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P49218

- MTR1A_RAT

UniProt

P49218 - MTR1A_RAT

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Protein

Melatonin receptor type 1A

Gene
Mtnr1a
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

GO - Molecular functioni

  1. melatonin receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Melatonin receptor type 1A
Short name:
Mel-1A-R
Short name:
Mel1a receptor
Gene namesi
Name:Mtnr1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620797. Mtnr1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921Helical; Name=1; Reviewed predictionAdd
BLAST
Transmembranei62 – 8221Helical; Name=2; Reviewed predictionAdd
BLAST
Transmembranei115 – 13521Helical; Name=3; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›156›156Melatonin receptor type 1APRO_0000069866Add
BLAST

Proteomic databases

PRIDEiP49218.

Expressioni

Tissue specificityi

At least in the brain, more precisely in the pars tuberalis and the suprachiasmatic nucleus.

Gene expression databases

GenevestigatoriP49218.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP49218.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG138016.
InParanoidiP49218.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002278. Mel_1A_rcpt.
IPR000025. Melatonin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01149. MELATONIN1AR.
PR00857. MELATONINR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P49218-1 [UniParc]FASTAAdd to Basket

« Hide

CYICHSLKYD RIYSNKNSLC YVFLIWTLTL IAIMPNLQTG TLQYDPRIYS    50
CTFTQSVSSA YTIALVVFHF VVPMIIVTFC YLRIWILVLQ VRRRVKPDSK 100
PKLKPQDFRN FVTMFVVFVL FALCWAPLNF IGLIVASDPA TMAPRIPEWL 150
FVASYY 156
Length:156
Mass (Da):18,214
Last modified:February 1, 1996 - v1
Checksum:i2B55EA40FBC6BAB1
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei156 – 1561

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14409 mRNA. Translation: AAA57191.1.
PIRiI62107.
UniGeneiRn.92357.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14409 mRNA. Translation: AAA57191.1 .
PIRi I62107.
UniGenei Rn.92357.

3D structure databases

ProteinModelPortali P49218.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P49218.
GuidetoPHARMACOLOGYi 287.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi P49218.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 620797. Mtnr1a.

Phylogenomic databases

eggNOGi NOG138016.
InParanoidi P49218.

Miscellaneous databases

PROi P49218.

Gene expression databases

Genevestigatori P49218.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002278. Mel_1A_rcpt.
IPR000025. Melatonin_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01149. MELATONIN1AR.
PR00857. MELATONINR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses."
    Reppert S.M., Weaver D.R., Ebisawa T.
    Neuron 13:1177-1185(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Hypothalamus and Pituitary.

Entry informationi

Entry nameiMTR1A_RAT
AccessioniPrimary (citable) accession number: P49218
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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