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P49221 (TGM4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 134. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein-glutamine gamma-glutamyltransferase 4

EC=2.3.2.13
Alternative name(s):
Fibrinoligase
Prostate transglutaminase
Prostate-specific transglutaminase
Transglutaminase P
Short name=TG(P)
Short name=TGP
Short name=TGase P
Transglutaminase-4
Short name=TGase-4
Gene names
Name:TGM4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length684 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.

Catalytic activity

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.

Cofactor

Binds 1 calcium ion per subunit By similarity.

Subunit structure

Homodimer By similarity.

Tissue specificity

Prostate.

Sequence similarities

Belongs to the transglutaminase superfamily. Transglutaminase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 684684Protein-glutamine gamma-glutamyltransferase 4
PRO_0000213711

Sites

Active site2681 By similarity
Active site3271 By similarity
Active site3501 By similarity
Metal binding3901Calcium By similarity
Metal binding3921Calcium By similarity
Metal binding4421Calcium By similarity
Metal binding4471Calcium By similarity

Natural variations

Natural variant1001E → D.
Corresponds to variant rs2271087 [ dbSNP | Ensembl ].
VAR_052555
Natural variant2441Y → H.
Corresponds to variant rs9818345 [ dbSNP | Ensembl ].
VAR_052556
Natural variant2491S → T.
Corresponds to variant rs937838 [ dbSNP | Ensembl ].
VAR_052557
Natural variant3131E → K. Ref.3
Corresponds to variant rs1995641 [ dbSNP | Ensembl ].
VAR_052558
Natural variant3721R → C.
Corresponds to variant rs3749195 [ dbSNP | Ensembl ].
VAR_052559
Natural variant3721R → H.
Corresponds to variant rs13326552 [ dbSNP | Ensembl ].
VAR_052560
Natural variant3761I → V.
Corresponds to variant rs17077022 [ dbSNP | Ensembl ].
VAR_052561
Natural variant4091V → I.
Corresponds to variant rs9876921 [ dbSNP | Ensembl ].
VAR_052562
Natural variant4371E → Q.
Corresponds to variant rs1395388 [ dbSNP | Ensembl ].
VAR_052563

Experimental info

Sequence conflict3531P → S in AAH07003. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P49221 [UniParc].

Last modified December 15, 1998. Version 2.
Checksum: 64A3E754EA46BFEC

FASTA68477,145
        10         20         30         40         50         60 
MMDASKELQV LHIDFLNQDN AVSHHTWEFQ TSSPVFRRGQ VFHLRLVLNQ PLQSYHQLKL 

        70         80         90        100        110        120 
EFSTGPNPSI AKHTLVVLDP RTPSDHYNWQ ATLQNESGKE VTVAVTSSPN AILGKYQLNV 

       130        140        150        160        170        180 
KTGNHILKSE ENILYLLFNP WCKEDMVFMP DEDERKEYIL NDTGCHYVGA ARSIKCKPWN 

       190        200        210        220        230        240 
FGQFEKNVLD CCISLLTESS LKPTDRRDPV LVCRAMCAMM SFEKGQGVLI GNWTGDYEGG 

       250        260        270        280        290        300 
TAPYKWTGSA PILQQYYNTK QAVCFGQCWV FAGILTTVLR ALGIPARSVT GFDSAHDTER 

       310        320        330        340        350        360 
NLTVDTYVNE NGEKITSMTH DSVWNFHVWT DAWMKRPDLP KGYDGWQAVD ATPQERSQGV 

       370        380        390        400        410        420 
FCCGPSPLTA IRKGDIFIVY DTRFVFSEVN GDRLIWLVKM VNGQEELHVI SMETTSIGKN 

       430        440        450        460        470        480 
ISTKAVGQDR RRDITYEYKY PEGSSEERQV MDHAFLLLSS EREHRRPVKE NFLHMSVQSD 

       490        500        510        520        530        540 
DVLLGNSVNF TVILKRKTAA LQNVNILGSF ELQLYTGKKM AKLCDLNKTS QIQGQVSEVT 

       550        560        570        580        590        600 
LTLDSKTYIN SLAILDDEPV IRGFIIAEIV ESKEIMASEV FTSFQYPEFS IELPNTGRIG 

       610        620        630        640        650        660 
QLLVCNCIFK NTLAIPLTDV KFSLESLGIS SLQTSDHGTV QPGETIQSQI KCTPIKTGPK 

       670        680 
KFIVKLSSKQ VKEINAQKIV LITK 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of a novel transglutaminase cDNA from a human prostate cDNA library."
Grant F.J., Taylor D.A., Sheppard P.O., Mathewes S.L., Lint W., Vanaja E., Bishop P.D., O'Hara P.J.
Biochem. Biophys. Res. Commun. 203:1117-1123(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Prostate.
[2]Grant F.J.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Tissue specific and androgen-regulated expression of human prostate-specific transglutaminase."
Dubbink H.J., Verkaik N.S., Faber P.W., Trapman J., Schroeder F.H., Romijn J.C.
Biochem. J. 315:901-908(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, VARIANT LYS-313.
Tissue: Prostate.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L34840 mRNA. Translation: AAB95430.1.
U31905 mRNA. Translation: AAC50516.1.
BC007003 mRNA. Translation: AAH07003.1.
CCDSCCDS2723.1.
PIRS71105.
RefSeqNP_003232.2. NM_003241.3.
UniGeneHs.438265.

3D structure databases

ProteinModelPortalP49221.
SMRP49221. Positions 8-676.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP49221. 2 interactions.
STRING9606.ENSP00000296125.

Chemistry

DrugBankDB00130. L-Glutamine.

PTM databases

PhosphoSiteP49221.

Polymorphism databases

DMDM3915892.

Proteomic databases

PaxDbP49221.
PRIDEP49221.

Protocols and materials databases

DNASU7047.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296125; ENSP00000296125; ENSG00000163810.
GeneID7047.
KEGGhsa:7047.
UCSCuc003coc.4. human.

Organism-specific databases

CTD7047.
GeneCardsGC03P044916.
HGNCHGNC:11780. TGM4.
HPACAB033571.
HPA032072.
MIM600585. gene.
neXtProtNX_P49221.
PharmGKBPA36493.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG80379.
HOGENOMHOG000231695.
HOVERGENHBG004342.
KOK05621.
OMAHVWTDAW.
OrthoDBEOG7WT40M.
PhylomeDBP49221.
TreeFamTF324278.

Gene expression databases

ArrayExpressP49221.
BgeeP49221.
CleanExHS_TGM4.
GenevestigatorP49221.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERPTHR11590. PTHR11590. 1 hit.
PfamPF00927. Transglut_C. 1 hit.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFPIRSF000459. TGM_EBP42. 1 hit.
SMARTSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTGM4.
GenomeRNAi7047.
NextBio27537.
PROP49221.
SOURCESearch...

Entry information

Entry nameTGM4_HUMAN
AccessionPrimary (citable) accession number: P49221
Secondary accession number(s): Q16707, Q96QN4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 15, 1998
Last modified: July 9, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM