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Protein

Calmodulin-related protein 97A

Gene

Acam

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in calcium-mediated signal transduction.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 311Add BLAST12
Calcium bindingi56 – 672PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi93 – 1043Add BLAST12
Calcium bindingi129 – 1404Add BLAST12

GO - Molecular functioni

  • calcium ion binding Source: FlyBase
  • myosin VI head/neck binding Source: FlyBase

GO - Biological processi

  • actin filament-based movement Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-related protein 97A
Alternative name(s):
Protein androcam
Gene namesi
Name:Acam
Synonyms:And, Camr97A
ORF Names:CG17769
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0011273. Acam.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • myosin VI complex Source: FlyBase
  • nucleus Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000735461 – 148Calmodulin-related protein 97AAdd BLAST148

Proteomic databases

PaxDbiP49258.
PRIDEiP49258.

Expressioni

Gene expression databases

BgeeiFBgn0011273.
GenevisibleiP49258. DM.

Interactioni

GO - Molecular functioni

  • myosin VI head/neck binding Source: FlyBase

Protein-protein interaction databases

BioGridi69379. 26 interactors.
DIPiDIP-19348N.
IntActiP49258. 5 interactors.
MINTiMINT-279609.
STRINGi7227.FBpp0291175.

Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 20Combined sources14
Beta strandi26 – 28Combined sources3
Helixi29 – 31Combined sources3
Helixi32 – 39Combined sources8
Helixi45 – 56Combined sources12
Beta strandi62 – 64Combined sources3
Helixi65 – 74Combined sources10
Turni75 – 81Combined sources7
Helixi82 – 93Combined sources12
Beta strandi97 – 100Combined sources4
Helixi102 – 112Combined sources11
Helixi118 – 128Combined sources11
Beta strandi134 – 137Combined sources4
Helixi138 – 145Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LMTNMR-A1-148[»]
2LMUNMR-A1-148[»]
2LMVNMR-A1-148[»]
ProteinModelPortaliP49258.
SMRiP49258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 42EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini43 – 78EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini80 – 115EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini116 – 148EF-hand 4PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the calmodulin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
InParanoidiP49258.
KOiK02183.
OMAiMMAKQMR.
OrthoDBiEOG091G0V73.
PhylomeDBiP49258.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49258-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELTEEQIA EFKDAFVQFD KEGTGKIATR ELGTLMRTLG QNPTEAELQD
60 70 80 90 100
LIAEAENNNN GQLNFTEFCG IMAKQMRETD TEEEMREAFK IFDRDGDGFI
110 120 130 140
SPAELRFVMI NLGEKVTDEE IDEMIREADF DGDGMINYEE FVWMISQK
Length:148
Mass (Da):17,015
Last modified:June 1, 2001 - v2
Checksum:i32DB8DC4B35C6CB8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105L → I in CAA53630 (PubMed:7980384).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76045 mRNA. Translation: CAA53630.1.
AE014297 Genomic DNA. Translation: AAF56511.1.
AE014297 Genomic DNA. Translation: ACZ95031.1.
AY070783 mRNA. Translation: AAL48405.1.
RefSeqiNP_001163737.1. NM_001170266.1.
NP_476988.1. NM_057640.3.
UniGeneiDm.3202.

Genome annotation databases

EnsemblMetazoaiFBtr0084904; FBpp0084278; FBgn0011273.
FBtr0301963; FBpp0291175; FBgn0011273.
GeneIDi44913.
KEGGidme:Dmel_CG17769.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76045 mRNA. Translation: CAA53630.1.
AE014297 Genomic DNA. Translation: AAF56511.1.
AE014297 Genomic DNA. Translation: ACZ95031.1.
AY070783 mRNA. Translation: AAL48405.1.
RefSeqiNP_001163737.1. NM_001170266.1.
NP_476988.1. NM_057640.3.
UniGeneiDm.3202.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LMTNMR-A1-148[»]
2LMUNMR-A1-148[»]
2LMVNMR-A1-148[»]
ProteinModelPortaliP49258.
SMRiP49258.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi69379. 26 interactors.
DIPiDIP-19348N.
IntActiP49258. 5 interactors.
MINTiMINT-279609.
STRINGi7227.FBpp0291175.

Proteomic databases

PaxDbiP49258.
PRIDEiP49258.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0084904; FBpp0084278; FBgn0011273.
FBtr0301963; FBpp0291175; FBgn0011273.
GeneIDi44913.
KEGGidme:Dmel_CG17769.

Organism-specific databases

CTDi44913.
FlyBaseiFBgn0011273. Acam.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
InParanoidiP49258.
KOiK02183.
OMAiMMAKQMR.
OrthoDBiEOG091G0V73.
PhylomeDBiP49258.

Miscellaneous databases

GenomeRNAii44913.
PROiP49258.

Gene expression databases

BgeeiFBgn0011273.
GenevisibleiP49258. DM.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALL_DROME
AccessioniPrimary (citable) accession number: P49258
Secondary accession number(s): E1JIY2, Q9VBL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.