Reviewed, UniProtKB/Swiss-Prot P49221 (TGM4_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein-glutamine gamma-glutamyltransferase 4
    EC=2.3.2.13
Alternative name(s):
    Transglutaminase-4
      Short name=TGase-4
    Prostate transglutaminase
    TGP
    TG(P)
    Prostate-specific transglutaminase
    Fibrinoligase

Gene names

Name:

TGM4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	684 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.
Catalytic activity	Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).
Cofactor	Binds 1 calcium ion per subunit By similarity.
Tissue specificity	Prostate.
Sequence similarities	Belongs to the transglutaminase superfamily. Transglutaminase family.

Ontologies

Keywords
Ligand	Calcium Metal-binding
Molecular function	Acyltransferase Transferase
Gene Ontology (GO)
Biological process	peptide cross-linking Non-traceable author statement. Source: UniProtKB protein amino acid polyamination Non-traceable author statement. Source: UniProtKB
Molecular function	acyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein-glutamine gamma-glutamyltransferase activity Ref.1 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 684	684	Protein-glutamine gamma-glutamyltransferase 4		PRO_0000213711
Sites
	Active site	268	1	By similarity
	Active site	327	1	By similarity
	Active site	350	1	By similarity
	Metal binding	390	1	Calcium By similarity
	Metal binding	392	1	Calcium By similarity
	Metal binding	442	1	Calcium By similarity
	Metal binding	447	1	Calcium By similarity
Experimental info
	Sequence conflict	313	1	E → K in AAC50516. Ref.3
	Sequence conflict	353	1	P → S in AAH07003. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P49221-1 [UniParc]. Last modified December 15, 1998. Version 2. Checksum: 64A3E754EA46BFEC	FASTA	684	77,145
	10 20 30 40 50 60 MMDASKELQV LHIDFLNQDN AVSHHTWEFQ TSSPVFRRGQ VFHLRLVLNQ PLQSYHQLKL 70 80 90 100 110 120 EFSTGPNPSI AKHTLVVLDP RTPSDHYNWQ ATLQNESGKE VTVAVTSSPN AILGKYQLNV 130 140 150 160 170 180 KTGNHILKSE ENILYLLFNP WCKEDMVFMP DEDERKEYIL NDTGCHYVGA ARSIKCKPWN 190 200 210 220 230 240 FGQFEKNVLD CCISLLTESS LKPTDRRDPV LVCRAMCAMM SFEKGQGVLI GNWTGDYEGG 250 260 270 280 290 300 TAPYKWTGSA PILQQYYNTK QAVCFGQCWV FAGILTTVLR ALGIPARSVT GFDSAHDTER 310 320 330 340 350 360 NLTVDTYVNE NGEKITSMTH DSVWNFHVWT DAWMKRPDLP KGYDGWQAVD ATPQERSQGV 370 380 390 400 410 420 FCCGPSPLTA IRKGDIFIVY DTRFVFSEVN GDRLIWLVKM VNGQEELHVI SMETTSIGKN 430 440 450 460 470 480 ISTKAVGQDR RRDITYEYKY PEGSSEERQV MDHAFLLLSS EREHRRPVKE NFLHMSVQSD 490 500 510 520 530 540 DVLLGNSVNF TVILKRKTAA LQNVNILGSF ELQLYTGKKM AKLCDLNKTS QIQGQVSEVT 550 560 570 580 590 600 LTLDSKTYIN SLAILDDEPV IRGFIIAEIV ESKEIMASEV FTSFQYPEFS IELPNTGRIG 610 620 630 640 650 660 QLLVCNCIFK NTLAIPLTDV KFSLESLGIS SLQTSDHGTV QPGETIQSQI KCTPIKTGPK 670 680 KFIVKLSSKQ VKEINAQKIV LITK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of a novel transglutaminase cDNA from a human prostate cDNA library." Grant F.J., Taylor D.A., Sheppard P.O., Mathewes S.L., Lint W., Vanaja E., Bishop P.D., O'Hara P.J. Biochem. Biophys. Res. Commun. 203:1117-1123(1994) [PubMed: 7916568] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Prostate.
[2]	Grant F.J. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"Tissue specific and androgen-regulated expression of human prostate-specific transglutaminase." Dubbink H.J., Verkaik N.S., Faber P.W., Trapman J., Schroeder F.H., Romijn J.C. Biochem. J. 315:901-908(1996) [PubMed: 8645175] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. Tissue: Prostate.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L34840 mRNA. Translation: AAB95430.1. U31905 mRNA. Translation: AAC50516.1. BC007003 mRNA. Translation: AAH07003.1.
PIR	S71105.
RefSeq	NP_003232.2.
UniGene	Hs.438265
3D structure databases
HSSP	HSSP built from PDB template 1L9M based on UniProtKB Q08188.
ModBase	Search...
PTM databases
PhosphoSite	P49221.
Genome annotation databases
Ensembl	ENSG00000163810. Homo sapiens. [Contig view]
GeneID	7047.
KEGG	hsa:7047.
Organism-specific databases
H-InvDB	HIX0003228.
HGNC	HGNC:11780. TGM4.
MIM	600585. gene.
PharmGKB	PA36493.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P49221.
HOVERGEN	P49221.
Gene expression databases
ArrayExpress	P49221.
CleanEx	HS_TGM4.
GermOnline	ENSG00000163810. Homo sapiens.
Family and domain databases
InterPro	IPR008957. Fibronectin_typ-III-like_fold. IPR013783. Ig-like_fold. IPR008958. Transglutaminase_C. IPR013808. Transglutaminase_CS. IPR001102. Transglutaminase_N. IPR002931. Trnsglumase_like. [Graphical view]
Gene3D	G3DSA:2.60.40.30. FN_III-like. 1 hit. G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
Pfam	PF00927. Transglut_C. 1 hit. PF01841. Transglut_core. 1 hit. PF00868. Transglut_N. 1 hit. [Graphical view]
SMART	SM00460. TGc. 1 hit. [Graphical view]
PROSITE	PS00547. TRANSGLUTAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB00130. L-Glutamine.
NextBio	27537.
SOURCE	Search...

Entry information

Entry name

TGM4_HUMAN

Accession

Primary (citable) accession number: P49221
Secondary accession number(s): Q16707, Q96QN4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	December 15, 1998
Last modified:	November 25, 2008
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)