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P49253 (AOF_ONCMY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Amine oxidase [flavin-containing]
EC=1.4.3.4
Alternative name(s):
Monoamine oxidase
Short name=MAO
Gene names
Name:mao
OrganismOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifier8022 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Protacanthopterygii › Salmoniformes › Salmonidae › Salmoninae › Oncorhynchus

Protein attributes

Sequence length522 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Oxidizes both 5-hydroxytryptamine (5-HT) and beta-phenylethylamine (PEA).

Catalytic activity

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactor

FAD.

Subcellular location

Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.

Sequence similarities

Belongs to the flavin monoamine oxidase family.

Sequence caution

The sequence AAA64302.1 differs from that shown. Reason: Frameshift at position 500. Probable frameshift identified on the basis of homology with other members of this family.

Ontologies

Keywords
   Cellular componentMembrane
Mitochondrion
Mitochondrion outer membrane
   DomainTransmembrane
Transmembrane helix
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial outer membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionoxidoreductase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 522522Amine oxidase [flavin-containing]
PRO_0000099864

Regions

Topological domain1 – 492492Cytoplasmic By similarity
Transmembrane493 – 51321Helical; Anchor for type IV membrane protein; By similarity
Topological domain514 – 5229Mitochondrial intermembrane By similarity

Sites

Site1581Important for catalytic activity By similarity
Site3671Important for catalytic activity By similarity
Site3841Important for catalytic activity By similarity

Amino acid modifications

Modified residue3991S-8alpha-FAD cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P49253 [UniParc].

Last modified December 15, 1998. Version 2.
Checksum: F82D6D15364D646D

FASTA52258,937
        10         20         30         40         50         60 
MTAQNTFDVI VIGGGISGLS AAKLLKEKGL SPVVLEARDR VGGRTFTVQN EQTKYVDLGG 

        70         80         90        100        110        120 
AYVGPTQNRI LRLAKECGVK TIKVNEEERL VHYVKGKSYP FKGSFPPMWN PFALMDYNNL 

       130        140        150        160        170        180 
WRKMDEMGSE IPREAPWKAP HAEEWDKMTM KQLFDKICWT SSARRFATLF VNVNVTSEPH 

       190        200        210        220        230        240 
EVSALWFLWY VKQCGGTMRI FSTTNGGQER KFLGGSSQIS ECMAKELGER VKMESPVYKI 

       250        260        270        280        290        300 
DQTGDMVEVE TLNKETYKAK YVIVATPPGL NLKMHFNPEL PPLRNQLIHR VPMGSVIKCI 

       310        320        330        340        350        360 
VYYRENFWRK KGYCGTMVIE EEEAPIGLTL DDTKPDGTVP AIMGFILARK CRKLCGLTKE 

       370        380        390        400        410        420 
ERKKRICEIY SRVLGSEEAL HPVHYEEKNW CEEEYSGGCY TAYFPPGILT QYGKVLREPV 

       430        440        450        460        470        480 
GRLYFAGTET ATEWSGYMEG AVQAGERAAR EVMYEMGRIP QSQIWQTEPE SVEVPALPFV 

       490        500        510        520 
TTFWERNLPS VGGFINFLAA SVLSVATAAG MLAYQKGLLT RS

« Hide

References

[1]"Cloning of a novel monoamine oxidase cDNA from trout liver."
Chen K., Wu H.-F., Grimsby J., Shih J.C.
Mol. Pharmacol. 46:1226-1233(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ACTIVITY.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L37878 mRNA. Translation: AAA64302.1. Frameshift.
PIRI51346.
RefSeqNP_001118160.1. NM_001124688.1.
UniGeneOmy.37002.

3D structure databases

ProteinModelPortalP49253.
SMRP49253. Positions 3-514.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100136729.

Organism-specific databases

CTD404730.

Phylogenomic databases

HOVERGENHBG004255.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSPR00757. AMINEOXDASEF.
ProtoNetSearch...

Entry information

Entry nameAOF_ONCMY
AccessionPrimary (citable) accession number: P49253
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 15, 1998
Last modified: May 29, 2013
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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