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Protein

Melatonin receptor type 1B

Gene

MTNR1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • melatonin receptor activity Source: ProtInc

GO - Biological processi

  • chemical synaptic transmission Source: ProtInc
  • circadian rhythm Source: GO_Central
  • glucose homeostasis Source: BHF-UCL
  • G-protein coupled receptor signaling pathway Source: Reactome
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  • regulation of insulin secretion Source: BHF-UCL

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-418594 G alpha (i) signalling events
SignaLinkiP49286

Names & Taxonomyi

Protein namesi
Recommended name:
Melatonin receptor type 1B
Short name:
Mel-1B-R
Short name:
Mel1b receptor
Gene namesi
Name:MTNR1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000134640.2
HGNCiHGNC:7464 MTNR1B
MIMi600804 gene
neXtProtiNX_P49286

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 42ExtracellularSequence analysisAdd BLAST42
Transmembranei43 – 63Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini64 – 76CytoplasmicSequence analysisAdd BLAST13
Transmembranei77 – 97Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini98 – 115ExtracellularSequence analysisAdd BLAST18
Transmembranei116 – 136Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini137 – 155CytoplasmicSequence analysisAdd BLAST19
Transmembranei156 – 176Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini177 – 200ExtracellularSequence analysisAdd BLAST24
Transmembranei201 – 221Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini222 – 253CytoplasmicSequence analysisAdd BLAST32
Transmembranei254 – 274Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini275 – 287ExtracellularSequence analysisAdd BLAST13
Transmembranei288 – 308Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini309 – 362CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4544
MalaCardsiMTNR1B
OpenTargetsiENSG00000134640
PharmGKBiPA31268

Chemistry databases

ChEMBLiCHEMBL1946
DrugBankiDB06594 Agomelatine
DB01065 Melatonin
DB00980 Ramelteon
DB09071 Tasimelteon
DB05359 VEC-162
GuidetoPHARMACOLOGYi288

Polymorphism and mutation databases

BioMutaiMTNR1B
DMDMi1346548

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000698701 – 362Melatonin receptor type 1BAdd BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi113 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49286
PRIDEiP49286

Expressioni

Tissue specificityi

Expressed in retina and less in brain and hippocampus.1 Publication

Gene expression databases

BgeeiENSG00000134640
CleanExiHS_MTNR1B
ExpressionAtlasiP49286 baseline and differential
GenevisibleiP49286 HS

Interactioni

Subunit structurei

Interacts with GPR61, GPR62 and GPR135 (PubMed:28827538).1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110640, 193 interactors
CORUMiP49286
IntActiP49286, 202 interactors
MINTiP49286
STRINGi9606.ENSP00000257068

Chemistry databases

BindingDBiP49286

Structurei

3D structure databases

ProteinModelPortaliP49286
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHFY Eukaryota
ENOG4111ZZV LUCA
GeneTreeiENSGT00440000033318
HOGENOMiHOG000037953
HOVERGENiHBG052528
InParanoidiP49286
KOiK04286
OMAiEVHCKAS
OrthoDBiEOG091G0GO0
PhylomeDBiP49286
TreeFamiTF331693

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002278 Mel_1A/1B_rcpt
IPR027459 Mel_rcpt_1
IPR000025 Melatonin_rcpt
PANTHERiPTHR43962 PTHR43962, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01149 MELATONIN1AR
PR00857 MELATONINR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P49286-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENGSFANC CEAGGWAVRP GWSGAGSARP SRTPRPPWVA PALSAVLIVT
60 70 80 90 100
TAVDVVGNLL VILSVLRNRK LRNAGNLFLV SLALADLVVA FYPYPLILVA
110 120 130 140 150
IFYDGWALGE EHCKASAFVM GLSVIGSVFN ITAIAINRYC YICHSMAYHR
160 170 180 190 200
IYRRWHTPLH ICLIWLLTVV ALLPNFFVGS LEYDPRIYSC TFIQTASTQY
210 220 230 240 250
TAAVVVIHFL LPIAVVSFCY LRIWVLVLQA RRKAKPESRL CLKPSDLRSF
260 270 280 290 300
LTMFVVFVIF AICWAPLNCI GLAVAINPQE MAPQIPEGLF VTSYLLAYFN
310 320 330 340 350
SCLNAIVYGL LNQNFRREYK RILLALWNPR HCIQDASKGS HAEGLQSPAP
360
PIIGVQHQAD AL
Length:362
Mass (Da):40,188
Last modified:February 1, 1996 - v1
Checksum:iEECD78649DD79121
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00926224G → E1 PublicationCorresponds to variant dbSNP:rs8192552Ensembl.1
Natural variantiVAR_00926366L → F1 PublicationCorresponds to variant dbSNP:rs370338802Ensembl.1
Natural variantiVAR_049421231R → H. Corresponds to variant dbSNP:rs8192553Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25341 mRNA Translation: AAC50612.1
AB033598 Genomic DNA Translation: BAA92315.1
AY521019 mRNA Translation: AAS00461.1
BC069163 mRNA Translation: AAH69163.1
CCDSiCCDS8290.1
PIRiI38990
RefSeqiNP_005950.1, NM_005959.3
XP_011541141.1, XM_011542839.2
UniGeneiHs.569039

Genome annotation databases

EnsembliENST00000257068; ENSP00000257068; ENSG00000134640
GeneIDi4544
KEGGihsa:4544
UCSCiuc001pdk.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMTR1B_HUMAN
AccessioniPrimary (citable) accession number: P49286
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 25, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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