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P49262 (CRP_MESAU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-reactive protein
Gene names
Name:CRP
Synonyms:PTX1
OrganismMesocricetus auratus (Golden hamster)
Taxonomic identifier10036 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Protein attributes

Sequence length225 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells By similarity.

Cofactor

Binds 2 calcium ions per subunit By similarity.

Subunit structure

Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits By similarity.

Subcellular location

Secreted.

Tissue specificity

Found in plasma.

Induction

By interleukin-1, interleukin-6, and TNF-alpha.

Sequence similarities

Belongs to the pentaxin family.

Contains 1 pentaxin domain.

Ontologies

Keywords
   Biological processAcute phase
   Cellular componentSecreted
   DomainSignal
   LigandCalcium
Metal-binding
   PTMDisulfide bond
Pyrrolidone carboxylic acid
Gene Ontology (GO)
   Biological_processacute-phase response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity
Chain20 – 225206C-reactive protein
PRO_0000023528

Regions

Domain20 – 225206Pentaxin

Sites

Metal binding801Calcium 1 By similarity
Metal binding1571Calcium 1 By similarity
Metal binding1571Calcium 2 By similarity
Metal binding1581Calcium 1; via carbonyl oxygen By similarity
Metal binding1591Calcium 1 By similarity
Metal binding1591Calcium 2 By similarity
Metal binding1691Calcium 2 By similarity

Amino acid modifications

Modified residue201Pyrrolidone carboxylic acid By similarity
Disulfide bond55 ↔ 116 By similarity

Sequences

Sequence LengthMass (Da)Tools
P49262 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 00B439C45D58E05A

FASTA22524,822
        10         20         30         40         50         60 
MEKLLWCSLV MIGFSQAFAQ KDMSKTAFVF PKESANSYVS LEAQSKKTLK AFTVCLHIFT 

        70         80         90        100        110        120 
ELSTTRSFSI FSYATKNSPN EILIFWSKDR GYAFGVGGPE VLFKASEIPE VPTHICASWE 

       130        140        150        160        170        180 
SATGIAELWV DGKPKVRKIL QKGYTVGTDA SIILGQEQDS YGGGFDANQS LVGDIGDVNM 

       190        200        210        220 
WDIVLSPEQI NTVCVGGTLD PSVLNWQALK YKVQGDVFIK PQLWP 

« Hide

References

[1]"C-reactive protein (CRP) of the Syrian hamster."
Dowton S.B., Holden S.N.
Biochemistry 30:9531-9538(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Web resources

Protein Spotlight

No more Christmas pudding? - Issue 30 of January 2003

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S56005 Genomic DNA. Translation: AAB19893.2.
PIRA40326.
RefSeqXP_005078251.1. XM_005078194.1.

3D structure databases

ProteinModelPortalP49262.
SMRP49262. Positions 20-225.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID101826636.

Organism-specific databases

CTD1401.

Phylogenomic databases

HOVERGENHBG005405.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001759. Pentaxin.
[Graphical view]
PfamPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSPR00895. PENTAXIN.
SMARTSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS00289. PENTAXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCRP_MESAU
AccessionPrimary (citable) accession number: P49262
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries