P49273 (ALL7_DERPT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mite allergen Der p 7

Alternative name(s):
Allergen Der p VII
Allergen=Der p 7

Gene names

Name:

DERP7

Organism

Dermatophagoides pteronyssinus (European house dust mite)

Taxonomic identifier

6956 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Acari › Acariformes › Sarcoptiformes › Astigmata › Psoroptidia › Analgoidea › Pyroglyphidae › Dermatophagoidinae › Dermatophagoides

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted.
Allergenic properties	Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.
Sequence similarities	Belongs to the mite group 7 allergen family.

Ontologies

Keywords
Cellular component	Secreted
Disease	Allergen
Domain	Signal
PTM	Glycoprotein
Technical term	3D-structure
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 17

17

Potential

Chain

18 – 215

198

Mite allergen Der p 7

PRO_0000001185

Amino acid modifications

Glycosylation

151

1

N-linked (GlcNAc...) Potential

Secondary structure

1

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215

Helix Strand Turn

Details...

Helix

22 – 42

21

Turn

45 – 48

4

Beta strand

49 – 51

3

Beta strand

54 – 59

6

Beta strand

63 – 65

3

Beta strand

68 – 79

12

Helix

81 – 83

3

Beta strand

91 – 95

5

Beta strand

98 – 107

10

Beta strand

112 – 120

9

Beta strand

128 – 146

19

Beta strand

152 – 159

8

Beta strand

165 – 169

5

Helix

177 – 188

12

Turn

189 – 192

4

Helix

193 – 210

18

Turn

211 – 214

4

Sequences

	Sequence		Length	Mass (Da)
	P49273 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 63AD03DB5C8CB1C0	FASTA	215	23,881
	10 20 30 40 50 60 MMKLLLIAAA AFVAVSADPI HYDKITEEIN KAVDEAVAAI EKSETFDPMK VPDHSDKFER 70 80 90 100 110 120 HIGIIDLKGE LDMRNIQVRG LKQMKRVGDA NVKSEDGVVK AHLLVGVHDD VVSMEYDLAY 130 140 150 160 170 180 KLGDLHPNTH VISDIQDFVV ELSLEVSEEG NMTLTSFEVR QFANVVNHIG GLSILDPIFA 190 200 210 VLSDVLTAIF QDTVRAEMTK VLAPAFKKEL ERNNQ

References

[1]	"Molecular cloning of a house dust mite allergen with common antibody binding specificities with multiple components in mite extracts." Shen H.-D., Chua K.-Y., Lin K.-L., Hsieh K.-H., Thomas W.R. Clin. Exp. Allergy 23:934-940(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U37044 mRNA. Translation: AAA80264.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3H4Z	X-ray	2.35	A/B/C	17-215	[»]

ModBase

Search...

Protein family/group databases

Allergome

321. Der p 7.
3268. Der p 7.0101.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR020234. Mite_allergen_group-7.
[Graphical view]

ProDom

PD037435. Mite_group-7_allergen. 1 hit.
[Graphical view] [Entries sharing at least one domain]

ProtoNet

Search...

Other

EvolutionaryTrace

P49273.

Entry information

Entry name

ALL7_DERPT

Accession

Primary (citable) accession number: P49273

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	October 3, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)