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Protein

U3-cyrtautoxin-As1a

Gene
N/A
Organism
Apomastus schlingeri (Trap-door spider) (Aptostichus schlingeri)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Is both paralytic and lethal, when injected into lepidopteran larvae. Is a slower acting toxin, being lethal at 24 hours, but not paralytic at 1 hour post-injection.

Keywordsi

Molecular functionNeurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
U3-cyrtautoxin-As1a
Short name:
U3-CUTX-As1a
Alternative name(s):
Aptotoxin VII
Aptotoxin-7
Paralytic peptide VII
Short name:
PP VII
OrganismiApomastus schlingeri (Trap-door spider) (Aptostichus schlingeri)
Taxonomic identifieri12944 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeMygalomorphaeEuctenizidaeApomastus

Organism-specific databases

ArachnoServeriAS000408. U3-cyrtautoxin-As1a.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 1.40 mg/kg by subcutaneous injection.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000449871 – 32U3-cyrtautoxin-As1aAdd BLAST32

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi4 ↔ 191 Publication
Disulfide bondi11 ↔ 241 Publication
Disulfide bondi18 ↔ 291 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

132
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 16Combined sources4
Beta strandi23 – 30Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WQBNMR-A1-32[»]
ProteinModelPortaliP49271.
SMRiP49271.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49271.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Sequence similaritiesi

To aptotoxin III.Curated

Keywords - Domaini

Knottin

Sequencei

Sequence statusi: Complete.

P49271-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
WLGCARVKEA CGPWEWPCCS GLKCDGSECH PQ
Length:32
Mass (Da):3,537
Last modified:February 1, 1996 - v1
Checksum:i2AFB15230F06BCF6
GO

Sequence databases

PIRiB44007.

Entry informationi

Entry nameiTXP7_APOSC
AccessioniPrimary (citable) accession number: P49271
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references