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Protein

Cocaine- and amphetamine-regulated transcript protein

Gene

Cartpt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus.By similarity

GO - Molecular functioni

GO - Biological processi

  • activation of MAPKK activity Source: HGNC
  • adult feeding behavior Source: HGNC
  • cellular glucose homeostasis Source: HGNC
  • cellular response to starvation Source: HGNC
  • chemical synaptic transmission Source: UniProtKB-KW
  • circadian regulation of gene expression Source: HGNC
  • gastric acid secretion Source: RGD
  • G-protein coupled receptor signaling pathway Source: HGNC
  • negative regulation of appetite Source: HGNC
  • negative regulation of bone resorption Source: Ensembl
  • negative regulation of glucagon secretion Source: RGD
  • neuropeptide signaling pathway Source: GO_Central
  • positive regulation of blood pressure Source: HGNC
  • positive regulation of epinephrine secretion Source: HGNC
  • positive regulation of transmission of nerve impulse Source: HGNC
  • regulation of insulin secretion Source: RGD
  • somatostatin secretion Source: RGD

Keywordsi

Molecular functionNeuropeptide, Neurotransmitter

Names & Taxonomyi

Protein namesi
Recommended name:
Cocaine- and amphetamine-regulated transcript protein
Cleaved into the following 3 chains:
Gene namesi
Name:Cartpt
Synonyms:Cart
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2272 Cartpt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000000444228 – 129Cocaine- and amphetamine-regulated transcript proteinAdd BLAST102
PeptideiPRO_000000444328 – 79CART(1-52)Add BLAST52
PeptideiPRO_000000444482 – 129CART(55-102)Add BLAST48
PeptideiPRO_000000444589 – 129CART(62-102)Sequence analysisAdd BLAST41

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphotyrosineCombined sources1
Modified residuei48PhosphoserineCombined sources1
Disulfide bondi95 ↔ 1131 Publication
Disulfide bondi101 ↔ 1211 Publication
Disulfide bondi115 ↔ 1281 Publication
Isoform Short (identifier: P49192-2)
Modified residuei48PhosphoserineCombined sources1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP49192
PRIDEiP49192

PTM databases

iPTMnetiP49192
PhosphoSitePlusiP49192

Expressioni

Tissue specificityi

Neuroendocrine tissues. Predominantly expressed in the hypothalamus, pituitary, and longitudinal muscle-myenteric plexus. Abundant expression is also seen in the midbrain/thalamus and eye. A lower level expression is seen in the other brain regions and adrenal.

Inductioni

By cocaine and amphetamine.

Gene expression databases

BgeeiENSRNOG00000017712
GenevisibleiP49192 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023869

Structurei

3D structure databases

ProteinModelPortaliP49192
SMRiP49192
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CART family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0KJ Eukaryota
ENOG410YRI1 LUCA
GeneTreeiENSGT00390000018319
HOGENOMiHOG000111306
HOVERGENiHBG018929
InParanoidiP49192
OMAiFGQVPTC
OrthoDBiEOG091G0Y1C
PhylomeDBiP49192
TreeFamiTF332948

Family and domain databases

Gene3Di4.10.40.30, 1 hit
InterProiView protein in InterPro
IPR009106 CART
IPR036722 CART_C_sf
PANTHERiPTHR16655 PTHR16655, 1 hit
PfamiView protein in Pfam
PF06373 CART, 1 hit
SUPFAMiSSF64546 SSF64546, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P49192-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESSRLRLLP VLGAALLLLL PLLGAGAQED AELQPRALDI YSAVDDASHE
60 70 80 90 100
KELPRRQLRA PGAVLQIEAL QEVLKKLKSK RIPIYEKKYG QVPMCDAGEQ
110 120
CAVRKGARIG KLCDCPRGTS CNSFLLKCL
Length:129
Mass (Da):14,140
Last modified:February 1, 1996 - v1
Checksum:i0FDE28B705BB2728
GO
Isoform Short (identifier: P49192-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-66: Missing.

Show »
Length:116
Mass (Da):12,696
Checksum:i5545F930A182BD61
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00079454 – 66Missing in isoform Short. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10071 mRNA Translation: AAA87897.1
RefSeqiNP_058806.1, NM_017110.1 [P49192-1]
XP_006231905.1, XM_006231843.3 [P49192-2]
UniGeneiRn.89164

Genome annotation databases

EnsembliENSRNOT00000023869; ENSRNOP00000023869; ENSRNOG00000017712 [P49192-1]
GeneIDi29131
KEGGirno:29131
UCSCiRGD:2272 rat [P49192-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCART_RAT
AccessioniPrimary (citable) accession number: P49192
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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