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P49279

- NRAM1_HUMAN

UniProt

P49279 - NRAM1_HUMAN

Protein

Natural resistance-associated macrophage protein 1

Gene

SLC11A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe2+ and Mn2+, cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

    GO - Molecular functioni

    1. manganese ion transmembrane transporter activity Source: BHF-UCL
    2. metal ion:proton antiporter activity Source: BHF-UCL
    3. protein homodimerization activity Source: UniProtKB
    4. transition metal ion transmembrane transporter activity Source: BHF-UCL

    GO - Biological processi

    1. activation of protein kinase activity Source: BHF-UCL
    2. antigen processing and presentation of peptide antigen Source: BHF-UCL
    3. cadmium ion transmembrane transport Source: BHF-UCL
    4. cellular cadmium ion homeostasis Source: BHF-UCL
    5. cellular iron ion homeostasis Source: BHF-UCL
    6. defense response to bacterium Source: BHF-UCL
    7. defense response to Gram-negative bacterium Source: BHF-UCL
    8. defense response to protozoan Source: BHF-UCL
    9. divalent metal ion export Source: BHF-UCL
    10. inflammatory response Source: BHF-UCL
    11. interaction with host Source: Reactome
    12. interleukin-2 production Source: BHF-UCL
    13. interleukin-3 production Source: BHF-UCL
    14. iron ion homeostasis Source: BHF-UCL
    15. iron ion transport Source: BHF-UCL
    16. L-arginine import Source: BHF-UCL
    17. macrophage activation Source: BHF-UCL
    18. manganese ion transport Source: BHF-UCL
    19. MHC class II biosynthetic process Source: BHF-UCL
    20. mRNA stabilization Source: BHF-UCL
    21. multicellular organismal iron ion homeostasis Source: BHF-UCL
    22. negative regulation of cytokine production Source: BHF-UCL
    23. nitrite transport Source: BHF-UCL
    24. phagocytosis Source: BHF-UCL
    25. phagosome maturation Source: Reactome
    26. positive regulation of cytokine production Source: BHF-UCL
    27. positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL
    28. positive regulation of gene expression Source: BHF-UCL
    29. positive regulation of interferon-gamma production Source: BHF-UCL
    30. positive regulation of phagocytosis Source: BHF-UCL
    31. positive regulation of T-helper 1 type immune response Source: BHF-UCL
    32. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    33. protein import into nucleus, translocation Source: Ensembl
    34. respiratory burst Source: BHF-UCL
    35. response to bacterium Source: UniProtKB
    36. response to interferon-gamma Source: BHF-UCL
    37. response to lipopolysaccharide Source: BHF-UCL
    38. T cell cytokine production Source: BHF-UCL
    39. T cell proliferation involved in immune response Source: BHF-UCL
    40. transmembrane transport Source: Reactome
    41. vacuolar acidification Source: BHF-UCL
    42. wound healing Source: BHF-UCL

    Keywords - Biological processi

    Ion transport, Iron transport, Transport

    Keywords - Ligandi

    Iron

    Enzyme and pathway databases

    ReactomeiREACT_121256. Phagosomal maturation (early endosomal stage).
    REACT_20547. Metal ion SLC transporters.

    Protein family/group databases

    TCDBi2.A.55.2.3. the metal ion (mn(2+)-iron) transporter (nramp) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Natural resistance-associated macrophage protein 1
    Short name:
    NRAMP 1
    Alternative name(s):
    Solute carrier family 11 member 1
    Gene namesi
    Name:SLC11A1
    Synonyms:LSH, NRAMP, NRAMP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:10907. SLC11A1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell outer membrane Source: Ensembl
    2. integral component of plasma membrane Source: UniProtKB
    3. late endosome Source: BHF-UCL
    4. late endosome membrane Source: Reactome
    5. lysosome Source: BHF-UCL
    6. phagocytic vesicle membrane Source: BHF-UCL
    7. plasma membrane Source: BHF-UCL
    8. tertiary granule membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    MIMi607948. phenotype.
    610446. phenotype.
    Orphaneti3389. Tuberculosis.
    PharmGKBiPA319.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 550550Natural resistance-associated macrophage protein 1PRO_0000212588Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi324 – 3241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi338 – 3381N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP49279.
    PRIDEiP49279.

