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Protein

60S ribosomal protein L34

Gene

RPL34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • RNA binding Source: ProtInc
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000109475-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L34
Gene namesi
Name:RPL34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:10340. RPL34.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • cytosolic large ribosomal subunit Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • mitochondrion Source: Ensembl
  • nucleolus Source: HPA
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi6164.
OpenTargetsiENSG00000109475.
PharmGKBiPA34723.

Polymorphism and mutation databases

BioMutaiRPL34.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001318312 – 11760S ribosomal protein L34Add BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineCombined sources1
Modified residuei36N6-acetyllysineCombined sources1
Modified residuei43N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP49207.
MaxQBiP49207.
PaxDbiP49207.
PeptideAtlasiP49207.
PRIDEiP49207.
TopDownProteomicsiP49207.

PTM databases

iPTMnetiP49207.
PhosphoSitePlusiP49207.
SwissPalmiP49207.

Expressioni

Gene expression databases

BgeeiENSG00000109475.
CleanExiHS_RPL34.
ExpressionAtlasiP49207. baseline and differential.
GenevisibleiP49207. HS.

Organism-specific databases

HPAiHPA035139.

Interactioni

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi112083. 87 interactors.
IntActiP49207. 10 interactors.
MINTiMINT-3017141.
STRINGi9606.ENSP00000378160.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Lg1-117[»]
4V6Xelectron microscopy5.00Cg1-117[»]
5AJ0electron microscopy3.50Ag1-117[»]
ProteinModelPortaliP49207.
SMRiP49207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L34e family.Curated

Phylogenomic databases

eggNOGiKOG1790. Eukaryota.
COG2174. LUCA.
GeneTreeiENSGT00390000008294.
HOGENOMiHOG000216922.
HOVERGENiHBG024280.
InParanoidiP49207.
KOiK02915.
OMAiRCGDCVK.
OrthoDBiEOG091G0WY7.
PhylomeDBiP49207.
TreeFamiTF314326.

Family and domain databases

InterProiIPR008195. Ribosomal_L34Ae.
IPR018065. Ribosomal_L34e_CS.
[Graphical view]
PANTHERiPTHR10759. PTHR10759. 1 hit.
PfamiPF01199. Ribosomal_L34e. 1 hit.
[Graphical view]
PRINTSiPR01250. RIBOSOMALL34.
PROSITEiPS01145. RIBOSOMAL_L34E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQRLTYRRR LSYNTASNKT RLSRTPGNRI VYLYTKKVGK APKSACGVCP
60 70 80 90 100
GRLRGVRAVR PKVLMRLSKT KKHVSRAYGG SMCAKCVRDR IKRAFLIEEQ
110
KIVVKVLKAQ AQSQKAK
Length:117
Mass (Da):13,293
Last modified:January 23, 2007 - v3
Checksum:iFC09D00B98CB770C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52R → K in AAC41916 (PubMed:7490091).Curated1
Sequence conflicti58A → P in AAC41916 (PubMed:7490091).Curated1
Sequence conflicti103V → I in AAC41916 (PubMed:7490091).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38941 mRNA. Translation: AAC41916.1.
AB061832 Genomic DNA. Translation: BAB79470.1.
CR542232 mRNA. Translation: CAG47028.1.
CR542242 mRNA. Translation: CAG47038.1.
BC001773 mRNA. Translation: AAH01773.1.
BC070208 mRNA. Translation: AAH70208.1.
BC106009 mRNA. Translation: AAI06010.1.
AB007181 Genomic DNA. Translation: BAA25840.1.
CCDSiCCDS3680.1.
PIRiI68524.
RefSeqiNP_000986.2. NM_000995.4.
NP_001306161.1. NM_001319232.1.
NP_001306163.1. NM_001319234.1.
NP_001306164.1. NM_001319235.1.
NP_001306165.1. NM_001319236.1.
NP_296374.1. NM_033625.3.
UniGeneiHs.438227.

