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Protein

Melatonin receptor type 1C

Gene

mtnr1c

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

High affinity receptor for melatonin. Likely to mediate the potent effects of melatonin on pigment aggregation in melanophores. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.2 Publications

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Melatonin receptor type 1C
Short name:
Mel-1C-R
Short name:
Mel1c (alpha) receptor
Short name:
Mel1c receptor
Gene namesi
Name:mtnr1c
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6466037. mtnr1c.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularSequence analysisAdd BLAST34
Transmembranei35 – 55Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini56 – 73CytoplasmicSequence analysisAdd BLAST18
Transmembranei74 – 94Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini95 – 106ExtracellularSequence analysisAdd BLAST12
Transmembranei107 – 127Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini128 – 152CytoplasmicSequence analysisAdd BLAST25
Transmembranei153 – 173Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini174 – 192ExtracellularSequence analysisAdd BLAST19
Transmembranei193 – 213Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini214 – 245CytoplasmicSequence analysisAdd BLAST32
Transmembranei246 – 266Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini267 – 279ExtracellularSequence analysisAdd BLAST13
Transmembranei280 – 303Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini304 – 420CytoplasmicSequence analysisAdd BLAST117

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5495.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000698771 – 420Melatonin receptor type 1CAdd BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi105 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Moderately expressed in dermal melanophores.1 Publication

Interactioni

Chemistry databases

BindingDBiP49219.

Structurei

3D structure databases

ProteinModelPortaliP49219.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG052528.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002279. Mel_rcpt_1C.
IPR000025. Melatonin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01150. MELATONIN1CR.
PR00857. MELATONINR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P49219-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMEVNSTCLD CRTPGTIRTE QDAQDSASQG LTSALAVVLI FTIVVDVLGN
60 70 80 90 100
ILVILSVLRN KKLQNAGNLF VVSLSIADLV VAVYPYPVIL IAIFQNGWTL
110 120 130 140 150
GNIHCQISGF LMGLSVIGSV FNITAIAINR YCYICHSLRY DKLYNQRSTW
160 170 180 190 200
CYLGLTWILT IIAIVPNFFV GSLQYDPRIF SCTFAQTVSS SYTITVVVVH
210 220 230 240 250
FIVPLSVVTF CYLRIWVLVI QVKHRVRQDF KQKLTQTDLR NFLTMFVVFV
260 270 280 290 300
LFAVCWAPLN FIGLAVAINP FHVAPKIPEW LFVLSYFMAY FNSCLNAVIY
310 320 330 340 350
GVLNQNFRKE YKRILMSLLT PRLLFLDTSR GGTEGLKSKP SPAVTNNNQA
360 370 380 390 400
DMLGEARSLW LSRRNGAKMV IIIRPRKAQI AIIHQIFWPQ SSWATCRQDT
410 420
KITGEEDGCR ELCKDGISQR
Length:420
Mass (Da):47,425
Last modified:February 1, 1996 - v1
Checksum:i81F8698D70CC0733
GO
Isoform 2 (identifier: P49219-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     353-354: LG → YV
     355-420: Missing.

Show »
Length:354
Mass (Da):39,881
Checksum:iBCF78D208F0C97A6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040031353 – 354LG → YV in isoform 2. 1 Publication2
Alternative sequenceiVSP_040032355 – 420Missing in isoform 2. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09561 mRNA. Translation: AAA70166.1.
U67879 mRNA. Translation: AAB48389.1.
U67880 mRNA. Translation: AAB48390.1.
PIRiI51666.
RefSeqiNP_001081388.1. NM_001087919.1. [P49219-1]
UniGeneiXl.94.

Genome annotation databases

GeneIDi397808.
KEGGixla:397808.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09561 mRNA. Translation: AAA70166.1.
U67879 mRNA. Translation: AAB48389.1.
U67880 mRNA. Translation: AAB48390.1.
PIRiI51666.
RefSeqiNP_001081388.1. NM_001087919.1. [P49219-1]
UniGeneiXl.94.

3D structure databases

ProteinModelPortaliP49219.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiP49219.
ChEMBLiCHEMBL5495.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397808.
KEGGixla:397808.

Organism-specific databases

CTDi4544.
XenbaseiXB-GENE-6466037. mtnr1c.

Phylogenomic databases

HOVERGENiHBG052528.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002279. Mel_rcpt_1C.
IPR000025. Melatonin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01150. MELATONIN1CR.
PR00857. MELATONINR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTR1C_XENLA
AccessioniPrimary (citable) accession number: P49219
Secondary accession number(s): P87499
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 11, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.