P49282 (NRAM2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Natural resistance-associated macrophage protein 2
Short name=NRAMP 2

Alternative name(s):
Divalent cation transporter 1
Divalent metal transporter 1
Short name=DMT-1

Gene names

Name:	Slc11a2
Synonyms:	Dct1, Dmt1, Nramp2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	568 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Important in metal transport, in particular iron. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. Ref.8 Ref.9
Subunit structure	Forms a complex with NDFIP1 and NEDD4L, in cortical neurons, in response to iron and colbalt exposure; this interaction leads to ubiquitination by NEDD4L and proteasome-dependent degradation. Interacts with NDFIP2 By similarity.
Subcellular location	Endosome membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Isoform 2 is abundantly expressed in erythroid precursor cells (at protein level). Expressed at low levels in most tissues analyzed. Expressed at low levels in small intestine and at higher levels in kidney. Ref.7 Ref.8
Induction	Isoform 1 is up-regulated under iron-depletion conditions in the proximal portion of the duodenum where it is abundantly expressed in the brush border of absorptive epithelial cells (at protein level). Ref.7
Post-translational modification	Ubiquitinated by WWP2. Ref.11
Involvement in disease	Defects in Slc11a2 are the cause of microcytic anemia (mk). Homozygous mk/mk mice have hypochromic microcytic anemia due to severe defects in intestinal iron absorption and erythroid iron utilization.
Disruption phenotype	Mice display no apparent anatomical abnormalities. They are however anemic, show progressive postnatal growth retardation, and at birth have elevated liver iron stores compared with wild-type littermates. None survive for more than 7 days. Heterozygotes appear normal, showing no significant hematological abnormalities. However, by 8 weeks, their liver iron content is lower than in wild-type littermates. Ref.9
Miscellaneous	Nifedipine induces duodenal iron accumulation and mobilizes iron from the liver of iron-overloaded mice.
Sequence similarities	Belongs to the NRAMP family.
Sequence caution	The sequence CAD38518.1 differs from that shown. Reason: Frameshift at position 69.

Ontologies

Keywords
Biological process	Ion transport Iron transport Transport
Cellular component	Endosome Membrane
Coding sequence diversity	Alternative splicing
Disease	Disease mutation
Domain	Transmembrane Transmembrane helix
Ligand	Iron
PTM	Glycoprotein Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from electronic annotation. Source: Compara cadmium ion transmembrane transport Inferred from electronic annotation. Source: Compara cellular response to oxidative stress Inferred from electronic annotation. Source: Compara cobalt ion transport Inferred from electronic annotation. Source: Compara copper ion transport Inferred from electronic annotation. Source: Compara dendrite morphogenesis Inferred from mutant phenotype PubMed 19211831. Source: MGI detection of oxygen Inferred from electronic annotation. Source: Compara erythrocyte development Inferred from mutant phenotype Ref.9. Source: MGI ferrous iron import Inferred from direct assay PubMed 15024413. Source: MGI ferrous iron transport Inferred from electronic annotation. Source: Compara heme biosynthetic process Inferred from mutant phenotype Ref.8. Source: MGI iron ion homeostasis Inferred from electronic annotation. Source: UniProtKB-KW lead ion transport Inferred from electronic annotation. Source: Compara learning or memory Inferred from mutant phenotype PubMed 19211831. Source: MGI manganese ion transmembrane transport Inferred from electronic annotation. Source: Compara multicellular organismal iron ion homeostasis Inferred from mutant phenotype PubMed 18076961PubMed 5070129. Source: MGI nickel cation transmembrane transport Inferred from electronic annotation. Source: Compara proton transport Inferred from electronic annotation. Source: GOC response to hypoxia Inferred from electronic annotation. Source: Compara
Cellular_component	apical plasma membrane Inferred from electronic annotation. Source: Compara basal part of cell Inferred from electronic annotation. Source: Compara brush border Inferred from direct assay PubMed 11090085. Source: MGI cell surface Inferred from direct assay PubMed 17097837. Source: MGI cytoplasmic vesicle Inferred from electronic annotation. Source: Compara early endosome Inferred from direct assay PubMed 12724326. Source: MGI endomembrane system Inferred from direct assay PubMed 12724326. Source: MGI endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW integral to plasma membrane Inferred from direct assay PubMed 10942769. Source: MGI late endosome Inferred from electronic annotation. Source: Compara lysosome Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara paraferritin complex Inferred from electronic annotation. Source: Compara perinuclear region of cytoplasm Inferred from electronic annotation. Source: Compara recycling endosome Inferred from direct assay Ref.8PubMed 16905747. Source: MGI trans-Golgi network Inferred from electronic annotation. Source: Compara
Molecular_function	cobalt ion transmembrane transporter activity Inferred from direct assay PubMed 10942769PubMed 12522007PubMed 12724326PubMed 16142913PubMed 16905747. Source: MGI ferrous iron transmembrane transporter activity Inferred from direct assay PubMed 10942769PubMed 12522007PubMed 15024413. Source: MGI hydrogen ion transmembrane transporter activity Inferred from direct assay PubMed 15024413. Source: MGI solute:hydrogen symporter activity Inferred from electronic annotation. Source: Compara vanadium ion transmembrane transporter activity Inferred from electronic annotation. Source: Compara zinc ion transmembrane transporter activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 2 (identifier: P49282-1)

