Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

3-oxoacyl-[acyl-carrier-protein] synthase III, chloroplastic

Gene

At1g62640

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. KAS III catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei179By similarity1
Active sitei330By similarity1
Active sitei360By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciARA:AT1G62640-MONOMER
UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase III, chloroplastic (EC:2.3.1.180)
Alternative name(s):
Beta-ketoacyl-ACP synthase III
Short name:
KAS III
Gene namesi
Ordered Locus Names:At1g62640
ORF Names:F23N19.2, T3P18.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G62640
TAIRilocus:2026167 AT1G62640

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 43ChloroplastCuratedAdd BLAST43
ChainiPRO_000000873244 – 4043-oxoacyl-[acyl-carrier-protein] synthase III, chloroplasticAdd BLAST361

Proteomic databases

PaxDbiP49243
PRIDEiP49243

Expressioni

Gene expression databases

ExpressionAtlasiP49243 baseline and differential
GenevisibleiP49243 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G62640.1

Structurei

3D structure databases

ProteinModelPortaliP49243
SMRiP49243
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FabH family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IH2M Eukaryota
COG0332 LUCA
HOGENOMiHOG000246674
InParanoidiP49243
KOiK00648
OMAiIGPTVWG
OrthoDBiEOG09360ECQ
PhylomeDBiP49243

Family and domain databases

Gene3Di3.40.47.10, 1 hit
HAMAPiMF_01815 FabH, 1 hit
InterProiView protein in InterPro
IPR013751 ACP_syn_III
IPR013747 ACP_syn_III_C
IPR004655 FabH_synth
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF08545 ACP_syn_III, 1 hit
PF08541 ACP_syn_III_C, 1 hit
SUPFAMiSSF53901 SSF53901, 1 hit
TIGRFAMsiTIGR00747 fabH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49243-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANASGFFTH PSIPNLRSRI HVPVRVSGSG FCVSNRFSKR VLCSSVSSVD
60 70 80 90 100
KDASSSPSQY QRPRLVPSGC KLIGCGSAVP SLLISNDDLA KIVDTNDEWI
110 120 130 140 150
ATRTGIRNRR VVSGKDSLVG LAVEAATKAL EMAEVVPEDI DLVLMCTSTP
160 170 180 190 200
DDLFGAAPQI QKALGCTKNP LAYDITAACS GFVLGLVSAA CHIRGGGFKN
210 220 230 240 250
VLVIGADSLS RFVDWTDRGT CILFGDAAGA VVVQACDIED DGLFSFDVHS
260 270 280 290 300
DGDGRRHLNA SVKESQNDGE SSSNGSVFGD FPPKQSSYSC IQMNGKEVFR
310 320 330 340 350
FAVKCVPQSI ESALQKAGLP ASAIDWLLLH QANQRIIDSV ATRLHFPPER
360 370 380 390 400
VISNLANYGN TSAASIPLAL DEAVRSGKVK PGHTIATSGF GAGLTWGSAI

MRWR
Length:404
Mass (Da):42,847
Last modified:January 10, 2003 - v2
Checksum:i72D49DFE4044B44E
GO

Sequence cautioni

The sequence AAD43621 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAF19534 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108N → T in AAA61348 (PubMed:7991698).Curated1
Sequence conflicti114G → A in AAA61348 (PubMed:7991698).Curated1
Sequence conflicti190A → D in AAA61348 (PubMed:7991698).Curated1
Sequence conflicti266 – 268QND → RNE in AAA61348 (PubMed:7991698).Curated3
Sequence conflicti343R → S in AAA61348 (PubMed:7991698).Curated1
Sequence conflicti401M → V in AAA61348 (PubMed:7991698).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31891 mRNA Translation: AAA61348.1
Y11689 Genomic DNA Translation: CAA72385.1
AC005698 Genomic DNA Translation: AAD43621.1 Sequence problems.
AC007190 Genomic DNA Translation: AAF19534.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE33989.1
CP002684 Genomic DNA Translation: AEE33990.1
AY063804 mRNA Translation: AAL36160.1
AY091275 mRNA Translation: AAM14214.1
RefSeqiNP_001031221.1, NM_001036144.2
NP_176452.1, NM_104942.4
UniGeneiAt.386

Genome annotation databases

EnsemblPlantsiAT1G62640.1; AT1G62640.1; AT1G62640
AT1G62640.2; AT1G62640.2; AT1G62640
GeneIDi842561
GrameneiAT1G62640.1; AT1G62640.1; AT1G62640
AT1G62640.2; AT1G62640.2; AT1G62640
KEGGiath:AT1G62640

Similar proteinsi

Entry informationi

Entry nameiFABH_ARATH
AccessioniPrimary (citable) accession number: P49243
Secondary accession number(s): P93722, Q9SI84, Q9SXD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 10, 2003
Last modified: April 25, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health