P49285 (MTR1A_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Melatonin receptor type 1A Short name=Mel-1A-R Short name=Mel1a receptor Alternative name(s): CKA
Organism	Gallus gallus (Chicken) [Reference proteome]
Taxonomic identifier	9031 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in optic tectum and retina, less in neostriatum, hypothalamus and thalamus.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of cGMP biosynthetic process Inferred from electronic annotation. Source: Compara
Cellular_component	integral to plasma membrane Inferred from electronic annotation. Source: Compara receptor complex Inferred from electronic annotation. Source: Compara
Molecular_function	hormone binding Inferred from electronic annotation. Source: Compara melatonin receptor activity Inferred from electronic annotation. Source: InterPro organic cyclic compound binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 353	353	Melatonin receptor type 1A		PRO_0000069868
Regions
	Topological domain	1 – 32	32	Extracellular Potential
	Transmembrane	33 – 53	21	Helical; Name=1; Potential
	Topological domain	54 – 66	13	Cytoplasmic Potential
	Transmembrane	67 – 87	21	Helical; Name=2; Potential
	Topological domain	88 – 105	18	Extracellular Potential
	Transmembrane	106 – 126	21	Helical; Name=3; Potential
	Topological domain	127 – 145	19	Cytoplasmic Potential
	Transmembrane	146 – 166	21	Helical; Name=4; Potential
	Topological domain	167 – 190	24	Extracellular Potential
	Transmembrane	191 – 211	21	Helical; Name=5; Potential
	Topological domain	212 – 243	32	Cytoplasmic Potential
	Transmembrane	244 – 264	21	Helical; Name=6; Potential
	Topological domain	265 – 277	13	Extracellular Potential
	Transmembrane	278 – 298	21	Helical; Name=7; Potential
	Topological domain	299 – 353	55	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	9	1	N-linked (GlcNAc...) Potential
	Disulfide bond	103 ↔ 180		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P49285 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: DBF078C7F2AF291D	FASTA	353	39,896
	10 20 30 40 50 60 MRANGSELNG TVLPRDPPAE GSPRRPPWVT STLATILIFT IVVDLLGNLL VILSVYRNKK 70 80 90 100 110 120 LRNAGNIFVV SLAIADLVVA IYPYPLVLTS VFHNGWNLGY LHCQISGFLM GLSVIGSIFN 130 140 150 160 170 180 ITGIAINRYC YICHSLKYDK LYSDKNSLCY VGLIWVLTVV AIVPNLFVGS LQYDPRIYSC 190 200 210 220 230 240 TFAQSVSSAY TIAVVFFHFI LPIAIVTYCY LRIWILVIQV RRRVKPDNNP RLKPHDFRNF 250 260 270 280 290 300 VTMFVVFVLF AVCWAPLNFI GLAVAVDPET IIPRIPEWLF VSSYYMAYFN SCLNAIIYGL 310 320 330 340 350 LNQNFRREYK KIVVSFCTAK AFFQDSSNDA ADRIRSKPSP LITNNNQVKV DSV

References

[1]	"Melatonin receptors are for the birds: molecular analysis of two receptor subtypes differentially expressed in chick brain." Reppert S.M., Weaver D.R., Cassone V.M., Godson C., Kolakowski L.F. Jr. Neuron 15:1003-1015(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U31820 mRNA. Translation: AAA92498.1.
IPI	IPI00573091.
RefSeq	NP_990693.1. NM_205362.1.
UniGene	Gga.762.
3D structure databases
ProteinModelPortal	P49285.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PaxDb	P49285.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000022097; ENSGALP00000022058; ENSGALG00000013576.
GeneID	396319.
KEGG	gga:396319.
Organism-specific databases
CTD	4543.
Phylogenomic databases
eggNOG	NOG138016.
GeneTree	ENSGT00440000033318.
HOGENOM	HOG000037953.
HOVERGEN	HBG052528.
InParanoid	P49285.
KO	K04285.
OMA	RVKPDNK.
OrthoDB	EOG4K3KWV.
Gene expression databases
ArrayExpress	P49285.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR002278. Mel_1A_rcpt. IPR000025. Melatonin_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01149. MELATONIN1AR. PR00857. MELATONINR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P49285.
ChEMBL	CHEMBL4555.
NextBio	20816367.

Entry information

Entry name

MTR1A_CHICK

Accession

Primary (citable) accession number: P49285

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program