CX3C chemokine receptor 1 - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot P49238 (CX3C1_HUMAN)

Last modified November 25, 2008. Version 76. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    CX3C chemokine receptor 1
      Short name=C-X3-C CKR-1
      Short name=CX3CR1
Alternative name(s):
    Fractalkine receptor
    G-protein coupled receptor 13
    V28
    Beta chemokine receptor-like 1
    CMK-BRL-1
    CMKBLR1

Gene names

Name:	CX3CR1
Synonyms:	CMKBRL1, GPR13

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	355 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV coreceptors than isoform 1.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in lymphoid and neural tissues.
Polymorphism	Variations in CX3CR1 are associated with rapid progression to AIDS [MIM:609423]. Increased susceptibility to HIV infection and rapid progression to AIDS are associated with the Ile-249/Met-280 haplotype.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

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Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Traceable author statement. Source: ProtInc cell adhesion Traceable author statement. Source: ProtInc cellular defense response Traceable author statement. Source: ProtInc chemotaxis Traceable author statement. Source: ProtInc response to wounding Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Ref.6 Traceable author statement. Source: ProtInc
Molecular function	C-X-C chemokine receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P49238-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P49238-2) The sequence of this isoform differs from the canonical sequence as follows: 1-1: M → MREPLEALKLADLDFRKSSLASGWRMASGAFT

Isoform 3 (identifier: P49238-3) The sequence of this isoform differs from the canonical sequence as follows: 1-1: M → MASGAFT

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 355

355

CX3C chemokine receptor 1

PRO_0000069326

Regions

Topological domain

1 – 31

Extracellular Potential

Transmembrane

32 – 59

1 Potential

Topological domain

60 – 69

Cytoplasmic Potential

Transmembrane

70 – 90

2 Potential

Topological domain

91 – 103

Extracellular Potential

Transmembrane

104 – 125

3 Potential

Topological domain

126 – 142

Cytoplasmic Potential

Transmembrane

143 – 167

4 Potential

Topological domain

168 – 195

Extracellular Potential

Transmembrane

196 – 215

5 Potential

Topological domain

216 – 231

Cytoplasmic Potential

Transmembrane

232 – 256

6 Potential

Topological domain

257 – 273

Extracellular Potential

Transmembrane

274 – 297

7 Potential

Topological domain

298 – 355

Cytoplasmic Potential

Amino acid modifications

Disulfide bond

102 ↔ 175

By similarity

Natural variations

Alternative sequence

M → MREPLEALKLADLDFRKSSL ASGWRMASGAFT in isoform 2.

VSP_009681

Alternative sequence

M → MASGAFT in isoform 3.

VSP_009682

Natural variant

T → A

VAR_010041

Natural variant

122

V → I

VAR_010042

Natural variant

147

V → I: dbSNP rs3732380.

VAR_022062

Natural variant

249

V → I Common polymorphism in Caucasian population; associated with a markedly reduced risk of acute coronary artery disease. dbSNP rs3732379.

VAR_010043

Natural variant

280

T → M Common polymorphism in Caucasian population. dbSNP rs3732378.

