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Protein

Melatonin receptor type 1B

Gene

MTNR1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc
  2. melatonin receptor activity Source: ProtInc

GO - Biological processi

  1. glucose homeostasis Source: BHF-UCL
  2. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  3. regulation of insulin secretion Source: BHF-UCL
  4. synaptic transmission Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14828. Class A/1 (Rhodopsin-like receptors).
REACT_19231. G alpha (i) signalling events.
SignaLinkiP49286.

Names & Taxonomyi

Protein namesi
Recommended name:
Melatonin receptor type 1B
Short name:
Mel-1B-R
Short name:
Mel1b receptor
Gene namesi
Name:MTNR1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:7464. MTNR1B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242ExtracellularSequence AnalysisAdd
BLAST
Transmembranei43 – 6321Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini64 – 7613CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei77 – 9721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini98 – 11518ExtracellularSequence AnalysisAdd
BLAST
Transmembranei116 – 13621Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini137 – 15519CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei156 – 17621Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini177 – 20024ExtracellularSequence AnalysisAdd
BLAST
Transmembranei201 – 22121Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini222 – 25332CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei254 – 27421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini275 – 28713ExtracellularSequence AnalysisAdd
BLAST
Transmembranei288 – 30821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini309 – 36254CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31268.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Melatonin receptor type 1BPRO_0000069870Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi113 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49286.
PRIDEiP49286.

Expressioni

Tissue specificityi

Expressed in retina and less in brain and hippocampus.

Gene expression databases

BgeeiP49286.
CleanExiHS_MTNR1B.
ExpressionAtlasiP49286. baseline and differential.
GenevestigatoriP49286.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MTNR1AP480392EBI-1188341,EBI-1188238
RGS20O760812EBI-1188341,EBI-1052678

Protein-protein interaction databases

BioGridi110640. 2 interactions.
IntActiP49286. 19 interactions.
MINTiMINT-8087067.
STRINGi9606.ENSP00000257068.

Structurei

3D structure databases

ProteinModelPortaliP49286.
SMRiP49286. Positions 42-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG138016.
GeneTreeiENSGT00440000033318.
HOGENOMiHOG000037953.
HOVERGENiHBG052528.
InParanoidiP49286.
KOiK04286.
OMAiRLFFQDT.
OrthoDBiEOG7MD4Q5.
PhylomeDBiP49286.
TreeFamiTF331693.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002278. Mel_1A_rcpt.
IPR027459. Mel_rcpt_1B.
IPR000025. Melatonin_rcpt.
[Graphical view]
PANTHERiPTHR24242:SF190. PTHR24242:SF190. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01149. MELATONIN1AR.
PR00857. MELATONINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49286-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENGSFANC CEAGGWAVRP GWSGAGSARP SRTPRPPWVA PALSAVLIVT
60 70 80 90 100
TAVDVVGNLL VILSVLRNRK LRNAGNLFLV SLALADLVVA FYPYPLILVA
110 120 130 140 150
IFYDGWALGE EHCKASAFVM GLSVIGSVFN ITAIAINRYC YICHSMAYHR
160 170 180 190 200
IYRRWHTPLH ICLIWLLTVV ALLPNFFVGS LEYDPRIYSC TFIQTASTQY
210 220 230 240 250
TAAVVVIHFL LPIAVVSFCY LRIWVLVLQA RRKAKPESRL CLKPSDLRSF
260 270 280 290 300
LTMFVVFVIF AICWAPLNCI GLAVAINPQE MAPQIPEGLF VTSYLLAYFN
310 320 330 340 350
SCLNAIVYGL LNQNFRREYK RILLALWNPR HCIQDASKGS HAEGLQSPAP
360
PIIGVQHQAD AL
Length:362
Mass (Da):40,188
Last modified:January 31, 1996 - v1
Checksum:iEECD78649DD79121
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241G → E.1 Publication
Corresponds to variant rs8192552 [ dbSNP | Ensembl ].
VAR_009262
Natural varianti66 – 661L → F.1 Publication
VAR_009263
Natural varianti231 – 2311R → H.
Corresponds to variant rs8192553 [ dbSNP | Ensembl ].
VAR_049421

