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P49262

- CRP_MESAU

UniProt

P49262 - CRP_MESAU

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Protein

C-reactive protein

Gene
CRP, PTX1
Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells By similarity.

Cofactori

Binds 2 calcium ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi80 – 801Calcium 1 By similarity
Metal bindingi157 – 1571Calcium 1 By similarity
Metal bindingi157 – 1571Calcium 2 By similarity
Metal bindingi158 – 1581Calcium 1; via carbonyl oxygen By similarity
Metal bindingi159 – 1591Calcium 1 By similarity
Metal bindingi159 – 1591Calcium 2 By similarity
Metal bindingi169 – 1691Calcium 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. acute-phase response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Acute phase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C-reactive protein
Gene namesi
Name:CRP
Synonyms:PTX1
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 By similarityAdd
BLAST
Chaini20 – 225206C-reactive proteinPRO_0000023528Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201Pyrrolidone carboxylic acid By similarity
Disulfide bondi55 ↔ 116 By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Found in plasma.

Inductioni

By interleukin-1, interleukin-6, and TNF-alpha.

Interactioni

Subunit structurei

Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits By similarity.

Structurei

3D structure databases

ProteinModelPortaliP49262.
SMRiP49262. Positions 20-225.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 225206PentaxinAdd
BLAST

Sequence similaritiesi

Belongs to the pentaxin family.
Contains 1 pentaxin domain.

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG005405.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001759. Pentaxin.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49262-1 [UniParc]FASTAAdd to Basket

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MEKLLWCSLV MIGFSQAFAQ KDMSKTAFVF PKESANSYVS LEAQSKKTLK    50
AFTVCLHIFT ELSTTRSFSI FSYATKNSPN EILIFWSKDR GYAFGVGGPE 100
VLFKASEIPE VPTHICASWE SATGIAELWV DGKPKVRKIL QKGYTVGTDA 150
SIILGQEQDS YGGGFDANQS LVGDIGDVNM WDIVLSPEQI NTVCVGGTLD 200
PSVLNWQALK YKVQGDVFIK PQLWP 225
Length:225
Mass (Da):24,822
Last modified:February 1, 1996 - v1
Checksum:i00B439C45D58E05A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S56005 Genomic DNA. Translation: AAB19893.2.
PIRiA40326.
RefSeqiXP_005078251.1. XM_005078194.1.

Genome annotation databases

GeneIDi101826636.

Cross-referencesi

Web resourcesi

Protein Spotlight

No more Christmas pudding? - Issue 30 of January 2003

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S56005 Genomic DNA. Translation: AAB19893.2 .
PIRi A40326.
RefSeqi XP_005078251.1. XM_005078194.1.

3D structure databases

ProteinModelPortali P49262.
SMRi P49262. Positions 20-225.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101826636.

Organism-specific databases

CTDi 1401.

Phylogenomic databases

HOVERGENi HBG005405.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001759. Pentaxin.
[Graphical view ]
Pfami PF00354. Pentaxin. 1 hit.
[Graphical view ]
PRINTSi PR00895. PENTAXIN.
SMARTi SM00159. PTX. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS00289. PENTAXIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "C-reactive protein (CRP) of the Syrian hamster."
    Dowton S.B., Holden S.N.
    Biochemistry 30:9531-9538(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCRP_MESAU
AccessioniPrimary (citable) accession number: P49262
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi