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Protein

Mite allergen Der p 7

Gene

DERP7

Organism
Dermatophagoides pteronyssinus (European house dust mite)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BRENDAi3.4.22.65. 1873.

Names & Taxonomyi

Protein namesi
Recommended name:
Mite allergen Der p 7
Alternative name(s):
Allergen Der p VII
Allergen: Der p 7
Gene namesi
Name:DERP7
OrganismiDermatophagoides pteronyssinus (European house dust mite)
Taxonomic identifieri6956 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei321. Der p 7.
3268. Der p 7.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 215198Mite allergen Der p 7PRO_0000001185Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

Secondary structure

1
215
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi22 – 4221Combined sources
Turni45 – 484Combined sources
Beta strandi49 – 513Combined sources
Beta strandi54 – 596Combined sources
Beta strandi63 – 653Combined sources
Beta strandi68 – 7912Combined sources
Helixi81 – 833Combined sources
Beta strandi91 – 955Combined sources
Beta strandi98 – 10710Combined sources
Beta strandi112 – 1209Combined sources
Beta strandi128 – 14619Combined sources
Beta strandi152 – 1598Combined sources
Beta strandi165 – 1695Combined sources
Helixi177 – 18812Combined sources
Turni189 – 1924Combined sources
Helixi193 – 21018Combined sources
Turni211 – 2144Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3H4ZX-ray2.35A/B/C17-215[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49273.

Family & Domainsi

Sequence similaritiesi

Belongs to the mite group 7 allergen family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR020234. Mite_allergen_group-7.
[Graphical view]
ProDomiPD037435. Mite_group-7_allergen. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKLLLIAAA AFVAVSADPI HYDKITEEIN KAVDEAVAAI EKSETFDPMK
60 70 80 90 100
VPDHSDKFER HIGIIDLKGE LDMRNIQVRG LKQMKRVGDA NVKSEDGVVK
110 120 130 140 150
AHLLVGVHDD VVSMEYDLAY KLGDLHPNTH VISDIQDFVV ELSLEVSEEG
160 170 180 190 200
NMTLTSFEVR QFANVVNHIG GLSILDPIFA VLSDVLTAIF QDTVRAEMTK
210
VLAPAFKKEL ERNNQ
Length:215
Mass (Da):23,881
Last modified:February 1, 1996 - v1
Checksum:i63AD03DB5C8CB1C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37044 mRNA. Translation: AAA80264.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37044 mRNA. Translation: AAA80264.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3H4ZX-ray2.35A/B/C17-215[»]
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei321. Der p 7.
3268. Der p 7.0101.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi3.4.22.65. 1873.

Miscellaneous databases

EvolutionaryTraceiP49273.

Family and domain databases

InterProiIPR020234. Mite_allergen_group-7.
[Graphical view]
ProDomiPD037435. Mite_group-7_allergen. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of a house dust mite allergen with common antibody binding specificities with multiple components in mite extracts."
    Shen H.-D., Chua K.-Y., Lin K.-L., Hsieh K.-H., Thomas W.R.
    Clin. Exp. Allergy 23:934-940(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiALL7_DERPT
AccessioniPrimary (citable) accession number: P49273
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 1, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.