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Protein

Kunitz-type protease inhibitor 3

Gene

SPINT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI02.969.

Names & Taxonomyi

Protein namesi
Recommended name:
Kunitz-type protease inhibitor 3
Alternative name(s):
HKIB9
Gene namesi
Name:SPINT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:11248. SPINT3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36078.

Polymorphism and mutation databases

BioMutaiSPINT3.
DMDMi152031689.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 8965Kunitz-type protease inhibitor 3PRO_0000016887Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 86PROSITE-ProRule annotation
Disulfide bondi45 ↔ 69PROSITE-ProRule annotation
Disulfide bondi61 ↔ 82PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP49223.
PeptideAtlasiP49223.
PRIDEiP49223.

Expressioni

Gene expression databases

BgeeiP49223.
CleanExiHS_SPINT3.
GenevisibleiP49223. HS.

Organism-specific databases

HPAiHPA057848.

Interactioni

Protein-protein interaction databases

BioGridi116029. 1 interaction.
STRINGi9606.ENSP00000217428.

Structurei

3D structure databases

ProteinModelPortaliP49223.
SMRiP49223. Positions 43-86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 8651BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BPTI/Kunitz inhibitor domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4295. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00530000063252.
HOGENOMiHOG000007327.
HOVERGENiHBG006193.
InParanoidiP49223.
OMAiCKPPGES.
OrthoDBiEOG754HSR.
PhylomeDBiP49223.
TreeFamiTF327278.

Family and domain databases

Gene3Di4.10.410.10. 1 hit.
InterProiIPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PfamiPF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 1 hit.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 1 hit.
PROSITEiPS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49223-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLQASLSFL LILTLCLELR SELARDTIKD LLPNVCAFPM EKGPCQTYMT
60 70 80
RWFFNFETGE CELFAYGGCG GNSNNFLRKE KCEKFCKFT
Length:89
Mass (Da):10,252
Last modified:July 10, 2007 - v3
Checksum:iC9C471371CD77A9F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771L → S.
Corresponds to variant rs6032259 [ dbSNP | Ensembl ].
VAR_059443

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY372172 mRNA. Translation: AAR17081.2.
AL031663 Genomic DNA. Translation: CAB37639.3.
X77166 Genomic DNA. Translation: CAA54410.1.
CCDSiCCDS46608.1.
PIRiS41399.
RefSeqiNP_006643.1. NM_006652.1.
UniGeneiHs.370724.

Genome annotation databases

EnsembliENST00000217428; ENSP00000217428; ENSG00000101446.
GeneIDi10816.
KEGGihsa:10816.
UCSCiuc010ghg.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY372172 mRNA. Translation: AAR17081.2.
AL031663 Genomic DNA. Translation: CAB37639.3.
X77166 Genomic DNA. Translation: CAA54410.1.
CCDSiCCDS46608.1.
PIRiS41399.
RefSeqiNP_006643.1. NM_006652.1.
UniGeneiHs.370724.

3D structure databases

ProteinModelPortaliP49223.
SMRiP49223. Positions 43-86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116029. 1 interaction.
STRINGi9606.ENSP00000217428.

Protein family/group databases

MEROPSiI02.969.

Polymorphism and mutation databases

BioMutaiSPINT3.
DMDMi152031689.

Proteomic databases

PaxDbiP49223.
PeptideAtlasiP49223.
PRIDEiP49223.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217428; ENSP00000217428; ENSG00000101446.
GeneIDi10816.
KEGGihsa:10816.
UCSCiuc010ghg.1. human.

Organism-specific databases

CTDi10816.
GeneCardsiSPINT3.
HGNCiHGNC:11248. SPINT3.
HPAiHPA057848.
MIMi613941. gene.
neXtProtiNX_P49223.
PharmGKBiPA36078.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4295. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00530000063252.
HOGENOMiHOG000007327.
HOVERGENiHBG006193.
InParanoidiP49223.
OMAiCKPPGES.
OrthoDBiEOG754HSR.
PhylomeDBiP49223.
TreeFamiTF327278.

Miscellaneous databases

GenomeRNAii10816.
PROiP49223.
SOURCEiSearch...

Gene expression databases

BgeeiP49223.
CleanExiHS_SPINT3.
GenevisibleiP49223. HS.

Family and domain databases

Gene3Di4.10.410.10. 1 hit.
InterProiIPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PfamiPF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 1 hit.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 1 hit.
PROSITEiPS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Several Kunitz-type serine proteinase inhibitors are expressed in the epididymis."
    Clauss A., Lundwall A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Epididymis.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "A novel human Kunitz-type protease inhibitor and variants thereof."
    Norris F., Norris K., Bjoern S.E., Petersen L.C., Foster D.C., Sprecher C.A.
    Patent number WO9314123, 22-JUL-1993
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-89.
    Tissue: Blood and Placenta.

Entry informationi

Entry nameiSPIT3_HUMAN
AccessioniPrimary (citable) accession number: P49223
Secondary accession number(s): A6NCQ6, Q6UDR8, Q96KK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 10, 2007
Last modified: July 6, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.