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P49298

- CISY_CITMA

UniProt

P49298 - CISY_CITMA

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Protein

Citrate synthase, mitochondrial

Gene

CIT

Organism
Citrus maxima (Pomelo) (Citrus grandis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei307 – 3071PROSITE-ProRule annotation
Active sitei353 – 3531PROSITE-ProRule annotation
Active sitei408 – 4081PROSITE-ProRule annotation

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: InterPro

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

BRENDAi2.3.3.1. 2323.
UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase, mitochondrial (EC:2.3.3.16)
Gene namesi
Name:CIT
OrganismiCitrus maxima (Pomelo) (Citrus grandis)
Taxonomic identifieri37334 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsSapindalesRutaceaeCitrus

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1818MitochondrionSequence AnalysisAdd
BLAST
Chaini19 – 471453Citrate synthase, mitochondrialPRO_0000005486Add
BLAST

Proteomic databases

PRIDEiP49298.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP49298.
SMRiP49298. Positions 35-465.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49298-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASLRSATAL SRLRSRAGQQ SNLSNSVRWL QMQSSADLDL HSQLKEMIPE
60 70 80 90 100
QQERLKKVKS DLGKAQLGNI TIDVVIGGMR GMTGLLWETS LLDPDEGIRF
110 120 130 140 150
RGLSIPECQK LLPAAKPDGE PLPEGLLWLL LTGKVPSKEQ VDGLSKELRD
160 170 180 190 200
RATVPDYVYK AIDALPVSAH PMTQFASGVM ALQVQSEFQE AYEKGIHKSK
210 220 230 240 250
SWEPTSEDSL NLIARVPVVA AYVYQRIYKD GKIIPKDDSL DYGGNFSHML
260 270 280 290 300
GFDDPKMLEL MRLYVTIHSD HEGGNVSAHT GHLVASALSD PYLSFLAALN
310 320 330 340 350
GLAGPLHGLA NQEVLLWIKS VVDECGENVT TEQLKDYVWK TLNSGKVVPG
360 370 380 390 400
FGHGVLRKTD PRYTCQREFA LKHLPDDPLF QLVSKLYEVV PPILTKLGKV
410 420 430 440 450
KNPWPNVDAH SGVLLNHFGL AEARYYTVLF GVSRSLGICS QLIWDRALGL
460 470
PLERPKSVTL DWIEKNCKKA A
Length:471
Mass (Da):52,183
Last modified:February 1, 1996 - v1
Checksum:i8EE1E23F7E154806
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19481 mRNA. Translation: AAA82743.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19481 mRNA. Translation: AAA82743.1 .

3D structure databases

ProteinModelPortali P49298.
SMRi P49298. Positions 35-465.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P49298.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .
BRENDAi 2.3.3.1. 2323.

Family and domain databases

Gene3Di 1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Canel C.
    Thesis (1994), University of California Riverside, United States
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Siamese Sweet 2240.

Entry informationi

Entry nameiCISY_CITMA
AccessioniPrimary (citable) accession number: P49298
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3