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Protein

Mite allergen Der f 6

Gene

DERF6

Organism
Dermatophagoides farinae (American house dust mite)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Protease that shows specificity similar to chymotrypsin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei94Charge relay systemBy similarity1
Active sitei140Charge relay systemBy similarity1
Active sitei233Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.245.

Names & Taxonomyi

Protein namesi
Recommended name:
Mite allergen Der f 6 (EC:3.4.21.-)
Alternative name(s):
Allergen Der f VI
DF5
Allergen: Der f 6
Gene namesi
Name:DERF6
OrganismiDermatophagoides farinae (American house dust mite)
Taxonomic identifieri6954 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei306. Der f 6.
3255. Der f 6.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000002814720 – 491 PublicationAdd BLAST30
ChainiPRO_000002814850 – 279Mite allergen Der f 6Add BLAST230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi79 ↔ 95PROSITE-ProRule annotation
Disulfide bondi204 ↔ 220PROSITE-ProRule annotation
Disulfide bondi229 ↔ 255PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliP49276.
SMRiP49276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 279Peptidase S1PROSITE-ProRule annotationAdd BLAST230

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiView protein in InterPro
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
PfamiView protein in Pfam
PF00089. Trypsin. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00020. Tryp_SPc. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiView protein in PROSITE
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49276-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKIFLVTIL IVITVTVDAR FPRSLQPKWA YLDSNEFPRS KIGDSPIAGV
60 70 80 90 100
VGGQDADLAE APFQISLLKD YLIMKRHMCG GSLISESTVV TAAHCTYGQK
110 120 130 140 150
ASSLSVRYGT NQRTSSSYGD LKVKPIIQHE SYEQDQTQTD KTIIILPNPV
160 170 180 190 200
VPSTNVQMNE IETEDIVDGD KVTIYGWGLT DGNGKDLPDK LQKGSMTIVG
210 220 230 240 250
NDRCNEKWGS INAIHPGMIC ALDKTQSGCN GDSGGPLVSA NRKLTGIVSW
260 270
GPSKCPPGEY MSVFTRPKYY LDWITKNIV
Length:279
Mass (Da):30,535
Last modified:June 20, 2001 - v2
Checksum:i5B29B6C46F185E56
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50V → A AA sequence (PubMed:8334537).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125187 mRNA. Translation: AAF28423.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDERF6_DERFA
AccessioniPrimary (citable) accession number: P49276
Secondary accession number(s): Q9NJS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: June 20, 2001
Last modified: July 5, 2017
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families