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P49254

- CRP_CAVPO

UniProt

P49254 - CRP_CAVPO

Protein

C-reactive protein

Gene

CRP

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells By similarity.By similarity

    Cofactori

    Binds 2 calcium ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi80 – 801Calcium 1By similarity
    Metal bindingi158 – 1581Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi159 – 1591Calcium 1By similarity
    Metal bindingi159 – 1591Calcium 2By similarity
    Metal bindingi169 – 1691Calcium 2By similarity

    GO - Molecular functioni

    1. low-density lipoprotein particle binding Source: Ensembl
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. acute-phase response Source: UniProtKB-KW
    2. negative regulation of lipid storage Source: Ensembl
    3. negative regulation of macrophage derived foam cell differentiation Source: Ensembl
    4. regulation of interleukin-8 secretion Source: UniProtKB

    Keywords - Biological processi

    Acute phase

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-reactive protein
    Gene namesi
    Name:CRP
    Synonyms:PTX1
    OrganismiCavia porcellus (Guinea pig)
    Taxonomic identifieri10141 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
    ProteomesiUP000005447: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919By similarityAdd
    BLAST
    Chaini20 – 225206C-reactive proteinPRO_0000023525Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi55 ↔ 116By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Found in plasma.

    Interactioni

    Subunit structurei

    Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Interacts with FCN1; may regulate monocyte activation by FCN1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10141.ENSCPOP00000011841.

    Structurei

    3D structure databases

    ProteinModelPortaliP49254.
    SMRiP49254. Positions 21-225.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 225206PentaxinAdd
    BLAST

    Sequence similaritiesi

    Belongs to the pentaxin family.Curated
    Contains 1 pentaxin domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG113288.
    GeneTreeiENSGT00650000093195.
    HOGENOMiHOG000247043.
    HOVERGENiHBG005405.
    InParanoidiP49254.
    OMAiETDNSYV.
    OrthoDBiEOG71RXMB.
    TreeFamiTF330208.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001759. Pentaxin.
    [Graphical view]
    PfamiPF00354. Pentaxin. 1 hit.
    [Graphical view]
    PRINTSiPR00895. PENTAXIN.
    SMARTiSM00159. PTX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS00289. PENTAXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P49254-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKLLLYFLL LTSLSDVFGG TDMSKKTFVF PKETDNSYVS LKAQLKKPLS    50
    AFTVCLHIYT ELFMTRGYSI FSYATEKEAN EILIFWSKDR GYILGVGGIE 100
    MPFKAPEIPS APVHICTSWE SVSGIIELWV DGKAQVRKSL QKGYFVGTEA 150
    MIILGQDQDS FGGSFDANQS FVGDIGDVNM WDFVLSPKEI DMVYSGGTFS 200
    PNVLSWRSLT YETHGEVFIK PQLWP 225
    Length:225
    Mass (Da):25,225
    Last modified:February 1, 1996 - v1
    Checksum:i47AF3E2D9A660F2E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S60422 Genomic DNA. Translation: AAC60662.1.
    PIRiJX0259.
    RefSeqiXP_003466601.1. XM_003466553.1.

    Genome annotation databases

    EnsembliENSCPOT00000013281; ENSCPOP00000011841; ENSCPOG00000013154.
    GeneIDi100727100.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    No more Christmas pudding? - Issue 30 of January 2003

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S60422 Genomic DNA. Translation: AAC60662.1 .
    PIRi JX0259.
    RefSeqi XP_003466601.1. XM_003466553.1.

    3D structure databases

    ProteinModelPortali P49254.
    SMRi P49254. Positions 21-225.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10141.ENSCPOP00000011841.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCPOT00000013281 ; ENSCPOP00000011841 ; ENSCPOG00000013154 .
    GeneIDi 100727100.

    Organism-specific databases

    CTDi 1401.

    Phylogenomic databases

    eggNOGi NOG113288.
    GeneTreei ENSGT00650000093195.
    HOGENOMi HOG000247043.
    HOVERGENi HBG005405.
    InParanoidi P49254.
    OMAi ETDNSYV.
    OrthoDBi EOG71RXMB.
    TreeFami TF330208.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001759. Pentaxin.
    [Graphical view ]
    Pfami PF00354. Pentaxin. 1 hit.
    [Graphical view ]
    PRINTSi PR00895. PENTAXIN.
    SMARTi SM00159. PTX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS00289. PENTAXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure, expression, and evolution of guinea pig serum amyloid P component and C-reactive protein."
      Rubio N., Sharp P.M., Rits M., Zahedi K., Whitehead A.S.
      J. Biochem. 113:277-284(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Hartley.

    Entry informationi

    Entry nameiCRP_CAVPO
    AccessioniPrimary (citable) accession number: P49254
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3