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P49207 (RL34_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
60S ribosomal protein L34
Gene names
Name:RPL34
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length117 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the ribosomal protein L34e family.

Ontologies

Keywords
   Molecular functionRibonucleoprotein
Ribosomal protein
   PTMAcetylation
Phosphoprotein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processRNA metabolic process

Traceable author statement. Source: Reactome

SRP-dependent cotranslational protein targeting to membrane

Traceable author statement. Source: Reactome

cellular protein metabolic process

Traceable author statement. Source: Reactome

gene expression

Traceable author statement. Source: Reactome

mRNA metabolic process

Traceable author statement. Source: Reactome

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Traceable author statement. Source: Reactome

translation

Non-traceable author statement Ref.6. Source: UniProtKB

translational elongation

Traceable author statement. Source: Reactome

translational initiation

Traceable author statement. Source: Reactome

translational termination

Traceable author statement. Source: Reactome

viral life cycle

Traceable author statement. Source: Reactome

viral process

Traceable author statement. Source: Reactome

viral transcription

Traceable author statement. Source: Reactome

   Cellular_componentcytoplasm

Inferred from direct assay. Source: HPA

cytosol

Traceable author statement. Source: Reactome

cytosolic large ribosomal subunit

Inferred from direct assay Ref.6. Source: UniProtKB

extracellular vesicular exosome

Inferred from direct assay PubMed 20458337. Source: UniProt

nucleolus

Inferred from direct assay. Source: HPA

   Molecular_functionRNA binding

Traceable author statement Ref.1. Source: ProtInc

structural constituent of ribosome

Non-traceable author statement Ref.6. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.6
Chain2 – 11711660S ribosomal protein L34
PRO_0000131831

Amino acid modifications

Modified residue121Phosphoserine Ref.10 Ref.12
Modified residue361N6-acetyllysine Ref.9
Modified residue431N6-acetyllysine By similarity

Experimental info

Sequence conflict521R → K in AAC41916. Ref.1
Sequence conflict581A → P in AAC41916. Ref.1
Sequence conflict1031V → I in AAC41916. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P49207 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: FC09D00B98CB770C

FASTA11713,293
        10         20         30         40         50         60 
MVQRLTYRRR LSYNTASNKT RLSRTPGNRI VYLYTKKVGK APKSACGVCP GRLRGVRAVR 

        70         80         90        100        110 
PKVLMRLSKT KKHVSRAYGG SMCAKCVRDR IKRAFLIEEQ KIVVKVLKAQ AQSQKAK 

« Hide

References

« Hide 'large scale' references
[1]"Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21."
Rommens J.M., Durocher F., McArthur J., Tonin P., Leblanc J.-F., Allen T., Samson C., Ferri L., Narod S., Morgan K., Simard J.
Genomics 28:530-542(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.
[2]"The human ribosomal protein genes: sequencing and comparative analysis of 73 genes."
Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N.
Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone and Eye.
[5]"A map of 75 human ribosomal protein genes."
Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C.
Genome Res. 8:509-523(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4-48.
[6]"Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing."
Odintsova T.I., Muller E.C., Ivanov A.V., Egorov T.A., Bienert R., Vladimirov S.N., Kostka S., Otto A., Wittmann-Liebold B., Karpova G.G.
J. Protein Chem. 22:249-258(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-12, IDENTIFICATION BY MASS SPECTROMETRY.
[7]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-36, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"Structures of the human and Drosophila 80S ribosome."
Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M., Wilson D.N., Beckmann R.
Nature 497:80-85(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L38941 mRNA. Translation: AAC41916.1.
AB061832 Genomic DNA. Translation: BAB79470.1.
CR542232 mRNA. Translation: CAG47028.1.
CR542242 mRNA. Translation: CAG47038.1.
BC001773 mRNA. Translation: AAH01773.1.
BC070208 mRNA. Translation: AAH70208.1.
BC106009 mRNA. Translation: AAI06010.1.
AB007181 Genomic DNA. Translation: BAA25840.1.
PIRI68524.
RefSeqNP_000986.2. NM_000995.3.
NP_296374.1. NM_033625.2.
XP_005263229.1. XM_005263172.2.
UniGeneHs.438227.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3J3Belectron microscopy5.00g1-117[»]
ProteinModelPortalP49207.
SMRP49207. Positions 2-115.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112083. 23 interactions.
IntActP49207. 6 interactions.
MINTMINT-3017141.
STRING9606.ENSP00000378160.

PTM databases

PhosphoSiteP49207.

Proteomic databases

PaxDbP49207.
PeptideAtlasP49207.
PRIDEP49207.

Protocols and materials databases

DNASU6164.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000394665; ENSP00000378160; ENSG00000109475.
ENST00000394667; ENSP00000378162; ENSG00000109475.
ENST00000394668; ENSP00000378163; ENSG00000109475.
ENST00000502534; ENSP00000423983; ENSG00000109475.
ENST00000506397; ENSP00000423316; ENSG00000109475.
GeneID6164.
KEGGhsa:6164.
UCSCuc003hyz.3. human.

Organism-specific databases

CTD6164.
GeneCardsGC04P109541.
H-InvDBHIX0004432.
HGNCHGNC:10340. RPL34.
HPAHPA035139.
neXtProtNX_P49207.
PharmGKBPA34723.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2174.
HOGENOMHOG000216922.
HOVERGENHBG024280.
InParanoidP49207.
KOK02915.
OMARCGDCVK.
OrthoDBEOG7QC7Z7.
PhylomeDBP49207.
TreeFamTF314326.

Enzyme and pathway databases

ReactomeREACT_116125. Disease.
REACT_17015. Metabolism of proteins.
REACT_1762. 3' -UTR-mediated translational regulation.
REACT_21257. Metabolism of RNA.
REACT_71. Gene Expression.

Gene expression databases

BgeeP49207.
CleanExHS_RPL34.
GenevestigatorP49207.

Family and domain databases

InterProIPR008195. Ribosomal_L34Ae.
IPR018065. Ribosomal_L34e_CS.
[Graphical view]
PANTHERPTHR10759. PTHR10759. 1 hit.
PfamPF01199. Ribosomal_L34e. 1 hit.
[Graphical view]
PRINTSPR01250. RIBOSOMALL34.
PROSITEPS01145. RIBOSOMAL_L34E. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRPL34. human.
GeneWikiRPL34.
GenomeRNAi6164.
NextBio23943.
PROP49207.

Entry information

Entry nameRL34_HUMAN
AccessionPrimary (citable) accession number: P49207
Secondary accession number(s): Q6FG66, Q9BUZ2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM