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P49296

- ACEA_CUCSA

UniProt

P49296 - ACEA_CUCSA

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Protein

Isocitrate lyase

Gene
N/A
Organism
Cucumis sativus (Cucumber)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in storage lipid mobilization during the growth of higher plant seedling.

Catalytic activityi

Isocitrate = succinate + glyoxylate.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei213 – 2131Curated

GO - Molecular functioni

  1. isocitrate lyase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00703; UER00719.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate lyase (EC:4.1.3.1)
Short name:
ICL
Short name:
Isocitrase
Short name:
Isocitratase
OrganismiCucumis sativus (Cucumber)
Taxonomic identifieri3659 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsCucurbitalesCucurbitaceaeBenincaseaeCucumis

Subcellular locationi

GO - Cellular componenti

  1. glyoxysome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Glyoxysome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576Isocitrate lyasePRO_0000068804Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP49296.
SMRiP49296. Positions 9-535.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi574 – 5763Microbody targeting signalSequence Analysis

Sequence similaritiesi

Phylogenomic databases

KOiK01637.

Family and domain databases

Gene3Di3.20.20.60. 2 hits.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamiPF00463. ICL. 1 hit.
[Graphical view]
PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49296-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAASFSVPSM IMEEEGRFEA EVAEVQAWWN SERFKLTRRP YTAKDVVSLR
60 70 80 90 100
GSLRQSYASN DLAKKLWRTL KTHQANGTAS RTFGALDPVQ VTMMAKHLDT
110 120 130 140 150
IYVSGWQCSS THTSTNEPGP DLADYPYDTV PNKVEHLFFA QQYHDRKQRE
160 170 180 190 200
ARMSMSREER AKTPYIDYLK PIIADGDTGF GGTTATVKLC KLFVERGAAG
210 220 230 240 250
VHIEDQSSVT KKCGHMAGKV LVAVSEHINR LVAARLQFDV MGVETILVAR
260 270 280 290 300
TDAVAATLIQ TNVDKRDHQF ILGATNPNLR GKSLAGALAE AMAAGKTGAE
310 320 330 340 350
LQALEDQWIS MAQLKTFSEC VTDAIMNTNA TENEKRRKLD EWMNHSSYEK
360 370 380 390 400
CISNEQGREI AEKLGLKNLF WDWDLPRTRE GFYRFKGSVM AAIVRGWAFA
410 420 430 440 450
PHADLIWMET SSPDLVECTT FAKGMKSIHP ETMLAYNLSP SFNWDASGMS
460 470 480 490 500
DKQMEEFIPR IARLGFCWQF ITLAGFHADA LVVDTFARDY ARRGMLAYVE
510 520 530 540 550
RIQREERNNG VDTLAHQKWS GANYYDRYLK TVQGGISSTA AMGKGVTEEQ
560 570
FKESWTREGA VNLGEEGNVV VAKSRM
Length:576
Mass (Da):64,611
Last modified:February 1, 1996 - v1
Checksum:i717D30B83CD81D6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35499 Genomic DNA. Translation: CAA84632.1.
PIRiS53505.
RefSeqiXP_004158557.1. XM_004158509.1.

Genome annotation databases

GeneIDi101214114.
KEGGicsv:101214114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35499 Genomic DNA. Translation: CAA84632.1 .
PIRi S53505.
RefSeqi XP_004158557.1. XM_004158509.1.

3D structure databases

ProteinModelPortali P49296.
SMRi P49296. Positions 9-535.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101214114.
KEGGi csv:101214114.

Phylogenomic databases

KOi K01637.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00719 .

Family and domain databases

Gene3Di 3.20.20.60. 2 hits.
InterProi IPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
Pfami PF00463. ICL. 1 hit.
[Graphical view ]
PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR01346. isocit_lyase. 1 hit.
PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The isocitrate lyase gene of cucumber: isolation, characterisation and expression in cotyledons following seed germination."
    Reynolds S.J., Smith S.M.
    Plant Mol. Biol. 27:487-497(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Masterpiece.
    Tissue: Leaf.

Entry informationi

Entry nameiACEA_CUCSA
AccessioniPrimary (citable) accession number: P49296
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3