    PTM databases

    PhosphoSiteiP49279.

    Expressioni

    Tissue specificityi

    Macrophages; peripheral blood leukocytes, lung, spleen and liver.

    Inductioni

    In response to lymphokine or bacterial products.

    Gene expression databases

    ArrayExpressiP49279.
    BgeeiP49279.
    CleanExiHS_SLC11A1.
    GenevestigatoriP49279.

    Organism-specific databases

    HPAiHPA029590.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000233202.

    Structurei

    3D structure databases

    ProteinModelPortaliP49279.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5858CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini77 – 859ExtracellularSequence Analysis
    Topological domaini106 – 14237CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini164 – 1674ExtracellularSequence Analysis
    Topological domaini188 – 1969CytoplasmicSequence Analysis
    Topological domaini218 – 24023ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini260 – 28728CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini308 – 34942ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini370 – 40031CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini419 – 42911ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini451 – 46616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini489 – 4968ExtracellularSequence Analysis
    Topological domaini517 – 55034CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei59 – 7618HelicalSequence AnalysisAdd
    BLAST
    Transmembranei86 – 10520HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei168 – 18720HelicalSequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei241 – 25919HelicalSequence AnalysisAdd
    BLAST
    Transmembranei288 – 30720HelicalSequence AnalysisAdd
    BLAST
    Transmembranei350 – 36920HelicalSequence AnalysisAdd
    BLAST
    Transmembranei401 – 41818HelicalSequence AnalysisAdd
    BLAST
    Transmembranei430 – 45021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei467 – 48822HelicalSequence AnalysisAdd
    BLAST
    Transmembranei497 – 51620HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi3 – 8078Pro/Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NRAMP family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1914.
    HOGENOMiHOG000152203.
    HOVERGENiHBG052665.
    InParanoidiP49279.
    KOiK12347.
    OMAiTSMPTLM.
    OrthoDBiEOG77127K.
    PhylomeDBiP49279.
    TreeFamiTF315185.

    Family and domain databases

    HAMAPiMF_00221. NRAMP.
    InterProiIPR001046. NRAMP_fam.
    [Graphical view]
    PANTHERiPTHR11706. PTHR11706. 1 hit.
    PfamiPF01566. Nramp. 1 hit.
    [Graphical view]
    PRINTSiPR00447. NATRESASSCMP.
    TIGRFAMsiTIGR01197. nramp. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P49279-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTGDKGPQRL SGSSYGSISS PTSPTSPGPQ QAPPRETYLS EKIPIPDTKP    50
    GTFSLRKLWA FTGPGFLMSI AFLDPGNIES DLQAGAVAGF KLLWVLLWAT 100
    VLGLLCQRLA ARLGVVTGKD LGEVCHLYYP KVPRTVLWLT IELAIVGSDM 150
    QEVIGTAIAF NLLSAGRIPL WGGVLITIVD TFFFLFLDNY GLRKLEAFFG 200
    LLITIMALTF GYEYVVARPE QGALLRGLFL PSCPGCGHPE LLQAVGIVGA 250
    IIMPHNIYLH SALVKSREID RARRADIREA NMYFLIEATI ALSVSFIINL 300
    FVMAVFGQAF YQKTNQAAFN ICANSSLHDY AKIFPMNNAT VAVDIYQGGV 350
    ILGCLFGPAA LYIWAIGLLA AGQSSTMTGT YAGQFVMEGF LRLRWSRFAR 400
    VLLTRSCAIL PTVLVAVFRD LRDLSGLNDL LNVLQSLLLP FAVLPILTFT 450
    SMPTLMQEFA NGLLNKVVTS SIMVLVCAIN LYFVVSYLPS LPHPAYFGLA 500
    ALLAAAYLGL STYLVWTCCL AHGATFLAHS SHHHFLYGLL EEDQKGETSG 550
    Length:550
    Mass (Da):59,872
    Last modified:February 1, 1996 - v1
    Checksum:iAA670763D52EEECC
    GO
    Isoform 2 (identifier: P49279-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-13: MTGDKGPQRLSGS → MVRCQLTATSTSQ
         14-131: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:432
    Mass (Da):47,292
    Checksum:i1C005994A512B944
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti54 – 541S → R in CAA57541. (PubMed:8529098)Curated
    Sequence conflicti84 – 841A → L(PubMed:8529098)Curated
    Sequence conflicti86 – 861A → P(PubMed:8529098)Curated
    Sequence conflicti275 – 2751A → V in CAA57541. (PubMed:8529098)Curated
    Sequence conflicti305 – 3051V → A in CAA57541. (PubMed:8529098)Curated
    Sequence conflicti315 – 3151N → K in CAA57541. (PubMed:8529098)Curated
    Sequence conflicti397 – 3971R → S in CAA57541. (PubMed:8529098)Curated
    Sequence conflicti441 – 4411F → V in CAA57541. (PubMed:8529098)Curated
    Sequence conflicti478 – 4781A → T in CAA57541. (PubMed:8529098)Curated
    Sequence conflicti544 – 5441Q → H in CAA57541. (PubMed:8529098)Curated