VAR_010044

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Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: C59DC5F4C4312F22 Show »	FASTA	355	40,396
10 20 30 40 50 60 MDQFPESVTE NFEYDDLAEA CYIGDIVVFG TVFLSIFYSV IFAIGLVGNL LVVFALTNSK 70 80 90 100 110 120 KPKSVTDIYL LNLALSDLLF VATLPFWTHY LINEKGLHNA MCKFTTAFFF IGFFGSIFFI 130 140 150 160 170 180 TVISIDRYLA IVLAANSMNN RTVQHGVTIS LGVWAAAILV AAPQFMFTKQ KENECLGDYP 190 200 210 220 230 240 EVLQEIWPVL RNVETNFLGF LLPLLIMSYC YFRIIQTLFS CKNHKKAKAI KLILLVVIVF 250 260 270 280 290 300 FLFWTPYNVM IFLETLKLYD FFPSCDMRKD LRLALSVTET VAFSHCCLNP LIYAFAGEKF 310 320 330 340 350 RRYLYHLYGK CLAVLCGRSV HVDFSSSESQ RSRHGSVLSS NFTYHTSDGD ALLLL « Hide
Isoform 2 [UniParc]. Checksum: 8067509EFF2DE3E7 Show »		386	43,803
10 20 30 40 50 60 MREPLEALKL ADLDFRKSSL ASGWRMASGA FTDQFPESVT ENFEYDDLAE ACYIGDIVVF 70 80 90 100 110 120 GTVFLSIFYS VIFAIGLVGN LLVVFALTNS KKPKSVTDIY LLNLALSDLL FVATLPFWTH 130 140 150 160 170 180 YLINEKGLHN AMCKFTTAFF FIGFFGSIFF ITVISIDRYL AIVLAANSMN NRTVQHGVTI 190 200 210 220 230 240 SLGVWAAAIL VAAPQFMFTK QKENECLGDY PEVLQEIWPV LRNVETNFLG FLLPLLIMSY 250 260 270 280 290 300 CYFRIIQTLF SCKNHKKAKA IKLILLVVIV FFLFWTPYNV MIFLETLKLY DFFPSCDMRK 310 320 330 340 350 360 DLRLALSVTE TVAFSHCCLN PLIYAFAGEK FRRYLYHLYG KCLAVLCGRS VHVDFSSSES 370 380 QRSRHGSVLS SNFTYHTSDG DALLLL « Hide
Isoform 3 [UniParc]. Checksum: A241334D4015A382 Show »		361	40,931
10 20 30 40 50 60 MASGAFTDQF PESVTENFEY DDLAEACYIG DIVVFGTVFL SIFYSVIFAI GLVGNLLVVF 70 80 90 100 110 120 ALTNSKKPKS VTDIYLLNLA LSDLLFVATL PFWTHYLINE KGLHNAMCKF TTAFFFIGFF 130 140 150 160 170 180 GSIFFITVIS IDRYLAIVLA ANSMNNRTVQ HGVTISLGVW AAAILVAAPQ FMFTKQKENE 190 200 210 220 230 240 CLGDYPEVLQ EIWPVLRNVE TNFLGFLLPL LIMSYCYFRI IQTLFSCKNH KKAKAIKLIL 250 260 270 280 290 300 LVVIVFFLFW TPYNVMIFLE TLKLYDFFPS CDMRKDLRLA LSVTETVAFS HCCLNPLIYA 310 320 330 340 350 360 FAGEKFRRYL YHLYGKCLAV LCGRSVHVDF SSSESQRSRH GSVLSSNFTY HTSDGDALLL L « Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues." Raport C.J., Schweickart V.L., Eddy R.L. Jr., Shows T.B., Gray P.W. Gene 163:295-299(1995) [PubMed: 7590284] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Cloning, chromosomal localization, and RNA expression of a human beta chemokine receptor-like gene." Combadiere C., Ahuja S.K., Murphy P.M. DNA Cell Biol. 14:673-680(1995) [PubMed: 7646814] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Genomic organization and evolution of the CX3CR1/CCR8 chemokine receptor locus." DeVries M.E., Cao H., Wang J., Xu L., Kelvin A.A., Ran L., Chau L.A., Madrenas J., Hegele R.A., Kelvin D.J. J. Biol. Chem. 278:11985-11994(2003) [PubMed: 12551893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Blood.
[5]	"Two novel fully functional isoforms of CX3CR1 are potent HIV coreceptors." Garin A., Tarantino N., Faure S., Daoudi M., Lecureuil C., Bourdais A., Debre P., Deterre P., Combadiere C. J. Immunol. 171:5305-5312(2003) [PubMed: 14607932] [Abstract] Cited for: ALTERNATIVE SPLICING, CHARACTERIZATION OF ISOFORMS 2 AND 3.
[6]	"Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion." Imai T., Hieshima K., Haskell C., Baba M., Nagira M., Nishimura M., Kakizaki M., Takagi S., Nomiyama H., Schall T.J., Yoshie O. Cell 91:521-530(1997) [PubMed: 9390561] [Abstract] Cited for: CHARACTERIZATION.
[7]	"Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1." Combadiere C., Salzwedel K., Smith E.D., Tiffany H.L., Berger E.A., Murphy P.M. J. Biol. Chem. 273:23799-23804(1998) [PubMed: 9726990] [Abstract] Cited for: CHARACTERIZATION.
[8]	"Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1." Faure S., Meyer L., Costagliola D., Vaneensberghe C., Genin E., Autran B., Delfraissy J.-F., McDermott D.H., Murphy P.M., Debre P., Theodorou I., Combadiere C. Science 287:2274-2277(2000) [PubMed: 10731151] [Abstract] Cited for: VARIANTS ALA-57; ILE-122; ILE-249 AND MET-280.
[9]	"Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease." Moatti D., Faure S., Fumeron F., Amara M.E.-W., Seknadji P., McDermott D.H., Debre P., Aumont M.C., Murphy P.M., de Prost D., Combadiere C. Blood 97:1925-1928(2001) [PubMed: 11264153] [Abstract] Cited for: VARIANT ILE-249.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	U20350 mRNA. Translation: AAA91783.1. U28934 mRNA. Translation: AAA87032.1. AY016370 Genomic DNA. Translation: AAK08627.1. BC028078 mRNA. Translation: AAH28078.1.
PIR	JC4304.
RefSeq	NP_001328.1.
UniGene	Hs.78913
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:5879N.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P49238.
Genome annotation databases
Ensembl	ENSG00000168329. Homo sapiens. [Contig view]
GeneID	1524.
KEGG	hsa:1524.
Organism-specific databases
H-InvDB	HIX0003188.
HGNC	HGNC:2558. CX3CR1.
MIM	601470. gene. 609423. phenotype.
PharmGKB	PA27054.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P49238.
HOVERGEN	P49238.
Gene expression databases
ArrayExpress	P49238.
CleanEx	HS_CX3CR1.
GermOnline	ENSG00000168329. Homo sapiens.
Family and domain databases
InterPro	IPR005387. CX3C_fract_rcpt. IPR001277. CXC_4_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00645. CXCCHMKINER4. PR01562. FRACTALKINER. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	6311.
SOURCE	Search...

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Entry information

Entry name

CX3C1_HUMAN

Accession

Primary (citable) accession number: P49238

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	November 25, 2008
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

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List of 7-transmembrane G-linked receptor entries

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Human chromosome 3: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents