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P49254

- CRP_CAVPO

UniProt

P49254 - CRP_CAVPO

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Protein

C-reactive protein

Gene
CRP, PTX1
Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells By similarity.

Cofactori

Binds 2 calcium ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi80 – 801Calcium 1 By similarity
Metal bindingi158 – 1581Calcium 1; via carbonyl oxygen By similarity
Metal bindingi159 – 1591Calcium 1 By similarity
Metal bindingi159 – 1591Calcium 2 By similarity
Metal bindingi169 – 1691Calcium 2 By similarity

GO - Molecular functioni

  1. low-density lipoprotein particle binding Source: Ensembl
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. acute-phase response Source: UniProtKB-KW
  2. negative regulation of lipid storage Source: Ensembl
  3. negative regulation of macrophage derived foam cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Acute phase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C-reactive protein
Gene namesi
Name:CRP
Synonyms:PTX1
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 By similarityAdd
BLAST
Chaini20 – 225206C-reactive proteinPRO_0000023525Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi55 ↔ 116 By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Found in plasma.

Interactioni

Subunit structurei

Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits By similarity.

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000011841.

Structurei

3D structure databases

ProteinModelPortaliP49254.
SMRiP49254. Positions 21-225.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 225206PentaxinAdd
BLAST

Sequence similaritiesi

Belongs to the pentaxin family.
Contains 1 pentaxin domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG113288.
GeneTreeiENSGT00650000093195.
HOGENOMiHOG000247043.
HOVERGENiHBG005405.
InParanoidiP49254.
OMAiETDNSYV.
OrthoDBiEOG71RXMB.
TreeFamiTF330208.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001759. Pentaxin.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49254-1 [UniParc]FASTAAdd to Basket

« Hide

MAKLLLYFLL LTSLSDVFGG TDMSKKTFVF PKETDNSYVS LKAQLKKPLS    50
AFTVCLHIYT ELFMTRGYSI FSYATEKEAN EILIFWSKDR GYILGVGGIE 100
MPFKAPEIPS APVHICTSWE SVSGIIELWV DGKAQVRKSL QKGYFVGTEA 150
MIILGQDQDS FGGSFDANQS FVGDIGDVNM WDFVLSPKEI DMVYSGGTFS 200
PNVLSWRSLT YETHGEVFIK PQLWP 225
Length:225
Mass (Da):25,225
Last modified:February 1, 1996 - v1
Checksum:i47AF3E2D9A660F2E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S60422 Genomic DNA. Translation: AAC60662.1.
PIRiJX0259.
RefSeqiXP_003466601.1. XM_003466553.1.

Genome annotation databases

EnsembliENSCPOT00000013281; ENSCPOP00000011841; ENSCPOG00000013154.
GeneIDi100727100.

Cross-referencesi

Web resourcesi

Protein Spotlight

No more Christmas pudding? - Issue 30 of January 2003

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S60422 Genomic DNA. Translation: AAC60662.1 .
PIRi JX0259.
RefSeqi XP_003466601.1. XM_003466553.1.

3D structure databases

ProteinModelPortali P49254.
SMRi P49254. Positions 21-225.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10141.ENSCPOP00000011841.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCPOT00000013281 ; ENSCPOP00000011841 ; ENSCPOG00000013154 .
GeneIDi 100727100.

Organism-specific databases

CTDi 1401.

Phylogenomic databases

eggNOGi NOG113288.
GeneTreei ENSGT00650000093195.
HOGENOMi HOG000247043.
HOVERGENi HBG005405.
InParanoidi P49254.
OMAi ETDNSYV.
OrthoDBi EOG71RXMB.
TreeFami TF330208.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001759. Pentaxin.
[Graphical view ]
Pfami PF00354. Pentaxin. 1 hit.
[Graphical view ]
PRINTSi PR00895. PENTAXIN.
SMARTi SM00159. PTX. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS00289. PENTAXIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure, expression, and evolution of guinea pig serum amyloid P component and C-reactive protein."
    Rubio N., Sharp P.M., Rits M., Zahedi K., Whitehead A.S.
    J. Biochem. 113:277-284(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Hartley.

Entry informationi

Entry nameiCRP_CAVPO
AccessioniPrimary (citable) accession number: P49254
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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