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Protein

Mite group 2 allergen Der p 2

Gene

DERP2

Organism
Dermatophagoides pteronyssinus (European house dust mite)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Mite group 2 allergen Der p 2
Alternative name(s):
Allergen Der p II
DPX
Allergen: Der p 2
Gene namesi
Name:DERP2
OrganismiDermatophagoides pteronyssinus (European house dust mite)
Taxonomic identifieri6956 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei316. Der p 2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 17171 PublicationAdd
BLAST
Chaini18 – 146129Mite group 2 allergen Der p 2PRO_0000019861Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 136
Disulfide bondi38 ↔ 44
Disulfide bondi90 ↔ 95

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

DIPiDIP-59729N.

Structurei

Secondary structure

1
146
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 283Combined sources
Beta strandi30 – 345Combined sources
Beta strandi40 – 423Combined sources
Beta strandi44 – 474Combined sources
Beta strandi50 – 5910Combined sources
Beta strandi68 – 758Combined sources
Beta strandi78 – 803Combined sources
Helixi89 – 913Combined sources
Beta strandi95 – 973Combined sources
Beta strandi102 – 1109Combined sources
Beta strandi121 – 1299Combined sources
Beta strandi132 – 1398Combined sources
Beta strandi142 – 1454Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A9VNMR-A19-146[»]
1KTJX-ray2.15A/B18-146[»]
ProteinModelPortaliP49278.
SMRiP49278. Positions 19-146.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49278.

Family & Domainsi

Sequence similaritiesi

Belongs to the NPC2 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.40.770. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR003172. ML_dom.
[Graphical view]
PfamiPF02221. E1_DerP2_DerF2. 1 hit.
[Graphical view]
SMARTiSM00737. ML. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49278-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMYKILCLSL LVAAVARDQV DVKDCANHEI KKVLVPGCHG SEPCIIHRGK
60 70 80 90 100
PFQLEAVFEA NQNTKTAKIE IKASIDGLEV DVPGIDPNAC HYMKCPLVKG
110 120 130 140
QQYDIKYTWN VPKIAPKSEN VVVTVKVMGD DGVLACAIAT HAKIRD
Length:146
Mass (Da):15,999
Last modified:February 1, 1996 - v1
Checksum:i591B2FA7FD26D3AF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391H → A.
Natural varianti40 – 401G → L.
Natural varianti44 – 441C → N.
Natural varianti47 – 471H → S.
Natural varianti49 – 491G → T.
Natural varianti56 – 561A → Y.
Natural varianti57 – 571V → L.
Natural varianti61 – 611N → L.
Natural varianti64 – 641T → S.
Natural varianti75 – 751I → Y.
Natural varianti78 – 781L → C.
Natural varianti81 – 811D → V.
Natural varianti95 – 951C → P.
Natural varianti98 – 981V → T.
Natural varianti108 – 1081T → V.
Natural varianti111 – 1111V → L.
Natural varianti114 – 1141I → N.
Natural varianti115 – 1151A → T.
Natural varianti116 – 1161P → A.
Natural varianti118 – 1181S → A.
Natural varianti127 – 1271V → L.
Natural varianti128 – 1281M → L.
Natural varianti131 – 1311D → N.
Natural varianti133 – 1331V → A.
Natural varianti144 – 1441I → L.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276239 mRNA. Translation: AAF86462.1.
PIRiA60381.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276239 mRNA. Translation: AAF86462.1.
PIRiA60381.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A9VNMR-A19-146[»]
1KTJX-ray2.15A/B18-146[»]
ProteinModelPortaliP49278.
SMRiP49278. Positions 19-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59729N.

Protein family/group databases

Allergomei316. Der p 2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP49278.

Family and domain databases

Gene3Di2.60.40.770. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR003172. ML_dom.
[Graphical view]
PfamiPF02221. E1_DerP2_DerF2. 1 hit.
[Graphical view]
SMARTiSM00737. ML. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiALL2_DERPT
AccessioniPrimary (citable) accession number: P49278
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 14, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.