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Protein

Kunitz-type protease inhibitor 3

Gene

SPINT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101446-MONOMER.

Protein family/group databases

MEROPSiI02.969.

Names & Taxonomyi

Protein namesi
Recommended name:
Kunitz-type protease inhibitor 3
Alternative name(s):
HKIB9
Gene namesi
Name:SPINT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:11248. SPINT3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101446.
PharmGKBiPA36078.

Polymorphism and mutation databases

BioMutaiSPINT3.
DMDMi152031689.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001688725 – 89Kunitz-type protease inhibitor 3Add BLAST65

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 86PROSITE-ProRule annotation
Disulfide bondi45 ↔ 69PROSITE-ProRule annotation
Disulfide bondi61 ↔ 82PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP49223.
PeptideAtlasiP49223.
PRIDEiP49223.

Expressioni

Gene expression databases

BgeeiENSG00000101446.
CleanExiHS_SPINT3.
GenevisibleiP49223. HS.

Organism-specific databases

HPAiHPA057848.

Interactioni

Protein-protein interaction databases

BioGridi116029. 1 interactor.
STRINGi9606.ENSP00000217428.

Structurei

3D structure databases

ProteinModelPortaliP49223.
SMRiP49223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 86BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd BLAST51

Sequence similaritiesi

Contains 1 BPTI/Kunitz inhibitor domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4295. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00740000114929.
HOGENOMiHOG000007327.
HOVERGENiHBG006193.
InParanoidiP49223.
OMAiCKPPGES.
OrthoDBiEOG091G14M8.
PhylomeDBiP49223.
TreeFamiTF327278.

Family and domain databases

Gene3Di4.10.410.10. 1 hit.
InterProiIPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PfamiPF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 1 hit.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 1 hit.
PROSITEiPS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49223-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLQASLSFL LILTLCLELR SELARDTIKD LLPNVCAFPM EKGPCQTYMT
60 70 80
RWFFNFETGE CELFAYGGCG GNSNNFLRKE KCEKFCKFT
Length:89
Mass (Da):10,252
Last modified:July 10, 2007 - v3
Checksum:iC9C471371CD77A9F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05944377L → S.Corresponds to variant rs6032259dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY372172 mRNA. Translation: AAR17081.2.
AL031663 Genomic DNA. Translation: CAB37639.3.
X77166 Genomic DNA. Translation: CAA54410.1.
CCDSiCCDS46608.1.
PIRiS41399.
RefSeqiNP_006643.1. NM_006652.1.
UniGeneiHs.370724.

Genome annotation databases

EnsembliENST00000217428; ENSP00000217428; ENSG00000101446.
GeneIDi10816.
KEGGihsa:10816.
UCSCiuc010ghg.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY372172 mRNA. Translation: AAR17081.2.
AL031663 Genomic DNA. Translation: CAB37639.3.
X77166 Genomic DNA. Translation: CAA54410.1.
CCDSiCCDS46608.1.
PIRiS41399.
RefSeqiNP_006643.1. NM_006652.1.
UniGeneiHs.370724.

3D structure databases

ProteinModelPortaliP49223.
SMRiP49223.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116029. 1 interactor.
STRINGi9606.ENSP00000217428.

Protein family/group databases

MEROPSiI02.969.

Polymorphism and mutation databases

BioMutaiSPINT3.
DMDMi152031689.

Proteomic databases

PaxDbiP49223.
PeptideAtlasiP49223.
PRIDEiP49223.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217428; ENSP00000217428; ENSG00000101446.
GeneIDi10816.
KEGGihsa:10816.
UCSCiuc010ghg.1. human.

Organism-specific databases

CTDi10816.
GeneCardsiSPINT3.
HGNCiHGNC:11248. SPINT3.
HPAiHPA057848.
MIMi613941. gene.
neXtProtiNX_P49223.
OpenTargetsiENSG00000101446.
PharmGKBiPA36078.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4295. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00740000114929.
HOGENOMiHOG000007327.
HOVERGENiHBG006193.
InParanoidiP49223.
OMAiCKPPGES.
OrthoDBiEOG091G14M8.
PhylomeDBiP49223.
TreeFamiTF327278.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101446-MONOMER.

Miscellaneous databases

GenomeRNAii10816.
PROiP49223.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101446.
CleanExiHS_SPINT3.
GenevisibleiP49223. HS.

Family and domain databases

Gene3Di4.10.410.10. 1 hit.
InterProiIPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PfamiPF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 1 hit.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 1 hit.
PROSITEiPS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPIT3_HUMAN
AccessioniPrimary (citable) accession number: P49223
Secondary accession number(s): A6NCQ6, Q6UDR8, Q96KK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 10, 2007
Last modified: November 30, 2016
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.