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Protein

Mite group 2 allergen Der p 2

Gene

DERP2

Organism
Dermatophagoides pteronyssinus (European house dust mite)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Mite group 2 allergen Der p 2
Alternative name(s):
Allergen Der p II
DPX
Allergen: Der p 2
Gene namesi
Name:DERP2
OrganismiDermatophagoides pteronyssinus (European house dust mite)
Taxonomic identifieri6956 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei316. Der p 2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
ChainiPRO_000001986118 – 146Mite group 2 allergen Der p 2Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 136
Disulfide bondi38 ↔ 44
Disulfide bondi90 ↔ 95

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

DIPiDIP-59729N.

Structurei

Secondary structure

1146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 28Combined sources3
Beta strandi30 – 34Combined sources5
Beta strandi40 – 42Combined sources3
Beta strandi44 – 47Combined sources4
Beta strandi50 – 59Combined sources10
Beta strandi68 – 75Combined sources8
Beta strandi78 – 80Combined sources3
Helixi89 – 91Combined sources3
Beta strandi95 – 97Combined sources3
Beta strandi102 – 110Combined sources9
Beta strandi121 – 129Combined sources9
Beta strandi132 – 139Combined sources8
Beta strandi142 – 145Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A9VNMR-A19-146[»]
1KTJX-ray2.15A/B18-146[»]
ProteinModelPortaliP49278.
SMRiP49278.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49278.

Family & Domainsi

Sequence similaritiesi

Belongs to the NPC2 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.40.770. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR003172. ML_dom.
[Graphical view]
PfamiPF02221. E1_DerP2_DerF2. 1 hit.
[Graphical view]
SMARTiSM00737. ML. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49278-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMYKILCLSL LVAAVARDQV DVKDCANHEI KKVLVPGCHG SEPCIIHRGK
60 70 80 90 100
PFQLEAVFEA NQNTKTAKIE IKASIDGLEV DVPGIDPNAC HYMKCPLVKG
110 120 130 140
QQYDIKYTWN VPKIAPKSEN VVVTVKVMGD DGVLACAIAT HAKIRD
Length:146
Mass (Da):15,999
Last modified:February 1, 1996 - v1
Checksum:i591B2FA7FD26D3AF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti39H → A.1
Natural varianti40G → L.1
Natural varianti44C → N.1
Natural varianti47H → S.1
Natural varianti49G → T.1
Natural varianti56A → Y.1
Natural varianti57V → L.1
Natural varianti61N → L.1
Natural varianti64T → S.1
Natural varianti75I → Y.1
Natural varianti78L → C.1
Natural varianti81D → V.1
Natural varianti95C → P.1
Natural varianti98V → T.1
Natural varianti108T → V.1
Natural varianti111V → L.1
Natural varianti114I → N.1
Natural varianti115A → T.1
Natural varianti116P → A.1
Natural varianti118S → A.1
Natural varianti127V → L.1
Natural varianti128M → L.1
Natural varianti131D → N.1
Natural varianti133V → A.1
Natural varianti144I → L.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276239 mRNA. Translation: AAF86462.1.
PIRiA60381.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276239 mRNA. Translation: AAF86462.1.
PIRiA60381.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A9VNMR-A19-146[»]
1KTJX-ray2.15A/B18-146[»]
ProteinModelPortaliP49278.
SMRiP49278.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59729N.

Protein family/group databases

Allergomei316. Der p 2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP49278.

Family and domain databases

Gene3Di2.60.40.770. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR003172. ML_dom.
[Graphical view]
PfamiPF02221. E1_DerP2_DerF2. 1 hit.
[Graphical view]
SMARTiSM00737. ML. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiALL2_DERPT
AccessioniPrimary (citable) accession number: P49278
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.