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P49298

- CISY_CITMA

UniProt

P49298 - CISY_CITMA

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Protein
Citrate synthase, mitochondrial
Gene
CIT
Organism
Citrus maxima (Pomelo) (Citrus grandis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei307 – 3071 By similarity
Active sitei353 – 3531 By similarity
Active sitei408 – 4081 By similarity

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: InterPro

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

BRENDAi2.3.3.1. 2323.
UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase, mitochondrial (EC:2.3.3.16)
Gene namesi
Name:CIT
OrganismiCitrus maxima (Pomelo) (Citrus grandis)
Taxonomic identifieri37334 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsSapindalesRutaceaeCitrus

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1818Mitochondrion Reviewed prediction
Add
BLAST
Chaini19 – 471453Citrate synthase, mitochondrial
PRO_0000005486Add
BLAST

Proteomic databases

PRIDEiP49298.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP49298.
SMRiP49298. Positions 35-465.

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49298-1 [UniParc]FASTAAdd to Basket

« Hide

MASLRSATAL SRLRSRAGQQ SNLSNSVRWL QMQSSADLDL HSQLKEMIPE    50
QQERLKKVKS DLGKAQLGNI TIDVVIGGMR GMTGLLWETS LLDPDEGIRF 100
RGLSIPECQK LLPAAKPDGE PLPEGLLWLL LTGKVPSKEQ VDGLSKELRD 150
RATVPDYVYK AIDALPVSAH PMTQFASGVM ALQVQSEFQE AYEKGIHKSK 200
SWEPTSEDSL NLIARVPVVA AYVYQRIYKD GKIIPKDDSL DYGGNFSHML 250
GFDDPKMLEL MRLYVTIHSD HEGGNVSAHT GHLVASALSD PYLSFLAALN 300
GLAGPLHGLA NQEVLLWIKS VVDECGENVT TEQLKDYVWK TLNSGKVVPG 350
FGHGVLRKTD PRYTCQREFA LKHLPDDPLF QLVSKLYEVV PPILTKLGKV 400
KNPWPNVDAH SGVLLNHFGL AEARYYTVLF GVSRSLGICS QLIWDRALGL 450
PLERPKSVTL DWIEKNCKKA A 471
Length:471
Mass (Da):52,183
Last modified:February 1, 1996 - v1
Checksum:i8EE1E23F7E154806
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19481 mRNA. Translation: AAA82743.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19481 mRNA. Translation: AAA82743.1 .

3D structure databases

ProteinModelPortali P49298.
SMRi P49298. Positions 35-465.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P49298.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .
BRENDAi 2.3.3.1. 2323.

Family and domain databases

Gene3Di 1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Canel C.
    Thesis (1994), University of California Riverside, United States
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Siamese Sweet 2240.

Entry informationi

Entry nameiCISY_CITMA
AccessioniPrimary (citable) accession number: P49298
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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