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Protein

3-oxoacyl-[acyl-carrier-protein] synthase III, chloroplastic

Gene

At1g62640

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. KAS III catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei179 – 1791By similarity
Active sitei330 – 3301By similarity
Active sitei360 – 3601By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciARA:AT1G62640-MONOMER.
ARA:GQT-1747-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase III, chloroplastic (EC:2.3.1.180)
Alternative name(s):
Beta-ketoacyl-ACP synthase III
Short name:
KAS III
Gene namesi
Ordered Locus Names:At1g62640
ORF Names:F23N19.2, T3P18.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G62640.

Subcellular locationi

GO - Cellular componenti

  • chloroplast Source: TAIR
  • chloroplast stroma Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 7474ChloroplastSequence analysisAdd
BLAST
Chaini75 – 4043303-oxoacyl-[acyl-carrier-protein] synthase III, chloroplasticPRO_0000008732Add
BLAST

Proteomic databases

PaxDbiP49243.
PRIDEiP49243.

Expressioni

Gene expression databases

GenevisibleiP49243. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G62640.1.

Structurei

3D structure databases

ProteinModelPortaliP49243.
SMRiP49243. Positions 71-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FabH family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IH2M. Eukaryota.
COG0332. LUCA.
HOGENOMiHOG000246674.
InParanoidiP49243.
KOiK00648.
OMAiESGMYEN.
OrthoDBiEOG09360ECQ.
PhylomeDBiP49243.

Family and domain databases

Gene3Di3.40.47.10. 3 hits.
HAMAPiMF_01815. FabH. 1 hit.
InterProiIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 1 hit.
TIGRFAMsiTIGR00747. fabH. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49243-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANASGFFTH PSIPNLRSRI HVPVRVSGSG FCVSNRFSKR VLCSSVSSVD
60 70 80 90 100
KDASSSPSQY QRPRLVPSGC KLIGCGSAVP SLLISNDDLA KIVDTNDEWI
110 120 130 140 150
ATRTGIRNRR VVSGKDSLVG LAVEAATKAL EMAEVVPEDI DLVLMCTSTP
160 170 180 190 200
DDLFGAAPQI QKALGCTKNP LAYDITAACS GFVLGLVSAA CHIRGGGFKN
210 220 230 240 250
VLVIGADSLS RFVDWTDRGT CILFGDAAGA VVVQACDIED DGLFSFDVHS
260 270 280 290 300
DGDGRRHLNA SVKESQNDGE SSSNGSVFGD FPPKQSSYSC IQMNGKEVFR
310 320 330 340 350
FAVKCVPQSI ESALQKAGLP ASAIDWLLLH QANQRIIDSV ATRLHFPPER
360 370 380 390 400
VISNLANYGN TSAASIPLAL DEAVRSGKVK PGHTIATSGF GAGLTWGSAI

MRWR
Length:404
Mass (Da):42,847
Last modified:January 10, 2003 - v2
Checksum:i72D49DFE4044B44E
GO

Sequence cautioni

The sequence AAD43621 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AAF19534 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti108 – 1081N → T in AAA61348 (PubMed:7991698).Curated
Sequence conflicti114 – 1141G → A in AAA61348 (PubMed:7991698).Curated
Sequence conflicti190 – 1901A → D in AAA61348 (PubMed:7991698).Curated
Sequence conflicti266 – 2683QND → RNE in AAA61348 (PubMed:7991698).Curated
Sequence conflicti343 – 3431R → S in AAA61348 (PubMed:7991698).Curated
Sequence conflicti401 – 4011M → V in AAA61348 (PubMed:7991698).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31891 mRNA. Translation: AAA61348.1.
Y11689 Genomic DNA. Translation: CAA72385.1.
AC005698 Genomic DNA. Translation: AAD43621.1. Sequence problems.
AC007190 Genomic DNA. Translation: AAF19534.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE33989.1.
CP002684 Genomic DNA. Translation: AEE33990.1.
AY063804 mRNA. Translation: AAL36160.1.
AY091275 mRNA. Translation: AAM14214.1.
RefSeqiNP_001031221.1. NM_001036144.1.
NP_176452.1. NM_104942.3.
UniGeneiAt.386.

Genome annotation databases

EnsemblPlantsiAT1G62640.1; AT1G62640.1; AT1G62640.
AT1G62640.2; AT1G62640.2; AT1G62640.
GeneIDi842561.
GrameneiAT1G62640.1; AT1G62640.1; AT1G62640.
AT1G62640.2; AT1G62640.2; AT1G62640.
KEGGiath:AT1G62640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31891 mRNA. Translation: AAA61348.1.
Y11689 Genomic DNA. Translation: CAA72385.1.
AC005698 Genomic DNA. Translation: AAD43621.1. Sequence problems.
AC007190 Genomic DNA. Translation: AAF19534.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE33989.1.
CP002684 Genomic DNA. Translation: AEE33990.1.
AY063804 mRNA. Translation: AAL36160.1.
AY091275 mRNA. Translation: AAM14214.1.
RefSeqiNP_001031221.1. NM_001036144.1.
NP_176452.1. NM_104942.3.
UniGeneiAt.386.

3D structure databases

ProteinModelPortaliP49243.
SMRiP49243. Positions 71-403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G62640.1.

Proteomic databases

PaxDbiP49243.
PRIDEiP49243.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G62640.1; AT1G62640.1; AT1G62640.
AT1G62640.2; AT1G62640.2; AT1G62640.
GeneIDi842561.
GrameneiAT1G62640.1; AT1G62640.1; AT1G62640.
AT1G62640.2; AT1G62640.2; AT1G62640.
KEGGiath:AT1G62640.

Organism-specific databases

TAIRiAT1G62640.

Phylogenomic databases

eggNOGiENOG410IH2M. Eukaryota.
COG0332. LUCA.
HOGENOMiHOG000246674.
InParanoidiP49243.
KOiK00648.
OMAiESGMYEN.
OrthoDBiEOG09360ECQ.
PhylomeDBiP49243.

Enzyme and pathway databases

UniPathwayiUPA00094.
BioCyciARA:AT1G62640-MONOMER.
ARA:GQT-1747-MONOMER.

Miscellaneous databases

PROiP49243.

Gene expression databases

GenevisibleiP49243. AT.

Family and domain databases

Gene3Di3.40.47.10. 3 hits.
HAMAPiMF_01815. FabH. 1 hit.
InterProiIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 1 hit.
TIGRFAMsiTIGR00747. fabH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFABH_ARATH
AccessioniPrimary (citable) accession number: P49243
Secondary accession number(s): P93722, Q9SI84, Q9SXD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 10, 2003
Last modified: September 7, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.