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P49253

- AOF_ONCMY

UniProt

P49253 - AOF_ONCMY

Protein

Amine oxidase [flavin-containing]

Gene

mao

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 2 (15 Dec 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Oxidizes both 5-hydroxytryptamine (5-HT) and beta-phenylethylamine (PEA).

    Catalytic activityi

    RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

    Cofactori

    FAD.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei158 – 1581Important for catalytic activityBy similarity
    Sitei367 – 3671Important for catalytic activityBy similarity
    Sitei384 – 3841Important for catalytic activityBy similarity

    GO - Molecular functioni

    1. oxidoreductase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Amine oxidase [flavin-containing] (EC:1.4.3.4)
    Alternative name(s):
    Monoamine oxidase
    Short name:
    MAO
    Gene namesi
    Name:mao
    OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
    Taxonomic identifieri8022 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 522522Amine oxidase [flavin-containing]PRO_0000099864Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei399 – 3991S-8alpha-FAD cysteineBy similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP49253.
    SMRiP49253. Positions 3-514.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 492492CytoplasmicBy similarityAdd
    BLAST
    Topological domaini514 – 5229Mitochondrial intermembraneBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei493 – 51321Helical; Anchor for type IV membrane proteinBy similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the flavin monoamine oxidase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG004255.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002937. Amino_oxidase.
    IPR001613. Flavin_amine_oxidase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01593. Amino_oxidase. 1 hit.
    [Graphical view]
    PRINTSiPR00757. AMINEOXDASEF.

    Sequencei

    Sequence statusi: Complete.

    P49253-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAQNTFDVI VIGGGISGLS AAKLLKEKGL SPVVLEARDR VGGRTFTVQN    50
    EQTKYVDLGG AYVGPTQNRI LRLAKECGVK TIKVNEEERL VHYVKGKSYP 100
    FKGSFPPMWN PFALMDYNNL WRKMDEMGSE IPREAPWKAP HAEEWDKMTM 150
    KQLFDKICWT SSARRFATLF VNVNVTSEPH EVSALWFLWY VKQCGGTMRI 200
    FSTTNGGQER KFLGGSSQIS ECMAKELGER VKMESPVYKI DQTGDMVEVE 250
    TLNKETYKAK YVIVATPPGL NLKMHFNPEL PPLRNQLIHR VPMGSVIKCI 300
    VYYRENFWRK KGYCGTMVIE EEEAPIGLTL DDTKPDGTVP AIMGFILARK 350
    CRKLCGLTKE ERKKRICEIY SRVLGSEEAL HPVHYEEKNW CEEEYSGGCY 400
    TAYFPPGILT QYGKVLREPV GRLYFAGTET ATEWSGYMEG AVQAGERAAR 450
    EVMYEMGRIP QSQIWQTEPE SVEVPALPFV TTFWERNLPS VGGFINFLAA 500
    SVLSVATAAG MLAYQKGLLT RS 522
    Length:522
    Mass (Da):58,937
    Last modified:December 15, 1998 - v2
    Checksum:iF82D6D15364D646D
    GO

    Sequence cautioni

    The sequence AAA64302.1 differs from that shown. Reason: Frameshift at position 500. Probable frameshift identified on the basis of homology with other members of this family.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37878 mRNA. Translation: AAA64302.1. Frameshift.
    PIRiI51346.
    RefSeqiNP_001118160.1. NM_001124688.1.
    UniGeneiOmy.37002.

    Genome annotation databases

    GeneIDi100136729.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37878 mRNA. Translation: AAA64302.1 . Frameshift.
    PIRi I51346.
    RefSeqi NP_001118160.1. NM_001124688.1.
    UniGenei Omy.37002.

    3D structure databases

    ProteinModelPortali P49253.
    SMRi P49253. Positions 3-514.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100136729.

    Organism-specific databases

    CTDi 404730.

    Phylogenomic databases

    HOVERGENi HBG004255.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002937. Amino_oxidase.
    IPR001613. Flavin_amine_oxidase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01593. Amino_oxidase. 1 hit.
    [Graphical view ]
    PRINTSi PR00757. AMINEOXDASEF.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a novel monoamine oxidase cDNA from trout liver."
      Chen K., Wu H.-F., Grimsby J., Shih J.C.
      Mol. Pharmacol. 46:1226-1233(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ACTIVITY.
      Tissue: Liver.

    Entry informationi

    Entry nameiAOF_ONCMY
    AccessioniPrimary (citable) accession number: P49253
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: December 15, 1998
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3