Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P49192

- CART_RAT

UniProt

P49192 - CART_RAT

Protein

Cocaine- and amphetamine-regulated transcript protein

Gene

Cartpt

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus.By similarity

    GO - Molecular functioni

    1. protein binding Source: RGD

    GO - Biological processi

    1. activation of MAPKK activity Source: HGNC
    2. adult feeding behavior Source: HGNC
    3. cellular glucose homeostasis Source: HGNC
    4. cellular response to starvation Source: HGNC
    5. circadian regulation of gene expression Source: HGNC
    6. gastric acid secretion Source: RGD
    7. G-protein coupled receptor signaling pathway Source: HGNC
    8. negative regulation of appetite Source: HGNC
    9. negative regulation of bone resorption Source: Ensembl
    10. negative regulation of glucagon secretion Source: RGD
    11. neuropeptide signaling pathway Source: UniProtKB-KW
    12. positive regulation of blood pressure Source: HGNC
    13. positive regulation of epinephrine secretion Source: HGNC
    14. positive regulation of transmission of nerve impulse Source: HGNC
    15. regulation of insulin secretion Source: RGD
    16. somatostatin secretion Source: RGD
    17. synaptic transmission Source: UniProtKB-KW

    Keywords - Molecular functioni

    Neuropeptide, Neurotransmitter

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cocaine- and amphetamine-regulated transcript protein
    Cleaved into the following 3 chains:
    Gene namesi
    Name:Cartpt
    Synonyms:Cart
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi2272. Cartpt.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular space Source: HGNC
    2. secretory granule Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 129102Cocaine- and amphetamine-regulated transcript proteinPRO_0000004442Add
    BLAST
    Peptidei28 – 7952CART(1-52)PRO_0000004443Add
    BLAST
    Peptidei82 – 12948CART(55-102)PRO_0000004444Add
    BLAST
    Peptidei89 – 12941CART(62-102)Sequence AnalysisPRO_0000004445Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi95 ↔ 1131 Publication
    Disulfide bondi101 ↔ 1211 Publication
    Disulfide bondi115 ↔ 1281 Publication

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PRIDEiP49192.

    PTM databases

    PhosphoSiteiP49192.

    Expressioni

    Tissue specificityi

    Neuroendocrine tissues. Predominantly expressed in the hypothalamus, pituitary, and longitudinal muscle-myenteric plexus. Abundant expression is also seen in the midbrain/thalamus and eye. A lower level expression is seen in the other brain regions and adrenal.

    Inductioni

    By cocaine and amphetamine.

    Gene expression databases

    ArrayExpressiP49192.
    GenevestigatoriP49192.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000023869.

    Structurei

    3D structure databases

    ProteinModelPortaliP49192.
    SMRiP49192. Positions 89-129.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CART family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47455.
    GeneTreeiENSGT00390000018319.
    HOGENOMiHOG000111306.
    HOVERGENiHBG018929.
    InParanoidiP49192.
    OMAiSHEKELP.
    OrthoDBiEOG7JDR0T.
    PhylomeDBiP49192.
    TreeFamiTF332948.

    Family and domain databases

    Gene3Di4.10.40.30. 1 hit.
    InterProiIPR009106. CART.
    [Graphical view]
    PANTHERiPTHR16655. PTHR16655. 1 hit.
    PfamiPF06373. CART. 1 hit.
    [Graphical view]
    SUPFAMiSSF64546. SSF64546. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: P49192-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESSRLRLLP VLGAALLLLL PLLGAGAQED AELQPRALDI YSAVDDASHE    50
    KELPRRQLRA PGAVLQIEAL QEVLKKLKSK RIPIYEKKYG QVPMCDAGEQ 100
    CAVRKGARIG KLCDCPRGTS CNSFLLKCL 129
    Length:129
    Mass (Da):14,140
    Last modified:February 1, 1996 - v1
    Checksum:i0FDE28B705BB2728
    GO
    Isoform Short (identifier: P49192-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         54-66: Missing.

    Show »
    Length:116
    Mass (Da):12,696
    Checksum:i5545F930A182BD61
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei54 – 6613Missing in isoform Short. 1 PublicationVSP_000794Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10071 mRNA. Translation: AAA87897.1.
    RefSeqiNP_058806.1. NM_017110.1. [P49192-1]
    XP_006231905.1. XM_006231843.1. [P49192-2]
    UniGeneiRn.89164.

    Genome annotation databases

    EnsembliENSRNOT00000023869; ENSRNOP00000023869; ENSRNOG00000017712. [P49192-1]
    GeneIDi29131.
    KEGGirno:29131.
    UCSCiRGD:2272. rat. [P49192-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10071 mRNA. Translation: AAA87897.1 .
    RefSeqi NP_058806.1. NM_017110.1. [P49192-1 ]
    XP_006231905.1. XM_006231843.1. [P49192-2 ]
    UniGenei Rn.89164.

    3D structure databases

    ProteinModelPortali P49192.
    SMRi P49192. Positions 89-129.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000023869.

    PTM databases

    PhosphoSitei P49192.

    Proteomic databases

    PRIDEi P49192.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000023869 ; ENSRNOP00000023869 ; ENSRNOG00000017712 . [P49192-1 ]
    GeneIDi 29131.
    KEGGi rno:29131.
    UCSCi RGD:2272. rat. [P49192-1 ]

    Organism-specific databases

    CTDi 9607.
    RGDi 2272. Cartpt.

    Phylogenomic databases

    eggNOGi NOG47455.
    GeneTreei ENSGT00390000018319.
    HOGENOMi HOG000111306.
    HOVERGENi HBG018929.
    InParanoidi P49192.
    OMAi SHEKELP.
    OrthoDBi EOG7JDR0T.
    PhylomeDBi P49192.
    TreeFami TF332948.

    Miscellaneous databases

    NextBioi 608079.
    PROi P49192.

    Gene expression databases

    ArrayExpressi P49192.
    Genevestigatori P49192.

    Family and domain databases

    Gene3Di 4.10.40.30. 1 hit.
    InterProi IPR009106. CART.
    [Graphical view ]
    PANTHERi PTHR16655. PTHR16655. 1 hit.
    Pfami PF06373. CART. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64546. SSF64546. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine."
      Douglass J.O., McKinzie A.A., Couceyro P.
      J. Neurosci. 15:2471-2481(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. "Purification and characterisation of a new hypothalamic satiety peptide, cocaine and amphetamine regulated transcript (CART), produced in yeast."
      Thim L., Nielsen P.F., Judge M.E., Andersen A.S., Diers I., Egel-Mitani M., Hastrup S.
      FEBS Lett. 428:263-268(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 81-97, IDENTIFICATION BY MASS SPECTROMETRY, DISULFIDE BONDS.

    Entry informationi

    Entry nameiCART_RAT
    AccessioniPrimary (citable) accession number: P49192
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3