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Protein

Serum amyloid P-component

Gene

PTX2

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi77Calcium 1PROSITE-ProRule annotation1
Metal bindingi78Calcium 1PROSITE-ProRule annotation1
Metal bindingi155Calcium 1PROSITE-ProRule annotation1
Metal bindingi155Calcium 2PROSITE-ProRule annotation1
Metal bindingi156Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi157Calcium 1PROSITE-ProRule annotation1
Metal bindingi157Calcium 2PROSITE-ProRule annotation1
Metal bindingi167Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAcute phase
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid P-component
Short name:
SAP
Gene namesi
Name:PTX2
Synonyms:SAP
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Amyloid, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000002353820 – 223Serum amyloid P-componentAdd BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi55 ↔ 114PROSITE-ProRule annotation
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000019069.

Structurei

3D structure databases

ProteinModelPortaliP49255.
SMRiP49255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 223Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST200

Sequence similaritiesi

Belongs to the pentraxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1FD. Eukaryota.
ENOG410YN8S. LUCA.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000247043.
HOVERGENiHBG005405.
InParanoidiP49255.
OMAiDHVNLIT.
OrthoDBiEOG091G0H6X.
TreeFamiTF330208.

Family and domain databases

CDDicd00152. PTX. 1 hit.
InterProiView protein in InterPro
IPR013320. ConA-like_dom.
IPR030476. Pentaxin_CS.
IPR001759. Pentraxin-related.
PfamiView protein in Pfam
PF00354. Pentaxin. 1 hit.
PRINTSiPR00895. PENTAXIN.
SMARTiView protein in SMART
SM00159. PTX. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS00289. PTX_1. 1 hit.
PS51828. PTX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKMLFWVSV FTIFLDVFAQ TDLDKKVFVF PRESSSDHVN LITKLETPLQ
60 70 80 90 100
EFTVCLRAYS DLSRHYSLFS YNTPGKDNEL LIYKEKLGEY SLYIGGTKVT
110 120 130 140 150
ARVPEEILAP VHICTSWESS SGIAEFWING KPLVKKGLKR GYSVAAHPKI
160 170 180 190 200
ILGQEQDSYG GKFDRGQSFL GEIGDVYMWD SVLSPDDVQA VYYGSYVNGS
210 220
ILNWQALNYE LNDYVIIKPR VWD
Length:223
Mass (Da):25,453
Last modified:February 1, 1996 - v1
Checksum:iA6FF1C7C6904EBB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S60421 Genomic DNA. Translation: AAC60661.1.
PIRiJX0260.
RefSeqiXP_003466600.1. XM_003466552.2.

Genome annotation databases

EnsembliENSCPOT00000022170; ENSCPOP00000019069; ENSCPOG00000009766.
GeneIDi100726823.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S60421 Genomic DNA. Translation: AAC60661.1.
PIRiJX0260.
RefSeqiXP_003466600.1. XM_003466552.2.

3D structure databases

ProteinModelPortaliP49255.
SMRiP49255.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000019069.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCPOT00000022170; ENSCPOP00000019069; ENSCPOG00000009766.
GeneIDi100726823.

Organism-specific databases

CTDi325.

Phylogenomic databases

eggNOGiENOG410J1FD. Eukaryota.
ENOG410YN8S. LUCA.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000247043.
HOVERGENiHBG005405.
InParanoidiP49255.
OMAiDHVNLIT.
OrthoDBiEOG091G0H6X.
TreeFamiTF330208.

Family and domain databases

CDDicd00152. PTX. 1 hit.
InterProiView protein in InterPro
IPR013320. ConA-like_dom.
IPR030476. Pentaxin_CS.
IPR001759. Pentraxin-related.
PfamiView protein in Pfam
PF00354. Pentaxin. 1 hit.
PRINTSiPR00895. PENTAXIN.
SMARTiView protein in SMART
SM00159. PTX. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS00289. PTX_1. 1 hit.
PS51828. PTX_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSAMP_CAVPO
AccessioniPrimary (citable) accession number: P49255
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 10, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.