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Protein

Protein-glutamine gamma-glutamyltransferase 4

Gene

TGM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei268PROSITE-ProRule annotation1
Active sitei327PROSITE-ProRule annotation1
Active sitei350PROSITE-ProRule annotation1
Metal bindingi390CalciumBy similarity1
Metal bindingi392CalciumBy similarity1
Metal bindingi442CalciumBy similarity1
Metal bindingi447CalciumBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:HS08943-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase 4 (EC:2.3.2.13)
Alternative name(s):
Fibrinoligase
Prostate transglutaminase
Prostate-specific transglutaminase
Transglutaminase P
Short name:
TG(P)
Short name:
TGP
Short name:
TGase P
Transglutaminase-4
Short name:
TGase-4
Gene namesi
Name:TGM4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:11780. TGM4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular matrix Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi7047.
OpenTargetsiENSG00000163810.
ENSG00000281886.
PharmGKBiPA36493.

Chemistry databases

DrugBankiDB00130. L-Glutamine.

Polymorphism and mutation databases

BioMutaiTGM4.
DMDMi3915892.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002137111 – 684Protein-glutamine gamma-glutamyltransferase 4Add BLAST684

Proteomic databases

MaxQBiP49221.
PaxDbiP49221.
PeptideAtlasiP49221.
PRIDEiP49221.

PTM databases

iPTMnetiP49221.
PhosphoSitePlusiP49221.

Expressioni

Tissue specificityi

Prostate.

Gene expression databases

BgeeiENSG00000163810.
CleanExiHS_TGM4.
ExpressionAtlasiP49221. baseline and differential.
GenevisibleiP49221. HS.

Organism-specific databases

HPAiCAB033571.
HPA032072.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi112905. 2 interactors.
IntActiP49221. 2 interactors.
STRINGi9606.ENSP00000296125.

Structurei

3D structure databases

ProteinModelPortaliP49221.
SMRiP49221.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IFMV. Eukaryota.
ENOG410XQEZ. LUCA.
GeneTreeiENSGT00760000119108.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiP49221.
KOiK05621.
OMAiTDAWMKR.
OrthoDBiEOG091G030K.
PhylomeDBiP49221.
TreeFamiTF324278.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR013808. Transglutaminase_AS.
IPR008958. Transglutaminase_C.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 1 hit.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49221-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDASKELQV LHIDFLNQDN AVSHHTWEFQ TSSPVFRRGQ VFHLRLVLNQ
60 70 80 90 100
PLQSYHQLKL EFSTGPNPSI AKHTLVVLDP RTPSDHYNWQ ATLQNESGKE
110 120 130 140 150
VTVAVTSSPN AILGKYQLNV KTGNHILKSE ENILYLLFNP WCKEDMVFMP
160 170 180 190 200
DEDERKEYIL NDTGCHYVGA ARSIKCKPWN FGQFEKNVLD CCISLLTESS
210 220 230 240 250
LKPTDRRDPV LVCRAMCAMM SFEKGQGVLI GNWTGDYEGG TAPYKWTGSA
260 270 280 290 300
PILQQYYNTK QAVCFGQCWV FAGILTTVLR ALGIPARSVT GFDSAHDTER
310 320 330 340 350
NLTVDTYVNE NGEKITSMTH DSVWNFHVWT DAWMKRPDLP KGYDGWQAVD
360 370 380 390 400
ATPQERSQGV FCCGPSPLTA IRKGDIFIVY DTRFVFSEVN GDRLIWLVKM
410 420 430 440 450
VNGQEELHVI SMETTSIGKN ISTKAVGQDR RRDITYEYKY PEGSSEERQV
460 470 480 490 500
MDHAFLLLSS EREHRRPVKE NFLHMSVQSD DVLLGNSVNF TVILKRKTAA
510 520 530 540 550
LQNVNILGSF ELQLYTGKKM AKLCDLNKTS QIQGQVSEVT LTLDSKTYIN
560 570 580 590 600
SLAILDDEPV IRGFIIAEIV ESKEIMASEV FTSFQYPEFS IELPNTGRIG
610 620 630 640 650
QLLVCNCIFK NTLAIPLTDV KFSLESLGIS SLQTSDHGTV QPGETIQSQI
660 670 680
KCTPIKTGPK KFIVKLSSKQ VKEINAQKIV LITK
Length:684
Mass (Da):77,145
Last modified:December 15, 1998 - v2
Checksum:i64A3E754EA46BFEC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti353P → S in AAH07003 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052555100E → D.Corresponds to variant rs2271087dbSNPEnsembl.1
Natural variantiVAR_052556244Y → H.Corresponds to variant rs9818345dbSNPEnsembl.1
Natural variantiVAR_052557249S → T.Corresponds to variant rs937838dbSNPEnsembl.1
Natural variantiVAR_052558313E → K.1 PublicationCorresponds to variant rs1995641dbSNPEnsembl.1
Natural variantiVAR_052559372R → C.Corresponds to variant rs3749195dbSNPEnsembl.1
Natural variantiVAR_052560372R → H.Corresponds to variant rs13326552dbSNPEnsembl.1
Natural variantiVAR_052561376I → V.Corresponds to variant rs17077022dbSNPEnsembl.1
Natural variantiVAR_052562409V → I.Corresponds to variant rs9876921dbSNPEnsembl.1
Natural variantiVAR_052563437E → Q.Corresponds to variant rs1395388dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34840 mRNA. Translation: AAB95430.1.
U31905 mRNA. Translation: AAC50516.1.
BC007003 mRNA. Translation: AAH07003.1.
CCDSiCCDS2723.1.
PIRiS71105.
RefSeqiNP_003232.2. NM_003241.3.
UniGeneiHs.438265.

