Reviewed,
UniProtKB/Swiss-Prot P49221 (TGM4_HUMAN)
Last modified
November 25, 2008.
Version 81.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Protein-glutamine gamma-glutamyltransferase 4 EC=2.3.2.13 Alternative name(s): Transglutaminase-4 Short name=TGase-4 Prostate transglutaminase TGP TG(P) Prostate-specific transglutaminase Fibrinoligase | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 684 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract. |
| Catalytic activity | Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3). |
| Cofactor | Binds 1 calcium ion per subunit By similarity. |
| Tissue specificity | Prostate. |
| Sequence similarities | Belongs to the transglutaminase superfamily. Transglutaminase family. |
Ontologies
Keywords | |
|---|---|
| Ligand | Calcium Metal-binding |
| Molecular function | Acyltransferase Transferase |
Gene Ontology (GO) | |
| Biological process | peptide cross-linking Non-traceable author statement. Source: UniProtKB protein amino acid polyaminationNon-traceable author statement. Source: UniProtKB |
| Molecular function | acyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW calcium ion bindingInferred from electronic annotation. Source: UniProtKB-KW protein-glutamine gamma-glutamyltransferase activity Ref.1Non-traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 684 | 684 | Protein-glutamine gamma-glutamyltransferase 4 | PRO_0000213711 | |||||
Sites | |||||||||
| Active site | 268 | 1 | By similarity | ||||||
| Active site | 327 | 1 | By similarity | ||||||
| Active site | 350 | 1 | By similarity | ||||||
| Metal binding | 390 | 1 | Calcium By similarity | ||||||
| Metal binding | 392 | 1 | Calcium By similarity | ||||||
| Metal binding | 442 | 1 | Calcium By similarity | ||||||
| Metal binding | 447 | 1 | Calcium By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 313 | 1 | E → K in AAC50516. Ref.3 | ||||||
| Sequence conflict | 353 | 1 | P → S in AAH07003. Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning and characterization of a novel transglutaminase cDNA from a human prostate cDNA library." Grant F.J., Taylor D.A., Sheppard P.O., Mathewes S.L., Lint W., Vanaja E., Bishop P.D., O'Hara P.J. Biochem. Biophys. Res. Commun. 203:1117-1123(1994) [PubMed: 7916568] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Prostate. |
| [2] | Grant F.J. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION. |
| [3] | "Tissue specific and androgen-regulated expression of human prostate-specific transglutaminase." Dubbink H.J., Verkaik N.S., Faber P.W., Trapman J., Schroeder F.H., Romijn J.C. Biochem. J. 315:901-908(1996) [PubMed: 8645175] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. Tissue: Prostate. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| L34840 mRNA. Translation: AAB95430.1. U31905 mRNA. Translation: AAC50516.1. BC007003 mRNA. Translation: AAH07003.1. | |
| PIR | S71105. |
| RefSeq | NP_003232.2. |
| UniGene | Hs.438265 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1L9M based on UniProtKB Q08188. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P49221. |
Genome annotation databases | |
| Ensembl | ENSG00000163810. Homo sapiens. [Contig view] |
| GeneID | 7047. |
| KEGG | hsa:7047. |
Organism-specific databases | |
| H-InvDB | HIX0003228. |
| HGNC | HGNC:11780. TGM4. |
| MIM | 600585. gene. |
| PharmGKB | PA36493. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | P49221. |
| HOVERGEN | P49221. |
Gene expression databases | |
| ArrayExpress | P49221. |
| CleanEx | HS_TGM4. |
| GermOnline | ENSG00000163810. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR008957. Fibronectin_typ-III-like_fold. IPR013783. Ig-like_fold. IPR008958. Transglutaminase_C. IPR013808. Transglutaminase_CS. IPR001102. Transglutaminase_N. IPR002931. Trnsglumase_like. [Graphical view] |
| Gene3D | G3DSA:2.60.40.30. FN_III-like. 1 hit. G3DSA:2.60.40.10. Ig-like_fold. 1 hit. |
| Pfam | PF00927. Transglut_C. 1 hit. PF01841. Transglut_core. 1 hit. PF00868. Transglut_N. 1 hit. [Graphical view] |
| SMART | SM00460. TGc. 1 hit. [Graphical view] |
| PROSITE | PS00547. TRANSGLUTAMINASES. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| DrugBank | DB00130. L-Glutamine. |
| NextBio | 27537. |
| SOURCE | Search... |
Entry information
| Entry name | TGM4_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P49221 Secondary accession number(s): Q16707, Q96QN4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 3 Human chromosome 3: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


