P49286 (MTR1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Melatonin receptor type 1B
Short name=Mel-1B-R
Short name=Mel1b receptor

Gene names

Name:

MTNR1B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in retina and less in brain and hippocampus.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Traceable author statement Ref.1. Source: ProtInc glucose homeostasis Inferred from mutant phenotype PubMed 20668700. Source: BHF-UCL regulation of insulin secretion Inferred from mutant phenotype PubMed 20668700. Source: BHF-UCL synaptic transmission Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	melatonin receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Melatonin receptor type 1B		PRO_0000069870
Regions
	Topological domain	1 – 42	42	Extracellular Potential
	Transmembrane	43 – 63	21	Helical; Name=1; Potential
	Topological domain	64 – 76	13	Cytoplasmic Potential
	Transmembrane	77 – 97	21	Helical; Name=2; Potential
	Topological domain	98 – 115	18	Extracellular Potential
	Transmembrane	116 – 136	21	Helical; Name=3; Potential
	Topological domain	137 – 155	19	Cytoplasmic Potential
	Transmembrane	156 – 176	21	Helical; Name=4; Potential
	Topological domain	177 – 200	24	Extracellular Potential
	Transmembrane	201 – 221	21	Helical; Name=5; Potential
	Topological domain	222 – 253	32	Cytoplasmic Potential
	Transmembrane	254 – 274	21	Helical; Name=6; Potential
	Topological domain	275 – 287	13	Extracellular Potential
	Transmembrane	288 – 308	21	Helical; Name=7; Potential
	Topological domain	309 – 362	54	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Disulfide bond	113 ↔ 190		By similarity
Natural variations
	Natural variant	24	1	G → E. Ref.2 Corresponds to variant rs8192552 [ dbSNP | Ensembl ].		VAR_009262
	Natural variant	66	1	L → F. Ref.2		VAR_009263
	Natural variant	231	1	R → H. Corresponds to variant rs8192553 [ dbSNP | Ensembl ].		VAR_049421

Sequences

	Sequence		Length	Mass (Da)
	P49286 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: EECD78649DD79121	FASTA	362	40,188
	10 20 30 40 50 60 MSENGSFANC CEAGGWAVRP GWSGAGSARP SRTPRPPWVA PALSAVLIVT TAVDVVGNLL 70 80 90 100 110 120 VILSVLRNRK LRNAGNLFLV SLALADLVVA FYPYPLILVA IFYDGWALGE EHCKASAFVM 130 140 150 160 170 180 GLSVIGSVFN ITAIAINRYC YICHSMAYHR IYRRWHTPLH ICLIWLLTVV ALLPNFFVGS 190 200 210 220 230 240 LEYDPRIYSC TFIQTASTQY TAAVVVIHFL LPIAVVSFCY LRIWVLVLQA RRKAKPESRL 250 260 270 280 290 300 CLKPSDLRSF LTMFVVFVIF AICWAPLNCI GLAVAINPQE MAPQIPEGLF VTSYLLAYFN 310 320 330 340 350 360 SCLNAIVYGL LNQNFRREYK RILLALWNPR HCIQDASKGS HAEGLQSPAP PIIGVQHQAD AL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor." Reppert S.M., Godson C., Mahle C.D., Weaver D.R., Slaugenhaupt S.A., Gusella J.F. Proc. Natl. Acad. Sci. U.S.A. 92:8734-8738(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genetic polymorphisms of human melatonin 1b receptor gene in circadian rhythm sleep disorders and controls." Ebisawa T., Uchiyama M., Kajimura N., Kamei Y., Shibui K., Kim K., Kudo Y., Iwase T., Sugishita M., Jodoi T., Ikeda M., Ozeki Y., Watanabe T., Sekimoto M., Katoh M., Yamada N., Toyoshima R., Okawa M., Takahashi K., Yamauchi T. Neurosci. Lett. 280:29-32(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLU-24 AND PHE-66.
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." King M.M., Aronstam R.S., Sharma S.V. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Retina.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Web resources

Wikipedia

Melatonin receptor entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	U25341 mRNA. Translation: AAC50612.1. AB033598 Genomic DNA. Translation: BAA92315.1. AY521019 mRNA. Translation: AAS00461.1. BC069163 mRNA. Translation: AAH69163.1.
IPI	IPI00026564.
PIR	I38990.
RefSeq	NP_005950.1. NM_005959.3.
UniGene	Hs.569039.
3D structure databases
ProteinModelPortal	P49286.
ModBase	Search...
Protein-protein interaction databases
IntAct	P49286. 17 interactions.
STRING	9606.ENSP00000257068.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	1346548.
Proteomic databases
PaxDb	P49286.
PRIDE	P49286.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000257068; ENSP00000257068; ENSG00000134640.
GeneID	4544.
KEGG	hsa:4544.
UCSC	uc001pdk.1. human.
Organism-specific databases
CTD	4544.
GeneCards	GC11P092705.
HGNC	HGNC:7464. MTNR1B.
MIM	600804. gene.
neXtProt	NX_P49286.
PharmGKB	PA31268.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG138016.
HOGENOM	HOG000037953.
HOVERGEN	HBG052528.
InParanoid	P49286.
KO	K04286.
OMA	ICHSVAY.
OrthoDB	EOG4K3KWV.
PhylomeDB	P49286.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P49286.
Bgee	P49286.
CleanEx	HS_MTNR1B.
Genevestigator	P49286.
GermOnline	ENSG00000134640. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR002278. Mel_1A_rcpt. IPR000025. Melatonin_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01149. MELATONIN1AR. PR00857. MELATONINR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P49286.
ChEMBL	CHEMBL1946.
DrugBank	DB00980. Ramelteon.
GenomeRNAi	4544.
NextBio	17525.
SOURCE	Search...

Entry information

Entry name

MTR1B_HUMAN

Accession

Primary (citable) accession number: P49286

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.