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P49254

- CRP_CAVPO

UniProt

P49254 - CRP_CAVPO

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Protein

C-reactive protein

Gene

CRP

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells (By similarity).By similarity

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi80 – 801Calcium 1By similarity
Metal bindingi158 – 1581Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi159 – 1591Calcium 1By similarity
Metal bindingi159 – 1591Calcium 2By similarity
Metal bindingi169 – 1691Calcium 2By similarity

GO - Molecular functioni

  1. calcium ion binding Source: Ensembl
  2. low-density lipoprotein particle binding Source: Ensembl

GO - Biological processi

  1. acute-phase response Source: UniProtKB-KW
  2. negative regulation of lipid storage Source: Ensembl
  3. negative regulation of macrophage derived foam cell differentiation Source: Ensembl
  4. regulation of interleukin-8 secretion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Acute phase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C-reactive protein
Gene namesi
Name:CRP
Synonyms:PTX1
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 225206C-reactive proteinPRO_0000023525Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi55 ↔ 116By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Found in plasma.

Interactioni

Subunit structurei

Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Interacts with FCN1; may regulate monocyte activation by FCN1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000011841.

Structurei

3D structure databases

ProteinModelPortaliP49254.
SMRiP49254. Positions 21-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 225206PentaxinAdd
BLAST

Sequence similaritiesi

Belongs to the pentaxin family.Curated
Contains 1 pentaxin domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG113288.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000247043.
HOVERGENiHBG005405.
InParanoidiP49254.
OMAiETDNSYV.
OrthoDBiEOG71RXMB.
TreeFamiTF330208.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49254-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKLLLYFLL LTSLSDVFGG TDMSKKTFVF PKETDNSYVS LKAQLKKPLS
60 70 80 90 100
AFTVCLHIYT ELFMTRGYSI FSYATEKEAN EILIFWSKDR GYILGVGGIE
110 120 130 140 150
MPFKAPEIPS APVHICTSWE SVSGIIELWV DGKAQVRKSL QKGYFVGTEA
160 170 180 190 200
MIILGQDQDS FGGSFDANQS FVGDIGDVNM WDFVLSPKEI DMVYSGGTFS
210 220
PNVLSWRSLT YETHGEVFIK PQLWP
Length:225
Mass (Da):25,225
Last modified:February 1, 1996 - v1
Checksum:i47AF3E2D9A660F2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S60422 Genomic DNA. Translation: AAC60662.1.
PIRiJX0259.
RefSeqiXP_003466601.1. XM_003466553.1.

Genome annotation databases

EnsembliENSCPOT00000013281; ENSCPOP00000011841; ENSCPOG00000013154.
GeneIDi100727100.

Cross-referencesi

Web resourcesi

Protein Spotlight

No more Christmas pudding? - Issue 30 of January 2003

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S60422 Genomic DNA. Translation: AAC60662.1 .
PIRi JX0259.
RefSeqi XP_003466601.1. XM_003466553.1.

3D structure databases

ProteinModelPortali P49254.
SMRi P49254. Positions 21-225.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10141.ENSCPOP00000011841.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCPOT00000013281 ; ENSCPOP00000011841 ; ENSCPOG00000013154 .
GeneIDi 100727100.

Organism-specific databases

CTDi 1401.

Phylogenomic databases

eggNOGi NOG113288.
GeneTreei ENSGT00760000119128.
HOGENOMi HOG000247043.
HOVERGENi HBG005405.
InParanoidi P49254.
OMAi ETDNSYV.
OrthoDBi EOG71RXMB.
TreeFami TF330208.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR001759. Pentaxin.
[Graphical view ]
Pfami PF00354. Pentaxin. 1 hit.
[Graphical view ]
PRINTSi PR00895. PENTAXIN.
SMARTi SM00159. PTX. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS00289. PENTAXIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure, expression, and evolution of guinea pig serum amyloid P component and C-reactive protein."
    Rubio N., Sharp P.M., Rits M., Zahedi K., Whitehead A.S.
    J. Biochem. 113:277-284(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Hartley.

Entry informationi

Entry nameiCRP_CAVPO
AccessioniPrimary (citable) accession number: P49254
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 26, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3