Genome annotation databases

EnsembliENST00000394665; ENSP00000378160; ENSG00000109475.
ENST00000394667; ENSP00000378162; ENSG00000109475.
ENST00000394668; ENSP00000378163; ENSG00000109475.
ENST00000502534; ENSP00000423983; ENSG00000109475.
ENST00000506397; ENSP00000423316; ENSG00000109475.
GeneIDi6164.
KEGGihsa:6164.
UCSCiuc003hza.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38941 mRNA. Translation: AAC41916.1.
AB061832 Genomic DNA. Translation: BAB79470.1.
CR542232 mRNA. Translation: CAG47028.1.
CR542242 mRNA. Translation: CAG47038.1.
BC001773 mRNA. Translation: AAH01773.1.
BC070208 mRNA. Translation: AAH70208.1.
BC106009 mRNA. Translation: AAI06010.1.
AB007181 Genomic DNA. Translation: BAA25840.1.
CCDSiCCDS3680.1.
PIRiI68524.
RefSeqiNP_000986.2. NM_000995.4.
NP_001306161.1. NM_001319232.1.
NP_001306163.1. NM_001319234.1.
NP_001306164.1. NM_001319235.1.
NP_001306165.1. NM_001319236.1.
NP_296374.1. NM_033625.3.
UniGeneiHs.438227.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Lg1-117[»]
4V6Xelectron microscopy5.00Cg1-117[»]
5AJ0electron microscopy3.50Ag1-117[»]
ProteinModelPortaliP49207.
SMRiP49207.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112083. 87 interactors.
IntActiP49207. 10 interactors.
MINTiMINT-3017141.
STRINGi9606.ENSP00000378160.

PTM databases

iPTMnetiP49207.
PhosphoSitePlusiP49207.
SwissPalmiP49207.

Polymorphism and mutation databases

BioMutaiRPL34.

Proteomic databases

EPDiP49207.
MaxQBiP49207.
PaxDbiP49207.
PeptideAtlasiP49207.
PRIDEiP49207.
TopDownProteomicsiP49207.

Protocols and materials databases

DNASUi6164.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394665; ENSP00000378160; ENSG00000109475.
ENST00000394667; ENSP00000378162; ENSG00000109475.
ENST00000394668; ENSP00000378163; ENSG00000109475.
ENST00000502534; ENSP00000423983; ENSG00000109475.
ENST00000506397; ENSP00000423316; ENSG00000109475.
GeneIDi6164.
KEGGihsa:6164.
UCSCiuc003hza.4. human.

Organism-specific databases

CTDi6164.
DisGeNETi6164.
GeneCardsiRPL34.
H-InvDBHIX0004432.
HGNCiHGNC:10340. RPL34.
HPAiHPA035139.
MIMi616862. gene.
neXtProtiNX_P49207.
OpenTargetsiENSG00000109475.
PharmGKBiPA34723.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1790. Eukaryota.
COG2174. LUCA.
GeneTreeiENSGT00390000008294.
HOGENOMiHOG000216922.
HOVERGENiHBG024280.
InParanoidiP49207.
KOiK02915.
OMAiRCGDCVK.
OrthoDBiEOG091G0WY7.
PhylomeDBiP49207.
TreeFamiTF314326.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000109475-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPL34. human.
GeneWikiiRPL34.
GenomeRNAii6164.
PROiP49207.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109475.
CleanExiHS_RPL34.
ExpressionAtlasiP49207. baseline and differential.
GenevisibleiP49207. HS.

Family and domain databases

InterProiIPR008195. Ribosomal_L34Ae.
IPR018065. Ribosomal_L34e_CS.
[Graphical view]
PANTHERiPTHR10759. PTHR10759. 1 hit.
PfamiPF01199. Ribosomal_L34e. 1 hit.
[Graphical view]
PRINTSiPR01250. RIBOSOMALL34.
PROSITEiPS01145. RIBOSOMAL_L34E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL34_HUMAN
AccessioniPrimary (citable) accession number: P49207
Secondary accession number(s): Q6FG66, Q9BUZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 150 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.