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P49219

- MTR1C_XENLA

UniProt

P49219 - MTR1C_XENLA

Protein

Melatonin receptor type 1C

Gene

mtnr1c

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    High affinity receptor for melatonin. Likely to mediate the potent effects of melatonin on pigment aggregation in melanophores. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.2 Publications

    GO - Molecular functioni

    1. melatonin receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Melatonin receptor type 1C
    Short name:
    Mel-1C-R
    Short name:
    Mel1c (alpha) receptor
    Short name:
    Mel1c receptor
    Gene namesi
    Name:mtnr1c
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6466037. mtnr1c.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 420420Melatonin receptor type 1CPRO_0000069877Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi105 ↔ 182PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Tissue specificityi

    Moderately expressed in dermal melanophores.1 Publication

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliP49219.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini56 – 7318CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini95 – 10612ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini128 – 15225CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini174 – 19219ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini214 – 24532CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini267 – 27913ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini304 – 420117CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei74 – 9421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei107 – 12721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei153 – 17321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei193 – 21321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei246 – 26621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei280 – 30324Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG052528.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002279. Mel_rcpt_1C.
    IPR000025. Melatonin_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01150. MELATONIN1CR.
    PR00857. MELATONINR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P49219-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMEVNSTCLD CRTPGTIRTE QDAQDSASQG LTSALAVVLI FTIVVDVLGN    50
    ILVILSVLRN KKLQNAGNLF VVSLSIADLV VAVYPYPVIL IAIFQNGWTL 100
    GNIHCQISGF LMGLSVIGSV FNITAIAINR YCYICHSLRY DKLYNQRSTW 150
    CYLGLTWILT IIAIVPNFFV GSLQYDPRIF SCTFAQTVSS SYTITVVVVH 200
    FIVPLSVVTF CYLRIWVLVI QVKHRVRQDF KQKLTQTDLR NFLTMFVVFV 250
    LFAVCWAPLN FIGLAVAINP FHVAPKIPEW LFVLSYFMAY FNSCLNAVIY 300
    GVLNQNFRKE YKRILMSLLT PRLLFLDTSR GGTEGLKSKP SPAVTNNNQA 350
    DMLGEARSLW LSRRNGAKMV IIIRPRKAQI AIIHQIFWPQ SSWATCRQDT 400
    KITGEEDGCR ELCKDGISQR 420
    Length:420
    Mass (Da):47,425
    Last modified:February 1, 1996 - v1
    Checksum:i81F8698D70CC0733
    GO
    Isoform 2 (identifier: P49219-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         353-354: LG → YV
         355-420: Missing.

    Show »
    Length:354
    Mass (Da):39,881
    Checksum:iBCF78D208F0C97A6
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei353 – 3542LG → YV in isoform 2. 1 PublicationVSP_040031
    Alternative sequencei355 – 42066Missing in isoform 2. 1 PublicationVSP_040032Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09561 mRNA. Translation: AAA70166.1.
    U67879 mRNA. Translation: AAB48389.1.
    U67880 mRNA. Translation: AAB48390.1.
    PIRiI51666.
    RefSeqiNP_001081388.1. NM_001087919.1. [P49219-1]
    UniGeneiXl.94.

    Genome annotation databases

    GeneIDi397808.
    KEGGixla:397808.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09561 mRNA. Translation: AAA70166.1 .
    U67879 mRNA. Translation: AAB48389.1 .
    U67880 mRNA. Translation: AAB48390.1 .
    PIRi I51666.
    RefSeqi NP_001081388.1. NM_001087919.1. [P49219-1 ]
    UniGenei Xl.94.

    3D structure databases

    ProteinModelPortali P49219.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P49219.
    ChEMBLi CHEMBL5495.

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 397808.
    KEGGi xla:397808.

    Organism-specific databases

    CTDi 4544.
    Xenbasei XB-GENE-6466037. mtnr1c.

    Phylogenomic databases

    HOVERGENi HBG052528.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002279. Mel_rcpt_1C.
    IPR000025. Melatonin_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01150. MELATONIN1CR.
    PR00857. MELATONINR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression cloning of a high-affinity melatonin receptor from Xenopus dermal melanophores."
      Ebisawa T., Karne S., Lerner M.R., Reppert S.M.
      Proc. Natl. Acad. Sci. U.S.A. 91:6133-6137(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
      Tissue: Dermal melanophore.
    2. "Novel isoforms of Mel1c melatonin receptors modulating intracellular cyclic guanosine 3',5'-monophosphate levels."
      Jockers R., Petit L., Lacroix I., de Coppet P., Barrett P., Morgan P.J., Guardiola B., Delagrange P., Marullo S., Strosberg A.D.
      Mol. Endocrinol. 11:1070-1081(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION.
      Tissue: Dermal melanophore.

    Entry informationi

    Entry nameiMTR1C_XENLA
    AccessioniPrimary (citable) accession number: P49219
    Secondary accession number(s): P87499
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3