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Protein

Calmodulin-related protein 97A

Gene

Acam

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in calcium-mediated signal transduction.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 311Add BLAST12
Calcium bindingi56 – 672PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi93 – 1043Add BLAST12
Calcium bindingi129 – 1404Add BLAST12

GO - Molecular functioni

  • calcium ion binding Source: FlyBase
  • myosin VI head/neck binding Source: FlyBase

GO - Biological processi

  • actin filament-based movement Source: FlyBase

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-related protein 97A
Alternative name(s):
Protein androcam
Gene namesi
Name:Acam
Synonyms:And, Camr97A
ORF Names:CG17769
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0011273 Acam

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000735461 – 148Calmodulin-related protein 97AAdd BLAST148

Proteomic databases

PaxDbiP49258
PRIDEiP49258

Expressioni

Gene expression databases

BgeeiFBgn0011273
GenevisibleiP49258 DM

Interactioni

GO - Molecular functioni

  • myosin VI head/neck binding Source: FlyBase

Protein-protein interaction databases

BioGridi69379, 27 interactors
DIPiDIP-19348N
IntActiP49258, 6 interactors
STRINGi7227.FBpp0291175

Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 20Combined sources14
Beta strandi26 – 28Combined sources3
Helixi29 – 31Combined sources3
Helixi32 – 39Combined sources8
Helixi45 – 56Combined sources12
Beta strandi62 – 64Combined sources3
Helixi65 – 74Combined sources10
Turni75 – 81Combined sources7
Helixi82 – 93Combined sources12
Beta strandi97 – 100Combined sources4
Helixi102 – 112Combined sources11
Helixi118 – 128Combined sources11
Beta strandi134 – 137Combined sources4
Helixi138 – 145Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LMTNMR-A1-148[»]
2LMUNMR-A1-148[»]
2LMVNMR-A1-148[»]
ProteinModelPortaliP49258
SMRiP49258
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 42EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini43 – 78EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini80 – 115EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini116 – 148EF-hand 4PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the calmodulin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118901
InParanoidiP49258
KOiK02183
OMAiEFVYMIT
OrthoDBiEOG091G0V73
PhylomeDBiP49258

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

P49258-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELTEEQIA EFKDAFVQFD KEGTGKIATR ELGTLMRTLG QNPTEAELQD
60 70 80 90 100
LIAEAENNNN GQLNFTEFCG IMAKQMRETD TEEEMREAFK IFDRDGDGFI
110 120 130 140
SPAELRFVMI NLGEKVTDEE IDEMIREADF DGDGMINYEE FVWMISQK
Length:148
Mass (Da):17,015
Last modified:June 1, 2001 - v2
Checksum:i32DB8DC4B35C6CB8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105L → I in CAA53630 (PubMed:7980384).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76045 mRNA Translation: CAA53630.1
AE014297 Genomic DNA Translation: AAF56511.1
AE014297 Genomic DNA Translation: ACZ95031.1
AY070783 mRNA Translation: AAL48405.1
RefSeqiNP_001163737.1, NM_001170266.1
NP_476988.1, NM_057640.3
UniGeneiDm.3202

Genome annotation databases

EnsemblMetazoaiFBtr0084904; FBpp0084278; FBgn0011273
FBtr0301963; FBpp0291175; FBgn0011273
GeneIDi44913
KEGGidme:Dmel_CG17769

Similar proteinsi

Entry informationi

Entry nameiCALL_DROME
AccessioniPrimary (citable) accession number: P49258
Secondary accession number(s): E1JIY2, Q9VBL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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