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P49297 (ACEA_SOLLC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate lyase

Short name=ICL
Short name=Isocitrase
Short name=Isocitratase
EC=4.1.3.1
OrganismSolanum lycopersicum (Tomato) (Lycopersicon esculentum) [Reference proteome]
Taxonomic identifier4081 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon

Protein attributes

Sequence length575 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in storage lipid mobilization during the growth of higher plant seedling.

Catalytic activity

Isocitrate = succinate + glyoxylate.

Pathway

Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.

Subunit structure

Homotetramer By similarity.

Subcellular location

Glyoxysome.

Sequence similarities

Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.

Ontologies

Keywords
   Biological processGlyoxylate bypass
Tricarboxylic acid cycle
   Cellular componentGlyoxysome
Peroxisome
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglyoxylate cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentglyoxysome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionisocitrate lyase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 575575Isocitrate lyase
PRO_0000068808

Regions

Motif573 – 5753Microbody targeting signal Potential

Sites

Active site2131 Probable

Sequences

Sequence LengthMass (Da)Tools
P49297 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: F398FA96C7110B4E

FASTA57564,720
        10         20         30         40         50         60 
MAASYSVPSM IMEEERRFEA EVAEVQAWWN TERFRLTKRA YSARDVVALR GTMRQSYASN 

        70         80         90        100        110        120 
ELAQKLWRTL KTHQANGTAS RTFGALDPVQ VTMMAKHLDT IYVSGWQCSS THTSTNEPGP 

       130        140        150        160        170        180 
DLADYPYDTV PNKVEHLFFA QQYHDRKQRE ARMSMCREER ARTPFIDYLK PIIADGDTGF 

       190        200        210        220        230        240 
GGATATVKLC KLFVERGAAG VHIEDQSSVT KKCGHMAGKV LVAVSEHINR LVAARLQFDV 

       250        260        270        280        290        300 
MGTETVLVAR TDAVAATLIQ TNVDTRDHQF ILGASNPNLK GKGLATHLSE AMAAGKTGPE 

       310        320        330        340        350        360 
LQAIEDNWLG MAELKTFSQC VTDAIKKMNL AEYEKQRKLN EWMNHSSYEK CLSHEQAREV 

       370        380        390        400        410        420 
AERLGLPNLF WDWDLPRTRE GFYRFQGSVE AAIVRGWAFA EYCDLVWMET SSPDMVECTK 

       430        440        450        460        470        480 
FSQGVKTLRP ELMLAYNLSP SFNWDASGMN DNQMMDFIPR IAKLGYCWQF ITLAGFHADA 

       490        500        510        520        530        540 
LIVDTFAKDF ARRGMLAYVE KIQREERSNG VDTLAHQKWS GANYYDRVLR TVQGGITSTA 

       550        560        570 
AMGKGVTEEQ FEEKWTRTGA TNLGDGSVVI AKARM 

« Hide

References

[1]"A cDNA clone for isocitrate lyase from tomato."
Janssen B.-J.
Plant Physiol. 108:1339-1339(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. UC82B.
Tissue: Leaf.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18678 mRNA. Translation: AAA82738.1.
PIRT06353.
RefSeqNP_001233878.1. NM_001246949.1.
UniGeneLes.2767.

3D structure databases

ProteinModelPortalP49297.
SMRP49297. Positions 9-535.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID544276.
KEGGsly:544276.

Phylogenomic databases

KOK01637.

Enzyme and pathway databases

UniPathwayUPA00703; UER00719.

Family and domain databases

Gene3D3.20.20.60. 2 hits.
InterProIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamPF00463. ICL. 1 hit.
[Graphical view]
PIRSFPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMSSF51621. SSF51621. 1 hit.
TIGRFAMsTIGR01346. isocit_lyase. 1 hit.
PROSITEPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACEA_SOLLC
AccessionPrimary (citable) accession number: P49297
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways