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P49297

- ACEA_SOLLC

UniProt

P49297 - ACEA_SOLLC

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Protein

Isocitrate lyase

Gene
N/A
Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in storage lipid mobilization during the growth of higher plant seedling.

Catalytic activityi

Isocitrate = succinate + glyoxylate.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei213 – 2131Curated

GO - Molecular functioni

  1. isocitrate lyase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. seed dormancy process Source: EnsemblPlants/Gramene
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00703; UER00719.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate lyase (EC:4.1.3.1)
Short name:
ICL
Short name:
Isocitrase
Short name:
Isocitratase
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
ProteomesiUP000004994: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. glyoxysome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Glyoxysome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 575575Isocitrate lyasePRO_0000068808Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP49297.
SMRiP49297. Positions 9-535.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi573 – 5753Microbody targeting signalSequence Analysis

Sequence similaritiesi

Phylogenomic databases

KOiK01637.

Family and domain databases

Gene3Di3.20.20.60. 2 hits.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamiPF00463. ICL. 1 hit.
[Graphical view]
PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49297-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAASYSVPSM IMEEERRFEA EVAEVQAWWN TERFRLTKRA YSARDVVALR
60 70 80 90 100
GTMRQSYASN ELAQKLWRTL KTHQANGTAS RTFGALDPVQ VTMMAKHLDT
110 120 130 140 150
IYVSGWQCSS THTSTNEPGP DLADYPYDTV PNKVEHLFFA QQYHDRKQRE
160 170 180 190 200
ARMSMCREER ARTPFIDYLK PIIADGDTGF GGATATVKLC KLFVERGAAG
210 220 230 240 250
VHIEDQSSVT KKCGHMAGKV LVAVSEHINR LVAARLQFDV MGTETVLVAR
260 270 280 290 300
TDAVAATLIQ TNVDTRDHQF ILGASNPNLK GKGLATHLSE AMAAGKTGPE
310 320 330 340 350
LQAIEDNWLG MAELKTFSQC VTDAIKKMNL AEYEKQRKLN EWMNHSSYEK
360 370 380 390 400
CLSHEQAREV AERLGLPNLF WDWDLPRTRE GFYRFQGSVE AAIVRGWAFA
410 420 430 440 450
EYCDLVWMET SSPDMVECTK FSQGVKTLRP ELMLAYNLSP SFNWDASGMN
460 470 480 490 500
DNQMMDFIPR IAKLGYCWQF ITLAGFHADA LIVDTFAKDF ARRGMLAYVE
510 520 530 540 550
KIQREERSNG VDTLAHQKWS GANYYDRVLR TVQGGITSTA AMGKGVTEEQ
560 570
FEEKWTRTGA TNLGDGSVVI AKARM
Length:575
Mass (Da):64,720
Last modified:February 1, 1996 - v1
Checksum:iF398FA96C7110B4E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18678 mRNA. Translation: AAA82738.1.
PIRiT06353.
RefSeqiNP_001233878.1. NM_001246949.1.
UniGeneiLes.2767.

Genome annotation databases

GeneIDi544276.
KEGGisly:544276.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18678 mRNA. Translation: AAA82738.1 .
PIRi T06353.
RefSeqi NP_001233878.1. NM_001246949.1.
UniGenei Les.2767.

3D structure databases

ProteinModelPortali P49297.
SMRi P49297. Positions 9-535.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 544276.
KEGGi sly:544276.

Phylogenomic databases

KOi K01637.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00719 .

Family and domain databases

Gene3Di 3.20.20.60. 2 hits.
InterProi IPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
Pfami PF00463. ICL. 1 hit.
[Graphical view ]
PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR01346. isocit_lyase. 1 hit.
PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A cDNA clone for isocitrate lyase from tomato."
    Janssen B.-J.
    Plant Physiol. 108:1339-1339(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. UC82B.
    Tissue: Leaf.

Entry informationi

Entry nameiACEA_SOLLC
AccessioniPrimary (citable) accession number: P49297
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3