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Protein

Heterogeneous nuclear ribonucleoprotein A1

Gene

Hnrnpa1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection (By similarity). May bind to specific miRNA hairpins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • alternative mRNA splicing, via spliceosome Source: MGI
  • cellular response to sodium arsenite Source: UniProtKB
  • mRNA transport Source: UniProtKB-KW
  • nuclear export Source: HGNC
  • nuclear import Source: HGNC
  • RNA splicing Source: MGI

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing, mRNA transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein A1
Short name:
hnRNP A1
Alternative name(s):
HDP-1
Helix-destabilizing protein
Single-strand-binding protein
Topoisomerase-inhibitor suppressed
hnRNP core protein A1
Cleaved into the following chain:
Gene namesi
Name:Hnrnpa1
Synonyms:Fli-2, Hnrpa1, Tis
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:104820 Hnrnpa1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000818301 – 320Heterogeneous nuclear ribonucleoprotein A1Add BLAST320
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00004245112 – 320Heterogeneous nuclear ribonucleoprotein A1, N-terminally processedAdd BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylserine; in Heterogeneous nuclear ribonucleoprotein A1, N-terminally processedBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei3N6-acetyllysine; alternateBy similarity1
Cross-linki3Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei4PhosphoserineBy similarity1
Modified residuei6PhosphoserineCombined sources1
Cross-linki8Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei22PhosphoserineCombined sources1
Cross-linki78Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki113Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki179Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki183Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei192Phosphoserine; by MKNK2By similarity1
Modified residuei194Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei194Dimethylated arginine; alternateBy similarity1
Modified residuei194Omega-N-methylarginine; alternateCombined sources1
Modified residuei199PhosphoserineBy similarity1
Modified residuei206Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei206Dimethylated arginine; alternateBy similarity1
Modified residuei206Omega-N-methylarginine; alternateCombined sources1
Modified residuei218Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei218Omega-N-methylarginine; alternateCombined sources1
Modified residuei225Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei225Dimethylated arginine; alternateBy similarity1
Modified residuei225Omega-N-methylarginine; alternateCombined sources1
Modified residuei232Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei232Omega-N-methylarginine; alternateCombined sources1
Modified residuei284Omega-N-methylarginineCombined sources1
Modified residuei285PhosphoserineBy similarity1
Modified residuei298N6-acetyllysine; alternateCombined sources1
Cross-linki298Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei300Omega-N-methylarginineCombined sources1
Modified residuei309PhosphoserineBy similarity1
Modified residuei310Phosphoserine; by MKNK2By similarity1
Modified residuei311Phosphoserine; by MKNK2By similarity1
Modified residuei312Phosphoserine; by MKNK2By similarity1
Modified residuei313PhosphoserineBy similarity1
Modified residuei316PhosphoserineBy similarity1
Modified residuei318Omega-N-methylarginineBy similarity1

Post-translational modificationi

Sumoylated.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP49312
MaxQBiP49312
PaxDbiP49312
PeptideAtlasiP49312
PRIDEiP49312
TopDownProteomicsiP49312-1 [P49312-1]

PTM databases

iPTMnetiP49312
PhosphoSitePlusiP49312

Expressioni

Gene expression databases

BgeeiENSMUSG00000046434
CleanExiMM_HNRNPA1
ExpressionAtlasiP49312 baseline and differential
GenevisibleiP49312 MM

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SEPT6. Interacts with C9orf72. Interacts with KHDRBS1. Interacts with UBQLN2.By similarity

Protein-protein interaction databases

BioGridi2003576 interactors.
IntActiP49312 7 interactors.
MINTiP49312
STRINGi10090.ENSMUSP00000137406

Structurei

3D structure databases

ProteinModelPortaliP49312
SMRiP49312
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 97RRM 1PROSITE-ProRule annotationAdd BLAST84
Domaini105 – 184RRM 2PROSITE-ProRule annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni4 – 94Globular A domainAdd BLAST91
Regioni95 – 185Globular B domainAdd BLAST91
Regioni218 – 240RNA-binding RGG-boxAdd BLAST23
Regioni268 – 305Nuclear targeting sequenceBy similarityAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi195 – 320Gly-richAdd BLAST126
Compositional biasi308 – 313Poly-Ser6

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00900000140828
HOGENOMiHOG000234442
HOVERGENiHBG002295
InParanoidiP49312
KOiK12741

Family and domain databases

CDDicd12761 RRM1_hnRNPA1, 1 hit
cd12580 RRM2_hnRNPA1, 1 hit
Gene3Di3.30.70.3302 hits
InterProiView protein in InterPro
IPR021662 HnRNPA1
IPR034845 hnRNPA1_RRM1
IPR034803 hnRNPA1_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF11627 HnRNPA1, 1 hit
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P49312-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKSESPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN
60 70 80 90 100
TKRSRGFGFV TYATVEEVDA AMNARPHKVD GRVVEPKRAV SREDSQRPGA
110 120 130 140 150
HLTVKKIFVG GIKEDTEEHH LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF
160 170 180 190 200
VTFDDHDSVD KIVIQKYHTV NGHNCEVRKA LSKQEMASAS SSQRGRSGSG
210 220 230 240 250
NFGGGRGGGF GGNDNFGRGG NFSGRGGFGG SRGGGGYGGS GDGYNGFGND
260 270 280 290 300
GSNFGGGGSY NDFGNYNNQS SNFGPMKGGN FGGRSSGPYG GGGQYFAKPR
310 320
NQGGYGGSSS SSSYGSGRRF
Length:320
Mass (Da):34,196
Last modified:January 23, 2007 - v2
Checksum:i59485C9FA1FF8AE1
GO
Isoform Short (identifier: P49312-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     252-303: Missing.

Show »
Length:268
Mass (Da):28,898
Checksum:i13A50CDCA6DFB3A2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005825252 – 303Missing in isoform Short. CuratedAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99167 mRNA Translation: AAA37633.1
D86729 mRNA Translation: BAA13162.1
D86728 mRNA Translation: BAA13161.1
AK007802 mRNA Translation: BAB25267.1
AK088308 mRNA Translation: BAC40273.1
AK131999 mRNA Translation: BAE20929.1
AK135391 mRNA Translation: BAE22518.1
AK161730 mRNA Translation: BAE36552.1
AK166901 mRNA Translation: BAE39104.1
AK167161 mRNA Translation: BAE39302.1
AK167810 mRNA Translation: BAE39837.1
AK167913 mRNA Translation: BAE39920.1
AK168420 mRNA Translation: BAE40333.1
AK168531 mRNA Translation: BAE40409.1
BC080675 mRNA Translation: AAH80675.1
BC083136 mRNA Translation: AAH83136.1
CCDSiCCDS37233.1 [P49312-1]
PIRiA44485
RefSeqiNP_034577.1, NM_010447.5 [P49312-1]
UniGeneiMm.237064
Mm.432031

Genome annotation databases

EnsembliENSMUST00000087351; ENSMUSP00000084609; ENSMUSG00000046434 [P49312-1]
GeneIDi15382
KEGGimmu:15382
UCSCiuc007xxp.2 mouse [P49312-1]
uc011zrp.1 mouse [P49312-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiROA1_MOUSE
AccessioniPrimary (citable) accession number: P49312
Secondary accession number(s): P97312, Q3V269
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome