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P49286 (MTR1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Melatonin receptor type 1B

Short name=Mel-1B-R
Short name=Mel1b receptor
Gene names
Name:MTNR1B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in retina and less in brain and hippocampus.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362Melatonin receptor type 1B
PRO_0000069870

Regions

Topological domain1 – 4242Extracellular Potential
Transmembrane43 – 6321Helical; Name=1; Potential
Topological domain64 – 7613Cytoplasmic Potential
Transmembrane77 – 9721Helical; Name=2; Potential
Topological domain98 – 11518Extracellular Potential
Transmembrane116 – 13621Helical; Name=3; Potential
Topological domain137 – 15519Cytoplasmic Potential
Transmembrane156 – 17621Helical; Name=4; Potential
Topological domain177 – 20024Extracellular Potential
Transmembrane201 – 22121Helical; Name=5; Potential
Topological domain222 – 25332Cytoplasmic Potential
Transmembrane254 – 27421Helical; Name=6; Potential
Topological domain275 – 28713Extracellular Potential
Transmembrane288 – 30821Helical; Name=7; Potential
Topological domain309 – 36254Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential
Disulfide bond113 ↔ 190 By similarity

Natural variations

Natural variant241G → E. Ref.2
Corresponds to variant rs8192552 [ dbSNP | Ensembl ].
VAR_009262
Natural variant661L → F. Ref.2
VAR_009263
Natural variant2311R → H.
Corresponds to variant rs8192553 [ dbSNP | Ensembl ].
VAR_049421

Sequences

Sequence LengthMass (Da)Tools
P49286 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: EECD78649DD79121

FASTA36240,188
        10         20         30         40         50         60 
MSENGSFANC CEAGGWAVRP GWSGAGSARP SRTPRPPWVA PALSAVLIVT TAVDVVGNLL 

        70         80         90        100        110        120 
VILSVLRNRK LRNAGNLFLV SLALADLVVA FYPYPLILVA IFYDGWALGE EHCKASAFVM 

       130        140        150        160        170        180 
GLSVIGSVFN ITAIAINRYC YICHSMAYHR IYRRWHTPLH ICLIWLLTVV ALLPNFFVGS 

       190        200        210        220        230        240 
LEYDPRIYSC TFIQTASTQY TAAVVVIHFL LPIAVVSFCY LRIWVLVLQA RRKAKPESRL 

       250        260        270        280        290        300 
CLKPSDLRSF LTMFVVFVIF AICWAPLNCI GLAVAINPQE MAPQIPEGLF VTSYLLAYFN 

       310        320        330        340        350        360 
SCLNAIVYGL LNQNFRREYK RILLALWNPR HCIQDASKGS HAEGLQSPAP PIIGVQHQAD 


AL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor."
Reppert S.M., Godson C., Mahle C.D., Weaver D.R., Slaugenhaupt S.A., Gusella J.F.
Proc. Natl. Acad. Sci. U.S.A. 92:8734-8738(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genetic polymorphisms of human melatonin 1b receptor gene in circadian rhythm sleep disorders and controls."
Ebisawa T., Uchiyama M., Kajimura N., Kamei Y., Shibui K., Kim K., Kudo Y., Iwase T., Sugishita M., Jodoi T., Ikeda M., Ozeki Y., Watanabe T., Sekimoto M., Katoh M., Yamada N., Toyoshima R., Okawa M., Takahashi K., Yamauchi T.
Neurosci. Lett. 280:29-32(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLU-24 AND PHE-66.
[3]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
King M.M., Aronstam R.S., Sharma S.V.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Retina.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Web resources

Wikipedia

Melatonin receptor entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U25341 mRNA. Translation: AAC50612.1.
AB033598 Genomic DNA. Translation: BAA92315.1.
AY521019 mRNA. Translation: AAS00461.1.
BC069163 mRNA. Translation: AAH69163.1.
CCDSCCDS8290.1.
PIRI38990.
RefSeqNP_005950.1. NM_005959.3.
UniGeneHs.569039.

3D structure databases

ProteinModelPortalP49286.
SMRP49286. Positions 42-324.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110640. 2 interactions.
IntActP49286. 19 interactions.
MINTMINT-8087067.
STRING9606.ENSP00000257068.

Chemistry

BindingDBP49286.
ChEMBLCHEMBL1946.
DrugBankDB00980. Ramelteon.
GuidetoPHARMACOLOGY288.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM1346548.

Proteomic databases

PaxDbP49286.
PRIDEP49286.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000257068; ENSP00000257068; ENSG00000134640.
GeneID4544.
KEGGhsa:4544.
UCSCuc001pdk.1. human.

Organism-specific databases

CTD4544.
GeneCardsGC11P092705.
HGNCHGNC:7464. MTNR1B.
MIM600804. gene.
neXtProtNX_P49286.
PharmGKBPA31268.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG138016.
HOGENOMHOG000037953.
HOVERGENHBG052528.
InParanoidP49286.
KOK04286.
OMAICHSVAY.
OrthoDBEOG7MD4Q5.
PhylomeDBP49286.
TreeFamTF331693.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
SignaLinkP49286.

Gene expression databases

ArrayExpressP49286.
BgeeP49286.
CleanExHS_MTNR1B.
GenevestigatorP49286.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002278. Mel_1A_rcpt.
IPR027459. Mel_rcpt_1B.
IPR000025. Melatonin_rcpt.
[Graphical view]
PANTHERPTHR24242:SF190. PTHR24242:SF190. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01149. MELATONIN1AR.
PR00857. MELATONINR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMelatonin_receptor_1B.
GenomeRNAi4544.
NextBio17525.
PROP49286.
SOURCESearch...

Entry information

Entry nameMTR1B_HUMAN
AccessionPrimary (citable) accession number: P49286
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries