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P49279

- NRAM1_HUMAN

UniProt

P49279 - NRAM1_HUMAN

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Protein
Natural resistance-associated macrophage protein 1
Gene
SLC11A1, LSH, NRAMP, NRAMP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe2+ and Mn2+, cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.UniRule annotation

GO - Molecular functioni

  1. manganese ion transmembrane transporter activity Source: BHF-UCL
  2. metal ion:proton antiporter activity Source: BHF-UCL
  3. protein homodimerization activity Source: UniProtKB
  4. transition metal ion transmembrane transporter activity Source: BHF-UCL

GO - Biological processi

  1. L-arginine import Source: BHF-UCL
  2. MHC class II biosynthetic process Source: BHF-UCL
  3. T cell cytokine production Source: BHF-UCL
  4. T cell proliferation involved in immune response Source: BHF-UCL
  5. activation of protein kinase activity Source: BHF-UCL
  6. antigen processing and presentation of peptide antigen Source: BHF-UCL
  7. cadmium ion transmembrane transport Source: BHF-UCL
  8. cellular cadmium ion homeostasis Source: BHF-UCL
  9. cellular iron ion homeostasis Source: BHF-UCL
  10. defense response to Gram-negative bacterium Source: BHF-UCL
  11. defense response to bacterium Source: BHF-UCL
  12. defense response to protozoan Source: BHF-UCL
  13. divalent metal ion export Source: BHF-UCL
  14. inflammatory response Source: BHF-UCL
  15. interaction with host Source: Reactome
  16. interleukin-2 production Source: BHF-UCL
  17. interleukin-3 production Source: BHF-UCL
  18. iron ion homeostasis Source: BHF-UCL
  19. iron ion transport Source: BHF-UCL
  20. mRNA stabilization Source: BHF-UCL
  21. macrophage activation Source: BHF-UCL
  22. manganese ion transport Source: BHF-UCL
  23. multicellular organismal iron ion homeostasis Source: BHF-UCL
  24. negative regulation of cytokine production Source: BHF-UCL
  25. nitrite transport Source: BHF-UCL
  26. phagocytosis Source: BHF-UCL
  27. phagosome maturation Source: Reactome
  28. positive regulation of T-helper 1 type immune response Source: BHF-UCL
  29. positive regulation of cytokine production Source: BHF-UCL
  30. positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL
  31. positive regulation of gene expression Source: BHF-UCL
  32. positive regulation of interferon-gamma production Source: BHF-UCL
  33. positive regulation of phagocytosis Source: BHF-UCL
  34. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  35. protein import into nucleus, translocation Source: Ensembl
  36. respiratory burst Source: BHF-UCL
  37. response to bacterium Source: UniProtKB
  38. response to interferon-gamma Source: BHF-UCL
  39. response to lipopolysaccharide Source: BHF-UCL
  40. transmembrane transport Source: Reactome
  41. vacuolar acidification Source: BHF-UCL
  42. wound healing Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

ReactomeiREACT_121256. Phagosomal maturation (early endosomal stage).
REACT_20547. Metal ion SLC transporters.

Protein family/group databases

TCDBi2.A.55.2.3. the metal ion (mn(2+)-iron) transporter (nramp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Natural resistance-associated macrophage protein 1
Short name:
NRAMP 1
Alternative name(s):
Solute carrier family 11 member 1
Gene namesi
Name:SLC11A1
Synonyms:LSH, NRAMP, NRAMP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:10907. SLC11A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5858Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei59 – 7618Helical; Reviewed prediction
Add
BLAST
Topological domaini77 – 859Extracellular Reviewed prediction
Transmembranei86 – 10520Helical; Reviewed prediction
Add
BLAST
Topological domaini106 – 14237Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei143 – 16321Helical; Reviewed prediction
Add
BLAST
Topological domaini164 – 1674Extracellular Reviewed prediction
Transmembranei168 – 18720Helical; Reviewed prediction
Add
BLAST
Topological domaini188 – 1969Cytoplasmic Reviewed prediction
Transmembranei197 – 21721Helical; Reviewed prediction
Add
BLAST
Topological domaini218 – 24023Extracellular Reviewed prediction
Add
BLAST
Transmembranei241 – 25919Helical; Reviewed prediction
Add
BLAST
Topological domaini260 – 28728Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei288 – 30720Helical; Reviewed prediction
Add
BLAST
Topological domaini308 – 34942Extracellular Reviewed prediction
Add
BLAST
Transmembranei350 – 36920Helical; Reviewed prediction
Add
BLAST
Topological domaini370 – 40031Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei401 – 41818Helical; Reviewed prediction
Add
BLAST
Topological domaini419 – 42911Extracellular Reviewed prediction
Add
BLAST
Transmembranei430 – 45021Helical; Reviewed prediction
Add
BLAST
Topological domaini451 – 46616Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei467 – 48822Helical; Reviewed prediction
Add
BLAST
Topological domaini489 – 4968Extracellular Reviewed prediction
Transmembranei497 – 51620Helical; Reviewed prediction
Add
BLAST
Topological domaini517 – 55034Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell outer membrane Source: Ensembl
  2. integral component of plasma membrane Source: UniProtKB
  3. late endosome Source: BHF-UCL
  4. late endosome membrane Source: Reactome
  5. lysosome Source: BHF-UCL
  6. phagocytic vesicle membrane Source: BHF-UCL
  7. plasma membrane Source: BHF-UCL
  8. tertiary granule membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

MIMi607948. phenotype.
610446. phenotype.
Orphaneti3389. Tuberculosis.
PharmGKBiPA319.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Natural resistance-associated macrophage protein 1UniRule annotation
PRO_0000212588Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi324 – 3241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi338 – 3381N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP49279.
PRIDEiP49279.

PTM databases

PhosphoSiteiP49279.

Expressioni

Tissue specificityi

Macrophages; peripheral blood leukocytes, lung, spleen and liver.

Inductioni

In response to lymphokine or bacterial products.UniRule annotation

Gene expression databases

ArrayExpressiP49279.
BgeeiP49279.
CleanExiHS_SLC11A1.
GenevestigatoriP49279.

Organism-specific databases

HPAiHPA029590.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000233202.

Structurei

3D structure databases

ProteinModelPortaliP49279.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 8078Pro/Ser-richUniRule annotation
Add
BLAST

Sequence similaritiesi

Belongs to the NRAMP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1914.
HOGENOMiHOG000152203.
HOVERGENiHBG052665.
InParanoidiP49279.
KOiK12347.
OMAiTSMPTLM.
OrthoDBiEOG77127K.
PhylomeDBiP49279.
TreeFamiTF315185.

Family and domain databases

HAMAPiMF_00221. NRAMP.
InterProiIPR001046. NRAMP_fam.
[Graphical view]
PANTHERiPTHR11706. PTHR11706. 1 hit.
PfamiPF01566. Nramp. 1 hit.
[Graphical view]
PRINTSiPR00447. NATRESASSCMP.
TIGRFAMsiTIGR01197. nramp. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P49279-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTGDKGPQRL SGSSYGSISS PTSPTSPGPQ QAPPRETYLS EKIPIPDTKP    50
GTFSLRKLWA FTGPGFLMSI AFLDPGNIES DLQAGAVAGF KLLWVLLWAT 100
VLGLLCQRLA ARLGVVTGKD LGEVCHLYYP KVPRTVLWLT IELAIVGSDM 150
QEVIGTAIAF NLLSAGRIPL WGGVLITIVD TFFFLFLDNY GLRKLEAFFG 200
LLITIMALTF GYEYVVARPE QGALLRGLFL PSCPGCGHPE LLQAVGIVGA 250
IIMPHNIYLH SALVKSREID RARRADIREA NMYFLIEATI ALSVSFIINL 300
FVMAVFGQAF YQKTNQAAFN ICANSSLHDY AKIFPMNNAT VAVDIYQGGV 350
ILGCLFGPAA LYIWAIGLLA AGQSSTMTGT YAGQFVMEGF LRLRWSRFAR 400
VLLTRSCAIL PTVLVAVFRD LRDLSGLNDL LNVLQSLLLP FAVLPILTFT 450
SMPTLMQEFA NGLLNKVVTS SIMVLVCAIN LYFVVSYLPS LPHPAYFGLA 500
ALLAAAYLGL STYLVWTCCL AHGATFLAHS SHHHFLYGLL EEDQKGETSG 550
Length:550
Mass (Da):59,872
Last modified:February 1, 1996 - v1
Checksum:iAA670763D52EEECC
GO
Isoform 2 (identifier: P49279-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MTGDKGPQRLSGS → MVRCQLTATSTSQ
     14-131: Missing.

Note: No experimental confirmation available.

Show »
Length:432
Mass (Da):47,292
Checksum:i1C005994A512B944
GO

Polymorphismi

Genetic variation in SLC11A1 is associated with susceptibility to infection with Mycobacterium ulcerans [MIMi:610446].UniRule annotation
Genetic variations in SLC11A1 determine Mycobacterium tuberculosis susceptibility [MIMi:607948].UniRule annotation

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti30 – 301Q → R.
VAR_004629
Natural varianti318 – 3181A → V.1 Publication
Corresponds to variant rs201565523 [ dbSNP | Ensembl ].
VAR_004630
Natural varianti543 – 5431D → N Associated with susceptibility to infection with Mycobacterium ulcerans. 2 Publications
Corresponds to variant rs17235409 [ dbSNP | Ensembl ].
VAR_004631

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1313MTGDK…RLSGS → MVRCQLTATSTSQ in isoform 2.
VSP_047875Add
BLAST
Alternative sequencei14 – 131118Missing in isoform 2.
VSP_047876Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541S → R in CAA57541. 1 Publication
Sequence conflicti84 – 841A → L1 Publication
Sequence conflicti86 – 861A → P1 Publication
Sequence conflicti275 – 2751A → V in CAA57541. 1 Publication
Sequence conflicti305 – 3051V → A in CAA57541. 1 Publication
Sequence conflicti315 – 3151N → K in CAA57541. 1 Publication
Sequence conflicti397 – 3971R → S in CAA57541. 1 Publication
Sequence conflicti441 – 4411F → V in CAA57541. 1 Publication
Sequence conflicti478 – 4781A → T in CAA57541. 1 Publication
Sequence conflicti544 – 5441Q → H in CAA57541. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L32185 mRNA. Translation: AAA57521.1.
L38593, L38592 Genomic DNA. Translation: AAA57557.1.
AF229163 Genomic DNA. Translation: AAG15405.1.
AC021016 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW70611.1.
BC071165 mRNA. Translation: AAH71165.1.
D50402 mRNA. Translation: BAA08907.1.
D50403 mRNA. Translation: BAA08908.1.
D38171 mRNA. Translation: BAA07370.1.
X82015 Genomic DNA. Translation: CAA57541.1.
CCDSiCCDS2415.1. [P49279-1]
PIRiI55679.
JC4095.
RefSeqiNP_000569.3. NM_000578.3. [P49279-1]
XP_005246850.1. XM_005246793.1.
XP_005246851.1. XM_005246794.1.
XP_006712772.1. XM_006712709.1. [P49279-2]
XP_006712773.1. XM_006712710.1. [P49279-2]
UniGeneiHs.591607.

Genome annotation databases

EnsembliENST00000233202; ENSP00000233202; ENSG00000018280. [P49279-1]
ENST00000539932; ENSP00000443435; ENSG00000018280. [P49279-2]
GeneIDi6556.
KEGGihsa:6556.
UCSCiuc002vhu.1. human. [P49279-1]
uc002vhw.3. human.

Polymorphism databases

DMDMi1352521.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L32185 mRNA. Translation: AAA57521.1 .
L38593 , L38592 Genomic DNA. Translation: AAA57557.1 .
AF229163 Genomic DNA. Translation: AAG15405.1 .
AC021016 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW70611.1 .
BC071165 mRNA. Translation: AAH71165.1 .
D50402 mRNA. Translation: BAA08907.1 .
D50403 mRNA. Translation: BAA08908.1 .
D38171 mRNA. Translation: BAA07370.1 .
X82015 Genomic DNA. Translation: CAA57541.1 .
CCDSi CCDS2415.1. [P49279-1 ]
PIRi I55679.
JC4095.
RefSeqi NP_000569.3. NM_000578.3. [P49279-1 ]
XP_005246850.1. XM_005246793.1.
XP_005246851.1. XM_005246794.1.
XP_006712772.1. XM_006712709.1. [P49279-2 ]
XP_006712773.1. XM_006712710.1. [P49279-2 ]
UniGenei Hs.591607.

3D structure databases

ProteinModelPortali P49279.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000233202.

Chemistry

ChEMBLi CHEMBL2052040.

Protein family/group databases

TCDBi 2.A.55.2.3. the metal ion (mn(2+)-iron) transporter (nramp) family.

PTM databases

PhosphoSitei P49279.

Polymorphism databases

DMDMi 1352521.

Proteomic databases

PaxDbi P49279.
PRIDEi P49279.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000233202 ; ENSP00000233202 ; ENSG00000018280 . [P49279-1 ]
ENST00000539932 ; ENSP00000443435 ; ENSG00000018280 . [P49279-2 ]
GeneIDi 6556.
KEGGi hsa:6556.
UCSCi uc002vhu.1. human. [P49279-1 ]
uc002vhw.3. human.

Organism-specific databases

CTDi 6556.
GeneCardsi GC02P219246.
HGNCi HGNC:10907. SLC11A1.
HPAi HPA029590.
MIMi 600266. gene.
607948. phenotype.
610446. phenotype.
neXtProti NX_P49279.
Orphaneti 3389. Tuberculosis.
PharmGKBi PA319.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1914.
HOGENOMi HOG000152203.
HOVERGENi HBG052665.
InParanoidi P49279.
KOi K12347.
OMAi TSMPTLM.
OrthoDBi EOG77127K.
PhylomeDBi P49279.
TreeFami TF315185.

Enzyme and pathway databases

Reactomei REACT_121256. Phagosomal maturation (early endosomal stage).
REACT_20547. Metal ion SLC transporters.

Miscellaneous databases

GeneWikii SLC11A1.
GenomeRNAii 6556.
NextBioi 25511.
PROi P49279.
SOURCEi Search...

Gene expression databases

ArrayExpressi P49279.
Bgeei P49279.
CleanExi HS_SLC11A1.
Genevestigatori P49279.

Family and domain databases

HAMAPi MF_00221. NRAMP.
InterProi IPR001046. NRAMP_fam.
[Graphical view ]
PANTHERi PTHR11706. PTHR11706. 1 hit.
Pfami PF01566. Nramp. 1 hit.
[Graphical view ]
PRINTSi PR00447. NATRESASSCMP.
TIGRFAMsi TIGR01197. nramp. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression."
    Cellier M., Govoni G., Vidal S., Kwan T., Groulx N., Liu J., Sanchez F., Skamene E., Schurr E., Gros P.
    J. Exp. Med. 180:1741-1752(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    Tissue: Spleen.
  2. "Identification of natural resistance-associated macrophage protein in peripheral blood lymphocytes."
    Kishi F., Nobumoto M.
    Immunol. Lett. 47:93-96(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Spleen.
  3. "Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35."
    Marquet S., Lepage P., Hudson T.J., Musser J.M., Schurr E.
    Mamm. Genome 11:755-762(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Blood.
  7. "Isolation and characterization of human Nramp cDNA."
    Kishi F.
    Biochem. Biophys. Res. Commun. 204:1074-1080(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 68-550 (ISOFORM 1).
  8. "Genomic organization and sequence of the human NRAMP gene: identification and mapping of a promoter region polymorphism."
    Blackwell J.M., Barton C.H., White J.K., Searle S., Baker A.-M., Williams H., Shaw M.-A.
    Mol. Med. 1:194-205(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  9. "Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene."
    Liu J., Fujiwara T.M., Buu N.T., Sanchez F.O., Cellier M., Paradis A.J., Frappier D., Skamene E., Gros P., Morgan K., Schurr E.
    Am. J. Hum. Genet. 56:845-853(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS VAL-318 AND ASN-543.
  10. Cited for: INVOLVEMENT IN MYCOBACTERIUM TUBERCULOSIS SUSCEPTIBILITY.
  11. Cited for: ASSOCIATION OF VARIANT ASN-543 WITH SUSCEPTIBILITY TO INFECTION WITH MYCOBACTERIUM ULCERANS.

Entry informationi

Entry nameiNRAM1_HUMAN
AccessioniPrimary (citable) accession number: P49279
Secondary accession number(s): C0H5Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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