P49245 (FABH2_CUPWR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 B, chloroplastic
EC=2.3.1.180

Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III B
Beta-ketoacyl-ACP synthase III B
Short name=KAS III B

Gene names

Name:

KAS3B

Organism

Cuphea wrightii (Wright's waxweed)

Taxonomic identifier

35942 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Myrtales › Lythraceae › Cuphea

Protein attributes

Sequence length	402 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. KAS III catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities By similarity.
Catalytic activity	Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2.
Pathway	Lipid metabolism; fatty acid biosynthesis.
Subcellular location	Plastid › chloroplast.
Sequence similarities	Belongs to the FabH family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Chloroplast Plastid
Domain	Transit peptide
Molecular function	Transferase
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chloroplast Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-oxoacyl-[acyl-carrier-protein] synthase activity Inferred from electronic annotation. Source: InterPro beta-ketoacyl-acyl-carrier-protein synthase III activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Chloroplast Potential
	Chain	? – 402		3-oxoacyl-[acyl-carrier-protein] synthase 3 B, chloroplastic		PRO_0000008734
Sites
	Active site	178	1	By similarity
	Active site	328	1	By similarity
	Active site	358	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P49245 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 6A6FB1234069EC74	FASTA	402	42,458
	10 20 30 40 50 60 MANAYGFVGH SVPTMKRAAQ FQQMGSGFCS ADSISKRVFC CSVVQGADKP ASGDSRTEYR 70 80 90 100 110 120 TPRLVSRGCK LVGSGSAMPA LQVSNDDLSK IVDTNDEWIS VRTGIRNRRV LTGKESLTNL 130 140 150 160 170 180 ATVAARKALE MAQVDANDVD MVLMCTSTPE DLFGSAPQIQ KALGCKKNPL AYDITAACSG 190 200 210 220 230 240 FVLGLVSAAC HIRGGGFNNI LVIGADSLSR YVDWTDRGTC ILFGDAAGAV LVQSCDAEED 250 260 270 280 290 300 GLFAFDLHSD GDGQRHLKAA ITENGIDHAV GSNGSVSDFP PRSSSYSCIQ MNGKEVFRFA 310 320 330 340 350 360 CRCVPQSIES ALGKAGLNGS NIDWLLLHQA NQRIIDAVAT RLEVPQERVI SNLANYGNTS 370 380 390 400 AASIPLALDE AVRGGKVKAG HLIATAGFGA GLTWGSAIVR WG

References

[1]	"cDNA clones encoding beta-ketoacyl-acyl carrier protein synthase III from Cuphea wrightii." Slabaugh M.B., Tai H., Jaworski J., Knapp S.J. Plant Physiol. 108:443-444(1995) [PubMed: 7784524] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U15934 mRNA. Translation: AAA97534.1.
3D structure databases
ProteinModelPortal	P49245.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
BRENDA	2.3.1.180. 1755.
Family and domain databases
InterPro	IPR013751. ACP_syn_III. IPR013747. ACP_syn_III_C. IPR004655. FabH_synth. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Gene3D	G3DSA:3.40.47.10. Thiolase-like_subgr. 3 hits.
Pfam	PF08545. ACP_syn_III. 1 hit. PF08541. ACP_syn_III_C. 1 hit. [Graphical view]
SUPFAM	SSF53901. Thiolase-like. 1 hit.
TIGRFAMs	TIGR00747. FabH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FABH2_CUPWR

Accession

Primary (citable) accession number: P49245

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	November 16, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program