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P49298 (CISY_CITMA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase, mitochondrial

EC=2.3.3.1
Gene names
Name:CIT
OrganismCitrus maxima (Pomelo) (Citrus grandis)
Taxonomic identifier37334 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsSapindalesRutaceaeCitrus

Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion matrix.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Cellular componentMitochondrion
   DomainTransit peptide
   Molecular functionTransferase
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncitrate (Si)-synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1818Mitochondrion Potential
Chain19 – 471453Citrate synthase, mitochondrial
PRO_0000005486

Sites

Active site3071 By similarity
Active site3531 By similarity
Active site4081 By similarity

Sequences

Sequence LengthMass (Da)Tools
P49298 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 8EE1E23F7E154806

FASTA47152,183
        10         20         30         40         50         60 
MASLRSATAL SRLRSRAGQQ SNLSNSVRWL QMQSSADLDL HSQLKEMIPE QQERLKKVKS 

        70         80         90        100        110        120 
DLGKAQLGNI TIDVVIGGMR GMTGLLWETS LLDPDEGIRF RGLSIPECQK LLPAAKPDGE 

       130        140        150        160        170        180 
PLPEGLLWLL LTGKVPSKEQ VDGLSKELRD RATVPDYVYK AIDALPVSAH PMTQFASGVM 

       190        200        210        220        230        240 
ALQVQSEFQE AYEKGIHKSK SWEPTSEDSL NLIARVPVVA AYVYQRIYKD GKIIPKDDSL 

       250        260        270        280        290        300 
DYGGNFSHML GFDDPKMLEL MRLYVTIHSD HEGGNVSAHT GHLVASALSD PYLSFLAALN 

       310        320        330        340        350        360 
GLAGPLHGLA NQEVLLWIKS VVDECGENVT TEQLKDYVWK TLNSGKVVPG FGHGVLRKTD 

       370        380        390        400        410        420 
PRYTCQREFA LKHLPDDPLF QLVSKLYEVV PPILTKLGKV KNPWPNVDAH SGVLLNHFGL 

       430        440        450        460        470 
AEARYYTVLF GVSRSLGICS QLIWDRALGL PLERPKSVTL DWIEKNCKKA A 

« Hide

References

[1]Canel C.
Thesis (1994), University of California Riverside, United States
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Siamese Sweet 2240.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U19481 mRNA. Translation: AAA82743.1.

3D structure databases

ProteinModelPortalP49298.
SMRP49298. Positions 35-465.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP49298.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.3.3.1. 2323.
UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01793. cit_synth_euk. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_CITMA
AccessionPrimary (citable) accession number: P49298
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways