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P49218

- MTR1A_RAT

UniProt

P49218 - MTR1A_RAT

Protein

Melatonin receptor type 1A

Gene

Mtnr1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

    GO - Molecular functioni

    1. melatonin receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Melatonin receptor type 1A
    Short name:
    Mel-1A-R
    Short name:
    Mel1a receptor
    Gene namesi
    Name:Mtnr1a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620797. Mtnr1a.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›156›156Melatonin receptor type 1APRO_0000069866Add
    BLAST

    Proteomic databases

    PRIDEiP49218.

    Expressioni

    Tissue specificityi

    At least in the brain, more precisely in the pars tuberalis and the suprachiasmatic nucleus.

    Gene expression databases

    GenevestigatoriP49218.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliP49218.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei19 – 3921Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei62 – 8221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei115 – 13521Helical; Name=3Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG138016.
    InParanoidiP49218.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002278. Mel_1A_rcpt.
    IPR000025. Melatonin_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01149. MELATONIN1AR.
    PR00857. MELATONINR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P49218-1 [UniParc]FASTAAdd to Basket

    « Hide

    CYICHSLKYD RIYSNKNSLC YVFLIWTLTL IAIMPNLQTG TLQYDPRIYS    50
    CTFTQSVSSA YTIALVVFHF VVPMIIVTFC YLRIWILVLQ VRRRVKPDSK 100
    PKLKPQDFRN FVTMFVVFVL FALCWAPLNF IGLIVASDPA TMAPRIPEWL 150
    FVASYY 156
    Length:156
    Mass (Da):18,214
    Last modified:February 1, 1996 - v1
    Checksum:i2B55EA40FBC6BAB1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei156 – 1561

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14409 mRNA. Translation: AAA57191.1.
    PIRiI62107.
    UniGeneiRn.92357.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14409 mRNA. Translation: AAA57191.1 .
    PIRi I62107.
    UniGenei Rn.92357.

    3D structure databases

    ProteinModelPortali P49218.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P49218.
    GuidetoPHARMACOLOGYi 287.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi P49218.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 620797. Mtnr1a.

    Phylogenomic databases

    eggNOGi NOG138016.
    InParanoidi P49218.

    Miscellaneous databases

    PROi P49218.

    Gene expression databases

    Genevestigatori P49218.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002278. Mel_1A_rcpt.
    IPR000025. Melatonin_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01149. MELATONIN1AR.
    PR00857. MELATONINR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses."
      Reppert S.M., Weaver D.R., Ebisawa T.
      Neuron 13:1177-1185(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Hypothalamus and Pituitary.

    Entry informationi

    Entry nameiMTR1A_RAT
    AccessioniPrimary (citable) accession number: P49218
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3