Also known as: Non-IRE;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: P49282-2)

Also known as: IRE;

The sequence of this isoform differs from the canonical sequence as follows:
     544-568: YRLGLTAQPELYLLNTVDADSVVSR → VSISKVLLSEDTSGGNIK

Isoform 3 (identifier: P49282-3)

Also known as: 1A-IRE;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGKKQPRAAAAAPNCELKSYSKSTDPQVSTM
     544-568: YRLGLTAQPELYLLNTVDADSVVSR → VSISKVLLSEDTSGGNIK

Note: No experimental confirmation available.

Isoform 4 (identifier: P49282-4)

Also known as: 1A-Non-IRE;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGKKQPRAAAAAPNCELKSYSKSTDPQVSTM

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 568	568	Natural resistance-associated macrophage protein 2		PRO_0000212595
Regions
	Topological domain	1 – 69	69	Cytoplasmic Potential
	Transmembrane	70 – 90	21	Helical; Potential
	Topological domain	91 – 95	5	Extracellular Potential
	Transmembrane	96 – 117	22	Helical; Potential
	Topological domain	118 – 154	37	Cytoplasmic Potential
	Transmembrane	155 – 175	21	Helical; Potential
	Topological domain	176 – 179	4	Extracellular Potential
	Transmembrane	180 – 194	15	Helical; Potential
	Topological domain	195 – 208	14	Cytoplasmic Potential
	Transmembrane	209 – 229	21	Helical; Potential
	Topological domain	230 – 255	26	Extracellular Potential
	Transmembrane	256 – 276	21	Helical; Potential
	Topological domain	277 – 301	25	Cytoplasmic Potential
	Transmembrane	302 – 322	21	Helical; Potential
	Topological domain	323 – 360	38	Extracellular Potential
	Transmembrane	361 – 381	21	Helical; Potential
	Topological domain	382 – 408	27	Cytoplasmic Potential
	Transmembrane	409 – 429	21	Helical; Potential
	Topological domain	430 – 440	11	Extracellular Potential
	Transmembrane	441 – 461	21	Helical; Potential
	Topological domain	462 – 482	21	Cytoplasmic Potential
	Transmembrane	483 – 503	21	Helical; Potential
	Topological domain	504 – 506	3	Extracellular Potential
	Transmembrane	507 – 527	21	Helical; Potential
	Topological domain	528 – 568	41	Cytoplasmic Potential
Amino acid modifications
	Modified residue	21	1	Phosphoserine Ref.12
	Modified residue	564	1	Phosphoserine Ref.12
	Modified residue	567	1	Phosphoserine Ref.12
	Glycosylation	336	1	N-linked (GlcNAc...) Potential
	Glycosylation	349	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1	1	M → MGKKQPRAAAAAPNCELKSY SKSTDPQVSTM in isoform 3 and isoform 4.		VSP_038145
	Alternative sequence	544 – 568	25	YRLGL…SVVSR → VSISKVLLSEDTSGGNIK in isoform 1 and isoform 3.		VSP_003596
	Natural variant	185	1	G → R in microcytic anemia. Ref.13
Experimental info
	Sequence conflict	6	1	K → E in BAE28454. Ref.3
	Sequence conflict	6	1	K → E in CAD38518. Ref.6
	Sequence conflict	68	1	R → S in AAC24496. Ref.2
