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P49218 (MTR1A_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Melatonin receptor type 1A

Short name=Mel-1A-R
Short name=Mel1a receptor
Gene names
Name:Mtnr1a
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length156 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

At least in the brain, more precisely in the pars tuberalis and the suprachiasmatic nucleus.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›156›156Melatonin receptor type 1A
PRO_0000069866

Regions

Transmembrane19 – 3921Helical; Name=1; Potential
Transmembrane62 – 8221Helical; Name=2; Potential
Transmembrane115 – 13521Helical; Name=3; Potential

Experimental info

Non-terminal residue11
Non-terminal residue1561

Sequences

Sequence LengthMass (Da)Tools
P49218 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 2B55EA40FBC6BAB1

FASTA15618,214
        10         20         30         40         50         60 
CYICHSLKYD RIYSNKNSLC YVFLIWTLTL IAIMPNLQTG TLQYDPRIYS CTFTQSVSSA 

        70         80         90        100        110        120 
YTIALVVFHF VVPMIIVTFC YLRIWILVLQ VRRRVKPDSK PKLKPQDFRN FVTMFVVFVL 

       130        140        150 
FALCWAPLNF IGLIVASDPA TMAPRIPEWL FVASYY 

« Hide

References

[1]"Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses."
Reppert S.M., Weaver D.R., Ebisawa T.
Neuron 13:1177-1185(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Hypothalamus and Pituitary.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U14409 mRNA. Translation: AAA57191.1.
PIRI62107.
UniGeneRn.92357.

3D structure databases

ProteinModelPortalP49218.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP49218.
GuidetoPHARMACOLOGY287.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEP49218.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

RGD620797. Mtnr1a.

Phylogenomic databases

eggNOGNOG138016.
InParanoidP49218.

Gene expression databases

GenevestigatorP49218.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002278. Mel_1A_rcpt.
IPR000025. Melatonin_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01149. MELATONIN1AR.
PR00857. MELATONINR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP49218.

Entry information

Entry nameMTR1A_RAT
AccessionPrimary (citable) accession number: P49218
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries