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P49253

- AOF_ONCMY

UniProt

P49253 - AOF_ONCMY

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Protein

Amine oxidase [flavin-containing]

Gene

mao

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Oxidizes both 5-hydroxytryptamine (5-HT) and beta-phenylethylamine (PEA).

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei158 – 1581Important for catalytic activityBy similarity
Sitei367 – 3671Important for catalytic activityBy similarity
Sitei384 – 3841Important for catalytic activityBy similarity

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing] (EC:1.4.3.4)
Alternative name(s):
Monoamine oxidase
Short name:
MAO
Gene namesi
Name:mao
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 492492CytoplasmicBy similarityAdd
BLAST
Transmembranei493 – 51321Helical; Anchor for type IV membrane proteinBy similarityAdd
BLAST
Topological domaini514 – 5229Mitochondrial intermembraneBy similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 522522Amine oxidase [flavin-containing]PRO_0000099864Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei399 – 3991S-8alpha-FAD cysteineBy similarity

Structurei

3D structure databases

ProteinModelPortaliP49253.
SMRiP49253. Positions 3-514.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the flavin monoamine oxidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004255.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.

Sequencei

Sequence statusi: Complete.

P49253-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTAQNTFDVI VIGGGISGLS AAKLLKEKGL SPVVLEARDR VGGRTFTVQN
60 70 80 90 100
EQTKYVDLGG AYVGPTQNRI LRLAKECGVK TIKVNEEERL VHYVKGKSYP
110 120 130 140 150
FKGSFPPMWN PFALMDYNNL WRKMDEMGSE IPREAPWKAP HAEEWDKMTM
160 170 180 190 200
KQLFDKICWT SSARRFATLF VNVNVTSEPH EVSALWFLWY VKQCGGTMRI
210 220 230 240 250
FSTTNGGQER KFLGGSSQIS ECMAKELGER VKMESPVYKI DQTGDMVEVE
260 270 280 290 300
TLNKETYKAK YVIVATPPGL NLKMHFNPEL PPLRNQLIHR VPMGSVIKCI
310 320 330 340 350
VYYRENFWRK KGYCGTMVIE EEEAPIGLTL DDTKPDGTVP AIMGFILARK
360 370 380 390 400
CRKLCGLTKE ERKKRICEIY SRVLGSEEAL HPVHYEEKNW CEEEYSGGCY
410 420 430 440 450
TAYFPPGILT QYGKVLREPV GRLYFAGTET ATEWSGYMEG AVQAGERAAR
460 470 480 490 500
EVMYEMGRIP QSQIWQTEPE SVEVPALPFV TTFWERNLPS VGGFINFLAA
510 520
SVLSVATAAG MLAYQKGLLT RS
Length:522
Mass (Da):58,937
Last modified:December 15, 1998 - v2
Checksum:iF82D6D15364D646D
GO

Sequence cautioni

The sequence AAA64302.1 differs from that shown. Reason: Frameshift at position 500. Probable frameshift identified on the basis of homology with other members of this family.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37878 mRNA. Translation: AAA64302.1. Frameshift.
PIRiI51346.
RefSeqiNP_001118160.1. NM_001124688.1.
UniGeneiOmy.37002.

Genome annotation databases

GeneIDi100136729.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37878 mRNA. Translation: AAA64302.1 . Frameshift.
PIRi I51346.
RefSeqi NP_001118160.1. NM_001124688.1.
UniGenei Omy.37002.

3D structure databases

ProteinModelPortali P49253.
SMRi P49253. Positions 3-514.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100136729.

Organism-specific databases

CTDi 404730.

Phylogenomic databases

HOVERGENi HBG004255.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
PRINTSi PR00757. AMINEOXDASEF.
ProtoNeti Search...

Publicationsi

  1. "Cloning of a novel monoamine oxidase cDNA from trout liver."
    Chen K., Wu H.-F., Grimsby J., Shih J.C.
    Mol. Pharmacol. 46:1226-1233(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ACTIVITY.
    Tissue: Liver.

Entry informationi

Entry nameiAOF_ONCMY
AccessioniPrimary (citable) accession number: P49253
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 15, 1998
Last modified: November 26, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3