    Polymorphismi

    Genetic variation in SLC11A1 is associated with susceptibility to infection with Mycobacterium ulcerans [MIMi:610446].
    Genetic variations in SLC11A1 determine Mycobacterium tuberculosis susceptibility [MIMi:607948].

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti30 – 301Q → R.
    VAR_004629
    Natural varianti318 – 3181A → V.1 Publication
    Corresponds to variant rs201565523 [ dbSNP | Ensembl ].
    VAR_004630
    Natural varianti543 – 5431D → N Associated with susceptibility to infection with Mycobacterium ulcerans. 1 Publication
    Corresponds to variant rs17235409 [ dbSNP | Ensembl ].
    VAR_004631

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1313MTGDK…RLSGS → MVRCQLTATSTSQ in isoform 2. 1 PublicationVSP_047875Add
    BLAST
    Alternative sequencei14 – 131118Missing in isoform 2. 1 PublicationVSP_047876Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L32185 mRNA. Translation: AAA57521.1.
    L38593, L38592 Genomic DNA. Translation: AAA57557.1.
    AF229163 Genomic DNA. Translation: AAG15405.1.
    AC021016 Genomic DNA. No translation available.
    CH471063 Genomic DNA. Translation: EAW70611.1.
    BC071165 mRNA. Translation: AAH71165.1.
    D50402 mRNA. Translation: BAA08907.1.
    D50403 mRNA. Translation: BAA08908.1.
    D38171 mRNA. Translation: BAA07370.1.
    X82015 Genomic DNA. Translation: CAA57541.1.
    CCDSiCCDS2415.1. [P49279-1]
    PIRiI55679.
    JC4095.
    RefSeqiNP_000569.3. NM_000578.3. [P49279-1]
    XP_005246850.1. XM_005246793.1.
    XP_005246851.1. XM_005246794.1.
    XP_006712772.1. XM_006712709.1. [P49279-2]
    XP_006712773.1. XM_006712710.1. [P49279-2]
    UniGeneiHs.591607.

    Genome annotation databases

    EnsembliENST00000233202; ENSP00000233202; ENSG00000018280. [P49279-1]
    ENST00000539932; ENSP00000443435; ENSG00000018280. [P49279-2]
    GeneIDi6556.
    KEGGihsa:6556.
    UCSCiuc002vhu.1. human. [P49279-1]
    uc002vhw.3. human.

    Polymorphism databases

    DMDMi1352521.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L32185 mRNA. Translation: AAA57521.1 .
    L38593 , L38592 Genomic DNA. Translation: AAA57557.1 .
    AF229163 Genomic DNA. Translation: AAG15405.1 .
    AC021016 Genomic DNA. No translation available.
    CH471063 Genomic DNA. Translation: EAW70611.1 .
    BC071165 mRNA. Translation: AAH71165.1 .
    D50402 mRNA. Translation: BAA08907.1 .
    D50403 mRNA. Translation: BAA08908.1 .
    D38171 mRNA. Translation: BAA07370.1 .
    X82015 Genomic DNA. Translation: CAA57541.1 .
    CCDSi CCDS2415.1. [P49279-1 ]
    PIRi I55679.
    JC4095.
    RefSeqi NP_000569.3. NM_000578.3. [P49279-1 ]
    XP_005246850.1. XM_005246793.1.
    XP_005246851.1. XM_005246794.1.
    XP_006712772.1. XM_006712709.1. [P49279-2 ]
    XP_006712773.1. XM_006712710.1. [P49279-2 ]
    UniGenei Hs.591607.

