Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P49262

- CRP_MESAU

UniProt

P49262 - CRP_MESAU

Protein

C-reactive protein

Gene

CRP

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells By similarity.By similarity

    Cofactori

    Binds 2 calcium ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi80 – 801Calcium 1By similarity
    Metal bindingi157 – 1571Calcium 1By similarity
    Metal bindingi157 – 1571Calcium 2By similarity
    Metal bindingi158 – 1581Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi159 – 1591Calcium 1By similarity
    Metal bindingi159 – 1591Calcium 2By similarity
    Metal bindingi169 – 1691Calcium 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. acute-phase response Source: UniProtKB-KW
    2. regulation of interleukin-8 secretion Source: UniProtKB

    Keywords - Biological processi

    Acute phase

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-reactive protein
    Gene namesi
    Name:CRP
    Synonyms:PTX1
    OrganismiMesocricetus auratus (Golden hamster)
    Taxonomic identifieri10036 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919By similarityAdd
    BLAST
    Chaini20 – 225206C-reactive proteinPRO_0000023528Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei20 – 201Pyrrolidone carboxylic acidBy similarity
    Disulfide bondi55 ↔ 116By similarity

    Keywords - PTMi

    Disulfide bond, Pyrrolidone carboxylic acid

    Expressioni

    Tissue specificityi

    Found in plasma.

    Inductioni

    By interleukin-1, interleukin-6, and TNF-alpha.

    Interactioni

    Subunit structurei

    Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Interacts with FCN1; may regulate monocyte activation by FCN1 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP49262.
    SMRiP49262. Positions 20-225.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 225206PentaxinAdd
    BLAST

    Sequence similaritiesi

    Belongs to the pentaxin family.Curated
    Contains 1 pentaxin domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG005405.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001759. Pentaxin.
    [Graphical view]
    PfamiPF00354. Pentaxin. 1 hit.
    [Graphical view]
    PRINTSiPR00895. PENTAXIN.
    SMARTiSM00159. PTX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS00289. PENTAXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P49262-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKLLWCSLV MIGFSQAFAQ KDMSKTAFVF PKESANSYVS LEAQSKKTLK    50
    AFTVCLHIFT ELSTTRSFSI FSYATKNSPN EILIFWSKDR GYAFGVGGPE 100
    VLFKASEIPE VPTHICASWE SATGIAELWV DGKPKVRKIL QKGYTVGTDA 150
    SIILGQEQDS YGGGFDANQS LVGDIGDVNM WDIVLSPEQI NTVCVGGTLD 200
    PSVLNWQALK YKVQGDVFIK PQLWP 225
    Length:225
    Mass (Da):24,822
    Last modified:February 1, 1996 - v1
    Checksum:i00B439C45D58E05A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S56005 Genomic DNA. Translation: AAB19893.2.
    PIRiA40326.
    RefSeqiXP_005078251.1. XM_005078194.1.

    Genome annotation databases

    GeneIDi101826636.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    No more Christmas pudding? - Issue 30 of January 2003

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S56005 Genomic DNA. Translation: AAB19893.2 .
    PIRi A40326.
    RefSeqi XP_005078251.1. XM_005078194.1.

    3D structure databases

    ProteinModelPortali P49262.
    SMRi P49262. Positions 20-225.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 101826636.

    Organism-specific databases

    CTDi 1401.

    Phylogenomic databases

    HOVERGENi HBG005405.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001759. Pentaxin.
    [Graphical view ]
    Pfami PF00354. Pentaxin. 1 hit.
    [Graphical view ]
    PRINTSi PR00895. PENTAXIN.
    SMARTi SM00159. PTX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS00289. PENTAXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "C-reactive protein (CRP) of the Syrian hamster."
      Dowton S.B., Holden S.N.
      Biochemistry 30:9531-9538(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCRP_MESAU
    AccessioniPrimary (citable) accession number: P49262
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3