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25341 mRNA. Translation: AAC50612.1.
AB033598 Genomic DNA. Translation: BAA92315.1.
AY521019 mRNA. Translation: AAS00461.1.
BC069163 mRNA. Translation: AAH69163.1.
CCDSiCCDS8290.1.
PIRiI38990.
RefSeqiNP_005950.1. NM_005959.3.
UniGeneiHs.569039.

Genome annotation databases

EnsembliENST00000257068; ENSP00000257068; ENSG00000134640.
GeneIDi4544.
KEGGihsa:4544.
UCSCiuc001pdk.1. human.

Polymorphism databases

DMDMi1346548.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Melatonin receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25341 mRNA. Translation: AAC50612.1.
AB033598 Genomic DNA. Translation: BAA92315.1.
AY521019 mRNA. Translation: AAS00461.1.
BC069163 mRNA. Translation: AAH69163.1.
CCDSiCCDS8290.1.
PIRiI38990.
RefSeqiNP_005950.1. NM_005959.3.
UniGeneiHs.569039.

3D structure databases

ProteinModelPortaliP49286.
SMRiP49286. Positions 42-324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110640. 2 interactions.
IntActiP49286. 19 interactions.
MINTiMINT-8087067.
STRINGi9606.ENSP00000257068.

Chemistry

BindingDBiP49286.
ChEMBLiCHEMBL2094268.
DrugBankiDB06594. Agomelatine.
DB01065. Melatonin.
DB00980. Ramelteon.
GuidetoPHARMACOLOGYi288.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi1346548.

Proteomic databases

PaxDbiP49286.
PRIDEiP49286.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257068; ENSP00000257068; ENSG00000134640.
GeneIDi4544.
KEGGihsa:4544.
UCSCiuc001pdk.1. human.

Organism-specific databases

CTDi4544.
GeneCardsiGC11P092705.
HGNCiHGNC:7464. MTNR1B.
MIMi600804. gene.
neXtProtiNX_P49286.
PharmGKBiPA31268.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG138016.
GeneTreeiENSGT00440000033318.
HOGENOMiHOG000037953.
HOVERGENiHBG052528.
InParanoidiP49286.
KOiK04286.
OMAiRLFFQDT.
OrthoDBiEOG7MD4Q5.
PhylomeDBiP49286.
TreeFamiTF331693.

Enzyme and pathway databases

ReactomeiREACT_14828. Class A/1 (Rhodopsin-like receptors).
REACT_19231. G alpha (i) signalling events.
SignaLinkiP49286.

Miscellaneous databases

GeneWikiiMelatonin_receptor_1B.
GenomeRNAii4544.
NextBioi17525.
PROiP49286.
SOURCEiSearch...

Gene expression databases

BgeeiP49286.
CleanExiHS_MTNR1B.
ExpressionAtlasiP49286. baseline and differential.
GenevestigatoriP49286.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002278. Mel_1A_rcpt.
IPR027459. Mel_rcpt_1B.
IPR000025. Melatonin_rcpt.
[Graphical view]
PANTHERiPTHR24242:SF190. PTHR24242:SF190. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01149. MELATONIN1AR.
PR00857. MELATONINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor."
    Reppert S.M., Godson C., Mahle C.D., Weaver D.R., Slaugenhaupt S.A., Gusella J.F.
    Proc. Natl. Acad. Sci. U.S.A. 92:8734-8738(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLU-24 AND PHE-66.
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    King M.M., Aronstam R.S., Sharma S.V.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retina.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiMTR1B_HUMAN
AccessioniPrimary (citable) accession number: P49286
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 1996
Last sequence update: January 31, 1996
Last modified: January 6, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.