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P49221

- TGM4_HUMAN

UniProt

P49221 - TGM4_HUMAN

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Protein

Protein-glutamine gamma-glutamyltransferase 4

Gene
TGM4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.

Cofactori

Binds 1 calcium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei268 – 2681 By similarity
Active sitei327 – 3271 By similarity
Active sitei350 – 3501 By similarity
Metal bindingi390 – 3901Calcium By similarity
Metal bindingi392 – 3921Calcium By similarity
Metal bindingi442 – 4421Calcium By similarity
Metal bindingi447 – 4471Calcium By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB

GO - Biological processi

  1. mating plug formation Source: Ensembl
  2. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase 4 (EC:2.3.2.13)
Alternative name(s):
Fibrinoligase
Prostate transglutaminase
Prostate-specific transglutaminase
Transglutaminase P
Short name:
TG(P)
Short name:
TGP
Short name:
TGase P
Transglutaminase-4
Short name:
TGase-4
Gene namesi
Name:TGM4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:11780. TGM4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProt
  2. extracellular matrix Source: UniProt
  3. extracellular vesicular exosome Source: UniProt
  4. Golgi apparatus Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36493.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 684684Protein-glutamine gamma-glutamyltransferase 4PRO_0000213711Add
BLAST

Proteomic databases

PaxDbiP49221.
PRIDEiP49221.

PTM databases

PhosphoSiteiP49221.

Expressioni

Tissue specificityi

Prostate.

Gene expression databases

ArrayExpressiP49221.
BgeeiP49221.
CleanExiHS_TGM4.
GenevestigatoriP49221.

Organism-specific databases

HPAiCAB033571.
HPA032072.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

IntActiP49221. 2 interactions.
STRINGi9606.ENSP00000296125.

Structurei

3D structure databases

ProteinModelPortaliP49221.
SMRiP49221. Positions 8-676.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG80379.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
KOiK05621.
OMAiHVWTDAW.
OrthoDBiEOG7WT40M.
PhylomeDBiP49221.
TreeFamiTF324278.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 1 hit.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49221-1 [UniParc]FASTAAdd to Basket

« Hide

MMDASKELQV LHIDFLNQDN AVSHHTWEFQ TSSPVFRRGQ VFHLRLVLNQ    50
PLQSYHQLKL EFSTGPNPSI AKHTLVVLDP RTPSDHYNWQ ATLQNESGKE 100
VTVAVTSSPN AILGKYQLNV KTGNHILKSE ENILYLLFNP WCKEDMVFMP 150
DEDERKEYIL NDTGCHYVGA ARSIKCKPWN FGQFEKNVLD CCISLLTESS 200
LKPTDRRDPV LVCRAMCAMM SFEKGQGVLI GNWTGDYEGG TAPYKWTGSA 250
PILQQYYNTK QAVCFGQCWV FAGILTTVLR ALGIPARSVT GFDSAHDTER 300
NLTVDTYVNE NGEKITSMTH DSVWNFHVWT DAWMKRPDLP KGYDGWQAVD 350
ATPQERSQGV FCCGPSPLTA IRKGDIFIVY DTRFVFSEVN GDRLIWLVKM 400
VNGQEELHVI SMETTSIGKN ISTKAVGQDR RRDITYEYKY PEGSSEERQV 450
MDHAFLLLSS EREHRRPVKE NFLHMSVQSD DVLLGNSVNF TVILKRKTAA 500
LQNVNILGSF ELQLYTGKKM AKLCDLNKTS QIQGQVSEVT LTLDSKTYIN 550
SLAILDDEPV IRGFIIAEIV ESKEIMASEV FTSFQYPEFS IELPNTGRIG 600
QLLVCNCIFK NTLAIPLTDV KFSLESLGIS SLQTSDHGTV QPGETIQSQI 650
KCTPIKTGPK KFIVKLSSKQ VKEINAQKIV LITK 684
Length:684
Mass (Da):77,145
Last modified:December 15, 1998 - v2
Checksum:i64A3E754EA46BFEC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti100 – 1001E → D.
Corresponds to variant rs2271087 [ dbSNP | Ensembl ].
VAR_052555
Natural varianti244 – 2441Y → H.
Corresponds to variant rs9818345 [ dbSNP | Ensembl ].
VAR_052556
Natural varianti249 – 2491S → T.
Corresponds to variant rs937838 [ dbSNP | Ensembl ].
VAR_052557
Natural varianti313 – 3131E → K.1 Publication
Corresponds to variant rs1995641 [ dbSNP | Ensembl ].
VAR_052558
Natural varianti372 – 3721R → C.
Corresponds to variant rs3749195 [ dbSNP | Ensembl ].
VAR_052559
Natural varianti372 – 3721R → H.
Corresponds to variant rs13326552 [ dbSNP | Ensembl ].
VAR_052560
Natural varianti376 – 3761I → V.
Corresponds to variant rs17077022 [ dbSNP | Ensembl ].
VAR_052561
Natural varianti409 – 4091V → I.
Corresponds to variant rs9876921 [ dbSNP | Ensembl ].
VAR_052562
Natural varianti437 – 4371E → Q.
Corresponds to variant rs1395388 [ dbSNP | Ensembl ].
VAR_052563

