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Protein

Non-heme chloroperoxidase

Gene

cpo

Organism
Streptomyces lividans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

RH + Cl- + H2O2 = RCl + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei97 – 971By similarity
Active sitei227 – 2271By similarity
Active sitei256 – 2561By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Ligandi

Chloride

Protein family/group databases

ESTHERistrli-cpoL. Haloperoxidase.
MEROPSiS33.992.
PeroxiBasei5557. SliHalNPrx.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-heme chloroperoxidase (EC:1.11.1.10)
Alternative name(s):
Chloride peroxidase
Chloroperoxidase L
Short name:
CPO-L
Gene namesi
Name:cpo
Synonyms:cpoL
OrganismiStreptomyces lividans
Taxonomic identifieri1916 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 276275Non-heme chloroperoxidasePRO_0000207063Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Structurei

Secondary structure

1
276
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 53Combined sources
Beta strandi11 – 188Combined sources
Beta strandi24 – 285Combined sources
Helixi35 – 384Combined sources
Helixi39 – 479Combined sources
Beta strandi51 – 555Combined sources
Helixi72 – 8615Combined sources
Beta strandi90 – 967Combined sources
Helixi99 – 10911Combined sources
Beta strandi114 – 1229Combined sources
Helixi140 – 15213Combined sources
Helixi154 – 16310Combined sources
Turni164 – 1707Combined sources
Helixi178 – 19013Combined sources
Helixi193 – 20513Combined sources
Helixi209 – 2146Combined sources
Beta strandi219 – 2246Combined sources
Beta strandi228 – 2303Combined sources
Turni233 – 2353Combined sources
Helixi236 – 2427Combined sources
Beta strandi246 – 2516Combined sources
Helixi258 – 2614Combined sources
Helixi263 – 27513Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A88X-ray1.90A/B/C2-276[»]
ProteinModelPortaliP49323.
SMRiP49323. Positions 2-276.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49323.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49323-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTVTTSDGT NIFYKDWGPR DGLPVVFHHG WPLSADDWDN QMLFFLSHGY
60 70 80 90 100
RVIAHDRRGH GRSDQPSTGH DMDTYAADVA ALTEALDLRG AVHIGHSTGG
110 120 130 140 150
GEVARYVARA EPGRVAKAVL VSAVPPVMVK SDTNPDGLPL EVFDEFRAAL
160 170 180 190 200
AANRAQFYID VPSGPFYGFN REGATVSQGL IDHWWLQGMM GAANAHYECI
210 220 230 240 250
AAFSETDFTD DLKRIDVPVL VAHGTDDQVV PYADAAPKSA ELLANATLKS
260 270
YEGLPHGMLS THPEVLNPDL LAFVKS
Length:276
Mass (Da):29,914
Last modified:January 23, 2007 - v2
Checksum:iCF8977B0C1FA53B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02635 Unassigned DNA. Translation: AAA18642.1.
PIRiA55211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02635 Unassigned DNA. Translation: AAA18642.1.
PIRiA55211.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A88X-ray1.90A/B/C2-276[»]
ProteinModelPortaliP49323.
SMRiP49323. Positions 2-276.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERistrli-cpoL. Haloperoxidase.
MEROPSiS33.992.
PeroxiBasei5557. SliHalNPrx.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP49323.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPRXC_STRLI
AccessioniPrimary (citable) accession number: P49323
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: October 14, 2015
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.