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Protein

Calmodulin-related protein 97A

Gene

Acam

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in calcium-mediated signal transduction.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi20 – 31121Add
BLAST
Calcium bindingi56 – 67122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi93 – 104123Add
BLAST
Calcium bindingi129 – 140124Add
BLAST

GO - Molecular functioni

  • calcium ion binding Source: FlyBase
  • myosin VI head/neck binding Source: FlyBase

GO - Biological processi

  • actin filament-based movement Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-related protein 97A
Alternative name(s):
Protein androcam
Gene namesi
Name:Acam
Synonyms:And, Camr97A
ORF Names:CG17769
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0011273. Acam.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • myosin VI complex Source: FlyBase
  • nucleus Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 148148Calmodulin-related protein 97APRO_0000073546Add
BLAST

Proteomic databases

PaxDbiP49258.

Expressioni

Gene expression databases

BgeeiFBgn0011273.
GenevisibleiP49258. DM.

Interactioni

GO - Molecular functioni

  • myosin VI head/neck binding Source: FlyBase

Protein-protein interaction databases

BioGridi69379. 26 interactions.
DIPiDIP-19348N.
IntActiP49258. 5 interactions.
MINTiMINT-279609.
STRINGi7227.FBpp0291175.

Structurei

Secondary structure

1
148
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 2014Combined sources
Beta strandi26 – 283Combined sources
Helixi29 – 313Combined sources
Helixi32 – 398Combined sources
Helixi45 – 5612Combined sources
Beta strandi62 – 643Combined sources
Helixi65 – 7410Combined sources
Turni75 – 817Combined sources
Helixi82 – 9312Combined sources
Beta strandi97 – 1004Combined sources
Helixi102 – 11211Combined sources
Helixi118 – 12811Combined sources
Beta strandi134 – 1374Combined sources
Helixi138 – 1458Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LMTNMR-A1-148[»]
2LMUNMR-A1-148[»]
2LMVNMR-A1-148[»]
ProteinModelPortaliP49258.
SMRiP49258. Positions 1-148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 4236EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini43 – 7836EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini80 – 11536EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini116 – 14833EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the calmodulin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
InParanoidiP49258.
OMAiMMAKQMR.
OrthoDBiEOG091G0V73.
PhylomeDBiP49258.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49258-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELTEEQIA EFKDAFVQFD KEGTGKIATR ELGTLMRTLG QNPTEAELQD
60 70 80 90 100
LIAEAENNNN GQLNFTEFCG IMAKQMRETD TEEEMREAFK IFDRDGDGFI
110 120 130 140
SPAELRFVMI NLGEKVTDEE IDEMIREADF DGDGMINYEE FVWMISQK
Length:148
Mass (Da):17,015
Last modified:June 1, 2001 - v2
Checksum:i32DB8DC4B35C6CB8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1051L → I in CAA53630 (PubMed:7980384).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76045 mRNA. Translation: CAA53630.1.
AE014297 Genomic DNA. Translation: AAF56511.1.
AE014297 Genomic DNA. Translation: ACZ95031.1.
AY070783 mRNA. Translation: AAL48405.1.
RefSeqiNP_001163737.1. NM_001170266.1.
NP_476988.1. NM_057640.3.
UniGeneiDm.3202.

Genome annotation databases

EnsemblMetazoaiFBtr0084904; FBpp0084278; FBgn0011273.
FBtr0301963; FBpp0291175; FBgn0011273.
GeneIDi44913.
KEGGidme:Dmel_CG17769.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76045 mRNA. Translation: CAA53630.1.
AE014297 Genomic DNA. Translation: AAF56511.1.
AE014297 Genomic DNA. Translation: ACZ95031.1.
AY070783 mRNA. Translation: AAL48405.1.
RefSeqiNP_001163737.1. NM_001170266.1.
NP_476988.1. NM_057640.3.
UniGeneiDm.3202.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LMTNMR-A1-148[»]
2LMUNMR-A1-148[»]
2LMVNMR-A1-148[»]
ProteinModelPortaliP49258.
SMRiP49258. Positions 1-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi69379. 26 interactions.
DIPiDIP-19348N.
IntActiP49258. 5 interactions.
MINTiMINT-279609.
STRINGi7227.FBpp0291175.

Proteomic databases

PaxDbiP49258.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0084904; FBpp0084278; FBgn0011273.
FBtr0301963; FBpp0291175; FBgn0011273.
GeneIDi44913.
KEGGidme:Dmel_CG17769.

Organism-specific databases

CTDi44913.
FlyBaseiFBgn0011273. Acam.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
InParanoidiP49258.
OMAiMMAKQMR.
OrthoDBiEOG091G0V73.
PhylomeDBiP49258.

Miscellaneous databases

GenomeRNAii44913.
PROiP49258.

Gene expression databases

BgeeiFBgn0011273.
GenevisibleiP49258. DM.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALL_DROME
AccessioniPrimary (citable) accession number: P49258
Secondary accession number(s): E1JIY2, Q9VBL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.