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P49221

- TGM4_HUMAN

UniProt

P49221 - TGM4_HUMAN

Protein

Protein-glutamine gamma-glutamyltransferase 4

Gene

TGM4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 2 (15 Dec 1998)
      Previous versions | rss
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    Functioni

    Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.

    Catalytic activityi

    Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei268 – 2681PROSITE-ProRule annotation
    Active sitei327 – 3271PROSITE-ProRule annotation
    Active sitei350 – 3501PROSITE-ProRule annotation
    Metal bindingi390 – 3901CalciumBy similarity
    Metal bindingi392 – 3921CalciumBy similarity
    Metal bindingi442 – 4421CalciumBy similarity
    Metal bindingi447 – 4471CalciumBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. mating plug formation Source: Ensembl
    2. peptide cross-linking Source: InterPro

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein-glutamine gamma-glutamyltransferase 4 (EC:2.3.2.13)
    Alternative name(s):
    Fibrinoligase
    Prostate transglutaminase
    Prostate-specific transglutaminase
    Transglutaminase P
    Short name:
    TG(P)
    Short name:
    TGP
    Short name:
    TGase P
    Transglutaminase-4
    Short name:
    TGase-4
    Gene namesi
    Name:TGM4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:11780. TGM4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProt
    2. extracellular matrix Source: UniProt
    3. extracellular vesicular exosome Source: UniProt
    4. Golgi apparatus Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36493.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 684684Protein-glutamine gamma-glutamyltransferase 4PRO_0000213711Add
    BLAST

    Proteomic databases

    PaxDbiP49221.
    PRIDEiP49221.

    PTM databases

    PhosphoSiteiP49221.

    Expressioni

    Tissue specificityi

    Prostate.

    Gene expression databases

    ArrayExpressiP49221.
    BgeeiP49221.
    CleanExiHS_TGM4.
    GenevestigatoriP49221.

    Organism-specific databases

    HPAiCAB033571.
    HPA032072.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiP49221. 2 interactions.
    STRINGi9606.ENSP00000296125.

    Structurei

    3D structure databases

    ProteinModelPortaliP49221.
    SMRiP49221. Positions 8-676.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG80379.
    HOGENOMiHOG000231695.
    HOVERGENiHBG004342.
    KOiK05621.
    OMAiHVWTDAW.
    OrthoDBiEOG7WT40M.
    PhylomeDBiP49221.
    TreeFamiTF324278.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view]
    PANTHERiPTHR11590. PTHR11590. 1 hit.
    PfamiPF00927. Transglut_C. 1 hit.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
    SMARTiSM00460. TGc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P49221-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMDASKELQV LHIDFLNQDN AVSHHTWEFQ TSSPVFRRGQ VFHLRLVLNQ    50
    PLQSYHQLKL EFSTGPNPSI AKHTLVVLDP RTPSDHYNWQ ATLQNESGKE 100
    VTVAVTSSPN AILGKYQLNV KTGNHILKSE ENILYLLFNP WCKEDMVFMP 150
    DEDERKEYIL NDTGCHYVGA ARSIKCKPWN FGQFEKNVLD CCISLLTESS 200
    LKPTDRRDPV LVCRAMCAMM SFEKGQGVLI GNWTGDYEGG TAPYKWTGSA 250
    PILQQYYNTK QAVCFGQCWV FAGILTTVLR ALGIPARSVT GFDSAHDTER 300
    NLTVDTYVNE NGEKITSMTH DSVWNFHVWT DAWMKRPDLP KGYDGWQAVD 350
    ATPQERSQGV FCCGPSPLTA IRKGDIFIVY DTRFVFSEVN GDRLIWLVKM 400
    VNGQEELHVI SMETTSIGKN ISTKAVGQDR RRDITYEYKY PEGSSEERQV 450
    MDHAFLLLSS EREHRRPVKE NFLHMSVQSD DVLLGNSVNF TVILKRKTAA 500
    LQNVNILGSF ELQLYTGKKM AKLCDLNKTS QIQGQVSEVT LTLDSKTYIN 550
    SLAILDDEPV IRGFIIAEIV ESKEIMASEV FTSFQYPEFS IELPNTGRIG 600
    QLLVCNCIFK NTLAIPLTDV KFSLESLGIS SLQTSDHGTV QPGETIQSQI 650
    KCTPIKTGPK KFIVKLSSKQ VKEINAQKIV LITK 684
    Length:684
    Mass (Da):77,145
    Last modified:December 15, 1998 - v2
    Checksum:i64A3E754EA46BFEC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti353 – 3531P → S in AAH07003. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti100 – 1001E → D.
    Corresponds to variant rs2271087 [ dbSNP | Ensembl ].
    VAR_052555
    Natural varianti244 – 2441Y → H.
    Corresponds to variant rs9818345 [ dbSNP | Ensembl ].
    VAR_052556
    Natural varianti249 – 2491S → T.
    Corresponds to variant rs937838 [ dbSNP | Ensembl ].
    VAR_052557
    Natural varianti313 – 3131E → K.1 Publication
    Corresponds to variant rs1995641 [ dbSNP | Ensembl ].
    VAR_052558
    Natural varianti372 – 3721R → C.
    Corresponds to variant rs3749195 [ dbSNP | Ensembl ].
    VAR_052559
    Natural varianti372 – 3721R → H.
    Corresponds to variant rs13326552 [ dbSNP | Ensembl ].
    VAR_052560
    Natural varianti376 – 3761I → V.
    Corresponds to variant rs17077022 [ dbSNP | Ensembl ].
    VAR_052561
    Natural varianti409 – 4091V → I.
    Corresponds to variant rs9876921 [ dbSNP | Ensembl ].
    VAR_052562
    Natural varianti437 – 4371E → Q.
    Corresponds to variant rs1395388 [ dbSNP | Ensembl ].
    VAR_052563

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34840 mRNA. Translation: AAB95430.1.
    U31905 mRNA. Translation: AAC50516.1.
    BC007003 mRNA. Translation: AAH07003.1.
    CCDSiCCDS2723.1.
    PIRiS71105.
    RefSeqiNP_003232.2. NM_003241.3.
    UniGeneiHs.438265.

    Genome annotation databases

    EnsembliENST00000296125; ENSP00000296125; ENSG00000163810.
    GeneIDi7047.
    KEGGihsa:7047.
    UCSCiuc003coc.4. human.

    Polymorphism databases

    DMDMi3915892.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34840 mRNA. Translation: AAB95430.1 .
    U31905 mRNA. Translation: AAC50516.1 .
    BC007003 mRNA. Translation: AAH07003.1 .
    CCDSi CCDS2723.1.
    PIRi S71105.
    RefSeqi NP_003232.2. NM_003241.3.
    UniGenei Hs.438265.

    3D structure databases

    ProteinModelPortali P49221.
    SMRi P49221. Positions 8-676.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P49221. 2 interactions.
    STRINGi 9606.ENSP00000296125.

    Chemistry

    DrugBanki DB00130. L-Glutamine.

    PTM databases

    PhosphoSitei P49221.

    Polymorphism databases

    DMDMi 3915892.

    Proteomic databases

    PaxDbi P49221.
    PRIDEi P49221.

    Protocols and materials databases

    DNASUi 7047.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296125 ; ENSP00000296125 ; ENSG00000163810 .
    GeneIDi 7047.
    KEGGi hsa:7047.
    UCSCi uc003coc.4. human.

    Organism-specific databases

    CTDi 7047.
    GeneCardsi GC03P044916.
    HGNCi HGNC:11780. TGM4.
    HPAi CAB033571.
    HPA032072.
    MIMi 600585. gene.
    neXtProti NX_P49221.
    PharmGKBi PA36493.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG80379.
    HOGENOMi HOG000231695.
    HOVERGENi HBG004342.
    KOi K05621.
    OMAi HVWTDAW.
    OrthoDBi EOG7WT40M.
    PhylomeDBi P49221.
    TreeFami TF324278.

    Miscellaneous databases

    GeneWikii TGM4.
    GenomeRNAii 7047.
    NextBioi 27537.
    PROi P49221.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P49221.
    Bgeei P49221.
    CleanExi HS_TGM4.
    Genevestigatori P49221.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view ]
    PANTHERi PTHR11590. PTHR11590. 1 hit.
    Pfami PF00927. Transglut_C. 1 hit.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
    SMARTi SM00460. TGc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a novel transglutaminase cDNA from a human prostate cDNA library."
      Grant F.J., Taylor D.A., Sheppard P.O., Mathewes S.L., Lint W., Vanaja E., Bishop P.D., O'Hara P.J.
      Biochem. Biophys. Res. Commun. 203:1117-1123(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Prostate.
    2. Grant F.J.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Tissue specific and androgen-regulated expression of human prostate-specific transglutaminase."
      Dubbink H.J., Verkaik N.S., Faber P.W., Trapman J., Schroeder F.H., Romijn J.C.
      Biochem. J. 315:901-908(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, VARIANT LYS-313.
      Tissue: Prostate.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.

    Entry informationi

    Entry nameiTGM4_HUMAN
    AccessioniPrimary (citable) accession number: P49221
    Secondary accession number(s): Q16707, Q96QN4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: December 15, 1998
    Last modified: October 1, 2014
    This is version 135 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3