P49218 (MTR1A_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Melatonin receptor type 1A
Short name=Mel-1A-R
Short name=Mel1a receptor

Gene names

Name:

Mtnr1a

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	156 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	At least in the brain, more precisely in the pars tuberalis and the suprachiasmatic nucleus.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	melatonin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›156	›156	Melatonin receptor type 1A		PRO_0000069866
Regions
	Transmembrane	19 – 39	21	Helical; Name=1; Potential
	Transmembrane	62 – 82	21	Helical; Name=2; Potential
	Transmembrane	115 – 135	21	Helical; Name=3; Potential
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	156	1

Sequences

	Sequence		Length	Mass (Da)
	P49218 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 2B55EA40FBC6BAB1	FASTA	156	18,214
	10 20 30 40 50 60 CYICHSLKYD RIYSNKNSLC YVFLIWTLTL IAIMPNLQTG TLQYDPRIYS CTFTQSVSSA 70 80 90 100 110 120 YTIALVVFHF VVPMIIVTFC YLRIWILVLQ VRRRVKPDSK PKLKPQDFRN FVTMFVVFVL 130 140 150 FALCWAPLNF IGLIVASDPA TMAPRIPEWL FVASYY

References

[1]	"Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses." Reppert S.M., Weaver D.R., Ebisawa T. Neuron 13:1177-1185(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Hypothalamus and Pituitary.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U14409 mRNA. Translation: AAA57191.1.
IPI	IPI00192571.
PIR	I62107.
UniGene	Rn.92357.
3D structure databases
ProteinModelPortal	P49218.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	P49218.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
RGD	620797. Mtnr1a.
Phylogenomic databases
eggNOG	NOG138016.
InParanoid	P49218.
OrthoDB	EOG4K3KWV.
Gene expression databases
ArrayExpress	P49218.
Genevestigator	P49218.
GermOnline	ENSRNOG00000028744. Rattus norvegicus.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR002278. Mel_1A_rcpt. IPR000025. Melatonin_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01149. MELATONIN1AR. PR00857. MELATONINR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. Partial match. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P49218.

Entry information

Entry name

MTR1A_RAT

Accession

Primary (citable) accession number: P49218

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program