P49219 (MTR1C_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Melatonin receptor type 1C
Short name=Mel-1C-R
Short name=Mel1c (alpha) receptor
Short name=Mel1c receptor

Gene names

Name:

mtnr1c

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	420 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	High affinity receptor for melatonin. Likely to mediate the potent effects of melatonin on pigment aggregation in melanophores. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Ref.1 Ref.2
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Moderately expressed in dermal melanophores. Ref.1
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	melatonin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P49219-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P49219-2)

The sequence of this isoform differs from the canonical sequence as follows:
     353-354: LG → YV
     355-420: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 420	420	Melatonin receptor type 1C		PRO_0000069877
Regions
	Topological domain	1 – 34	34	Extracellular Potential
	Transmembrane	35 – 55	21	Helical; Name=1; Potential
	Topological domain	56 – 73	18	Cytoplasmic Potential
	Transmembrane	74 – 94	21	Helical; Name=2; Potential
	Topological domain	95 – 106	12	Extracellular Potential
	Transmembrane	107 – 127	21	Helical; Name=3; Potential
	Topological domain	128 – 152	25	Cytoplasmic Potential
	Transmembrane	153 – 173	21	Helical; Name=4; Potential
	Topological domain	174 – 192	19	Extracellular Potential
	Transmembrane	193 – 213	21	Helical; Name=5; Potential
	Topological domain	214 – 245	32	Cytoplasmic Potential
	Transmembrane	246 – 266	21	Helical; Name=6; Potential
	Topological domain	267 – 279	13	Extracellular Potential
	Transmembrane	280 – 303	24	Helical; Name=7; Potential
	Topological domain	304 – 420	117	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	105 ↔ 182		By similarity
Natural variations
	Alternative sequence	353 – 354	2	LG → YV in isoform 2.		VSP_040031
	Alternative sequence	355 – 420	66	Missing in isoform 2.		VSP_040032

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 81F8698D70CC0733	FASTA	420	47,425
	10 20 30 40 50 60 MMEVNSTCLD CRTPGTIRTE QDAQDSASQG LTSALAVVLI FTIVVDVLGN ILVILSVLRN 70 80 90 100 110 120 KKLQNAGNLF VVSLSIADLV VAVYPYPVIL IAIFQNGWTL GNIHCQISGF LMGLSVIGSV 130 140 150 160 170 180 FNITAIAINR YCYICHSLRY DKLYNQRSTW CYLGLTWILT IIAIVPNFFV GSLQYDPRIF 190 200 210 220 230 240 SCTFAQTVSS SYTITVVVVH FIVPLSVVTF CYLRIWVLVI QVKHRVRQDF KQKLTQTDLR 250 260 270 280 290 300 NFLTMFVVFV LFAVCWAPLN FIGLAVAINP FHVAPKIPEW LFVLSYFMAY FNSCLNAVIY 310 320 330 340 350 360 GVLNQNFRKE YKRILMSLLT PRLLFLDTSR GGTEGLKSKP SPAVTNNNQA DMLGEARSLW 370 380 390 400 410 420 LSRRNGAKMV IIIRPRKAQI AIIHQIFWPQ SSWATCRQDT KITGEEDGCR ELCKDGISQR
	Isoform 2 [UniParc]. Checksum: BCF78D208F0C97A6	FASTA	354	39,881
	10 20 30 40 50 60 MMEVNSTCLD CRTPGTIRTE QDAQDSASQG LTSALAVVLI FTIVVDVLGN ILVILSVLRN 70 80 90 100 110 120 KKLQNAGNLF VVSLSIADLV VAVYPYPVIL IAIFQNGWTL GNIHCQISGF LMGLSVIGSV 130 140 150 160 170 180 FNITAIAINR YCYICHSLRY DKLYNQRSTW CYLGLTWILT IIAIVPNFFV GSLQYDPRIF 190 200 210 220 230 240 SCTFAQTVSS SYTITVVVVH FIVPLSVVTF CYLRIWVLVI QVKHRVRQDF KQKLTQTDLR 250 260 270 280 290 300 NFLTMFVVFV LFAVCWAPLN FIGLAVAINP FHVAPKIPEW LFVLSYFMAY FNSCLNAVIY 310 320 330 340 350 GVLNQNFRKE YKRILMSLLT PRLLFLDTSR GGTEGLKSKP SPAVTNNNQA DMYV

References

[1]

"Expression cloning of a high-affinity melatonin receptor from Xenopus dermal melanophores." Ebisawa T., Karne S., Lerner M.R., Reppert S.M. Proc. Natl. Acad. Sci. U.S.A. 91:6133-6137(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY. Tissue: Dermal melanophore.

[2]

"Novel isoforms of Mel1c melatonin receptors modulating intracellular cyclic guanosine 3',5'-monophosphate levels." Jockers R., Petit L., Lacroix I., de Coppet P., Barrett P., Morgan P.J., Guardiola B., Delagrange P., Marullo S., Strosberg A.D. Mol. Endocrinol. 11:1070-1081(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION. Tissue: Dermal melanophore.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U09561 mRNA. Translation: AAA70166.1. U67879 mRNA. Translation: AAB48389.1. U67880 mRNA. Translation: AAB48390.1.
PIR	I51666.
RefSeq	NP_001081388.1. NM_001087919.1.
UniGene	Xl.94.
3D structure databases
ProteinModelPortal	P49219.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	397808.
KEGG	xla:397808.
Organism-specific databases
CTD	4544.
Xenbase	XB-GENE-6466037. mtnr1c.
Phylogenomic databases
HOVERGEN	HBG052528.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR002279. Mel_rcpt_1C. IPR000025. Melatonin_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01150. MELATONIN1CR. PR00857. MELATONINR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P49219.
ChEMBL	CHEMBL5495.

Entry information

Entry name

MTR1C_XENLA

Accession

Primary (citable) accession number: P49219
Secondary accession number(s): P87499

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program