	Sequence conflict	69 – 70	2	Missing in CAD38518. Ref.6
	Sequence conflict	142	1	P → R in BAC38930. Ref.3
	Sequence conflict	182	1	L → V in AAC42051. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2 (Non-IRE) [UniParc]. Last modified September 22, 2009. Version 2. Checksum: 603AAF697AAD3C74	FASTA	568	62,368
	10 20 30 40 50 60 MVLDPKEKMP DDGASGDHGD SASLGAINPA YSNSSLPHST GDSEEPFTTY FDEKIPIPEE 70 80 90 100 110 120 EYSCFSFRKL WAFTGPGFLM SIAYLDPGNI ESDLQSGAVA GFKLLWVLLL ATIVGLLLQR 130 140 150 160 170 180 LAARLGVVTG LHLAEVCHRQ YPKVPRIILW LMVELAIIGS DMQEVIGSAI AINLLSAGRV 190 200 210 220 230 240 PLWGGVLITI ADTFVFLFLD KYGLRKLEAF FGFLITIMAL TFGYEYITVK PSQSQVLRGM 250 260 270 280 290 300 FVPSCPGCRT PQVEQAVGIV GAVIMPHNMY LHSALVKSRQ VNRANKQEVR EANKYFFIES 310 320 330 340 350 360 CIALFVSFII NVFVVSVFAE AFFEKTNKQV VEVCKNNSSP HADLFPSDNS TLAVDIYKGG 370 380 390 400 410 420 VVLGCYFGPA ALYIWAVGIL AAGQSSTMTG TYSGQFVMEG FLNLKWSRFA RVILTRSIAI 430 440 450 460 470 480 IPTLLVAVFQ DVEHLTGMND FLNVLQSLQL PFALIPILTF TSLRPVMSEF SNGIGWRIAG 490 500 510 520 530 540 GILVLIVCSI NMYFVVVYVQ ELGHVALYVV AAVVSVAYLT FVFYLGWQCL IALGLSFLDC 550 560 GRSYRLGLTA QPELYLLNTV DADSVVSR
	Isoform 1 (IRE) [UniParc]. Checksum: D2FAA52B8F73FFBC	FASTA	561	61,421
	10 20 30 40 50 60 MVLDPKEKMP DDGASGDHGD SASLGAINPA YSNSSLPHST GDSEEPFTTY FDEKIPIPEE 70 80 90 100 110 120 EYSCFSFRKL WAFTGPGFLM SIAYLDPGNI ESDLQSGAVA GFKLLWVLLL ATIVGLLLQR 130 140 150 160 170 180 LAARLGVVTG LHLAEVCHRQ YPKVPRIILW LMVELAIIGS DMQEVIGSAI AINLLSAGRV 190 200 210 220 230 240 PLWGGVLITI ADTFVFLFLD KYGLRKLEAF FGFLITIMAL TFGYEYITVK PSQSQVLRGM 250 260 270 280 290 300 FVPSCPGCRT PQVEQAVGIV GAVIMPHNMY LHSALVKSRQ VNRANKQEVR EANKYFFIES 310 320 330 340 350 360 CIALFVSFII NVFVVSVFAE AFFEKTNKQV VEVCKNNSSP HADLFPSDNS TLAVDIYKGG 370 380 390 400 410 420 VVLGCYFGPA ALYIWAVGIL AAGQSSTMTG TYSGQFVMEG FLNLKWSRFA RVILTRSIAI 430 440 450 460 470 480 IPTLLVAVFQ DVEHLTGMND FLNVLQSLQL PFALIPILTF TSLRPVMSEF SNGIGWRIAG 490 500 510 520 530 540 GILVLIVCSI NMYFVVVYVQ ELGHVALYVV AAVVSVAYLT FVFYLGWQCL IALGLSFLDC 550 560 GRSVSISKVL LSEDTSGGNI K
	Isoform 3 (1A-IRE) [UniParc]. Checksum: F8119C955315B2F6	FASTA	591	64,568
	10 20 30 40 50 60 MGKKQPRAAA AAPNCELKSY SKSTDPQVST MVLDPKEKMP DDGASGDHGD SASLGAINPA 70 80 90 100 110 120 YSNSSLPHST GDSEEPFTTY FDEKIPIPEE EYSCFSFRKL WAFTGPGFLM SIAYLDPGNI 130 140 150 160 170 180 ESDLQSGAVA GFKLLWVLLL ATIVGLLLQR LAARLGVVTG LHLAEVCHRQ YPKVPRIILW 190 200 210 220 230 240 LMVELAIIGS DMQEVIGSAI AINLLSAGRV PLWGGVLITI ADTFVFLFLD KYGLRKLEAF 250 260 270 280 290 300 FGFLITIMAL TFGYEYITVK PSQSQVLRGM FVPSCPGCRT PQVEQAVGIV GAVIMPHNMY 310 320 330 340 350 360 LHSALVKSRQ VNRANKQEVR EANKYFFIES CIALFVSFII NVFVVSVFAE AFFEKTNKQV 370 380 390 400 410 420 VEVCKNNSSP HADLFPSDNS TLAVDIYKGG VVLGCYFGPA ALYIWAVGIL AAGQSSTMTG 430 440 450 460 470 480 TYSGQFVMEG FLNLKWSRFA RVILTRSIAI IPTLLVAVFQ DVEHLTGMND FLNVLQSLQL 490 500 510 520 530 540 PFALIPILTF TSLRPVMSEF SNGIGWRIAG GILVLIVCSI NMYFVVVYVQ ELGHVALYVV 550 560 570 580 590 AAVVSVAYLT FVFYLGWQCL IALGLSFLDC GRSVSISKVL LSEDTSGGNI K