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti353 – 3531P → S in AAH07003. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34840 mRNA. Translation: AAB95430.1.
U31905 mRNA. Translation: AAC50516.1.
BC007003 mRNA. Translation: AAH07003.1.
CCDSiCCDS2723.1.
PIRiS71105.
RefSeqiNP_003232.2. NM_003241.3.
UniGeneiHs.438265.

Genome annotation databases

EnsembliENST00000296125; ENSP00000296125; ENSG00000163810.
GeneIDi7047.
KEGGihsa:7047.
UCSCiuc003coc.4. human.

Polymorphism databases

DMDMi3915892.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34840 mRNA. Translation: AAB95430.1 .
U31905 mRNA. Translation: AAC50516.1 .
BC007003 mRNA. Translation: AAH07003.1 .
CCDSi CCDS2723.1.
PIRi S71105.
RefSeqi NP_003232.2. NM_003241.3.
UniGenei Hs.438265.

3D structure databases

ProteinModelPortali P49221.
SMRi P49221. Positions 8-676.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P49221. 2 interactions.
STRINGi 9606.ENSP00000296125.

Chemistry

DrugBanki DB00130. L-Glutamine.

PTM databases

PhosphoSitei P49221.

Polymorphism databases

DMDMi 3915892.

Proteomic databases

PaxDbi P49221.
PRIDEi P49221.

Protocols and materials databases

DNASUi 7047.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296125 ; ENSP00000296125 ; ENSG00000163810 .
GeneIDi 7047.
KEGGi hsa:7047.
UCSCi uc003coc.4. human.

Organism-specific databases

CTDi 7047.
GeneCardsi GC03P044916.
HGNCi HGNC:11780. TGM4.
HPAi CAB033571.
HPA032072.
MIMi 600585. gene.
neXtProti NX_P49221.
PharmGKBi PA36493.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG80379.
HOGENOMi HOG000231695.
HOVERGENi HBG004342.
KOi K05621.
OMAi HVWTDAW.
OrthoDBi EOG7WT40M.
PhylomeDBi P49221.
TreeFami TF324278.

Miscellaneous databases

GeneWikii TGM4.
GenomeRNAii 7047.
NextBioi 27537.
PROi P49221.
SOURCEi Search...

Gene expression databases

ArrayExpressi P49221.
Bgeei P49221.
CleanExi HS_TGM4.
Genevestigatori P49221.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 1 hit.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel transglutaminase cDNA from a human prostate cDNA library."
    Grant F.J., Taylor D.A., Sheppard P.O., Mathewes S.L., Lint W., Vanaja E., Bishop P.D., O'Hara P.J.
    Biochem. Biophys. Res. Commun. 203:1117-1123(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Prostate.
  2. Grant F.J.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Tissue specific and androgen-regulated expression of human prostate-specific transglutaminase."
    Dubbink H.J., Verkaik N.S., Faber P.W., Trapman J., Schroeder F.H., Romijn J.C.
    Biochem. J. 315:901-908(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, VARIANT LYS-313.
    Tissue: Prostate.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiTGM4_HUMAN
AccessioniPrimary (citable) accession number: P49221
Secondary accession number(s): Q16707, Q96QN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 15, 1998
Last modified: July 9, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3