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Protein

Melatonin receptor type 1A

Gene

Mtnr1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

GO - Molecular functioni

  1. melatonin receptor activity Source: InterPro

GO - Biological processi

  1. aging Source: RGD
  2. camera-type eye development Source: RGD
  3. circadian rhythm Source: RGD
  4. negative regulation of insulin secretion Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Melatonin receptor type 1A
Short name:
Mel-1A-R
Short name:
Mel1a receptor
Gene namesi
Name:Mtnr1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620797. Mtnr1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei62 – 8221Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei115 – 13521Helical; Name=3Sequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. neuronal cell body Source: RGD
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›156›156Melatonin receptor type 1APRO_0000069866Add
BLAST

Proteomic databases

PRIDEiP49218.

Expressioni

Tissue specificityi

At least in the brain, more precisely in the pars tuberalis and the suprachiasmatic nucleus.

Gene expression databases

GenevestigatoriP49218.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP49218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG138016.
InParanoidiP49218.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002278. Mel_1A_rcpt.
IPR000025. Melatonin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01149. MELATONIN1AR.
PR00857. MELATONINR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P49218-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
CYICHSLKYD RIYSNKNSLC YVFLIWTLTL IAIMPNLQTG TLQYDPRIYS
60 70 80 90 100
CTFTQSVSSA YTIALVVFHF VVPMIIVTFC YLRIWILVLQ VRRRVKPDSK
110 120 130 140 150
PKLKPQDFRN FVTMFVVFVL FALCWAPLNF IGLIVASDPA TMAPRIPEWL

FVASYY
Length:156
Mass (Da):18,214
Last modified:February 1, 1996 - v1
Checksum:i2B55EA40FBC6BAB1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei156 – 1561

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14409 mRNA. Translation: AAA57191.1.
PIRiI62107.
UniGeneiRn.92357.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14409 mRNA. Translation: AAA57191.1.
PIRiI62107.
UniGeneiRn.92357.

3D structure databases

ProteinModelPortaliP49218.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiP49218.
GuidetoPHARMACOLOGYi287.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiP49218.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi620797. Mtnr1a.

Phylogenomic databases

eggNOGiNOG138016.
InParanoidiP49218.

Miscellaneous databases

PROiP49218.

Gene expression databases

GenevestigatoriP49218.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002278. Mel_1A_rcpt.
IPR000025. Melatonin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01149. MELATONIN1AR.
PR00857. MELATONINR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses."
    Reppert S.M., Weaver D.R., Ebisawa T.
    Neuron 13:1177-1185(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Hypothalamus and Pituitary.

Entry informationi

Entry nameiMTR1A_RAT
AccessioniPrimary (citable) accession number: P49218
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 1, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.