##gff-version 3 P49281 UniProtKB Chain 1 568 . . . ID=PRO_0000212594;Note=Natural resistance-associated macrophage protein 2 P49281 UniProtKB Topological domain 1 69 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Transmembrane 70 90 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Topological domain 91 96 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Transmembrane 97 117 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Topological domain 118 154 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Transmembrane 155 175 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Topological domain 176 179 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Transmembrane 180 200 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Topological domain 201 208 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Transmembrane 209 229 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Topological domain 230 255 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Transmembrane 256 276 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Topological domain 277 301 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Transmembrane 302 322 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Topological domain 323 360 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Transmembrane 361 381 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Topological domain 382 408 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Transmembrane 409 429 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Topological domain 430 440 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Transmembrane 441 461 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Topological domain 462 482 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Transmembrane 483 503 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Topological domain 504 506 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Transmembrane 507 527 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Topological domain 528 568 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Region 1 40 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P49281 UniProtKB Region 555 559 . . . Note=Required for early endosome targeting;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12475959;Dbxref=PMID:12475959 P49281 UniProtKB Compositional bias 16 40 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P49281 UniProtKB Modified residue 564 564 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P49282 P49281 UniProtKB Modified residue 567 567 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P49282 P49281 UniProtKB Glycosylation 336 336 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Glycosylation 349 349 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P49281 UniProtKB Alternative sequence 1 12 . . . ID=VSP_046058;Note=In isoform 5. MVLGPEQKMSDD->MSTVDYLN;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P49281 UniProtKB Alternative sequence 1 1 . . . ID=VSP_038144;Note=In isoform 3 and isoform 4. M->MRKKQLKTEAAPHCELKSYSKNSATQVSTM;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12209011,ECO:0000303|PubMed:15489334;Dbxref=PMID:12209011,PMID:15489334 P49281 UniProtKB Alternative sequence 544 568 . . . ID=VSP_003595;Note=In isoform 1%2C isoform 3 and isoform 5. CHLGLTAQPELYLLNTMDADSLVSR->VSISKGLLTEEATRGYVK;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12209011,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7613023,ECO:0000303|PubMed:9464519,ECO:0000303|PubMed:9642100;Dbxref=PMID:12209011,PMID:14702039,PMID:15489334,PMID:7613023,PMID:9464519,PMID:9642100 P49281 UniProtKB Natural variant 48 48 . . . ID=VAR_036434;Note=In a colorectal cancer sample%3B somatic mutation. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs760028045,PMID:16959974 P49281 UniProtKB Natural variant 114 114 . . . ID=VAR_033011;Note=In AHMIO1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16439678;Dbxref=PMID:16439678 P49281 UniProtKB Natural variant 212 212 . . . ID=VAR_033012;Note=In AHMIO1. G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16439678;Dbxref=dbSNP:rs121918367,PMID:16439678 P49281 UniProtKB Natural variant 399 399 . . . ID=VAR_033013;Note=In AHMIO1%3B increased skipping of exon 12. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15459009;Dbxref=dbSNP:rs121918365,PMID:15459009 P49281 UniProtKB Natural variant 416 416 . . . ID=VAR_033014;Note=In AHMIO1. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16160008;Dbxref=dbSNP:rs121918366,PMID:16160008 P49281 UniProtKB Natural variant 435 435 . . . ID=VAR_008882;Note=L->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9642100;Dbxref=dbSNP:rs144863268,PMID:9642100 P49281 UniProtKB Mutagenesis 86 86 . . . Note=Abolishes metal ion transport. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25326704;Dbxref=PMID:25326704 P49281 UniProtKB Mutagenesis 89 89 . . . Note=Decreases affinity for divalent metal cations. Impairs metal ion transport. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25326704;Dbxref=PMID:25326704 P49281 UniProtKB Mutagenesis 265 265 . . . Note=Abolishes metal ion transport. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25326704;Dbxref=PMID:25326704 P49281 UniProtKB Mutagenesis 338 338 . . . Note=Abolishes N-glycosylation%3B when associated with A-351. Does not affect endosome targeting%3B when associated with A-351. Impairs sorting to the apical membrane%3B when associated with A-351. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12475959;Dbxref=PMID:12475959 P49281 UniProtKB Mutagenesis 351 351 . . . Note=Abolishes N-glycosylation%3B when associated with A-338. Does not affect endosome targeting%3B when associated with A-338. Impairs sorting to the apical membrane%3B when associated with A-338. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12475959;Dbxref=PMID:12475959 P49281 UniProtKB Mutagenesis 555 555 . . . Note=Abolishes localization at early endosomes and leads to localization at late endosomes and lysosomes. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12475959;Dbxref=PMID:12475959 P49281 UniProtKB Mutagenesis 557 557 . . . Note=Abolishes localization at early endosomes and leads to localization at late endosomes and lysosomes. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12475959;Dbxref=PMID:12475959 P49281 UniProtKB Sequence conflict 58 59 . . . Note=PE->GM;Ontology_term=ECO:0000305;evidence=ECO:0000305 P49281 UniProtKB Sequence conflict 81 81 . . . Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 P49281 UniProtKB Sequence conflict 119 119 . . . Note=Q->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 P49281 UniProtKB Sequence conflict 124 124 . . . Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 P49281 UniProtKB Sequence conflict 462 463 . . . Note=SL->YV;Ontology_term=ECO:0000305;evidence=ECO:0000305 P49281 UniProtKB Sequence conflict 476 476 . . . Note=W->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 P49281 UniProtKB Beta strand 554 556 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5F0P P49281 UniProtKB Sequence conflict 6 6 . . . Note=Y->S;Ontology_term=ECO:0000305;evidence=ECO:0000305