    3D structure databases

    ProteinModelPortali P49279.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000233202.

    Chemistry

    ChEMBLi CHEMBL2052040.

    Protein family/group databases

    TCDBi 2.A.55.2.3. the metal ion (mn(2+)-iron) transporter (nramp) family.

    PTM databases

    PhosphoSitei P49279.

    Polymorphism databases

    DMDMi 1352521.

    Proteomic databases

    PaxDbi P49279.
    PRIDEi P49279.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000233202 ; ENSP00000233202 ; ENSG00000018280 . [P49279-1 ]
    ENST00000539932 ; ENSP00000443435 ; ENSG00000018280 . [P49279-2 ]
    GeneIDi 6556.
    KEGGi hsa:6556.
    UCSCi uc002vhu.1. human. [P49279-1 ]
    uc002vhw.3. human.

    Organism-specific databases

    CTDi 6556.
    GeneCardsi GC02P219246.
    HGNCi HGNC:10907. SLC11A1.
    HPAi HPA029590.
    MIMi 600266. gene.
    607948. phenotype.
    610446. phenotype.
    neXtProti NX_P49279.
    Orphaneti 3389. Tuberculosis.
    PharmGKBi PA319.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1914.
    HOGENOMi HOG000152203.
    HOVERGENi HBG052665.
    InParanoidi P49279.
    KOi K12347.
    OMAi TSMPTLM.
    OrthoDBi EOG77127K.
    PhylomeDBi P49279.
    TreeFami TF315185.

    Enzyme and pathway databases

    Reactomei REACT_121256. Phagosomal maturation (early endosomal stage).
    REACT_20547. Metal ion SLC transporters.

    Miscellaneous databases

    GeneWikii SLC11A1.
    GenomeRNAii 6556.
    NextBioi 25511.
    PROi P49279.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P49279.
    Bgeei P49279.
    CleanExi HS_SLC11A1.
    Genevestigatori P49279.

    Family and domain databases

    HAMAPi MF_00221. NRAMP.
    InterProi IPR001046. NRAMP_fam.
    [Graphical view ]
    PANTHERi PTHR11706. PTHR11706. 1 hit.
    Pfami PF01566. Nramp. 1 hit.
    [Graphical view ]
    PRINTSi PR00447. NATRESASSCMP.
    TIGRFAMsi TIGR01197. nramp. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression."
      Cellier M., Govoni G., Vidal S., Kwan T., Groulx N., Liu J., Sanchez F., Skamene E., Schurr E., Gros P.
      J. Exp. Med. 180:1741-1752(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
      Tissue: Spleen.
    2. "Identification of natural resistance-associated macrophage protein in peripheral blood lymphocytes."
      Kishi F., Nobumoto M.
      Immunol. Lett. 47:93-96(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Spleen.
    3. "Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35."
      Marquet S., Lepage P., Hudson T.J., Musser J.M., Schurr E.
      Mamm. Genome 11:755-762(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Blood.
    7. "Isolation and characterization of human Nramp cDNA."
      Kishi F.
      Biochem. Biophys. Res. Commun. 204:1074-1080(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 68-550 (ISOFORM 1).
    8. "Genomic organization and sequence of the human NRAMP gene: identification and mapping of a promoter region polymorphism."
      Blackwell J.M., Barton C.H., White J.K., Searle S., Baker A.-M., Williams H., Shaw M.-A.
      Mol. Med. 1:194-205(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    9. "Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene."
      Liu J., Fujiwara T.M., Buu N.T., Sanchez F.O., Cellier M., Paradis A.J., Frappier D., Skamene E., Gros P., Morgan K., Schurr E.
      Am. J. Hum. Genet. 56:845-853(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS VAL-318 AND ASN-543.
    10. Cited for: INVOLVEMENT IN MYCOBACTERIUM TUBERCULOSIS SUSCEPTIBILITY.
    11. Cited for: ASSOCIATION OF VARIANT ASN-543 WITH SUSCEPTIBILITY TO INFECTION WITH MYCOBACTERIUM ULCERANS.

    Entry informationi

    Entry nameiNRAM1_HUMAN
    AccessioniPrimary (citable) accession number: P49279
    Secondary accession number(s): C0H5Y3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3