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P49219 (MTR1C_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Melatonin receptor type 1C

Short name=Mel-1C-R
Short name=Mel1c (alpha) receptor
Short name=Mel1c receptor
Gene names
Name:mtnr1c
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

High affinity receptor for melatonin. Likely to mediate the potent effects of melatonin on pigment aggregation in melanophores. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Ref.1 Ref.2

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Moderately expressed in dermal melanophores. Ref.1

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmelatonin receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P49219-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P49219-2)

The sequence of this isoform differs from the canonical sequence as follows:
     353-354: LG → YV
     355-420: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 420420Melatonin receptor type 1C
PRO_0000069877

Regions

Topological domain1 – 3434Extracellular Potential
Transmembrane35 – 5521Helical; Name=1; Potential
Topological domain56 – 7318Cytoplasmic Potential
Transmembrane74 – 9421Helical; Name=2; Potential
Topological domain95 – 10612Extracellular Potential
Transmembrane107 – 12721Helical; Name=3; Potential
Topological domain128 – 15225Cytoplasmic Potential
Transmembrane153 – 17321Helical; Name=4; Potential
Topological domain174 – 19219Extracellular Potential
Transmembrane193 – 21321Helical; Name=5; Potential
Topological domain214 – 24532Cytoplasmic Potential
Transmembrane246 – 26621Helical; Name=6; Potential
Topological domain267 – 27913Extracellular Potential
Transmembrane280 – 30324Helical; Name=7; Potential
Topological domain304 – 420117Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond105 ↔ 182 By similarity

Natural variations

Alternative sequence353 – 3542LG → YV in isoform 2.
VSP_040031
Alternative sequence355 – 42066Missing in isoform 2.
VSP_040032

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 81F8698D70CC0733

FASTA42047,425
        10         20         30         40         50         60 
MMEVNSTCLD CRTPGTIRTE QDAQDSASQG LTSALAVVLI FTIVVDVLGN ILVILSVLRN 

        70         80         90        100        110        120 
KKLQNAGNLF VVSLSIADLV VAVYPYPVIL IAIFQNGWTL GNIHCQISGF LMGLSVIGSV 

       130        140        150        160        170        180 
FNITAIAINR YCYICHSLRY DKLYNQRSTW CYLGLTWILT IIAIVPNFFV GSLQYDPRIF 

       190        200        210        220        230        240 
SCTFAQTVSS SYTITVVVVH FIVPLSVVTF CYLRIWVLVI QVKHRVRQDF KQKLTQTDLR 

       250        260        270        280        290        300 
NFLTMFVVFV LFAVCWAPLN FIGLAVAINP FHVAPKIPEW LFVLSYFMAY FNSCLNAVIY 

       310        320        330        340        350        360 
GVLNQNFRKE YKRILMSLLT PRLLFLDTSR GGTEGLKSKP SPAVTNNNQA DMLGEARSLW 

       370        380        390        400        410        420 
LSRRNGAKMV IIIRPRKAQI AIIHQIFWPQ SSWATCRQDT KITGEEDGCR ELCKDGISQR 

« Hide

Isoform 2 [UniParc].

Checksum: BCF78D208F0C97A6
Show »

FASTA35439,881

References

[1]"Expression cloning of a high-affinity melatonin receptor from Xenopus dermal melanophores."
Ebisawa T., Karne S., Lerner M.R., Reppert S.M.
Proc. Natl. Acad. Sci. U.S.A. 91:6133-6137(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
Tissue: Dermal melanophore.
[2]"Novel isoforms of Mel1c melatonin receptors modulating intracellular cyclic guanosine 3',5'-monophosphate levels."
Jockers R., Petit L., Lacroix I., de Coppet P., Barrett P., Morgan P.J., Guardiola B., Delagrange P., Marullo S., Strosberg A.D.
Mol. Endocrinol. 11:1070-1081(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION.
Tissue: Dermal melanophore.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U09561 mRNA. Translation: AAA70166.1.
U67879 mRNA. Translation: AAB48389.1.
U67880 mRNA. Translation: AAB48390.1.
PIRI51666.
RefSeqNP_001081388.1. NM_001087919.1.
UniGeneXl.94.

3D structure databases

ProteinModelPortalP49219.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP49219.
ChEMBLCHEMBL5495.

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID397808.
KEGGxla:397808.

Organism-specific databases

CTD4544.
XenbaseXB-GENE-6466037. mtnr1c.

Phylogenomic databases

HOVERGENHBG052528.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002279. Mel_rcpt_1C.
IPR000025. Melatonin_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01150. MELATONIN1CR.
PR00857. MELATONINR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTR1C_XENLA
AccessionPrimary (citable) accession number: P49219
Secondary accession number(s): P87499
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries