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Protein

Melatonin receptor type 1A

Gene

Mtnr1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

GO - Molecular functioni

GO - Biological processi

  • aging Source: RGD
  • camera-type eye development Source: RGD
  • circadian rhythm Source: RGD
  • negative regulation of insulin secretion Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Melatonin receptor type 1A
Short name:
Mel-1A-R
Short name:
Mel1a receptor
Gene namesi
Name:Mtnr1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620797 Mtnr1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei62 – 82Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei115 – 135Helical; Name=3Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000069866‹1 – ›156Melatonin receptor type 1AAdd BLAST›156

Proteomic databases

PaxDbiP49218
PRIDEiP49218

Expressioni

Tissue specificityi

At least in the brain, more precisely in the pars tuberalis and the suprachiasmatic nucleus.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034328

Chemistry databases

BindingDBiP49218

Structurei

3D structure databases

ProteinModelPortaliP49218
SMRiP49218
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHFY Eukaryota
ENOG4111ZZV LUCA
InParanoidiP49218

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002278 Mel_1A/1B_rcpt
IPR027459 Mel_rcpt_1
IPR000025 Melatonin_rcpt
PANTHERiPTHR43962 PTHR43962, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01149 MELATONIN1AR
PR00857 MELATONINR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Fragment.

P49218-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
CYICHSLKYD RIYSNKNSLC YVFLIWTLTL IAIMPNLQTG TLQYDPRIYS
60 70 80 90 100
CTFTQSVSSA YTIALVVFHF VVPMIIVTFC YLRIWILVLQ VRRRVKPDSK
110 120 130 140 150
PKLKPQDFRN FVTMFVVFVL FALCWAPLNF IGLIVASDPA TMAPRIPEWL

FVASYY
Length:156
Mass (Da):18,214
Last modified:February 1, 1996 - v1
Checksum:i2B55EA40FBC6BAB1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1561

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14409 mRNA Translation: AAA57191.1
PIRiI62107
UniGeneiRn.92357

Similar proteinsi

Entry informationi

Entry nameiMTR1A_RAT
AccessioniPrimary (citable) accession number: P49218
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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