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P49219

- MTR1C_XENLA

UniProt

P49219 - MTR1C_XENLA

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Protein

Melatonin receptor type 1C

Gene

mtnr1c

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

High affinity receptor for melatonin. Likely to mediate the potent effects of melatonin on pigment aggregation in melanophores. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.2 Publications

GO - Molecular functioni

  1. melatonin receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Melatonin receptor type 1C
Short name:
Mel-1C-R
Short name:
Mel1c (alpha) receptor
Short name:
Mel1c receptor
Gene namesi
Name:mtnr1c
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6466037. mtnr1c.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Melatonin receptor type 1CPRO_0000069877Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi105 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Moderately expressed in dermal melanophores.1 Publication

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP49219.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularSequence AnalysisAdd
BLAST
Topological domaini56 – 7318CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini95 – 10612ExtracellularSequence AnalysisAdd
BLAST
Topological domaini128 – 15225CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini174 – 19219ExtracellularSequence AnalysisAdd
BLAST
Topological domaini214 – 24532CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini267 – 27913ExtracellularSequence AnalysisAdd
BLAST
Topological domaini304 – 420117CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei74 – 9421Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei107 – 12721Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei153 – 17321Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei193 – 21321Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei246 – 26621Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei280 – 30324Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG052528.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002279. Mel_rcpt_1C.
IPR000025. Melatonin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01150. MELATONIN1CR.
PR00857. MELATONINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P49219-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMEVNSTCLD CRTPGTIRTE QDAQDSASQG LTSALAVVLI FTIVVDVLGN
60 70 80 90 100
ILVILSVLRN KKLQNAGNLF VVSLSIADLV VAVYPYPVIL IAIFQNGWTL
110 120 130 140 150
GNIHCQISGF LMGLSVIGSV FNITAIAINR YCYICHSLRY DKLYNQRSTW
160 170 180 190 200
CYLGLTWILT IIAIVPNFFV GSLQYDPRIF SCTFAQTVSS SYTITVVVVH
210 220 230 240 250
FIVPLSVVTF CYLRIWVLVI QVKHRVRQDF KQKLTQTDLR NFLTMFVVFV
260 270 280 290 300
LFAVCWAPLN FIGLAVAINP FHVAPKIPEW LFVLSYFMAY FNSCLNAVIY
310 320 330 340 350
GVLNQNFRKE YKRILMSLLT PRLLFLDTSR GGTEGLKSKP SPAVTNNNQA
360 370 380 390 400
DMLGEARSLW LSRRNGAKMV IIIRPRKAQI AIIHQIFWPQ SSWATCRQDT
410 420
KITGEEDGCR ELCKDGISQR
Length:420
Mass (Da):47,425
Last modified:February 1, 1996 - v1
Checksum:i81F8698D70CC0733
GO
Isoform 2 (identifier: P49219-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     353-354: LG → YV
     355-420: Missing.

Show »
Length:354
Mass (Da):39,881
Checksum:iBCF78D208F0C97A6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei353 – 3542LG → YV in isoform 2. 1 PublicationVSP_040031
Alternative sequencei355 – 42066Missing in isoform 2. 1 PublicationVSP_040032Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09561 mRNA. Translation: AAA70166.1.
U67879 mRNA. Translation: AAB48389.1.
U67880 mRNA. Translation: AAB48390.1.
PIRiI51666.
RefSeqiNP_001081388.1. NM_001087919.1. [P49219-1]
UniGeneiXl.94.

Genome annotation databases

GeneIDi397808.
KEGGixla:397808.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09561 mRNA. Translation: AAA70166.1 .
U67879 mRNA. Translation: AAB48389.1 .
U67880 mRNA. Translation: AAB48390.1 .
PIRi I51666.
RefSeqi NP_001081388.1. NM_001087919.1. [P49219-1 ]
UniGenei Xl.94.

3D structure databases

ProteinModelPortali P49219.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P49219.
ChEMBLi CHEMBL5495.

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397808.
KEGGi xla:397808.

Organism-specific databases

CTDi 4544.
Xenbasei XB-GENE-6466037. mtnr1c.

Phylogenomic databases

HOVERGENi HBG052528.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002279. Mel_rcpt_1C.
IPR000025. Melatonin_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01150. MELATONIN1CR.
PR00857. MELATONINR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression cloning of a high-affinity melatonin receptor from Xenopus dermal melanophores."
    Ebisawa T., Karne S., Lerner M.R., Reppert S.M.
    Proc. Natl. Acad. Sci. U.S.A. 91:6133-6137(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Dermal melanophore.
  2. "Novel isoforms of Mel1c melatonin receptors modulating intracellular cyclic guanosine 3',5'-monophosphate levels."
    Jockers R., Petit L., Lacroix I., de Coppet P., Barrett P., Morgan P.J., Guardiola B., Delagrange P., Marullo S., Strosberg A.D.
    Mol. Endocrinol. 11:1070-1081(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION.
    Tissue: Dermal melanophore.

Entry informationi

Entry nameiMTR1C_XENLA
AccessioniPrimary (citable) accession number: P49219
Secondary accession number(s): P87499
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3