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P49286

- MTR1B_HUMAN

UniProt

P49286 - MTR1B_HUMAN

Protein

Melatonin receptor type 1B

Gene

MTNR1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc
    2. melatonin receptor activity Source: ProtInc
    3. protein binding Source: IntAct

    GO - Biological processi

    1. glucose homeostasis Source: BHF-UCL
    2. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
    3. regulation of insulin secretion Source: BHF-UCL
    4. synaptic transmission Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14828. Class A/1 (Rhodopsin-like receptors).
    REACT_19231. G alpha (i) signalling events.
    SignaLinkiP49286.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Melatonin receptor type 1B
    Short name:
    Mel-1B-R
    Short name:
    Mel1b receptor
    Gene namesi
    Name:MTNR1B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:7464. MTNR1B.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31268.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 362362Melatonin receptor type 1BPRO_0000069870Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi113 ↔ 190PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP49286.
    PRIDEiP49286.

    Expressioni

    Tissue specificityi

    Expressed in retina and less in brain and hippocampus.

    Gene expression databases

    ArrayExpressiP49286.
    BgeeiP49286.
    CleanExiHS_MTNR1B.
    GenevestigatoriP49286.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MTNR1AP480392EBI-1188341,EBI-1188238
    RGS20O760812EBI-1188341,EBI-1052678

    Protein-protein interaction databases

    BioGridi110640. 2 interactions.
    IntActiP49286. 19 interactions.
    MINTiMINT-8087067.
    STRINGi9606.ENSP00000257068.

    Structurei

    3D structure databases

    ProteinModelPortaliP49286.
    SMRiP49286. Positions 42-324.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4242ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini64 – 7613CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini98 – 11518ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini137 – 15519CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini177 – 20024ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini222 – 25332CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini275 – 28713ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini309 – 36254CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei43 – 6321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei116 – 13621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei156 – 17621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei254 – 27421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG138016.
    HOGENOMiHOG000037953.
    HOVERGENiHBG052528.
    InParanoidiP49286.
    KOiK04286.
    OMAiICHSVAY.
    OrthoDBiEOG7MD4Q5.
    PhylomeDBiP49286.
    TreeFamiTF331693.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002278. Mel_1A_rcpt.
    IPR027459. Mel_rcpt_1B.
    IPR000025. Melatonin_rcpt.
    [Graphical view]
    PANTHERiPTHR24242:SF190. PTHR24242:SF190. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01149. MELATONIN1AR.
    PR00857. MELATONINR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P49286-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSENGSFANC CEAGGWAVRP GWSGAGSARP SRTPRPPWVA PALSAVLIVT    50
    TAVDVVGNLL VILSVLRNRK LRNAGNLFLV SLALADLVVA FYPYPLILVA 100
    IFYDGWALGE EHCKASAFVM GLSVIGSVFN ITAIAINRYC YICHSMAYHR 150
    IYRRWHTPLH ICLIWLLTVV ALLPNFFVGS LEYDPRIYSC TFIQTASTQY 200
    TAAVVVIHFL LPIAVVSFCY LRIWVLVLQA RRKAKPESRL CLKPSDLRSF 250
    LTMFVVFVIF AICWAPLNCI GLAVAINPQE MAPQIPEGLF VTSYLLAYFN 300
    SCLNAIVYGL LNQNFRREYK RILLALWNPR HCIQDASKGS HAEGLQSPAP 350
    PIIGVQHQAD AL 362
    Length:362
    Mass (Da):40,188
    Last modified:February 1, 1996 - v1
    Checksum:iEECD78649DD79121
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti24 – 241G → E.1 Publication
    Corresponds to variant rs8192552 [ dbSNP | Ensembl ].
    VAR_009262
    Natural varianti66 – 661L → F.1 Publication
    VAR_009263
    Natural varianti231 – 2311R → H.
    Corresponds to variant rs8192553 [ dbSNP | Ensembl ].
    VAR_049421

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U25341 mRNA. Translation: AAC50612.1.
    AB033598 Genomic DNA. Translation: BAA92315.1.
    AY521019 mRNA. Translation: AAS00461.1.
    BC069163 mRNA. Translation: AAH69163.1.
    CCDSiCCDS8290.1.
    PIRiI38990.
    RefSeqiNP_005950.1. NM_005959.3.
    UniGeneiHs.569039.

    Genome annotation databases

    EnsembliENST00000257068; ENSP00000257068; ENSG00000134640.
    GeneIDi4544.
    KEGGihsa:4544.
    UCSCiuc001pdk.1. human.

    Polymorphism databases

    DMDMi1346548.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Melatonin receptor entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U25341 mRNA. Translation: AAC50612.1 .
    AB033598 Genomic DNA. Translation: BAA92315.1 .
    AY521019 mRNA. Translation: AAS00461.1 .
    BC069163 mRNA. Translation: AAH69163.1 .
    CCDSi CCDS8290.1.
    PIRi I38990.
    RefSeqi NP_005950.1. NM_005959.3.
    UniGenei Hs.569039.

    3D structure databases

    ProteinModelPortali P49286.
    SMRi P49286. Positions 42-324.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110640. 2 interactions.
    IntActi P49286. 19 interactions.
    MINTi MINT-8087067.
    STRINGi 9606.ENSP00000257068.

    Chemistry

    BindingDBi P49286.
    ChEMBLi CHEMBL1946.
    DrugBanki DB00980. Ramelteon.
    GuidetoPHARMACOLOGYi 288.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 1346548.

    Proteomic databases

    PaxDbi P49286.
    PRIDEi P49286.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000257068 ; ENSP00000257068 ; ENSG00000134640 .
    GeneIDi 4544.
    KEGGi hsa:4544.
    UCSCi uc001pdk.1. human.

    Organism-specific databases

    CTDi 4544.
    GeneCardsi GC11P092705.
    HGNCi HGNC:7464. MTNR1B.
    MIMi 600804. gene.
    neXtProti NX_P49286.
    PharmGKBi PA31268.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG138016.
    HOGENOMi HOG000037953.
    HOVERGENi HBG052528.
    InParanoidi P49286.
    KOi K04286.
    OMAi ICHSVAY.
    OrthoDBi EOG7MD4Q5.
    PhylomeDBi P49286.
    TreeFami TF331693.

    Enzyme and pathway databases

    Reactomei REACT_14828. Class A/1 (Rhodopsin-like receptors).
    REACT_19231. G alpha (i) signalling events.
    SignaLinki P49286.

    Miscellaneous databases

    GeneWikii Melatonin_receptor_1B.
    GenomeRNAii 4544.
    NextBioi 17525.
    PROi P49286.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P49286.
    Bgeei P49286.
    CleanExi HS_MTNR1B.
    Genevestigatori P49286.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002278. Mel_1A_rcpt.
    IPR027459. Mel_rcpt_1B.
    IPR000025. Melatonin_rcpt.
    [Graphical view ]
    PANTHERi PTHR24242:SF190. PTHR24242:SF190. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01149. MELATONIN1AR.
    PR00857. MELATONINR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor."
      Reppert S.M., Godson C., Mahle C.D., Weaver D.R., Slaugenhaupt S.A., Gusella J.F.
      Proc. Natl. Acad. Sci. U.S.A. 92:8734-8738(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLU-24 AND PHE-66.
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      King M.M., Aronstam R.S., Sharma S.V.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Retina.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiMTR1B_HUMAN
    AccessioniPrimary (citable) accession number: P49286
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3