P49254 (CRP_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-reactive protein

Gene names

Name:	CRP
Synonyms:	PTX1

Organism

Cavia porcellus (Guinea pig) [Reference proteome]

Taxonomic identifier

10141 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells By similarity.
Cofactor	Binds 2 calcium ions per subunit By similarity.
Subunit structure	Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits By similarity.
Subcellular location	Secreted.
Tissue specificity	Found in plasma.
Sequence similarities	Belongs to the pentaxin family. Contains 1 pentaxin domain.

Ontologies

Keywords
Biological process	Acute phase
Cellular component	Secreted
Domain	Signal
Ligand	Calcium Metal-binding
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	acute-phase response Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of lipid storage Inferred from electronic annotation. Source: Compara negative regulation of macrophage derived foam cell differentiation Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	low-density lipoprotein particle binding Inferred from electronic annotation. Source: Compara metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	By similarity
	Chain	20 – 225	206	C-reactive protein		PRO_0000023525
Regions
	Domain	20 – 225	206	Pentaxin
Sites
	Metal binding	80	1	Calcium 1 By similarity
	Metal binding	158	1	Calcium 1; via carbonyl oxygen By similarity
	Metal binding	159	1	Calcium 1 By similarity
	Metal binding	159	1	Calcium 2 By similarity
	Metal binding	169	1	Calcium 2 By similarity
Amino acid modifications
	Disulfide bond	55 ↔ 116		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P49254 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 47AF3E2D9A660F2E	FASTA	225	25,225
	10 20 30 40 50 60 MAKLLLYFLL LTSLSDVFGG TDMSKKTFVF PKETDNSYVS LKAQLKKPLS AFTVCLHIYT 70 80 90 100 110 120 ELFMTRGYSI FSYATEKEAN EILIFWSKDR GYILGVGGIE MPFKAPEIPS APVHICTSWE 130 140 150 160 170 180 SVSGIIELWV DGKAQVRKSL QKGYFVGTEA MIILGQDQDS FGGSFDANQS FVGDIGDVNM 190 200 210 220 WDFVLSPKEI DMVYSGGTFS PNVLSWRSLT YETHGEVFIK PQLWP

References

[1]	"Structure, expression, and evolution of guinea pig serum amyloid P component and C-reactive protein." Rubio N., Sharp P.M., Rits M., Zahedi K., Whitehead A.S. J. Biochem. 113:277-284(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Hartley.

Web resources

Protein Spotlight

No more Christmas pudding? - Issue 30 of January 2003

Cross-references

Sequence databases
EMBL GenBank DDBJ	S60422 Genomic DNA. Translation: AAC60662.1.
PIR	JX0259.
RefSeq	XP_003466601.1. XM_003466553.1.
3D structure databases
ProteinModelPortal	P49254.
SMR	P49254. Positions 21-225.
ModBase	Search...
Protein-protein interaction databases
STRING	10141.ENSCPOP00000011841.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSCPOT00000013281; ENSCPOP00000011841; ENSCPOG00000013154.
GeneID	100727100.
Phylogenomic databases
eggNOG	NOG113288.
GeneTree	ENSGT00650000093195.
HOGENOM	HOG000247043.
HOVERGEN	HBG005405.
InParanoid	P49254.
OMA	SAPVHIC.
OrthoDB	EOG4R23VS.
Family and domain databases
Gene3D	2.60.120.200. 1 hit.
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR001759. Pentaxin. [Graphical view]
Pfam	PF00354. Pentaxin. 1 hit. [Graphical view]
PRINTS	PR00895. PENTAXIN.
SMART	SM00159. PTX. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS00289. PENTAXIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CRP_CAVPO

Accession

Primary (citable) accession number: P49254

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program