	Isoform 4 (1A-Non-IRE) [UniParc]. Checksum: ED4B62ED656BAEBE	FASTA	598	65,515
	10 20 30 40 50 60 MGKKQPRAAA AAPNCELKSY SKSTDPQVST MVLDPKEKMP DDGASGDHGD SASLGAINPA 70 80 90 100 110 120 YSNSSLPHST GDSEEPFTTY FDEKIPIPEE EYSCFSFRKL WAFTGPGFLM SIAYLDPGNI 130 140 150 160 170 180 ESDLQSGAVA GFKLLWVLLL ATIVGLLLQR LAARLGVVTG LHLAEVCHRQ YPKVPRIILW 190 200 210 220 230 240 LMVELAIIGS DMQEVIGSAI AINLLSAGRV PLWGGVLITI ADTFVFLFLD KYGLRKLEAF 250 260 270 280 290 300 FGFLITIMAL TFGYEYITVK PSQSQVLRGM FVPSCPGCRT PQVEQAVGIV GAVIMPHNMY 310 320 330 340 350 360 LHSALVKSRQ VNRANKQEVR EANKYFFIES CIALFVSFII NVFVVSVFAE AFFEKTNKQV 370 380 390 400 410 420 VEVCKNNSSP HADLFPSDNS TLAVDIYKGG VVLGCYFGPA ALYIWAVGIL AAGQSSTMTG 430 440 450 460 470 480 TYSGQFVMEG FLNLKWSRFA RVILTRSIAI IPTLLVAVFQ DVEHLTGMND FLNVLQSLQL 490 500 510 520 530 540 PFALIPILTF TSLRPVMSEF SNGIGWRIAG GILVLIVCSI NMYFVVVYVQ ELGHVALYVV 550 560 570 580 590 AAVVSVAYLT FVFYLGWQCL IALGLSFLDC GRSYRLGLTA QPELYLLNTV DADSVVSR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of a second mouse Nramp gene." Gruenheid S., Cellier M., Vidal S., Gros P. Genomics 25:514-525(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport." Fleming M.D., Romano M.A., Su M.A., Garrick L.M., Garrick M.D., Andrews N.C. Proc. Natl. Acad. Sci. U.S.A. 95:1148-1153(1998) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: DBA.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6J. Tissue: Embryo and Hippocampus.
[4]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: FVB/N. Tissue: Kidney.
[6]	"Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function." Hubert N., Hentze M.W. Proc. Natl. Acad. Sci. U.S.A. 99:12345-12350(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-80 (ISOFORMS 3/4), ALTERNATIVE SPLICING. Strain: C57BL/6. Tissue: Duodenum.
[7]	"Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron." Canonne-Hergaux F., Gruenheid S., Ponka P., Gros P. Blood 93:4406-4417(1999) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, INDUCTION.
[8]	"Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice." Canonne-Hergaux F., Zhang A.-S., Ponka P., Gros P. Blood 98:3823-3830(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[9]	"Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver." Gunshin H., Fujiwara Y., Custodio A.O., Direnzo C., Robine S., Andrews N.C. J. Clin. Invest. 115:1258-1266(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[10]	"Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1." Ludwiczek S., Theurl I., Muckenthaler M.U., Jakab M., Mair S.M., Theurl M., Kiss J., Paulmichl M., Hentze M.W., Ritter M., Weiss G. Nat. Med. 13:448-454(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NIFEDIPINE TREATMENT.
