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P49254 (CRP_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-reactive protein
Gene names
Name:CRP
Synonyms:PTX1
OrganismCavia porcellus (Guinea pig) [Reference proteome]
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Protein attributes

Sequence length225 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells By similarity.

Cofactor

Binds 2 calcium ions per subunit By similarity.

Subunit structure

Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits By similarity.

Subcellular location

Secreted.

Tissue specificity

Found in plasma.

Sequence similarities

Belongs to the pentaxin family.

Contains 1 pentaxin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity
Chain20 – 225206C-reactive protein
PRO_0000023525

Regions

Domain20 – 225206Pentaxin

Sites

Metal binding801Calcium 1 By similarity
Metal binding1581Calcium 1; via carbonyl oxygen By similarity
Metal binding1591Calcium 1 By similarity
Metal binding1591Calcium 2 By similarity
Metal binding1691Calcium 2 By similarity

Amino acid modifications

Disulfide bond55 ↔ 116 By similarity

Sequences

Sequence LengthMass (Da)Tools
P49254 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 47AF3E2D9A660F2E

FASTA22525,225
        10         20         30         40         50         60 
MAKLLLYFLL LTSLSDVFGG TDMSKKTFVF PKETDNSYVS LKAQLKKPLS AFTVCLHIYT 

        70         80         90        100        110        120 
ELFMTRGYSI FSYATEKEAN EILIFWSKDR GYILGVGGIE MPFKAPEIPS APVHICTSWE 

       130        140        150        160        170        180 
SVSGIIELWV DGKAQVRKSL QKGYFVGTEA MIILGQDQDS FGGSFDANQS FVGDIGDVNM 

       190        200        210        220 
WDFVLSPKEI DMVYSGGTFS PNVLSWRSLT YETHGEVFIK PQLWP 

« Hide

References

[1]"Structure, expression, and evolution of guinea pig serum amyloid P component and C-reactive protein."
Rubio N., Sharp P.M., Rits M., Zahedi K., Whitehead A.S.
J. Biochem. 113:277-284(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Hartley.

Web resources

Protein Spotlight

No more Christmas pudding? - Issue 30 of January 2003

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S60422 Genomic DNA. Translation: AAC60662.1.
PIRJX0259.
RefSeqXP_003466601.1. XM_003466553.1.

3D structure databases

ProteinModelPortalP49254.
SMRP49254. Positions 21-225.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10141.ENSCPOP00000011841.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCPOT00000013281; ENSCPOP00000011841; ENSCPOG00000013154.
GeneID100727100.

Organism-specific databases

CTD1401.

Phylogenomic databases

eggNOGNOG113288.
GeneTreeENSGT00650000093195.
HOGENOMHOG000247043.
HOVERGENHBG005405.
InParanoidP49254.
OMAETDNSYV.
OrthoDBEOG71RXMB.
TreeFamTF330208.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001759. Pentaxin.
[Graphical view]
PfamPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSPR00895. PENTAXIN.
SMARTSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS00289. PENTAXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCRP_CAVPO
AccessionPrimary (citable) accession number: P49254
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries