLM
510 520 530
TRVVERSSSM TSTMTIGKFM LALAFFAIII AYF
Length:533
Mass (Da):60,221
Last modified:January 23, 2007 - v2
Checksum:iF9D9F092F1DD71DA
GO
Isoform 2 (identifier: P49326-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     278-285: ALSQHPTL → SKDIALTE
     286-533: Missing.

Note: No experimental confirmation available.
Show »
Length:285
Mass (Da):32,480
Checksum:i4DE507F329B99046
GO
Isoform 3 (identifier: P49326-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     419-464: RYVESQRHTI...TDPKLALHLL → SLTMRKTSDK...CPGIKGPKET
     465-533: Missing.

Note: No experimental confirmation available.
Show »
Length:464
Mass (Da):52,477
Checksum:i1989AA851C48E893
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti351S → P in CAA87633 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022308400P → A1 PublicationCorresponds to variant dbSNP:rs28381218Ensembl.1
Natural variantiVAR_015370457P → L1 PublicationCorresponds to variant dbSNP:rs72549314Ensembl.1
Natural variantiVAR_022309506R → S1 PublicationCorresponds to variant dbSNP:rs28381223Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042729278 – 285ALSQHPTL → SKDIALTE in isoform 2. 1 Publication8
Alternative sequenceiVSP_042730286 – 533Missing in isoform 2. 1 PublicationAdd BLAST248
Alternative sequenceiVSP_045616419 – 464RYVES…ALHLL → SLTMRKTSDKPKLKNILQIP DYLKTVKIINKESLRNCPGI KGPKET in isoform 3. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_045617465 – 533Missing in isoform 3. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37080 mRNA. Translation: AAA67849.1.
Z47553 mRNA. Translation: CAA87633.1.
AY902236 Genomic DNA. Translation: AAW69390.1.
AK314647 mRNA. Translation: BAG37208.1.
AK225739 mRNA. No translation available.
AL356378 Genomic DNA. Translation: CAH72648.1.
AL356378 Genomic DNA. Translation: CAH72649.1.
CH471223 Genomic DNA. Translation: EAW50939.1.
CH471223 Genomic DNA. Translation: EAW50940.1.
BC035687 mRNA. Translation: AAH35687.1.
CCDSiCCDS44209.1. [P49326-3]
CCDS44210.1. [P49326-2]
CCDS926.1. [P49326-1]
PIRiS51131.
S71618.
RefSeqiNP_001138301.1. NM_001144829.2. [P49326-3]
NP_001138302.1. NM_001144830.2. [P49326-2]
NP_001452.2. NM_001461.3. [P49326-1]
XP_005273003.1. XM_005272946.4. [P49326-1]
XP_005273004.1. XM_005272947.4. [P49326-1]
XP_005273005.1. XM_005272948.4. [P49326-1]
XP_006711308.1. XM_006711245.3. [P49326-2]
XP_011507652.1. XM_011509350.2. [P49326-1]
UniGeneiHs.642706.

Genome annotation databases

EnsembliENST00000254090; ENSP00000254090; ENSG00000131781. [P49326-1]
ENST00000369272; ENSP00000358277; ENSG00000131781. [P49326-2]
ENST00000441068; ENSP00000416011; ENSG00000131781. [P49326-3]
ENST00000578284; ENSP00000462062; ENSG00000131781. [P49326-3]
GeneIDi2330.
KEGGihsa:2330.
UCSCiuc001eph.5. human. [P49326-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFMO5_HUMAN
AccessioniPrimary (citable) accession number: P49326
Secondary accession number(s): B2RBG1, C9JJD1, Q8IV22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families