Genome annotation databases

EnsembliENST00000296125; ENSP00000296125; ENSG00000163810.
ENST00000628744; ENSP00000487307; ENSG00000281886.
GeneIDi7047.
KEGGihsa:7047.
UCSCiuc003coc.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34840 mRNA. Translation: AAB95430.1.
U31905 mRNA. Translation: AAC50516.1.
BC007003 mRNA. Translation: AAH07003.1.
CCDSiCCDS2723.1.
PIRiS71105.
RefSeqiNP_003232.2. NM_003241.3.
UniGeneiHs.438265.

3D structure databases

ProteinModelPortaliP49221.
SMRiP49221.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112905. 2 interactors.
IntActiP49221. 2 interactors.
STRINGi9606.ENSP00000296125.

Chemistry databases

DrugBankiDB00130. L-Glutamine.

PTM databases

iPTMnetiP49221.
PhosphoSitePlusiP49221.

Polymorphism and mutation databases

BioMutaiTGM4.
DMDMi3915892.

Proteomic databases

MaxQBiP49221.
PaxDbiP49221.
PeptideAtlasiP49221.
PRIDEiP49221.

Protocols and materials databases

DNASUi7047.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296125; ENSP00000296125; ENSG00000163810.
ENST00000628744; ENSP00000487307; ENSG00000281886.
GeneIDi7047.
KEGGihsa:7047.
UCSCiuc003coc.5. human.

Organism-specific databases

CTDi7047.
DisGeNETi7047.
GeneCardsiTGM4.
HGNCiHGNC:11780. TGM4.
HPAiCAB033571.
HPA032072.
MIMi600585. gene.
neXtProtiNX_P49221.
OpenTargetsiENSG00000163810.
ENSG00000281886.
PharmGKBiPA36493.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFMV. Eukaryota.
ENOG410XQEZ. LUCA.
GeneTreeiENSGT00760000119108.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiP49221.
KOiK05621.
OMAiTDAWMKR.
OrthoDBiEOG091G030K.
PhylomeDBiP49221.
TreeFamiTF324278.

Enzyme and pathway databases

BioCyciZFISH:HS08943-MONOMER.

Miscellaneous databases

GeneWikiiTGM4.
GenomeRNAii7047.
PROiP49221.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163810.
CleanExiHS_TGM4.
ExpressionAtlasiP49221. baseline and differential.
GenevisibleiP49221. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR013808. Transglutaminase_AS.
IPR008958. Transglutaminase_C.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 1 hit.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTGM4_HUMAN
AccessioniPrimary (citable) accession number: P49221
Secondary accession number(s): Q16707, Q96QN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 15, 1998
Last modified: November 2, 2016
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.