Reviewed, UniProtKB/Swiss-Prot P49319 (CATA1_TOBAC)

Names and origin

Protein names

Recommended name:
    Catalase isozyme 1
    EC=1.11.1.6
Alternative name(s):
    Salicylic acid-binding protein
      Short name=SABP

Gene names

Name:

CAT-1

Organism

Nicotiana tabacum (Common tobacco)

Taxonomic identifier

4097 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Nicotianoideae › Nicotianeae › Nicotiana

Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
Catalytic activity	2 H(2)O(2) = O(2) + 2 H(2)O.
Cofactor	Heme group.
Enzyme regulation	Inhibited by salicylic acid.
Subunit structure	Homotetramer By similarity.
Subcellular location	PeroxisomeBy similarity. GlyoxysomeBy similarity.
Sequence similarities	Belongs to the catalase family.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Cellular component	Glyoxysome Peroxisome
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	glyoxysome Inferred from electronic annotation. Source: UniProtKB-KW peroxisome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	catalase activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 492	492	Catalase isozyme 1		PRO_0000084966
Sites
	Active site	65	1	By similarity
	Active site	138	1	By similarity
	Metal binding	348	1	Iron (heme axial ligand) By similarity
Experimental info
	Sequence conflict	140	1	V → F AA sequence Ref.2
	Sequence conflict	145	1	N → I AA sequence Ref.2
	Sequence conflict	171	1	K → R in AAC48918. Ref.2
	Sequence conflict	438	1	W → F AA sequence Ref.2
	Sequence conflict	439	1	E → T AA sequence Ref.2
	Sequence conflict	453	1	H → A AA sequence Ref.2
	Sequence conflict	469 – 470	2	SY → CS in AAC48918. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P49319-1 [UniParc]. Last modified October 1, 1996. Version 2. Checksum: 8AD3ED82F7CCE94E	FASTA	492	56,824
	10 20 30 40 50 60 MDLSKFRPSS AYDSPFLTTN AGGPVYNNVS SLTVGPRGPV LLEDYHLIEK LATFDRERIP 70 80 90 100 110 120 ERVVHARGAS AKGFFEVTHD ISHLTCADFL RAPGVQTPVI CRFSTVVHER GSPESLRDIR 130 140 150 160 170 180 GFAVKFYTRE GNFDLVGNNV PVFFNRDAKS FPDTIRALKP NPKSHIQEYW KILDFFSFLP 190 200 210 220 230 240 ESLHTFAWFF DDVCLPTDYR HMEGYGVHAY QLINKAGKAH YVKFHWKPTC GVKCMSEEEA 250 260 270 280 290 300 IRVGGTNHSH ATKDLYDSIA AGNYPEWKLF IQIMDTEDVD KFDFDPLDVT KTWPEDILPL 310 320 330 340 350 360 MPVGRLVLNR NIDNFFAENE QLAFNPGHIV PGLYYSEDKL LQTRIFAYAD TQRHRIGPNY 370 380 390 400 410 420 MQLPVNAPKC AHHNNHRDGA MNFMHRDEEV DYLPSRFDPC RHAEQYPIPS RVLTGRREMC 430 440 450 460 470 480 VIEKENNFKQ AGERYRSWEP DRQDRYVSKW VEHLSDPRVT YEIRSIWISY LSQADKSCGQ 490 KVASRLTLKP TM

References

[1]	"The primary leaf catalase gene from Nicotiana tabacum and Nicotiana sylvestris." Schultes N.P., Zelitch I., McGonigle B., Nelson T. Plant Physiol. 106:399-400(1994) [PubMed: 7972525] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Petit Havana SR1. Tissue: Leaf.
[2]	"Active oxygen species in the induction of plant systemic acquired resistance by salicylic acid." Chen Z., Silva H., Klessig D.F. Science 262:1883-1886(1993) [PubMed: 8266079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-492, PARTIAL PROTEIN SEQUENCE. Strain: cv. SR1 and cv. Xanthi NC. Tissue: Leaf.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U07627 mRNA. Translation: AAA57552.1. U03473 mRNA. Translation: AAC48918.1.
PIR	A49388.
3D structure databases
HSSP	HSSP built from PDB template 1M7S based on UniProtKB P46206.
ModBase	Search...
Family and domain databases
InterPro	IPR002226. Catalase. IPR011614. Catalase_N. [Graphical view]
Gene3D	G3DSA:2.40.180.10. Catalase_N. 1 hit.
PANTHER	PTHR11465. Catalase. 1 hit.
Pfam	PF00199. Catalase. 1 hit. [Graphical view]
PRINTS	PR00067. CATALASE.
ProDom	PD000510. Catalase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00437. CATALASE_1. 1 hit. PS00438. CATALASE_2. 1 hit. PS51402. CATALASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATA1_TOBAC

Accession

Primary (citable) accession number: P49319

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 25, 2008
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)