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Protein

C-reactive protein

Gene

CRP

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells (By similarity).By similarity

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi80Calcium 1By similarity1
Metal bindingi157Calcium 1By similarity1
Metal bindingi157Calcium 2PROSITE-ProRule annotation1
Metal bindingi158Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi159Calcium 1By similarity1
Metal bindingi159Calcium 2PROSITE-ProRule annotation1
Metal bindingi169Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAcute phase
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C-reactive protein
Gene namesi
Name:CRP
Synonyms:PTX1
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000002352820 – 225C-reactive proteinAdd BLAST206

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi55 ↔ 116PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Found in plasma.

Inductioni

By interleukin-1, interleukin-6, and TNF-alpha.

Interactioni

Subunit structurei

Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits. Interacts with FCN1; may regulate monocyte activation by FCN1 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP49262.
SMRiP49262.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 225Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST202

Sequence similaritiesi

Belongs to the pentraxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG005405.
OrthoDBiEOG091G0H6X.

Family and domain databases

CDDicd00152. PTX. 1 hit.
Gene3Di2.60.120.200. 1 hit.
InterProiView protein in InterPro
IPR013320. ConA-like_dom.
IPR030476. Pentaxin_CS.
IPR001759. Pentraxin-related.
PfamiView protein in Pfam
PF00354. Pentaxin. 1 hit.
PRINTSiPR00895. PENTAXIN.
SMARTiView protein in SMART
SM00159. PTX. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS00289. PTX_1. 1 hit.
PS51828. PTX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49262-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLLWCSLV MIGFSQAFAQ KDMSKTAFVF PKESANSYVS LEAQSKKTLK
60 70 80 90 100
AFTVCLHIFT ELSTTRSFSI FSYATKNSPN EILIFWSKDR GYAFGVGGPE
110 120 130 140 150
VLFKASEIPE VPTHICASWE SATGIAELWV DGKPKVRKIL QKGYTVGTDA
160 170 180 190 200
SIILGQEQDS YGGGFDANQS LVGDIGDVNM WDIVLSPEQI NTVCVGGTLD
210 220
PSVLNWQALK YKVQGDVFIK PQLWP
Length:225
Mass (Da):24,822
Last modified:February 1, 1996 - v1
Checksum:i00B439C45D58E05A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S56005 Genomic DNA. Translation: AAB19893.2.
PIRiA40326.
RefSeqiXP_005078251.1. XM_005078194.2.

Genome annotation databases

GeneIDi101826636.

Cross-referencesi

Web resourcesi

Protein Spotlight

No more Christmas pudding? - Issue 30 of January 2003

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S56005 Genomic DNA. Translation: AAB19893.2.
PIRiA40326.
RefSeqiXP_005078251.1. XM_005078194.2.

3D structure databases

ProteinModelPortaliP49262.
SMRiP49262.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101826636.

Organism-specific databases

CTDi1401.

Phylogenomic databases

HOVERGENiHBG005405.
OrthoDBiEOG091G0H6X.

Family and domain databases

CDDicd00152. PTX. 1 hit.
Gene3Di2.60.120.200. 1 hit.
InterProiView protein in InterPro
IPR013320. ConA-like_dom.
IPR030476. Pentaxin_CS.
IPR001759. Pentraxin-related.
PfamiView protein in Pfam
PF00354. Pentaxin. 1 hit.
PRINTSiPR00895. PENTAXIN.
SMARTiView protein in SMART
SM00159. PTX. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS00289. PTX_1. 1 hit.
PS51828. PTX_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCRP_MESAU
AccessioniPrimary (citable) accession number: P49262
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 15, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.