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P49299

- CYSZ_CUCMA

UniProt

P49299 - CYSZ_CUCMA

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Protein
Citrate synthase, glyoxysomal
Gene
N/A
Organism
Cucurbita maxima (Pumpkin) (Winter squash)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei329 – 3291 By similarity
Active sitei368 – 3681 By similarity
Active sitei424 – 4241 By similarity

GO - Molecular functioni

  1. transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00703; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase, glyoxysomal (EC:2.3.3.16)
Alternative name(s):
GCS
OrganismiCucurbita maxima (Pumpkin) (Winter squash)
Taxonomic identifieri3661 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsCucurbitalesCucurbitaceaeCucurbiteaeCucurbita

Subcellular locationi

GO - Cellular componenti

  1. glyoxysome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Glyoxysome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4343Glyoxysome1 Publication
Add
BLAST
Chaini44 – 516473Citrate synthase, glyoxysomal
PRO_0000005490Add
BLAST

Proteomic databases

PRIDEiP49299.

Structurei

3D structure databases

ProteinModelPortaliP49299.

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49299-1 [UniParc]FASTAAdd to Basket

« Hide

MPTDMELSPS NVARHRLAVL AAHLSAASLE PPVMASSLEA HCVSAQTMVA    50
PPELVKGTLT IVDERTGKRY QVQVSEEGTI KATDLKKITT GPNDKGLKLY 100
DPGYLNTAPV RSSISYIDGD LGILRYRGYP IEELAESSTY VEVAYLLMYG 150
NLPSQSQLAD WEFAISQHSA VPQGLVDIIQ AMPHDAHPMG VLVSAMSALS 200
VFHPDANPAL RGQDLYKSKQ VRDKQIARII GKAPTIAAAA YLRLAGRPPV 250
LPSSNLSYSE NFLYMLDSLG NRSYKPNPRL ARVLDILFIL HAEHEMNCST 300
SAARHLASSG VDVFTALSGA VGALYGPLHG GANEAVLKML SEIGTVNNIP 350
EFIEGVKNRK RKMSGFGHRV YKNYDPRAKV IRKLAEEVFS IVGRDPLIEV 400
AVALEKAALS DEYFVKRKLY PNVDFYSGLI YRAMGFPPEF FTVLFAIPRM 450
AGYLAHWRES LDDPDTKIIR PQQVYTGEWL RHYIPPNERL VPAKADRLGQ 500
VSVSNASKRR LSGSGI 516
Length:516
Mass (Da):56,759
Last modified:February 1, 1996 - v1
Checksum:i162F6270284A3F6B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38132 mRNA. Translation: BAA07328.1.
PIRiS53008.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38132 mRNA. Translation: BAA07328.1 .
PIRi S53008.

3D structure databases

ProteinModelPortali P49299.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P49299.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00717 .

Family and domain databases

Gene3Di 1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PIRSFi PIRSF001369. Citrate_synth. 1 hit.
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of a glyoxysomal citrate synthase that is synthesized as a precursor of higher molecular mass in pumpkin."
    Kato A., Hayashi M., Mori H., Nishimura M.
    Plant Mol. Biol. 27:377-390(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 44-51.
    Strain: cv. Kurokawa Amakuri Nankin.
    Tissue: Etiolated cotyledon.

Entry informationi

Entry nameiCYSZ_CUCMA
AccessioniPrimary (citable) accession number: P49299
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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