[11]	"Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2." Foot N.J., Dalton H.E., Shearwin-Whyatt L.M., Dorstyn L., Tan S.S., Yang B., Kumar S. Blood 112:4268-4275(2008) [PubMed] [Europe PMC] [Abstract] Cited for: UBIQUITINATION.
[12]	"The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21; SER-564 AND SER-567, MASS SPECTROMETRY. Tissue: Macrophage.
[13]	"Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene." Fleming M.D., Trenor C.C. III, Su M.A., Foernzler D., Beier D.R., Dietrich W.F., Andrews N.C. Nat. Genet. 16:383-386(1997) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT MK ARG-185.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L33415 mRNA. Translation: AAC42051.1. AF029758 mRNA. Translation: AAC24496.1. AK049856 mRNA. Translation: BAC33960.1. AK083478 mRNA. Translation: BAC38930.1. AK148276 mRNA. Translation: BAE28454.1. CH466550 Genomic DNA. Translation: EDL04090.1. BC019137 mRNA. Translation: AAH19137.1. AJ493663 mRNA. Translation: CAD38518.1. Frameshift.
IPI	IPI00315758. IPI00379015. IPI00461614. IPI00944806.
PIR	A56852.
RefSeq	NP_001139633.1. NM_001146161.1. NP_032758.2. NM_008732.2.
UniGene	Mm.234608.
3D structure databases
ProteinModelPortal	P49282.
ModBase	Search...
PTM databases
PhosphoSite	P49282.
Proteomic databases
PaxDb	P49282.
PRIDE	P49282.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000023774; ENSMUSP00000023774; ENSMUSG00000023030. ENSMUST00000138843; ENSMUSP00000116463; ENSMUSG00000023030.
GeneID	18174.
KEGG	mmu:18174.
UCSC	uc007xrc.2. mouse. uc007xrd.2. mouse.
Organism-specific databases
CTD	4891.
MGI	MGI:1345279. Slc11a2.
Phylogenomic databases
eggNOG	COG1914.
GeneTree	ENSGT00390000006526.
HOVERGEN	HBG052665.
InParanoid	Q8BWV3.
KO	K12347.
OMA	VIPVIIC.
OrthoDB	EOG4RFKSH.
Gene expression databases
ArrayExpress	P49282.
Bgee	P49282.
Genevestigator	P49282.
GermOnline	ENSMUSG00000023030. Mus musculus.
Family and domain databases
InterPro	IPR001046. Nat-R-assoc-macro_Nramp. [Graphical view]
PANTHER	PTHR11706. PTHR11706. 1 hit.
Pfam	PF01566. Nramp. 1 hit. [Graphical view]
PRINTS	PR00447. NATRESASSCMP.
TIGRFAMs	TIGR01197. nramp. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	SLC11A2. mouse.
NextBio	293478.
SOURCE	Search...

Entry information

Entry name

NRAM2_MOUSE

Accession

Primary (citable) accession number: P49282
Secondary accession number(s): O54903 , Q3UFV5, Q8BJL2, Q8BWV3, Q8CFA0, Q8VCU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	September 22, 2009
Last modified:	April 3, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program